JP2010513901A5 - - Google Patents

Info

Publication number

JP2010513901A5

JP2010513901A5 JP2009542216A JP2009542216A JP2010513901A5 JP 2010513901 A5 JP2010513901 A5 JP 2010513901A5 JP 2009542216 A JP2009542216 A JP 2009542216A JP 2009542216 A JP2009542216 A JP 2009542216A JP 2010513901 A5 JP2010513901 A5 JP 2010513901A5

Authority

JP

Japan

Prior art keywords

peptide

seq

fragment

hox

homeodomain

Prior art date

2007-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 37
• 238000000034 method Methods 0.000 claims 32
• 239000012634 fragment Substances 0.000 claims 26
• 101100285412 Gallus gallus EN2 gene Proteins 0.000 claims 16
• 108010048671 Homeodomain Proteins Proteins 0.000 claims 10
• 102000009331 Homeodomain Proteins Human genes 0.000 claims 10
• 102000040945 Transcription factor Human genes 0.000 claims 10
• 108091023040 Transcription factor Proteins 0.000 claims 10
• 210000001124 body fluid Anatomy 0.000 claims 8
• 239000010839 body fluid Substances 0.000 claims 8
• 238000001514 detection method Methods 0.000 claims 8
• 239000000523 sample Substances 0.000 claims 8
• 206010060862 Prostate cancer Diseases 0.000 claims 7
• 238000011002 quantification Methods 0.000 claims 7
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims 6
• 206010028980 Neoplasm Diseases 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 102100029240 Homeobox protein Hox-B5 Human genes 0.000 claims 4
• 102100025056 Homeobox protein Hox-B6 Human genes 0.000 claims 4
• 102100020759 Homeobox protein Hox-C4 Human genes 0.000 claims 4
• 101000840553 Homo sapiens Homeobox protein Hox-B5 Proteins 0.000 claims 4
• 101001077542 Homo sapiens Homeobox protein Hox-B6 Proteins 0.000 claims 4
• 101001002994 Homo sapiens Homeobox protein Hox-C4 Proteins 0.000 claims 4
• 238000002965 ELISA Methods 0.000 claims 3
• 238000003018 immunoassay Methods 0.000 claims 3
• 239000003446 ligand Substances 0.000 claims 3
• 238000012360 testing method Methods 0.000 claims 3
• 230000001225 therapeutic effect Effects 0.000 claims 3
• 102100039541 Homeobox protein Hox-A3 Human genes 0.000 claims 2
• 102100034864 Homeobox protein Hox-D9 Human genes 0.000 claims 2
• 101000962622 Homo sapiens Homeobox protein Hox-A3 Proteins 0.000 claims 2
• 101001019766 Homo sapiens Homeobox protein Hox-D9 Proteins 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000012472 biological sample Substances 0.000 claims 2
• 239000000090 biomarker Substances 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 2
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims 2
• 229910052737 gold Inorganic materials 0.000 claims 2
• 239000010931 gold Substances 0.000 claims 2
• 238000004811 liquid chromatography Methods 0.000 claims 2
• 238000012544 monitoring process Methods 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 102100031680 Beta-catenin-interacting protein 1 Human genes 0.000 claims 1
• 102000004190 Enzymes Human genes 0.000 claims 1
• 108090000790 Enzymes Proteins 0.000 claims 1
• 101000993469 Homo sapiens Beta-catenin-interacting protein 1 Proteins 0.000 claims 1
• 238000005481 NMR spectroscopy Methods 0.000 claims 1
• 238000000692 Student's t-test Methods 0.000 claims 1
• 238000004458 analytical method Methods 0.000 claims 1
• 238000003556 assay Methods 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 238000004587 chromatography analysis Methods 0.000 claims 1
• 238000009509 drug development Methods 0.000 claims 1
• 238000007877 drug screening Methods 0.000 claims 1
• 238000011156 evaluation Methods 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• -1 for example Proteins 0.000 claims 1
• 238000001114 immunoprecipitation Methods 0.000 claims 1
• 239000004816 latex Substances 0.000 claims 1
• 229920000126 latex Polymers 0.000 claims 1
• 239000006249 magnetic particle Substances 0.000 claims 1
• 238000004949 mass spectrometry Methods 0.000 claims 1
• 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 claims 1
• 230000002250 progressing effect Effects 0.000 claims 1
• 238000003127 radioimmunoassay Methods 0.000 claims 1
• 210000003296 saliva Anatomy 0.000 claims 1
• 238000012216 screening Methods 0.000 claims 1
• 210000000582 semen Anatomy 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 229910052709 silver Inorganic materials 0.000 claims 1
• 239000004332 silver Substances 0.000 claims 1
• 230000006641 stabilisation Effects 0.000 claims 1
• 238000011105 stabilization Methods 0.000 claims 1
• 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims 1
• 238000012353 t test Methods 0.000 claims 1
• 238000004809 thin layer chromatography Methods 0.000 claims 1
• 238000011282 treatment Methods 0.000 claims 1
• 210000002700 urine Anatomy 0.000 claims 1
• 238000001262 western blot Methods 0.000 claims 1