JP2010512169A5 - - Google Patents
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- Publication number
- JP2010512169A5 JP2010512169A5 JP2009541546A JP2009541546A JP2010512169A5 JP 2010512169 A5 JP2010512169 A5 JP 2010512169A5 JP 2009541546 A JP2009541546 A JP 2009541546A JP 2009541546 A JP2009541546 A JP 2009541546A JP 2010512169 A5 JP2010512169 A5 JP 2010512169A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- seq
- solvent
- nucleoside
- coupling solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86958806P | 2006-12-12 | 2006-12-12 | |
| US60/869,588 | 2006-12-12 | ||
| PCT/US2007/087183 WO2008073960A2 (en) | 2006-12-12 | 2007-12-12 | Oligonucleotides containing high concentrations of guanine monomers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010512169A JP2010512169A (ja) | 2010-04-22 |
| JP2010512169A5 true JP2010512169A5 (https=) | 2011-03-24 |
| JP5389662B2 JP5389662B2 (ja) | 2014-01-15 |
Family
ID=39456527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009541546A Active JP5389662B2 (ja) | 2006-12-12 | 2007-12-12 | 高濃度のグアニン・モノマーを含有するオリゴヌクレオチド |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8586728B2 (https=) |
| EP (1) | EP2125854B1 (https=) |
| JP (1) | JP5389662B2 (https=) |
| CN (1) | CN101611048B (https=) |
| AU (1) | AU2007333147B2 (https=) |
| CA (1) | CA2671873C (https=) |
| WO (1) | WO2008073960A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008063490B4 (de) * | 2008-12-17 | 2023-06-15 | Merck Patent Gmbh | Organische Elektrolumineszenzvorrichtung und Verfahren zum Einstellen des Farbortes einer weiß emittierenden Elektrolumineszenzvorrichtung |
| WO2012059510A1 (en) | 2010-11-02 | 2012-05-10 | Girindus America, Inc. | Back pressure control during solid-phase synthesis on polymeric supports |
| US10040048B1 (en) | 2014-09-25 | 2018-08-07 | Synthego Corporation | Automated modular system and method for production of biopolymers |
| DK3240801T3 (da) | 2014-12-31 | 2021-02-08 | Checkmate Pharmaceuticals Inc | Kombinationstumorimmunterapi |
| WO2017005818A1 (en) * | 2015-07-08 | 2017-01-12 | Kuros Biosciences Ag | Guanine-rich oligonucleotides |
| JPWO2017111137A1 (ja) | 2015-12-22 | 2018-10-18 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| WO2017173334A1 (en) | 2016-04-01 | 2017-10-05 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| US20190076814A1 (en) | 2017-09-11 | 2019-03-14 | Synthego Corporation | Biopolymer synthesis system and method |
| CN111246936B (zh) * | 2017-10-25 | 2022-05-03 | 深圳华大生命科学研究院 | 用于核酸合成的微流控芯片 |
| US12246031B2 (en) | 2018-02-13 | 2025-03-11 | Checkmate Pharmaceuticals, Inc. | Compositions and methods for tumor immunotherapy |
| KR102890791B1 (ko) | 2018-04-09 | 2025-11-24 | 체크메이트 파마슈티칼스, 인크. | 바이러스-유사 입자 내로의 올리고뉴클레오타이드의 포장 |
| EP3850096A1 (en) * | 2018-09-11 | 2021-07-21 | Amgen Inc. | Purification methods for guanine-rich oligonucleotides |
| WO2020090822A1 (ja) * | 2018-10-30 | 2020-05-07 | 東レ株式会社 | 核酸の非特異結合抑制剤、ハイブリダイゼーション用試薬および核酸のハイブリダイゼーション方法 |
| CN112969527A (zh) * | 2018-11-08 | 2021-06-15 | 深圳华大生命科学研究院 | 一种微流控芯片及其制备方法和dna合成方法 |
| EP4047004B1 (en) * | 2019-10-18 | 2024-03-06 | FUJIFILM Wako Pure Chemical Corporation | Phosphoramidite activator |
| US20230322842A1 (en) * | 2020-04-14 | 2023-10-12 | Sumitomo Chemical Company, Limited | Composition containing nucleic acid oligomer |
| CN114425443B (zh) * | 2020-10-29 | 2025-10-31 | 江苏金斯瑞生物科技有限公司 | 一种寡核苷酸合成催化剂 |
| GB202114688D0 (en) | 2021-10-14 | 2021-12-01 | Exactmer Ltd | Solution phase polymer synthesis |
| GB202414228D0 (en) | 2024-09-27 | 2024-11-13 | Exactmer Ltd | Solvent recycling in a liquid-phase process for preparing a defined monomoer sequence polymer |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1984004749A1 (en) | 1983-06-01 | 1984-12-06 | Beckman Instruments Inc | Novel preparation of nucleoside phosphoramidite intermediates |
| US20030050263A1 (en) | 1994-07-15 | 2003-03-13 | The University Of Iowa Research Foundation | Methods and products for treating HIV infection |
| ES2241042T3 (es) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | Conjugados de polinucleotido inmunoestimulador/ molecula inmunomoduladora. |
| AU7350798A (en) | 1997-04-29 | 1998-11-24 | Universiteit Utrecht | Corona virus-like particles as tools for vaccination and therapy |
| EP0980257A1 (en) | 1997-05-01 | 2000-02-23 | Chiron Corporation | Use of virus-like particles as adjuvants |
| US6171591B1 (en) | 1997-12-08 | 2001-01-09 | Pentamer Pharmaceuticals, Inc. | Recombinant nodavirus compositions and methods |
| US6541438B1 (en) | 1998-05-01 | 2003-04-01 | The Procter & Gamble Company | Laundry detergent and/or fabric care compositions comprising a modified cellulase |
| ATE314095T1 (de) | 1998-10-21 | 2006-01-15 | Us Health | Virusähnliche partikel zur induktion von autoantikörpern |
| NZ512456A (en) | 1998-11-30 | 2003-10-31 | Cytos Biotechnology Ag | Ordered molecular presentation of antigens |
| EP1165773A4 (en) | 1999-02-02 | 2005-01-05 | Biocache Pharmaceuticals Inc | IMPROVED PLATFORM FOR PRESENTING ANTIGENS |
| US8206749B1 (en) | 1999-02-26 | 2012-06-26 | Novartis Vaccines And Diagnostics, Inc. | Microemulsions with adsorbed macromolecules and microparticles |
| SK287400B6 (sk) | 1999-09-25 | 2010-08-09 | University Of Iowa Research Foundation | Prostriedok s obsahom imunostimulačnej nukleovej kyseliny a jeho použitie na stimuláciu imunitnej reakcie |
| EP1220684B2 (en) | 1999-09-27 | 2010-07-14 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| US6949520B1 (en) | 1999-09-27 | 2005-09-27 | Coley Pharmaceutical Group, Inc. | Methods related to immunostimulatory nucleic acid-induced interferon |
| DE60043708D1 (de) | 1999-10-13 | 2010-03-04 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
| ATE290399T1 (de) | 1999-11-24 | 2005-03-15 | Chiron Corp | Hbv/hcv virus-ohnliche particle |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| AU2001239873A1 (en) | 2000-02-24 | 2001-09-03 | The Board Of Trustees Of The Leland Stanford Junior University | Adjuvant treatment by in vivo activation of dendritic cells |
| WO2002053141A2 (en) | 2000-12-14 | 2002-07-11 | Coley Pharmaceutical Group, Inc. | Inhibition of angiogenesis by nucleic acids |
| US20030050268A1 (en) | 2001-03-29 | 2003-03-13 | Krieg Arthur M. | Immunostimulatory nucleic acid for treatment of non-allergic inflammatory diseases |
| AU2002339224B2 (en) | 2001-09-14 | 2008-10-09 | Kuros Us Llc | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| JP4360906B2 (ja) | 2001-09-14 | 2009-11-11 | サイトス バイオテクノロジー アーゲー | ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化 |
| US7524950B2 (en) * | 2001-10-31 | 2009-04-28 | Agilent Technologies, Inc. | Uses of cationic salts for polynucleotide synthesis |
| CA2488856A1 (en) | 2002-06-20 | 2003-12-31 | Cytos Biotechnology Ag | Packaged virus-like particles for use as adjuvants: method of preparation and use |
| US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
| EP1605972A2 (en) | 2003-03-26 | 2005-12-21 | Cytos Biotechnology AG | Hiv-peptide-carrier-conjugates |
| US20060210588A1 (en) | 2003-03-26 | 2006-09-21 | Cytos Biotechnology Ag | Hiv-peptide-carrier-conjugates |
| EP1644034B1 (en) | 2003-07-10 | 2011-01-12 | Cytos Biotechnology AG | Composition for enhancing an immune response comprising packaged virus-like particles |
| CA2544240A1 (en) * | 2003-07-22 | 2005-02-17 | Cytos Biotechnology Ag | Cpg-packaged liposomes |
| JP4628686B2 (ja) * | 2004-02-25 | 2011-02-09 | 独立行政法人科学技術振興機構 | ホスホロアミダイトを含む３’末端ヌクレオシドユニット |
| CN101076546B (zh) * | 2004-09-02 | 2011-10-26 | Isis药物公司 | 用于低聚物合成的聚合珠 |
| CA2580208A1 (en) | 2004-09-21 | 2006-03-30 | Cytos Biotechnology Ag | Virus-like particles comprising a fusion protein of the coat protein of ap205 and an antigenic polypeptide |
| EP1973608A1 (en) | 2005-12-14 | 2008-10-01 | Cytos Biotechnology AG | Immunostimulatory nucleic acid packaged particles for the treatment of hypersensitivity |
-
2007
- 2007-12-12 CA CA2671873A patent/CA2671873C/en active Active
- 2007-12-12 EP EP07865549.5A patent/EP2125854B1/en active Active
- 2007-12-12 WO PCT/US2007/087183 patent/WO2008073960A2/en not_active Ceased
- 2007-12-12 CN CN2007800498509A patent/CN101611048B/zh active Active
- 2007-12-12 US US11/954,511 patent/US8586728B2/en active Active
- 2007-12-12 AU AU2007333147A patent/AU2007333147B2/en active Active
- 2007-12-12 JP JP2009541546A patent/JP5389662B2/ja active Active
-
2013
- 2013-10-15 US US14/054,068 patent/US20140200338A1/en not_active Abandoned
-
2015
- 2015-06-23 US US14/748,045 patent/US9914746B2/en active Active
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