CA2671873C - Oligonucleotides containing high concentrations of guanine monomers - Google Patents

Oligonucleotides containing high concentrations of guanine monomers Download PDF

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Publication number
CA2671873C
CA2671873C CA2671873A CA2671873A CA2671873C CA 2671873 C CA2671873 C CA 2671873C CA 2671873 A CA2671873 A CA 2671873A CA 2671873 A CA2671873 A CA 2671873A CA 2671873 C CA2671873 C CA 2671873C
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Prior art keywords
oligonucleotide
solvent
coupling
seq
nucleoside
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CA2671873A
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English (en)
French (fr)
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CA2671873A1 (en
Inventor
Brian Stephen Sproat
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Kuros US LLC
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Kuros Biosciences AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2671873A 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers Active CA2671873C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86958806P 2006-12-12 2006-12-12
US60/869,588 2006-12-12
PCT/US2007/087183 WO2008073960A2 (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Publications (2)

Publication Number Publication Date
CA2671873A1 CA2671873A1 (en) 2008-06-19
CA2671873C true CA2671873C (en) 2018-10-09

Family

ID=39456527

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2671873A Active CA2671873C (en) 2006-12-12 2007-12-12 Oligonucleotides containing high concentrations of guanine monomers

Country Status (7)

Country Link
US (3) US8586728B2 (https=)
EP (1) EP2125854B1 (https=)
JP (1) JP5389662B2 (https=)
CN (1) CN101611048B (https=)
AU (1) AU2007333147B2 (https=)
CA (1) CA2671873C (https=)
WO (1) WO2008073960A2 (https=)

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WO2017111137A1 (ja) 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法
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US20190076814A1 (en) 2017-09-11 2019-03-14 Synthego Corporation Biopolymer synthesis system and method
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WO2019160866A2 (en) 2018-02-13 2019-08-22 Checkmate Pharmaceuticals, Inc. Compositions and methods for tumor immunotherapy
BR112020020479A2 (pt) 2018-04-09 2021-01-12 Checkmate Pharmaceuticals Empacotamento de oligonucleotídeos em partículas similares a vírus
EP3850096A1 (en) * 2018-09-11 2021-07-21 Amgen Inc. Purification methods for guanine-rich oligonucleotides
CA3117823A1 (en) * 2018-10-30 2020-05-07 Toray Industries, Inc. Inhibitor of non-specific binding of nucleic acid, hybridization reagent and nucleic acid hybridization method
WO2020093322A1 (zh) * 2018-11-08 2020-05-14 深圳华大生命科学研究院 一种微流控芯片及其制备方法和dna合成方法
EP4047004B1 (en) * 2019-10-18 2024-03-06 FUJIFILM Wako Pure Chemical Corporation Phosphoramidite activator
US20230322842A1 (en) * 2020-04-14 2023-10-12 Sumitomo Chemical Company, Limited Composition containing nucleic acid oligomer
CN114425443B (zh) * 2020-10-29 2025-10-31 江苏金斯瑞生物科技有限公司 一种寡核苷酸合成催化剂
GB202114688D0 (en) 2021-10-14 2021-12-01 Exactmer Ltd Solution phase polymer synthesis
GB202414228D0 (en) 2024-09-27 2024-11-13 Exactmer Ltd Solvent recycling in a liquid-phase process for preparing a defined monomoer sequence polymer

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Also Published As

Publication number Publication date
CN101611048B (zh) 2012-11-07
EP2125854A2 (en) 2009-12-02
US8586728B2 (en) 2013-11-19
US20160145293A1 (en) 2016-05-26
AU2007333147A1 (en) 2008-06-19
WO2008073960A3 (en) 2008-08-07
AU2007333147B2 (en) 2013-12-19
JP2010512169A (ja) 2010-04-22
US9914746B2 (en) 2018-03-13
CN101611048A (zh) 2009-12-23
JP5389662B2 (ja) 2014-01-15
CA2671873A1 (en) 2008-06-19
US20140200338A1 (en) 2014-07-17
EP2125854B1 (en) 2016-10-26
WO2008073960A2 (en) 2008-06-19
US20080139797A1 (en) 2008-06-12

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