JP2010511667A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010511667A5 JP2010511667A5 JP2009539737A JP2009539737A JP2010511667A5 JP 2010511667 A5 JP2010511667 A5 JP 2010511667A5 JP 2009539737 A JP2009539737 A JP 2009539737A JP 2009539737 A JP2009539737 A JP 2009539737A JP 2010511667 A5 JP2010511667 A5 JP 2010511667A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- het
- compound according
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 cyano, formyl Chemical group 0.000 claims 50
- 125000000217 alkyl group Chemical group 0.000 claims 43
- 150000001875 compounds Chemical class 0.000 claims 29
- 125000003118 aryl group Chemical group 0.000 claims 28
- 125000003545 alkoxy group Chemical group 0.000 claims 15
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000001475 halogen functional group Chemical group 0.000 claims 13
- 150000002431 hydrogen Chemical class 0.000 claims 12
- 125000003710 aryl alkyl group Chemical group 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 10
- 125000001188 haloalkyl group Chemical group 0.000 claims 8
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 125000004414 alkyl thio group Chemical group 0.000 claims 6
- 125000005984 hexahydro-1H-1,4-diazepinyl group Chemical group 0.000 claims 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 6
- 125000004076 pyridyl group Chemical group 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 125000005943 1,2,3,6-tetrahydropyridyl group Chemical group 0.000 claims 4
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 4
- 239000002585 base Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000002883 imidazolyl group Chemical group 0.000 claims 4
- 125000003373 pyrazinyl group Chemical group 0.000 claims 4
- 125000003226 pyrazolyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims 4
- 125000001425 triazolyl group Chemical group 0.000 claims 4
- 241000894006 Bacteria Species 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000815 N-oxide group Chemical group 0.000 claims 3
- 241000191967 Staphylococcus aureus Species 0.000 claims 3
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004103 aminoalkyl group Chemical group 0.000 claims 3
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001624 naphthyl group Chemical group 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims 3
- 125000001422 pyrrolinyl group Chemical group 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims 3
- 125000004306 triazinyl group Chemical group 0.000 claims 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 125000005418 aryl aryl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 2
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 125000002632 imidazolidinyl group Chemical group 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 150000001204 N-oxides Chemical class 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 125000005094 alkyl carbonyl amino alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005129 aryl carbonyl group Chemical group 0.000 claims 1
- 125000004104 aryloxy group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000001041 indolyl group Chemical group 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 125000001288 lysyl group Chemical group 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 229910000104 sodium hydride Inorganic materials 0.000 claims 1
- 239000012312 sodium hydride Substances 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 238000000844 transformation Methods 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 0 *C1c2ccccc2N=C(*)[C@@]1C(*)=C(*)C*C=C Chemical compound *C1c2ccccc2N=C(*)[C@@]1C(*)=C(*)C*C=C 0.000 description 3
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125546 | 2006-12-06 | ||
| EP06125546.9 | 2006-12-06 | ||
| PCT/EP2007/063312 WO2008068266A1 (en) | 2006-12-06 | 2007-12-04 | Antibacterial quinoline derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010511667A JP2010511667A (ja) | 2010-04-15 |
| JP2010511667A5 true JP2010511667A5 (https=) | 2010-11-18 |
| JP5356244B2 JP5356244B2 (ja) | 2013-12-04 |
Family
ID=38038656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009539737A Expired - Fee Related JP5356244B2 (ja) | 2006-12-06 | 2007-12-04 | 抗菌性キノリン誘導体 |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US20100069366A1 (https=) |
| EP (1) | EP2099762B1 (https=) |
| JP (1) | JP5356244B2 (https=) |
| KR (1) | KR101514992B1 (https=) |
| CN (1) | CN101547907B (https=) |
| AP (1) | AP2478A (https=) |
| AR (1) | AR064153A1 (https=) |
| AT (1) | ATE467619T1 (https=) |
| AU (1) | AU2007328980B2 (https=) |
| BR (1) | BRPI0719920B8 (https=) |
| CA (1) | CA2668515C (https=) |
| CL (1) | CL2007003519A1 (https=) |
| CY (1) | CY1111188T1 (https=) |
| DE (1) | DE602007006553D1 (https=) |
| DK (1) | DK2099762T3 (https=) |
| EA (1) | EA200970534A1 (https=) |
| ES (1) | ES2345463T3 (https=) |
| HR (1) | HRP20100428T1 (https=) |
| IL (1) | IL199079A (https=) |
| JO (1) | JO2684B1 (https=) |
| ME (1) | ME01127B (https=) |
| MX (1) | MX2009005982A (https=) |
| MY (1) | MY145924A (https=) |
| NO (1) | NO341996B1 (https=) |
| NZ (1) | NZ576863A (https=) |
| PL (1) | PL2099762T3 (https=) |
| PT (1) | PT2099762E (https=) |
| RS (1) | RS51382B (https=) |
| SI (1) | SI2099762T1 (https=) |
| TW (1) | TWI484959B (https=) |
| UA (1) | UA101305C2 (https=) |
| WO (1) | WO2008068266A1 (https=) |
| ZA (1) | ZA200903947B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5857511B2 (ja) * | 2010-08-10 | 2016-02-10 | 住友化学株式会社 | 植物病害防除組成物およびその用途 |
| CN104254527B (zh) | 2012-04-27 | 2017-05-31 | 詹森药业有限公司 | 抗菌的喹啉衍生物 |
| ES2607879T3 (es) | 2012-04-27 | 2017-04-04 | Janssen Pharmaceutica N.V. | Derivados de quinolina antibacterianos |
| CN105017147B (zh) * | 2014-04-30 | 2019-02-01 | 中国医学科学院药物研究所 | 一种回收和利用Bedaquiline立体化学异构体的方法 |
| JP6362235B2 (ja) * | 2014-07-14 | 2018-07-25 | ツーセン ファーマシューティカル カンパニー リミテッド | ピリジン誘導体およびその抗マイコバクテリウムにおける使用 |
| CN105330595B (zh) * | 2014-07-14 | 2019-12-10 | 上海嘉坦医药科技有限公司 | 吡啶衍生物及其作为抗分支杆菌的应用 |
| WO2017121323A1 (zh) * | 2016-01-13 | 2017-07-20 | 辰欣药业股份有限公司 | 一种吡啶衍生物类化合物的制备方法及其中间体和晶型 |
| BR122023025283A2 (pt) * | 2016-03-07 | 2024-02-20 | Global Alliance For Tb Drug Development Inc | Compostos antibacterianos e seus usos |
| CN109384716B (zh) * | 2017-08-11 | 2021-06-29 | 海创药业股份有限公司 | 一种氘代喹啉化合物及其制备和用途 |
| KR20240161147A (ko) | 2022-03-14 | 2024-11-12 | 슬랩 파마슈티컬스 엘엘씨 | 다중 사이클릭 화합물 |
| CN116925723B (zh) * | 2022-03-30 | 2025-04-01 | 中国石油天然气股份有限公司 | 油气田用杂环有机硅季铵盐与活性炭共混杀菌剂及制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998018326A1 (en) * | 1996-10-28 | 1998-05-07 | Department Of The Army, U.S. Government | Compounds, compositions and methods for treating antibiotic-resistant infections |
| ATE463482T1 (de) * | 2002-07-25 | 2010-04-15 | Janssen Pharmaceutica Nv | Chinolinderivate und deren verwendung als mycobakterielle inhibitoren |
| EA011277B1 (ru) * | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Производные хинолина и их применение в качестве ингибиторов микобактерий |
| EA011359B1 (ru) * | 2004-01-23 | 2009-02-27 | Янссен Фармацевтика Н.В. | Замещенные хинолины и их применение в качестве микобактериальных ингибиторов |
| CA2554049C (en) * | 2004-01-29 | 2012-12-18 | Janssen Pharmaceutica N.V. | Quinoline derivatives for use as mycobacterial inhibitors |
| PL1753427T3 (pl) * | 2004-05-28 | 2008-09-30 | Janssen Pharmaceutica Nv | Zastosowanie podstawionych pochodnych chinoliny do leczenia chorób wywoływanych przez prątki lekooporne |
| EP1677083A1 (fr) * | 2004-12-22 | 2006-07-05 | Roxer Industries S.A. | Capteur de niveau d'un liquide. |
| CA2528849C (en) * | 2005-06-08 | 2014-01-14 | Janssen Pharmaceutica N.V. | Quinoline derivatives as antibacterial agents |
-
2007
- 2007-11-29 JO JO2007503A patent/JO2684B1/en active
- 2007-12-04 ME MEP-2010-128A patent/ME01127B/me unknown
- 2007-12-04 MY MYPI20092285A patent/MY145924A/en unknown
- 2007-12-04 EA EA200970534A patent/EA200970534A1/ru unknown
- 2007-12-04 US US12/515,593 patent/US20100069366A1/en not_active Abandoned
- 2007-12-04 EP EP07857252A patent/EP2099762B1/en active Active
- 2007-12-04 WO PCT/EP2007/063312 patent/WO2008068266A1/en not_active Ceased
- 2007-12-04 DK DK07857252.6T patent/DK2099762T3/da active
- 2007-12-04 DE DE602007006553T patent/DE602007006553D1/de active Active
- 2007-12-04 SI SI200730306T patent/SI2099762T1/sl unknown
- 2007-12-04 CA CA2668515A patent/CA2668515C/en active Active
- 2007-12-04 AT AT07857252T patent/ATE467619T1/de active
- 2007-12-04 HR HR20100428T patent/HRP20100428T1/hr unknown
- 2007-12-04 RS RSP-2010/0351A patent/RS51382B/sr unknown
- 2007-12-04 BR BRPI0719920A patent/BRPI0719920B8/pt not_active IP Right Cessation
- 2007-12-04 KR KR1020097013405A patent/KR101514992B1/ko not_active Expired - Fee Related
- 2007-12-04 PT PT07857252T patent/PT2099762E/pt unknown
- 2007-12-04 ES ES07857252T patent/ES2345463T3/es active Active
- 2007-12-04 CN CN200780044917XA patent/CN101547907B/zh not_active Expired - Fee Related
- 2007-12-04 MX MX2009005982A patent/MX2009005982A/es active IP Right Grant
- 2007-12-04 PL PL07857252T patent/PL2099762T3/pl unknown
- 2007-12-04 UA UAA200904216A patent/UA101305C2/ru unknown
- 2007-12-04 JP JP2009539737A patent/JP5356244B2/ja not_active Expired - Fee Related
- 2007-12-04 AP AP2009004872A patent/AP2478A/xx active
- 2007-12-04 NZ NZ576863A patent/NZ576863A/en not_active IP Right Cessation
- 2007-12-04 AU AU2007328980A patent/AU2007328980B2/en not_active Ceased
- 2007-12-05 CL CL200703519A patent/CL2007003519A1/es unknown
- 2007-12-05 AR ARP070105446A patent/AR064153A1/es unknown
- 2007-12-05 TW TW096146219A patent/TWI484959B/zh not_active IP Right Cessation
-
2009
- 2009-06-02 IL IL199079A patent/IL199079A/en active IP Right Grant
- 2009-06-05 ZA ZA200903947A patent/ZA200903947B/xx unknown
- 2009-07-06 NO NO20092539A patent/NO341996B1/no unknown
-
2010
- 2010-08-09 CY CY20101100742T patent/CY1111188T1/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010511667A5 (https=) | ||
| JP2010511668A5 (https=) | ||
| HRP20160585T1 (hr) | Antibakterijski derivati kinolina | |
| HRP20100428T1 (hr) | Antibakterijski derivati kvinolina | |
| JP2010511671A5 (https=) | ||
| US20210317122A1 (en) | Substituted heterocyclic inhibitors of ptpn11 | |
| EP3157521A1 (en) | Substituted indazole compounds as irak4 inhibitors | |
| JP2011518831A5 (https=) | ||
| AU2013286894A1 (en) | Heterocyclic modulators of lipid synthesis | |
| CA2493225A1 (en) | Quinoline derivatives and their use as mycobacterial inhibitors | |
| CA2548654A1 (en) | Piperidine-amino-benzimidazole derivatives as inhibitors of respiratory syncytial virus replication | |
| KR20130095831A (ko) | 퀴놀론 화합물 | |
| CA2478229A1 (en) | Pyridinoylpiperidines as 5-ht1f agonists | |
| RU2009125520A (ru) | Антибактериальные хинолиновые производные | |
| CA3081423A1 (en) | Antibacterial compounds | |
| EP2750504A1 (en) | Antibacterial compounds and methods for use | |
| JP2009503024A5 (https=) | ||
| JP2010511670A5 (https=) | ||
| EP3259250A1 (en) | Novel n-acyl-arylsulfonamide derivatives as aminoacyl-trna synthetase inhibitors | |
| JP2009503025A5 (https=) | ||
| RU2009125525A (ru) | Антибактериальные производные хинолина | |
| PE20061137A1 (es) | Compuestos derivados de macrolidos amino sustituidas | |
| JP2010511672A5 (https=) | ||
| JP2010511669A5 (https=) | ||
| EP0869956A1 (en) | Pharmaceutical compositions |