JP2010508360A - Ｃ型肝炎ウイルスの阻害剤 - Google Patents

Ｃ型肝炎ウイルスの阻害剤 Download PDF

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Publication number
JP2010508360A
JP2010508360A JP2009535434A JP2009535434A JP2010508360A JP 2010508360 A JP2010508360 A JP 2010508360A JP 2009535434 A JP2009535434 A JP 2009535434A JP 2009535434 A JP2009535434 A JP 2009535434A JP 2010508360 A JP2010508360 A JP 2010508360A
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JP
Japan
Prior art keywords
alkyl
cycloalkyl
mmol
hcv
compound
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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JP2009535434A
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English (en)
Japanese (ja)
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JP2010508360A5 (en:Method
Inventor
スタンリー・ダンドレア
ジジェン・バーバラ・ジェン
ポール・マイケル・スコーラ
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2010508360A publication Critical patent/JP2010508360A/ja
Publication of JP2010508360A5 publication Critical patent/JP2010508360A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009535434A 2006-11-01 2007-10-31 Ｃ型肝炎ウイルスの阻害剤 Withdrawn JP2010508360A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86383706P 2006-11-01 2006-11-01
PCT/US2007/083120 WO2008057871A2 (en) 2006-11-01 2007-10-31 Inhibitors of hepatitis c virus

Publications (2)

Publication Number Publication Date
JP2010508360A true JP2010508360A (ja) 2010-03-18
JP2010508360A5 JP2010508360A5 (en:Method) 2010-10-28

Family

ID=39218835

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009535434A Withdrawn JP2010508360A (ja) 2006-11-01 2007-10-31 Ｃ型肝炎ウイルスの阻害剤

Country Status (6)

Country Link
US (1) US8343477B2 (en:Method)
EP (1) EP2089385B1 (en:Method)
JP (1) JP2010508360A (en:Method)
CN (1) CN101646667A (en:Method)
NO (1) NO20091704L (en:Method)
WO (1) WO2008057871A2 (en:Method)

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US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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CN103965286B (zh) * 2014-04-22 2017-11-03 南京安赛莱医药科技有限公司 丙型肝炎病毒（hcv）ns3蛋白酶抑制剂
US10842763B2 (en) 2015-07-31 2020-11-24 The Johns Hopkins University Methods for cancer and immunotherapy using prodrugs of glutamine analogs
CN108348492B (zh) 2015-07-31 2021-09-28 约翰霍普金斯大学 使用谷氨酰胺类似物的用于癌症和免疫疗法的方法
CA2994258C (en) 2015-07-31 2024-09-10 The Johns Hopkins University PROMEDICAMENTS OF GLUTAMINE ANALOGUES
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Also Published As

Publication number Publication date
US8343477B2 (en) 2013-01-01
EP2089385B1 (en) 2016-01-06
NO20091704L (no) 2009-07-27
WO2008057871A3 (en) 2008-10-09
EP2089385A2 (en) 2009-08-19
WO2008057871A2 (en) 2008-05-15
CN101646667A (zh) 2010-02-10
US20080107624A1 (en) 2008-05-08

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