JP2010508349A5 - - Google Patents
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- Publication number
- JP2010508349A5 JP2010508349A5 JP2009535306A JP2009535306A JP2010508349A5 JP 2010508349 A5 JP2010508349 A5 JP 2010508349A5 JP 2009535306 A JP2009535306 A JP 2009535306A JP 2009535306 A JP2009535306 A JP 2009535306A JP 2010508349 A5 JP2010508349 A5 JP 2010508349A5
- Authority
- JP
- Japan
- Prior art keywords
- dcp
- administering
- subject
- effective amount
- modulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 11
- HNXQXTQTPAJEJL-UHFFFAOYSA-N 2-aminopteridin-4-ol Chemical compound C1=CN=C2NC(N)=NC(=O)C2=N1 HNXQXTQTPAJEJL-UHFFFAOYSA-N 0.000 claims 6
- 239000000725 suspension Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- IGBSGKOLQRKFIU-UHFFFAOYSA-N O.O.O.O.O.[Ca] Chemical compound O.O.O.O.O.[Ca] IGBSGKOLQRKFIU-UHFFFAOYSA-N 0.000 claims 2
- BMQYVXCPAOLZOK-UHFFFAOYSA-N Trihydroxypropylpterisin Natural products OCC(O)C(O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-UHFFFAOYSA-N 0.000 claims 2
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 2
- 229910052793 cadmium Inorganic materials 0.000 claims 2
- 230000015556 catabolic process Effects 0.000 claims 2
- 238000006731 degradation reaction Methods 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000006058 immune tolerance Effects 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- BMQYVXCPAOLZOK-XINAWCOVSA-N neopterin Chemical compound OC[C@@H](O)[C@@H](O)C1=CN=C2NC(N)=NC(=O)C2=N1 BMQYVXCPAOLZOK-XINAWCOVSA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000003756 stirring Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000002244 precipitate Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 238000001308 synthesis method Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86354706P | 2006-10-30 | 2006-10-30 | |
| PCT/US2007/023012 WO2008054793A2 (en) | 2006-10-30 | 2007-10-30 | Dipterinyl calcium pentahydrate (dcp) and therapeutic methods based thereon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010508349A JP2010508349A (ja) | 2010-03-18 |
| JP2010508349A5 true JP2010508349A5 (https=) | 2010-11-11 |
Family
ID=39344907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009535306A Pending JP2010508349A (ja) | 2006-10-30 | 2007-10-30 | ジプテリニルカルシウム五水和物（ｄｃｐ）およびそれに基づく治療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7662820B2 (https=) |
| EP (1) | EP2094715B1 (https=) |
| JP (1) | JP2010508349A (https=) |
| CN (1) | CN101663308A (https=) |
| CA (1) | CA2668262A1 (https=) |
| ES (1) | ES2394227T3 (https=) |
| WO (1) | WO2008054793A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1535616B1 (en) | 2002-08-22 | 2009-05-13 | Dainippon Sumitomo Pharma Co., Ltd. | Remedy for integration dysfunction syndrome |
| KR101113630B1 (ko) | 2003-06-23 | 2012-02-13 | 다이닛본 스미토모 세이야꾸 가부시끼가이샤 | 노인성 치매 치료제 |
| US20070160537A1 (en) * | 2004-02-20 | 2007-07-12 | Takeo Ishiyama | In vivo screening method of therapeutic agent for memory/learning dysfunctions by schizophrenia |
| ES2444695T3 (es) * | 2006-06-23 | 2014-02-26 | Alethia Biotherapeutics Inc. | Polinucleótidos y polipéptidos implicados en el cáncer |
| CN101663308A (zh) * | 2006-10-30 | 2010-03-03 | 桑尔克斯药品公司 | N-甲基色胺钙五水合物(dcp)和基于它的治疗方法 |
| US20120251495A1 (en) * | 2008-01-18 | 2012-10-04 | Phillip Moheno | Pterin based therapies for inflammatory conditions |
| CA2740900C (en) | 2008-11-03 | 2019-09-24 | Alethia Biotherapeutics Inc. | Antibodies that specifically block the biological activity of a tumor antigen |
| US8258139B2 (en) | 2010-11-08 | 2012-09-04 | Dainippon Sumitomo Pharma Co., Ltd. | Method of treatment for mental disorders |
| SI3173427T1 (sl) | 2011-03-31 | 2019-08-30 | ADC Therapeutics SA, | Protitelesa proti antigenu 1, povezanemu z ledvicami, in antigen vezavni fragmenti le-tega |
| KR102102239B1 (ko) | 2012-01-09 | 2020-04-21 | 에이디씨 테라퓨틱스 에스에이 | 유방암을 치료하기 위한 방법 |
| US20150010509A1 (en) * | 2012-01-30 | 2015-01-08 | Sanrx Pharmaceuticals, Inc. | Calcium folate (cafolate) and therapeutic methods based thereon |
| CN104788300B (zh) * | 2014-01-22 | 2017-01-11 | 南京华威医药科技开发有限公司 | 欧司哌米芬多晶型 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000012137A1 (en) | 1998-09-02 | 2000-03-09 | Allergan Sales, Inc. | Preserved cyclodextrin-containing compositions |
| AU1223400A (en) * | 1998-10-22 | 2000-05-08 | Phillip B. B. Moheno | Novel pterin antineoplastic agents |
| DE19944767A1 (de) * | 1999-09-17 | 2001-03-29 | Vasopharm Biotech Gmbh & Co Kg | N-substituierte 4-Aminopteridine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| CN101663308A (zh) * | 2006-10-30 | 2010-03-03 | 桑尔克斯药品公司 | N-甲基色胺钙五水合物(dcp)和基于它的治疗方法 |
-
2007
- 2007-10-30 CN CN200780048992A patent/CN101663308A/zh active Pending
- 2007-10-30 JP JP2009535306A patent/JP2010508349A/ja active Pending
- 2007-10-30 US US11/981,398 patent/US7662820B2/en not_active Expired - Fee Related
- 2007-10-30 WO PCT/US2007/023012 patent/WO2008054793A2/en not_active Ceased
- 2007-10-30 EP EP07867329A patent/EP2094715B1/en not_active Not-in-force
- 2007-10-30 ES ES07867329T patent/ES2394227T3/es active Active
- 2007-10-30 CA CA002668262A patent/CA2668262A1/en not_active Abandoned
-
2009
- 2009-12-21 US US12/643,752 patent/US20100105692A1/en not_active Abandoned
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