JP2010507585A5 - - Google Patents
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- JP2010507585A5 JP2010507585A5 JP2009533572A JP2009533572A JP2010507585A5 JP 2010507585 A5 JP2010507585 A5 JP 2010507585A5 JP 2009533572 A JP2009533572 A JP 2009533572A JP 2009533572 A JP2009533572 A JP 2009533572A JP 2010507585 A5 JP2010507585 A5 JP 2010507585A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- deuterium
- pharmaceutical composition
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 R 21 Chemical compound 0.000 claims 53
- 150000001875 compounds Chemical class 0.000 claims 33
- 229910052805 deuterium Inorganic materials 0.000 claims 15
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 11
- 239000001257 hydrogen Substances 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 239000000651 prodrug Substances 0.000 claims 7
- 229940002612 prodrug Drugs 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 230000036470 plasma concentration Effects 0.000 claims 6
- 102000001708 Protein Isoforms Human genes 0.000 claims 5
- 108010029485 Protein Isoforms Proteins 0.000 claims 5
- 102000010909 Monoamine Oxidase Human genes 0.000 claims 4
- 108010062431 Monoamine oxidase Proteins 0.000 claims 4
- 239000002207 metabolite Substances 0.000 claims 4
- 102000018832 Cytochromes Human genes 0.000 claims 3
- 108010052832 Cytochromes Proteins 0.000 claims 3
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 claims 2
- 108010000561 Cytochrome P-450 CYP2C8 Proteins 0.000 claims 2
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 claims 2
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 2
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 2
- 102100029363 Cytochrome P450 2C19 Human genes 0.000 claims 2
- 102100029359 Cytochrome P450 2C8 Human genes 0.000 claims 2
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 claims 2
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 2
- 108010022037 Retinoic Acid 4-Hydroxylase Proteins 0.000 claims 2
- 230000007012 clinical effect Effects 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 102100027518 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Human genes 0.000 claims 1
- 108010073030 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Proteins 0.000 claims 1
- 102100036285 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Human genes 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 108010074918 Cytochrome P-450 CYP1A1 Proteins 0.000 claims 1
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 claims 1
- 108010020070 Cytochrome P-450 CYP2B6 Proteins 0.000 claims 1
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 claims 1
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 claims 1
- 102100027417 Cytochrome P450 1B1 Human genes 0.000 claims 1
- 102100039282 Cytochrome P450 26A1 Human genes 0.000 claims 1
- 102100039281 Cytochrome P450 26B1 Human genes 0.000 claims 1
- 102100038742 Cytochrome P450 2A13 Human genes 0.000 claims 1
- 102100036194 Cytochrome P450 2A6 Human genes 0.000 claims 1
- 102100038739 Cytochrome P450 2B6 Human genes 0.000 claims 1
- 102100029368 Cytochrome P450 2C18 Human genes 0.000 claims 1
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 1
- 102100031461 Cytochrome P450 2J2 Human genes 0.000 claims 1
- 102100026515 Cytochrome P450 2S1 Human genes 0.000 claims 1
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 claims 1
- 102100039208 Cytochrome P450 3A5 Human genes 0.000 claims 1
- 102100039203 Cytochrome P450 3A7 Human genes 0.000 claims 1
- 102100027567 Cytochrome P450 4A11 Human genes 0.000 claims 1
- 102100027419 Cytochrome P450 4B1 Human genes 0.000 claims 1
- 102100024916 Cytochrome P450 4F11 Human genes 0.000 claims 1
- 102100024918 Cytochrome P450 4F12 Human genes 0.000 claims 1
- 102100024902 Cytochrome P450 4F2 Human genes 0.000 claims 1
- 102100024901 Cytochrome P450 4F3 Human genes 0.000 claims 1
- 102100024899 Cytochrome P450 4F8 Human genes 0.000 claims 1
- 102100022027 Cytochrome P450 4X1 Human genes 0.000 claims 1
- 102100022034 Cytochrome P450 4Z1 Human genes 0.000 claims 1
- 102100038637 Cytochrome P450 7A1 Human genes 0.000 claims 1
- 108010036233 Cytochrome P450 Family 46 Proteins 0.000 claims 1
- 102000023526 Cytochrome P450 Family 46 Human genes 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 101000861278 Homo sapiens 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Proteins 0.000 claims 1
- 101000725164 Homo sapiens Cytochrome P450 1B1 Proteins 0.000 claims 1
- 101000957389 Homo sapiens Cytochrome P450 2A13 Proteins 0.000 claims 1
- 101000875170 Homo sapiens Cytochrome P450 2A6 Proteins 0.000 claims 1
- 101000919360 Homo sapiens Cytochrome P450 2C18 Proteins 0.000 claims 1
- 101000941723 Homo sapiens Cytochrome P450 2J2 Proteins 0.000 claims 1
- 101000855328 Homo sapiens Cytochrome P450 2S1 Proteins 0.000 claims 1
- 101000745715 Homo sapiens Cytochrome P450 3A7 Proteins 0.000 claims 1
- 101000725111 Homo sapiens Cytochrome P450 4A11 Proteins 0.000 claims 1
- 101000909111 Homo sapiens Cytochrome P450 4F11 Proteins 0.000 claims 1
- 101000909108 Homo sapiens Cytochrome P450 4F12 Proteins 0.000 claims 1
- 101000909122 Homo sapiens Cytochrome P450 4F2 Proteins 0.000 claims 1
- 101000909121 Homo sapiens Cytochrome P450 4F3 Proteins 0.000 claims 1
- 101000909112 Homo sapiens Cytochrome P450 4F8 Proteins 0.000 claims 1
- 101000896935 Homo sapiens Cytochrome P450 4Z1 Proteins 0.000 claims 1
- 101000957672 Homo sapiens Cytochrome P450 7A1 Proteins 0.000 claims 1
- 101000875401 Homo sapiens Sterol 26-hydroxylase, mitochondrial Proteins 0.000 claims 1
- 101000653005 Homo sapiens Thromboxane-A synthase Proteins 0.000 claims 1
- 101000855326 Homo sapiens Vitamin D 25-hydroxylase Proteins 0.000 claims 1
- 102100021695 Lanosterol 14-alpha demethylase Human genes 0.000 claims 1
- 101710146773 Lanosterol 14-alpha demethylase Proteins 0.000 claims 1
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 108010045510 NADPH-Ferrihemoprotein Reductase Proteins 0.000 claims 1
- 101150053185 P450 gene Proteins 0.000 claims 1
- 102100026372 Putative inactive cytochrome P450 2G1 Human genes 0.000 claims 1
- 102100036325 Sterol 26-hydroxylase, mitochondrial Human genes 0.000 claims 1
- 102100030973 Thromboxane-A synthase Human genes 0.000 claims 1
- 102100026523 Vitamin D 25-hydroxylase Human genes 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 108010026647 cytochrome P-450 4X1 Proteins 0.000 claims 1
- 108010062869 cytochrome P-450 CYP2G1 Proteins 0.000 claims 1
- 108010018719 cytochrome P-450 CYP4B1 Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 0 *c1c(*)[n](*)c2c(*)c(*)c(*)c(*)c12 Chemical compound *c1c(*)[n](*)c2c(*)c(*)c(*)c(*)c12 0.000 description 5
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85324306P | 2006-10-19 | 2006-10-19 | |
| PCT/US2007/081977 WO2008049116A2 (en) | 2006-10-19 | 2007-10-19 | Substituted indoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010507585A JP2010507585A (ja) | 2010-03-11 |
| JP2010507585A5 true JP2010507585A5 (enExample) | 2010-12-09 |
Family
ID=39192780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009533572A Pending JP2010507585A (ja) | 2006-10-19 | 2007-10-19 | 置換インドール |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080103189A1 (enExample) |
| EP (1) | EP2081893B1 (enExample) |
| JP (1) | JP2010507585A (enExample) |
| CN (1) | CN101687788A (enExample) |
| AT (1) | ATE502921T1 (enExample) |
| AU (1) | AU2007310949A1 (enExample) |
| BR (1) | BRPI0715579A2 (enExample) |
| CA (1) | CA2666149A1 (enExample) |
| DE (1) | DE602007013440D1 (enExample) |
| WO (1) | WO2008049116A2 (enExample) |
Families Citing this family (45)
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| SG10201406839VA (en) * | 2009-10-26 | 2014-12-30 | Otsuka Pharma Co Ltd | Benzazepine compound |
| WO2011059080A1 (ja) * | 2009-11-16 | 2011-05-19 | 第一三共株式会社 | 同位体置換されたジアミン誘導体 |
| EP2771341A4 (en) | 2011-10-28 | 2015-09-23 | Univ Texas | NEW COMPOSITIONS AND METHOD FOR THE TREATMENT OF CANCER |
| KR20160117596A (ko) | 2014-02-07 | 2016-10-10 | 오스펙스 파마슈티칼스, 인코포레이티드 | 신규 제약 제제 |
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| US11219212B2 (en) | 2015-07-10 | 2022-01-11 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and imazamox |
| JP6875368B2 (ja) | 2015-07-10 | 2021-05-26 | ビーエーエスエフ アグロ ベー．ブイ． | シンメチリン及びアセトクロール又はプレチラクロールを含む除草剤組成物 |
| US11219215B2 (en) | 2015-07-10 | 2022-01-11 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and specific inhibitors of protoporphyrinogen oxidase |
| DK3319434T3 (da) | 2015-07-10 | 2019-07-29 | Basf Agro Bv | Herbicidsammensætning, der omfatter cinmethylin og pethoxamid |
| WO2017009061A1 (en) | 2015-07-10 | 2017-01-19 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and saflufenacil |
| WO2017009090A1 (en) | 2015-07-10 | 2017-01-19 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and pyroxasulfone |
| WO2017009142A1 (en) | 2015-07-10 | 2017-01-19 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and specific pigment synthesis inhibitors |
| EP3319436B1 (en) | 2015-07-10 | 2019-09-11 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and quinmerac |
| US12336536B2 (en) | 2015-07-10 | 2025-06-24 | BASF Agro B.V. | Method for controlling herbicide resistant or tolerant weeds |
| AU2016292399B2 (en) | 2015-07-10 | 2020-06-25 | BASF Agro B.V. | Herbicidal composition comprising cinmethylin and dimethenamid |
| CN106397359B (zh) * | 2016-08-31 | 2017-12-05 | 重庆华森制药股份有限公司 | 阿莫曲坦中间体4‑(1‑吡咯烷基磺酰甲基)‑苯肼的制备方法 |
| SI3565550T1 (sl) * | 2017-01-04 | 2021-04-30 | Axsome Therapeutics, Inc. | Farmacevtske sestave, ki vsebujejo meloksikam in rizatriptan |
| CN108440452A (zh) * | 2017-04-05 | 2018-08-24 | 嘉兴市第二医院 | 一种阿莫曲坦的关键中间体1-（4-氨基-苯甲基磺酰基）吡咯烷的制备方法 |
| EP4467600A3 (en) | 2017-05-10 | 2025-03-12 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| DE102017004546B4 (de) * | 2017-05-12 | 2022-01-05 | L/N Health And Beauty Aps | Kit zur Nagelkorrektur |
| KR102815027B1 (ko) * | 2018-07-03 | 2025-05-30 | 액섬 테라퓨틱스, 인크. | 멜록시캄을 포함하는 약학적 조성물 |
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| CA3188636A1 (en) * | 2020-08-21 | 2022-02-24 | Matthias GRILL | Novel psilocin derivatives having prodrug properties |
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2007
- 2007-10-19 CA CA002666149A patent/CA2666149A1/en not_active Abandoned
- 2007-10-19 AU AU2007310949A patent/AU2007310949A1/en not_active Abandoned
- 2007-10-19 US US11/875,670 patent/US20080103189A1/en not_active Abandoned
- 2007-10-19 AT AT07844472T patent/ATE502921T1/de not_active IP Right Cessation
- 2007-10-19 CN CN200780042774A patent/CN101687788A/zh active Pending
- 2007-10-19 JP JP2009533572A patent/JP2010507585A/ja active Pending
- 2007-10-19 BR BRPI0715579-4A patent/BRPI0715579A2/pt not_active IP Right Cessation
- 2007-10-19 EP EP07844472A patent/EP2081893B1/en active Active
- 2007-10-19 WO PCT/US2007/081977 patent/WO2008049116A2/en not_active Ceased
- 2007-10-19 DE DE602007013440T patent/DE602007013440D1/de active Active