JP2010512343A5 - - Google Patents
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- Publication number
- JP2010512343A5 JP2010512343A5 JP2009540513A JP2009540513A JP2010512343A5 JP 2010512343 A5 JP2010512343 A5 JP 2010512343A5 JP 2009540513 A JP2009540513 A JP 2009540513A JP 2009540513 A JP2009540513 A JP 2009540513A JP 2010512343 A5 JP2010512343 A5 JP 2010512343A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- compared
- isotopically enriched
- deuterium
- plasma concentration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 38
- -1 R 21 Chemical compound 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 8
- 229910052805 deuterium Inorganic materials 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- 230000036470 plasma concentration Effects 0.000 claims 8
- 239000002207 metabolite Substances 0.000 claims 6
- 239000000651 prodrug Substances 0.000 claims 5
- 229940002612 prodrug Drugs 0.000 claims 5
- 239000012453 solvate Substances 0.000 claims 5
- 102000010909 Monoamine Oxidase Human genes 0.000 claims 4
- 108010062431 Monoamine oxidase Proteins 0.000 claims 4
- 102000001708 Protein Isoforms Human genes 0.000 claims 4
- 108010029485 Protein Isoforms Proteins 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 102000018832 Cytochromes Human genes 0.000 claims 3
- 108010052832 Cytochromes Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 241000222122 Candida albicans Species 0.000 claims 2
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 claims 2
- 108010000561 Cytochrome P-450 CYP2C8 Proteins 0.000 claims 2
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 claims 2
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 2
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 2
- 102100029363 Cytochrome P450 2C19 Human genes 0.000 claims 2
- 102100029359 Cytochrome P450 2C8 Human genes 0.000 claims 2
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 claims 2
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 241000223259 Trichoderma Species 0.000 claims 2
- 208000024386 fungal infectious disease Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 108010073030 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Proteins 0.000 claims 1
- 102100036285 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Human genes 0.000 claims 1
- 201000002909 Aspergillosis Diseases 0.000 claims 1
- 208000036641 Aspergillus infections Diseases 0.000 claims 1
- 206010007134 Candida infections Diseases 0.000 claims 1
- 241000223205 Coccidioides immitis Species 0.000 claims 1
- 201000007336 Cryptococcosis Diseases 0.000 claims 1
- 241000221204 Cryptococcus neoformans Species 0.000 claims 1
- 108010074918 Cytochrome P-450 CYP1A1 Proteins 0.000 claims 1
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 claims 1
- 108010020070 Cytochrome P-450 CYP2B6 Proteins 0.000 claims 1
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 1
- 102100031476 Cytochrome P450 1A1 Human genes 0.000 claims 1
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 claims 1
- 102100027417 Cytochrome P450 1B1 Human genes 0.000 claims 1
- 102100038742 Cytochrome P450 2A13 Human genes 0.000 claims 1
- 102100036194 Cytochrome P450 2A6 Human genes 0.000 claims 1
- 102100038739 Cytochrome P450 2B6 Human genes 0.000 claims 1
- 102100029368 Cytochrome P450 2C18 Human genes 0.000 claims 1
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 1
- 102100031461 Cytochrome P450 2J2 Human genes 0.000 claims 1
- 102100026515 Cytochrome P450 2S1 Human genes 0.000 claims 1
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 claims 1
- 102100039208 Cytochrome P450 3A5 Human genes 0.000 claims 1
- 102100039203 Cytochrome P450 3A7 Human genes 0.000 claims 1
- 102100027567 Cytochrome P450 4A11 Human genes 0.000 claims 1
- 102100027419 Cytochrome P450 4B1 Human genes 0.000 claims 1
- 102100024916 Cytochrome P450 4F11 Human genes 0.000 claims 1
- 102100024918 Cytochrome P450 4F12 Human genes 0.000 claims 1
- 102100024902 Cytochrome P450 4F2 Human genes 0.000 claims 1
- 102100024901 Cytochrome P450 4F3 Human genes 0.000 claims 1
- 102100024899 Cytochrome P450 4F8 Human genes 0.000 claims 1
- 102100022027 Cytochrome P450 4X1 Human genes 0.000 claims 1
- 102100022034 Cytochrome P450 4Z1 Human genes 0.000 claims 1
- 102100038637 Cytochrome P450 7A1 Human genes 0.000 claims 1
- 102100038698 Cytochrome P450 7B1 Human genes 0.000 claims 1
- 108010036233 Cytochrome P450 Family 46 Proteins 0.000 claims 1
- 102000023526 Cytochrome P450 Family 46 Human genes 0.000 claims 1
- 206010012504 Dermatophytosis Diseases 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 208000025309 Hair disease Diseases 0.000 claims 1
- 201000002563 Histoplasmosis Diseases 0.000 claims 1
- 101000725164 Homo sapiens Cytochrome P450 1B1 Proteins 0.000 claims 1
- 101000957389 Homo sapiens Cytochrome P450 2A13 Proteins 0.000 claims 1
- 101000875170 Homo sapiens Cytochrome P450 2A6 Proteins 0.000 claims 1
- 101000919360 Homo sapiens Cytochrome P450 2C18 Proteins 0.000 claims 1
- 101000941723 Homo sapiens Cytochrome P450 2J2 Proteins 0.000 claims 1
- 101000855328 Homo sapiens Cytochrome P450 2S1 Proteins 0.000 claims 1
- 101000745715 Homo sapiens Cytochrome P450 3A7 Proteins 0.000 claims 1
- 101000725111 Homo sapiens Cytochrome P450 4A11 Proteins 0.000 claims 1
- 101000909111 Homo sapiens Cytochrome P450 4F11 Proteins 0.000 claims 1
- 101000909108 Homo sapiens Cytochrome P450 4F12 Proteins 0.000 claims 1
- 101000909122 Homo sapiens Cytochrome P450 4F2 Proteins 0.000 claims 1
- 101000909121 Homo sapiens Cytochrome P450 4F3 Proteins 0.000 claims 1
- 101000909112 Homo sapiens Cytochrome P450 4F8 Proteins 0.000 claims 1
- 101000896935 Homo sapiens Cytochrome P450 4Z1 Proteins 0.000 claims 1
- 101000957672 Homo sapiens Cytochrome P450 7A1 Proteins 0.000 claims 1
- 101000957674 Homo sapiens Cytochrome P450 7B1 Proteins 0.000 claims 1
- 101000653005 Homo sapiens Thromboxane-A synthase Proteins 0.000 claims 1
- 101000855326 Homo sapiens Vitamin D 25-hydroxylase Proteins 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 102100021695 Lanosterol 14-alpha demethylase Human genes 0.000 claims 1
- 101710146773 Lanosterol 14-alpha demethylase Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000003351 Melanosis Diseases 0.000 claims 1
- 241001460074 Microsporum distortum Species 0.000 claims 1
- 208000008756 Mycetoma Diseases 0.000 claims 1
- 108010045510 NADPH-Ferrihemoprotein Reductase Proteins 0.000 claims 1
- 208000010195 Onychomycosis Diseases 0.000 claims 1
- 206010033767 Paracoccidioides infections Diseases 0.000 claims 1
- 201000000301 Paracoccidioidomycosis Diseases 0.000 claims 1
- 208000005384 Pneumocystis Pneumonia Diseases 0.000 claims 1
- 206010073755 Pneumocystis jirovecii pneumonia Diseases 0.000 claims 1
- 102100033075 Prostacyclin synthase Human genes 0.000 claims 1
- 102100026372 Putative inactive cytochrome P450 2G1 Human genes 0.000 claims 1
- 206010041736 Sporotrichosis Diseases 0.000 claims 1
- 102100030973 Thromboxane-A synthase Human genes 0.000 claims 1
- 208000002474 Tinea Diseases 0.000 claims 1
- 102100026523 Vitamin D 25-hydroxylase Human genes 0.000 claims 1
- 206010061418 Zygomycosis Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 201000007691 actinomycosis Diseases 0.000 claims 1
- 229940095731 candida albicans Drugs 0.000 claims 1
- 201000003984 candidiasis Diseases 0.000 claims 1
- 201000003486 coccidioidomycosis Diseases 0.000 claims 1
- 108010026647 cytochrome P-450 4X1 Proteins 0.000 claims 1
- 108010062869 cytochrome P-450 CYP2G1 Proteins 0.000 claims 1
- 108010018719 cytochrome P-450 CYP4B1 Proteins 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 208000034653 disorder of pilosebaceous unit Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002615 epidermis Anatomy 0.000 claims 1
- 201000005889 eumycotic mycetoma Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 201000007524 mucormycosis Diseases 0.000 claims 1
- 201000000317 pneumocystosis Diseases 0.000 claims 1
- 108010064377 prostacyclin synthetase Proteins 0.000 claims 1
- 201000005882 tinea unguium Diseases 0.000 claims 1
- 0 CCCCCCOC(CC*CC)(*(CC)CC)*(C(*)(**CC)c1c(c(*(CC)CC)c(*CC)c(*CC)c2N(CC)P)c2c(CCC)c(C(C)*[Cn])c1*(CC)CC)C(*CC)(C(C)*CC)C(*CC)=C(C#CC(C(CC*C)(*(CC)CC)*(C)(C)CC)(C(*CC)(*CC)C(C)*N)C(*CC)(C(C)*[Np])*(*)CC)N(CC)CCC Chemical compound CCCCCCOC(CC*CC)(*(CC)CC)*(C(*)(**CC)c1c(c(*(CC)CC)c(*CC)c(*CC)c2N(CC)P)c2c(CCC)c(C(C)*[Cn])c1*(CC)CC)C(*CC)(C(C)*CC)C(*CC)=C(C#CC(C(CC*C)(*(CC)CC)*(C)(C)CC)(C(*CC)(*CC)C(C)*N)C(*CC)(C(C)*[Np])*(*)CC)N(CC)CCC 0.000 description 30
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86930906P | 2006-12-08 | 2006-12-08 | |
| PCT/US2007/086917 WO2008073863A2 (en) | 2006-12-08 | 2007-12-10 | Preparation and utility of substituted allylamines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010512343A JP2010512343A (ja) | 2010-04-22 |
| JP2010512343A5 true JP2010512343A5 (enExample) | 2010-06-03 |
Family
ID=39402913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009540513A Withdrawn JP2010512343A (ja) | 2006-12-08 | 2007-12-10 | 置換アリルアミン類の調製および実用性 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20080167312A1 (enExample) |
| EP (1) | EP2121572A2 (enExample) |
| JP (1) | JP2010512343A (enExample) |
| WO (1) | WO2008073863A2 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926813B1 (fr) * | 2008-01-28 | 2011-10-21 | Inst Francais Du Petrole | Procede de separation du propane et du propylene mettant en oeuvre une colonne a distiller et une unite de separation par membrane |
| TWI523652B (zh) | 2008-07-15 | 2016-03-01 | 泰瑞克公司 | 氘化苄基苯衍生物及使用方法 |
| BRPI0913518A2 (pt) * | 2008-09-03 | 2016-07-26 | Teva Pharma | composto, composição farmacêutica, e, método de tratamento de um distúrbio mediado por função imune |
| US20120315244A1 (en) | 2009-09-30 | 2012-12-13 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Inhibiting Gene Products |
| CN106414392B (zh) * | 2014-06-10 | 2019-05-14 | 华东理工大学 | 6,7,8,9-四氢-5h-苯并[7]轮烯-2-烷基胺类化合物及其用途 |
| CN105016966A (zh) * | 2015-07-31 | 2015-11-04 | 江苏恒润制药有限公司 | 一种（e）-1-氯-6,6-二甲基-2-庚烯-4-炔的制备方法 |
| CN111514860B (zh) * | 2020-05-09 | 2022-12-30 | 江南大学 | 一种羊毛废弃物的高效综合回收再利用方法 |
| CN114380696B (zh) * | 2021-12-23 | 2022-11-25 | 山东诚汇双达药业有限公司 | 一种盐酸特比萘芬的制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3069633D1 (en) * | 1979-08-22 | 1984-12-20 | Sandoz Ag | Propenylamines, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals |
| US4870095A (en) * | 1988-06-13 | 1989-09-26 | Sterling Drug, Inc. | 1H-pyrazole-1-alkanamides, antiarrhythmic compositions and use |
| HU223343B1 (hu) * | 1991-05-20 | 2004-06-28 | Novartis Ag. | Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| GB9509631D0 (en) * | 1995-05-12 | 1995-07-05 | Sandoz Ltd | Antifungal combination |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| DE60001623T2 (de) * | 1999-12-03 | 2003-12-18 | Pfizer Products Inc., Groton | Sulfamoylheteroarylpyrazolverbindungen zur Verwendung als analgetisches/entzündungshemmendes Mittel |
| EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| DE10162121A1 (de) * | 2001-12-12 | 2003-06-18 | Berolina Drug Dev Ab Svedala | Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| US7514068B2 (en) * | 2005-09-14 | 2009-04-07 | Concert Pharmaceuticals Inc. | Biphenyl-pyrazolecarboxamide compounds |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| US20090082469A1 (en) * | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched terbinafine |
-
2007
- 2007-12-10 US US11/953,195 patent/US20080167312A1/en not_active Abandoned
- 2007-12-10 WO PCT/US2007/086917 patent/WO2008073863A2/en not_active Ceased
- 2007-12-10 JP JP2009540513A patent/JP2010512343A/ja not_active Withdrawn
- 2007-12-10 EP EP07865444A patent/EP2121572A2/en not_active Withdrawn
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