JP2010501580A5 - - Google Patents
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- Publication number
- JP2010501580A5 JP2010501580A5 JP2009525662A JP2009525662A JP2010501580A5 JP 2010501580 A5 JP2010501580 A5 JP 2010501580A5 JP 2009525662 A JP2009525662 A JP 2009525662A JP 2009525662 A JP2009525662 A JP 2009525662A JP 2010501580 A5 JP2010501580 A5 JP 2010501580A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acids
- amino
- sequence
- core
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000001014 amino acid Nutrition 0.000 claims description 236
- 229940024606 amino acid Drugs 0.000 claims description 236
- 150000001413 amino acids Chemical class 0.000 claims description 208
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 34
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 32
- 235000004279 alanine Nutrition 0.000 claims description 32
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims description 32
- 210000004899 c-terminal region Anatomy 0.000 claims description 32
- 229920001184 polypeptide Polymers 0.000 claims description 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 32
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims description 32
- -1 NS2 amino acids Chemical class 0.000 claims description 28
- 239000000203 mixture Substances 0.000 claims description 24
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 18
- 239000004475 Arginine Substances 0.000 claims description 16
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 16
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 16
- 239000004472 Lysine Substances 0.000 claims description 16
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 16
- 239000004473 Threonine Substances 0.000 claims description 16
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 16
- 229960001230 asparagine Drugs 0.000 claims description 16
- 235000009582 asparagine Nutrition 0.000 claims description 16
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims description 16
- 229930182817 methionine Natural products 0.000 claims description 16
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims description 16
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 14
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 14
- 230000004927 fusion Effects 0.000 claims description 10
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 239000002157 polynucleotide Substances 0.000 claims description 8
- 108091026890 Coding region Proteins 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000024932 T cell mediated immunity Effects 0.000 claims description 5
- 230000004936 stimulating effect Effects 0.000 claims description 5
- 230000001900 immune effect Effects 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 230000003308 immunostimulating effect Effects 0.000 claims description 4
- 108020004707 nucleic acids Proteins 0.000 claims description 4
- 102000039446 nucleic acids Human genes 0.000 claims description 4
- 150000007523 nucleic acids Chemical class 0.000 claims description 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000002253 acid Substances 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- 241001024304 Mino Species 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84016206P | 2006-08-25 | 2006-08-25 | |
| US60/840,162 | 2006-08-25 | ||
| PCT/US2007/018940 WO2008024518A2 (en) | 2006-08-25 | 2007-08-27 | Hcv fusion polypeptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013241514A Division JP2014036675A (ja) | 2006-08-25 | 2013-11-22 | Ｈｃｖ融合ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010501580A JP2010501580A (ja) | 2010-01-21 |
| JP2010501580A5 true JP2010501580A5 (enExample) | 2010-11-11 |
| JP5474547B2 JP5474547B2 (ja) | 2014-04-16 |
Family
ID=38969483
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009525662A Active JP5474547B2 (ja) | 2006-08-25 | 2007-08-27 | Ｈｃｖ融合ポリペプチド |
| JP2013241514A Withdrawn JP2014036675A (ja) | 2006-08-25 | 2013-11-22 | Ｈｃｖ融合ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013241514A Withdrawn JP2014036675A (ja) | 2006-08-25 | 2013-11-22 | Ｈｃｖ融合ポリペプチド |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8216590B2 (enExample) |
| EP (1) | EP2061888A2 (enExample) |
| JP (2) | JP5474547B2 (enExample) |
| CA (1) | CA2661492A1 (enExample) |
| WO (1) | WO2008024518A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011163558A1 (en) * | 2010-06-25 | 2011-12-29 | Abbott Laboratories | Materials and methods for assay of anti-hepatitis c virus (hcv) antibodies |
| US10300131B2 (en) | 2015-07-07 | 2019-05-28 | The Governors Of The University Of Alberta | Hepatitis C virus immunogenic compositions and methods of use thereof |
| WO2018055535A2 (en) | 2016-09-21 | 2018-03-29 | The Governors Of The University Of Alberta | Hepatitis c virus immunogenic compositions and methods of use thereof |
| BR102018071672A2 (pt) * | 2018-10-22 | 2021-11-16 | Fundação Oswaldo Cruz | Polipeptídeo, cassete de expressão, vetor de expressão, célula hospedeira, kit para triagem imunológica de hcv e/ou diagnóstico de hepatite c, composição, uso de pelo menos um polipeptídeo, e, métodos para produzir um polipeptídeo, para triagem imunológica de hcv e para o diagnóstico de hepatite c |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5683864A (en) * | 1987-11-18 | 1997-11-04 | Chiron Corporation | Combinations of hepatitis C virus (HCV) antigens for use in immunoassays for anti-HCV antibodies |
| US5350671A (en) | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| ES2188583T3 (es) | 1991-06-24 | 2003-07-01 | Chiron Corp | Polipeptidos para el virus de la hepatitis c (hcv). |
| UA39944C2 (uk) | 1992-07-07 | 2001-07-16 | Чірон Корпорейшн | Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі |
| US6514731B1 (en) | 1996-05-24 | 2003-02-04 | Chiron Corporation | Methods for the preparation of hepatitis C virus multiple copy epitope fusion antigens |
| US6054424A (en) | 1998-04-15 | 2000-04-25 | Church & Dwight Co., Inc. | Process for the production of a liquid laundry detergent composition of desired viscosity containing nonionic and anionic surfactants |
| ES2281179T3 (es) | 1998-06-09 | 2007-09-16 | Andrea D. Branch | Nuevos peptidos del virus de la hepatitis c y usos de los mismos. |
| US6562346B1 (en) | 1999-10-27 | 2003-05-13 | Chiron Corporation | Activation of HCV-specific T cells |
| EP1233982B1 (en) * | 1999-11-24 | 2007-10-24 | Novartis Vaccines and Diagnostics, Inc. | Novel hcv non-structural polypeptide |
| CA2491508A1 (en) * | 2002-07-02 | 2004-01-15 | Chiron Corporation | Hcv fusion proteins with modified ns3 domains |
| WO2004039950A2 (en) | 2002-10-25 | 2004-05-13 | Chiron Corporation | Activation of hcv-specific cells |
| RU2006144714A (ru) * | 2004-05-17 | 2008-06-27 | Чирон Корпорейшн (Us) | Усеченный ns5 домен вируса гепатита с и содержащие его слитые белки |
| ES2377978T3 (es) * | 2004-08-27 | 2012-04-03 | Novartis Vaccines And Diagnostics, Inc. | Mutantes de proteínas no estructurales de VHC y usos de los mismos |
-
2007
- 2007-08-27 EP EP07811569A patent/EP2061888A2/en not_active Withdrawn
- 2007-08-27 US US12/310,406 patent/US8216590B2/en active Active
- 2007-08-27 JP JP2009525662A patent/JP5474547B2/ja active Active
- 2007-08-27 CA CA002661492A patent/CA2661492A1/en not_active Abandoned
- 2007-08-27 WO PCT/US2007/018940 patent/WO2008024518A2/en not_active Ceased
-
2013
- 2013-11-22 JP JP2013241514A patent/JP2014036675A/ja not_active Withdrawn