JP2010500025A5 - - Google Patents

Info

Publication number

JP2010500025A5

JP2010500025A5 JP2009523833A JP2009523833A JP2010500025A5 JP 2010500025 A5 JP2010500025 A5 JP 2010500025A5 JP 2009523833 A JP2009523833 A JP 2009523833A JP 2009523833 A JP2009523833 A JP 2009523833A JP 2010500025 A5 JP2010500025 A5 JP 2010500025A5

Authority

JP

Japan

Prior art keywords

nucleic acid

strand

pharmaceutical composition

seq

promoter

Prior art date

2007-08-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108020004707 nucleic acids Proteins 0.000 claims 43
• 102000039446 nucleic acids Human genes 0.000 claims 43
• 150000007523 nucleic acids Chemical class 0.000 claims 43
• 239000008194 pharmaceutical composition Substances 0.000 claims 21
• 230000014509 gene expression Effects 0.000 claims 19
• 239000002773 nucleotide Substances 0.000 claims 15
• 125000003729 nucleotide group Chemical group 0.000 claims 15
• 239000013598 vector Substances 0.000 claims 12
• 241000282414 Homo sapiens Species 0.000 claims 10
• 241000282553 Macaca Species 0.000 claims 8
• 210000004027 cell Anatomy 0.000 claims 8
• 230000000295 complement effect Effects 0.000 claims 5
• 210000002569 neuron Anatomy 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 239000003814 drug Substances 0.000 claims 4
• 208000023105 Huntington disease Diseases 0.000 claims 3
• 231100000433 cytotoxic Toxicity 0.000 claims 3
• 230000001472 cytotoxic effect Effects 0.000 claims 3
• 239000013603 viral vector Substances 0.000 claims 3
• 101710177611 DNA polymerase II large subunit Proteins 0.000 claims 2
• 101710184669 DNA polymerase II small subunit Proteins 0.000 claims 2
• 102000006010 Protein Disulfide-Isomerase Human genes 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 230000002401 inhibitory effect Effects 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 238000011321 prophylaxis Methods 0.000 claims 2
• 108020003519 protein disulfide isomerase Proteins 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 102000034342 Calnexin Human genes 0.000 claims 1
• 108010056891 Calnexin Proteins 0.000 claims 1
• 241000702421 Dependoparvovirus Species 0.000 claims 1
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 1
• 210000004556 brain Anatomy 0.000 claims 1
• 210000001159 caudate nucleus Anatomy 0.000 claims 1
• 230000004064 dysfunction Effects 0.000 claims 1
• 210000002472 endoplasmic reticulum Anatomy 0.000 claims 1
• 230000009368 gene silencing by RNA Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 210000004962 mammalian cell Anatomy 0.000 claims 1
• 239000003550 marker Substances 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 230000037023 motor activity Effects 0.000 claims 1
• 210000001577 neostriatum Anatomy 0.000 claims 1
• 230000008488 polyadenylation Effects 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 210000002637 putamen Anatomy 0.000 claims 1
• 241000894007 species Species 0.000 claims 1
• 241001446247 uncultured actinomycete Species 0.000 claims 1