JP2010047611A5 - - Google Patents
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- JP2010047611A5 JP2010047611A5 JP2009272002A JP2009272002A JP2010047611A5 JP 2010047611 A5 JP2010047611 A5 JP 2010047611A5 JP 2009272002 A JP2009272002 A JP 2009272002A JP 2009272002 A JP2009272002 A JP 2009272002A JP 2010047611 A5 JP2010047611 A5 JP 2010047611A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- angiotensin
- cyclodextrin
- receptor antagonist
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 45
- 102000005862 Angiotensin II Human genes 0.000 claims 24
- 101800000733 Angiotensin-2 Proteins 0.000 claims 24
- CZGUSIXMZVURDU-JZXHSEFVSA-N Ile(5)-angiotensin II Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC=1C=CC=CC=1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 CZGUSIXMZVURDU-JZXHSEFVSA-N 0.000 claims 24
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims 24
- 239000000400 angiotensin II type 1 receptor blocker Substances 0.000 claims 24
- 229950006323 angiotensin ii Drugs 0.000 claims 24
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 22
- 229920000858 Cyclodextrin Polymers 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 8
- 239000003085 diluting agent Substances 0.000 claims 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims 6
- 239000002083 C09CA01 - Losartan Substances 0.000 claims 5
- 229960004773 losartan Drugs 0.000 claims 5
- KJJZZJSZUJXYEA-UHFFFAOYSA-N losartan Chemical group CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C=2[N]N=NN=2)C=C1 KJJZZJSZUJXYEA-UHFFFAOYSA-N 0.000 claims 5
- 208000037849 arterial hypertension Diseases 0.000 claims 4
- 229920000249 biocompatible polymer Polymers 0.000 claims 4
- 229920002988 biodegradable polymer Polymers 0.000 claims 4
- 238000013270 controlled release Methods 0.000 claims 4
- RMMXLENWKUUMAY-UHFFFAOYSA-N telmisartan Chemical compound CCCC1=NC2=C(C)C=C(C=3N(C4=CC=CC=C4N=3)C)C=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C(O)=O RMMXLENWKUUMAY-UHFFFAOYSA-N 0.000 claims 4
- 230000001976 improved effect Effects 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 206010003210 Arteriosclerosis Diseases 0.000 claims 2
- 239000002080 C09CA02 - Eprosartan Substances 0.000 claims 2
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 2
- 239000002947 C09CA04 - Irbesartan Substances 0.000 claims 2
- 239000002053 C09CA06 - Candesartan Substances 0.000 claims 2
- 239000005537 C09CA07 - Telmisartan Substances 0.000 claims 2
- 206010019280 Heart failures Diseases 0.000 claims 2
- PVHLMTREZMEJCG-GDTLVBQBSA-N Ile(5)-angiotensin II (1-7) Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C([O-])=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)[C@@H]([NH3+])CC([O-])=O)C(C)C)C1=CC=C(O)C=C1 PVHLMTREZMEJCG-GDTLVBQBSA-N 0.000 claims 2
- 229920000954 Polyglycolide Polymers 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 108010021281 angiotensin I (1-7) Proteins 0.000 claims 2
- 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
- 229960000932 candesartan Drugs 0.000 claims 2
- SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 claims 2
- 208000026106 cerebrovascular disease Diseases 0.000 claims 2
- 208000029078 coronary artery disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 229960004563 eprosartan Drugs 0.000 claims 2
- OROAFUQRIXKEMV-LDADJPATSA-N eprosartan Chemical compound C=1C=C(C(O)=O)C=CC=1CN1C(CCCC)=NC=C1\C=C(C(O)=O)/CC1=CC=CS1 OROAFUQRIXKEMV-LDADJPATSA-N 0.000 claims 2
- 238000010255 intramuscular injection Methods 0.000 claims 2
- 239000007927 intramuscular injection Substances 0.000 claims 2
- 238000010253 intravenous injection Methods 0.000 claims 2
- 229960002198 irbesartan Drugs 0.000 claims 2
- YCPOHTHPUREGFM-UHFFFAOYSA-N irbesartan Chemical compound O=C1N(CC=2C=CC(=CC=2)C=2C(=CC=CC=2)C=2[N]N=NN=2)C(CCCC)=NC21CCCC2 YCPOHTHPUREGFM-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 238000010254 subcutaneous injection Methods 0.000 claims 2
- 239000007929 subcutaneous injection Substances 0.000 claims 2
- 229960005187 telmisartan Drugs 0.000 claims 2
- 229960004699 valsartan Drugs 0.000 claims 2
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 2
- XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 claims 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI0102252-0B1A BR0102252B1 (pt) | 2001-04-10 | 2001-04-10 | Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578949A Division JP4439814B2 (ja) | 2001-04-10 | 2002-04-09 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010047611A JP2010047611A (ja) | 2010-03-04 |
| JP2010047611A5 true JP2010047611A5 (https=) | 2011-03-03 |
Family
ID=3947403
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578949A Expired - Fee Related JP4439814B2 (ja) | 2001-04-10 | 2002-04-09 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
| JP2009272002A Pending JP2010047611A (ja) | 2001-04-10 | 2009-11-30 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002578949A Expired - Fee Related JP4439814B2 (ja) | 2001-04-10 | 2002-04-09 | 動脈性高血圧症、他の心血管疾患、及びその合併症を治療するためのアンギオテンシンｉｉａｔ１受容体拮抗薬製剤の調製 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US7858597B2 (https=) |
| EP (1) | EP1389106A1 (https=) |
| JP (2) | JP4439814B2 (https=) |
| CN (1) | CN1523985B (https=) |
| BR (1) | BR0102252B1 (https=) |
| CA (1) | CA2444145C (https=) |
| WO (1) | WO2002080910A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0102252B1 (pt) * | 2001-04-10 | 2013-10-22 | Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso | |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| BRPI0105509B8 (pt) * | 2001-11-05 | 2021-05-25 | Univ Minas Gerais | formulações do peptídeo angiotensina-(1-7) usando as ciclodextrinas, lipossomas e o polímero plga |
| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| KR20050005437A (ko) | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
| US7041832B2 (en) | 2002-04-29 | 2006-05-09 | Tava Pharmaceutical Industries, Ltd. | Processes for preparing losartan and losartan potassium |
| KR100554156B1 (ko) | 2003-07-26 | 2006-02-22 | 학교법인 포항공과대학교 | 쿠커비투릴 유도체가 응집되어 형성된 나노 입자, 그 나노입자에 약물이 담지된 약제학적 조성물, 및 이들의 제조방법 |
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| JP2008530185A (ja) * | 2005-02-21 | 2008-08-07 | フラメル・テクノロジー | ロサルタンの経口医薬剤形態 |
| FR2882260A1 (fr) * | 2005-02-21 | 2006-08-25 | Flamel Technologies Sa | Forme pharmaceutique orale multimicroparticulaire a liberation modifiee d'antagonistes des recepteurs de l'angiotensine ii |
| FR2884145A1 (fr) * | 2005-04-06 | 2006-10-13 | Flamel Technologies Sa | Forme pharmaceutique orale de losartan |
| WO2008052295A1 (en) * | 2006-10-30 | 2008-05-08 | Universidade Federal De Minas Gerais | Process for the preparation of compounds of at1 receptor antagonists with angiotensin-(1-7), analogues thereof and/or mixtures of these systems, pharmaceutical compositions thereof and use of their derivative products |
| WO2008089532A1 (en) * | 2007-01-26 | 2008-07-31 | Universidade Federal De Minas Gerais - Ufmg | Pharmaceutical compositions and methods for treating erectile dysfunction |
| EP2197416A1 (en) * | 2007-10-09 | 2010-06-23 | Novartis Ag | Pharmaceutical formulation of valsartan |
| BRPI0800585B8 (pt) | 2008-02-13 | 2021-05-25 | Univ Minas Gerais | composições farmacêuticas do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) e uso do peptídeo des-[asp1]-[ala1]-angiotensina-(1-7) |
| BR102012009317B1 (pt) * | 2012-04-20 | 2022-05-31 | Universidade Federal De Minas Gerais - Ufmg | Processo de preparação de compostos de inclusão envolvendo ciclodextrinas e fármacos, usando um sistema de fluxo contínuo |
| CN108367079B (zh) * | 2015-11-12 | 2022-11-22 | 灰色视觉公司 | 用于治疗的聚集性微粒 |
| CA3056923A1 (en) | 2017-03-23 | 2018-09-27 | Graybug Vision, Inc. | Drugs and compositions for the treatment of ocular disorders |
| US11160870B2 (en) | 2017-05-10 | 2021-11-02 | Graybug Vision, Inc. | Extended release microparticles and suspensions thereof for medical therapy |
| CN115175664A (zh) * | 2020-03-25 | 2022-10-11 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 包含ati受体阻滞剂的脂质体制剂及其用途 |
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| BR0102252B1 (pt) * | 2001-04-10 | 2013-10-22 | Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso |
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2001
- 2001-04-10 BR BRPI0102252-0B1A patent/BR0102252B1/pt not_active IP Right Cessation
-
2002
- 2002-04-09 JP JP2002578949A patent/JP4439814B2/ja not_active Expired - Fee Related
- 2002-04-09 CA CA002444145A patent/CA2444145C/en not_active Expired - Fee Related
- 2002-04-09 WO PCT/BR2002/000051 patent/WO2002080910A1/en not_active Ceased
- 2002-04-09 EP EP02713951A patent/EP1389106A1/en not_active Withdrawn
- 2002-04-09 US US10/474,640 patent/US7858597B2/en not_active Expired - Fee Related
- 2002-04-09 CN CN028106814A patent/CN1523985B/zh not_active Expired - Fee Related
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2007
- 2007-10-31 US US11/980,345 patent/US20080108575A1/en not_active Abandoned
-
2009
- 2009-11-30 JP JP2009272002A patent/JP2010047611A/ja active Pending
-
2010
- 2010-12-23 US US12/977,402 patent/US8293723B2/en not_active Expired - Fee Related
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2012
- 2012-10-22 US US13/656,941 patent/US20130164341A1/en not_active Abandoned
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