ATE214388T1 - Verfahren zur kristallisation von losartan - Google Patents

Verfahren zur kristallisation von losartan

Info

Publication number
ATE214388T1
ATE214388T1 AT97913800T AT97913800T ATE214388T1 AT E214388 T1 ATE214388 T1 AT E214388T1 AT 97913800 T AT97913800 T AT 97913800T AT 97913800 T AT97913800 T AT 97913800T AT E214388 T1 ATE214388 T1 AT E214388T1
Authority
AT
Austria
Prior art keywords
losartan
crystallization
Prior art date
Application number
AT97913800T
Other languages
English (en)
Inventor
Patrick Breen
Erik A Dienemann
Albert D Epstein
Karen A Larson
Michael T Kennedy
Hari Mahadevan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625804.1A external-priority patent/GB9625804D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE214388T1 publication Critical patent/ATE214388T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
AT97913800T 1996-10-29 1997-10-24 Verfahren zur kristallisation von losartan ATE214388T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2932696P 1996-10-29 1996-10-29
GBGB9625804.1A GB9625804D0 (en) 1996-12-12 1996-12-12 Process for the crystallization of losartan
PCT/US1997/019442 WO1998018787A1 (en) 1996-10-29 1997-10-24 Process for the crystallization of losartan

Publications (1)

Publication Number Publication Date
ATE214388T1 true ATE214388T1 (de) 2002-03-15

Family

ID=26310606

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97913800T ATE214388T1 (de) 1996-10-29 1997-10-24 Verfahren zur kristallisation von losartan

Country Status (18)

Country Link
US (1) US5859258A (de)
EP (1) EP0937068B1 (de)
JP (1) JP3249827B2 (de)
CN (1) CN1101393C (de)
AR (1) AR010256A1 (de)
AT (1) ATE214388T1 (de)
AU (1) AU5089898A (de)
BR (1) BR9712390A (de)
CZ (1) CZ291672B6 (de)
DE (1) DE69711068T2 (de)
DK (1) DK0937068T3 (de)
EA (1) EA001046B1 (de)
ES (1) ES2173433T3 (de)
HR (1) HRP970565B1 (de)
PT (1) PT937068E (de)
SK (1) SK282875B6 (de)
TW (1) TW411338B (de)
WO (1) WO1998018787A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001226372A (ja) * 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
JP2002080354A (ja) * 2000-09-05 2002-03-19 Kao Corp 血圧降下剤組成物
BR0102252B1 (pt) * 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
SK722003A3 (en) * 2001-05-18 2003-12-02 Aurobindo Pharma Ltd Process for the crystallization of losartan potassium
WO2003033462A2 (en) * 2001-10-15 2003-04-24 The Regents Of The University Of Michigan Systems and methods for the generation of crystalline polymorphs
EP1438027A1 (de) * 2001-10-25 2004-07-21 DepoMed, Inc. Behandlungsmethode unter verwendung einer losartan enthaltenden darreichungsform mit verlängerter magenverweilzeit
EP1634880A3 (de) 2002-04-29 2006-04-12 Teva Pharmaceutical Industries Ltd. Verfahren zur Herstellung von Losartan und Kaliumlosartan
US20040097568A1 (en) * 2002-07-29 2004-05-20 Dr. Reddy's Laboratories Limited Crystalline form of losartan potassium
DE60315417T2 (de) * 2002-10-17 2008-04-30 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von losartan kaliumsalz mit verbesserten fliesseigenschaften
WO2004039352A2 (en) * 2002-10-31 2004-05-13 Ranbaxy Laboratories Limited Amorphous form of losartan potassium
ATE487478T1 (de) * 2003-01-30 2010-11-15 Lek Pharmaceuticals Herstellung eines neuen pharmazeutisch geeigneten losartan-salzes und von seinen formen mittels neuer reinigungs- und isolationsverfahren
WO2004076442A1 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Polymorphs of losartan
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
ITMI20032472A1 (it) * 2003-12-16 2005-06-17 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di losartan potassio cristallino
EP1709034A2 (de) * 2004-01-06 2006-10-11 IPCA Laboratories Limited Verbessertes verfahren zur synthese von losartan-kalium
RU2384346C2 (ru) * 2004-06-23 2010-03-20 Зольвай Фармасьютиклз Гмбх Фармацевтические композиции, содержащие nep-ингибиторы, ингибиторы эндогенной эндотелинпродуцирующей системы и антагонисты at1-рецептора
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
ITMI20050551A1 (it) * 2005-04-01 2006-10-02 Dipharma Spa Forma cristallina alfa di losartan potassio
WO2008058402A1 (en) 2006-11-17 2008-05-22 Queen's University At Kingston Compounds and methods for treating protein folding disorders
ES2315141B1 (es) * 2006-11-23 2009-12-22 Quimica Sintetica, S.A Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
ATE395341T1 (de) * 1991-11-18 2008-05-15 Du Pont 2-(2'-triphenylmethyl-2'h-tetrazol-5'- yl)phenylborsäure als zwischenprodukt zur synthese von a ii receptorenantagonisten
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
CA2179067A1 (en) * 1993-12-23 1995-06-29 Gordon Creston Campbell, Jr. Polymorphs of losartan and the process for the preparation of form ii of losartan

Also Published As

Publication number Publication date
CZ151599A3 (cs) 1999-10-13
TW411338B (en) 2000-11-11
HRP970565B1 (en) 2003-02-28
ES2173433T3 (es) 2002-10-16
DE69711068D1 (de) 2002-04-18
SK282875B6 (sk) 2003-01-09
SK57099A3 (en) 2000-02-14
JP2000504343A (ja) 2000-04-11
AR010256A1 (es) 2000-06-07
PT937068E (pt) 2002-07-31
CN1101393C (zh) 2003-02-12
AU5089898A (en) 1998-05-22
EA001046B1 (ru) 2000-08-28
EP0937068B1 (de) 2002-03-13
HRP970565A2 (en) 1998-08-31
WO1998018787A1 (en) 1998-05-07
US5859258A (en) 1999-01-12
EA199900427A1 (ru) 1999-10-28
DE69711068T2 (de) 2002-09-12
CZ291672B6 (cs) 2003-04-16
EP0937068A1 (de) 1999-08-25
JP3249827B2 (ja) 2002-01-21
CN1241186A (zh) 2000-01-12
BR9712390A (pt) 1999-08-31
DK0937068T3 (da) 2002-05-21

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Legal Events

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EEFA Change of the company name