DK0937068T3 - Fremgangsmåde til krystallisation af losartan - Google Patents

Fremgangsmåde til krystallisation af losartan

Info

Publication number
DK0937068T3
DK0937068T3 DK97913800T DK97913800T DK0937068T3 DK 0937068 T3 DK0937068 T3 DK 0937068T3 DK 97913800 T DK97913800 T DK 97913800T DK 97913800 T DK97913800 T DK 97913800T DK 0937068 T3 DK0937068 T3 DK 0937068T3
Authority
DK
Denmark
Prior art keywords
losartan
crystallization
Prior art date
Application number
DK97913800T
Other languages
English (en)
Inventor
Patrick Breen
Erik A Dienemann
Albert D Epstein
Karen A Larson
Michael T Kennedy
Hari Mahadevan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9625804.1A external-priority patent/GB9625804D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0937068T3 publication Critical patent/DK0937068T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
DK97913800T 1996-10-29 1997-10-24 Fremgangsmåde til krystallisation af losartan DK0937068T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2932696P 1996-10-29 1996-10-29
GBGB9625804.1A GB9625804D0 (en) 1996-12-12 1996-12-12 Process for the crystallization of losartan
PCT/US1997/019442 WO1998018787A1 (en) 1996-10-29 1997-10-24 Process for the crystallization of losartan

Publications (1)

Publication Number Publication Date
DK0937068T3 true DK0937068T3 (da) 2002-05-21

Family

ID=26310606

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97913800T DK0937068T3 (da) 1996-10-29 1997-10-24 Fremgangsmåde til krystallisation af losartan

Country Status (18)

Country Link
US (1) US5859258A (da)
EP (1) EP0937068B1 (da)
JP (1) JP3249827B2 (da)
CN (1) CN1101393C (da)
AR (1) AR010256A1 (da)
AT (1) ATE214388T1 (da)
AU (1) AU5089898A (da)
BR (1) BR9712390A (da)
CZ (1) CZ291672B6 (da)
DE (1) DE69711068T2 (da)
DK (1) DK0937068T3 (da)
EA (1) EA001046B1 (da)
ES (1) ES2173433T3 (da)
HR (1) HRP970565B1 (da)
PT (1) PT937068E (da)
SK (1) SK282875B6 (da)
TW (1) TW411338B (da)
WO (1) WO1998018787A1 (da)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001226372A (ja) 1999-12-06 2001-08-21 Sumika Fine Chemicals Co Ltd ロサルタンの結晶性または結晶化された酸付加塩およびロサルタンの精製方法
JP2002080354A (ja) * 2000-09-05 2002-03-19 Kao Corp 血圧降下剤組成物
BR0102252B1 (pt) * 2001-04-10 2013-10-22 Sistema de liberação controlada para antagonista do receptor AT1 da angiotensina II, composição farmacêutica e seu uso
JP2004520446A (ja) * 2001-05-18 2004-07-08 オーロビンド ファーマ リミテッド ロサルタンカリウムの結晶化方法
AU2002334987A1 (en) * 2001-10-15 2003-04-28 The Regents Of The University Of Michigan Systems and methods for the generation of crystalline polymorphs
JP2005508358A (ja) * 2001-10-25 2005-03-31 デポメド・インコーポレイテッド 胃滞留型ロサルタン投与量を用いる治療方法
EP1634880A3 (en) 2002-04-29 2006-04-12 Teva Pharmaceutical Industries Ltd. Processes for preparing losartan and losartan potassium
US20040097568A1 (en) * 2002-07-29 2004-05-20 Dr. Reddy's Laboratories Limited Crystalline form of losartan potassium
WO2004035049A1 (en) * 2002-10-17 2004-04-29 Teva Pharmaceutical Industries Ltd. Process for preparing losartan potassium with improved flowability
WO2004039352A2 (en) * 2002-10-31 2004-05-13 Ranbaxy Laboratories Limited Amorphous form of losartan potassium
DE602004029982D1 (de) * 2003-01-30 2010-12-23 Lek Pharmaceuticals Herstellung eines neuen pharmazeutisch geeigneten losartan-salzes und von seinen formen mittels neuer reinigungs- und isolationsverfahren
WO2004076442A1 (en) * 2003-02-28 2004-09-10 Ranbaxy Laboratories Limited Polymorphs of losartan
US7345071B2 (en) 2003-05-07 2008-03-18 Ipca Laboratories Limited Process for the synthesis of Losartan potassium
ITMI20032472A1 (it) * 2003-12-16 2005-06-17 Dinamite Dipharma S P A In Forma A Bbreviata Diph Procedimento per la preparazione di losartan potassio cristallino
EP1709034A2 (en) * 2004-01-06 2006-10-11 IPCA Laboratories Limited An improved process for the synthesis of losartan potassium
RU2384346C2 (ru) * 2004-06-23 2010-03-20 Зольвай Фармасьютиклз Гмбх Фармацевтические композиции, содержащие nep-ингибиторы, ингибиторы эндогенной эндотелинпродуцирующей системы и антагонисты at1-рецептора
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
ITMI20050551A1 (it) * 2005-04-01 2006-10-02 Dipharma Spa Forma cristallina alfa di losartan potassio
US8362066B2 (en) 2006-11-17 2013-01-29 Treventis Corporation Compounds and methods for treating protein folding disorders
ES2315141B1 (es) * 2006-11-23 2009-12-22 Quimica Sintetica, S.A Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
KR100212257B1 (ko) * 1991-11-18 1999-08-02 미리암 디. 메코나헤이 Aii 수용체 길항물질을 합성하기 위한 테트라졸릴페닐보론산 중간체의 제조 방법
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
US5130439A (en) * 1991-11-18 1992-07-14 Lo Young S Tetrazolylphenylboronic acid intermediates for the synthesis of AII receptor antagonists
EP0736021A4 (en) * 1993-12-23 1997-04-02 Merck & Co Inc LOSARTANE POLYMORPHS AND PROCESS FOR THE PREPARATION OF FORM II OF LOSARTANE

Also Published As

Publication number Publication date
EP0937068B1 (en) 2002-03-13
CZ151599A3 (cs) 1999-10-13
CZ291672B6 (cs) 2003-04-16
AU5089898A (en) 1998-05-22
WO1998018787A1 (en) 1998-05-07
JP2000504343A (ja) 2000-04-11
PT937068E (pt) 2002-07-31
EA001046B1 (ru) 2000-08-28
HRP970565A2 (en) 1998-08-31
HRP970565B1 (en) 2003-02-28
CN1101393C (zh) 2003-02-12
SK282875B6 (sk) 2003-01-09
EA199900427A1 (ru) 1999-10-28
TW411338B (en) 2000-11-11
DE69711068T2 (de) 2002-09-12
DE69711068D1 (de) 2002-04-18
US5859258A (en) 1999-01-12
AR010256A1 (es) 2000-06-07
CN1241186A (zh) 2000-01-12
EP0937068A1 (en) 1999-08-25
SK57099A3 (en) 2000-02-14
BR9712390A (pt) 1999-08-31
ATE214388T1 (de) 2002-03-15
JP3249827B2 (ja) 2002-01-21
ES2173433T3 (es) 2002-10-16

Similar Documents

Publication Publication Date Title
DK0937068T3 (da) Fremgangsmåde til krystallisation af losartan
DK0770615T3 (da) Fremgangsmåde til fremstilling af dihalogenazolopyrimidiner
DK0773940T4 (da) Fremgangsmåde til syntese af substituerede sulfoxider
DK1772141T3 (da) Fremgangsmåde til gennemföring af krystallisation i fast tilstand
DK0812845T3 (da) Fremgangsmåde til fremstilling af sildenafil
DK0790226T3 (da) Fremgangsmåde til fremstilling af methanol
DK1005517T3 (da) Fremgangsmåde til fremstilling af diglycerider
DK0937055T3 (da) Fremgangsmåde til fremstilling af d,I-alfa-tocopherol
DK0786450T3 (da) Fremgangsmåde til fremstilling af enantiomerer fra O-demethyltramadol
DK89294A (da) Fremgangsmåde til krystallisation af iodamidol
DK0925285T3 (da) Fremgangsmåde til fremstilling af pyrimidinforbindelser
DK0768310T3 (da) Fremgangsmåde til fremstilling af imidazo-benzodiazepin-derivater
DK0839138T3 (da) Fremgangsmåde til fremstilling af N-substituerede 3-hydroxypyrazoler
DK0877738T3 (da) Fremgangsmåde til fremstilling af phenylimidazolidinderivater
DK0912576T3 (da) Fremgangsmåde til syntese af carbapenem-antibiotika
DK1042228T3 (da) Fremgangsmåde til behandling af cementslam
DK1027315T3 (da) Fremgangsmåde til fremstilling af n-butanol
DK0912603T3 (da) Fremgangsmåde til fremstilling af visse azacyclohexapeptider
DK0880498T3 (da) Fremgangsmåde til fremstilling af diketonforbindelser
DK0946514T3 (da) Fremgangsmåde til fremstilling af n-substituerede 3-hydroxypyrazoler
DK0973769T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK0842930T3 (da) Fremgangsmåde til syntese af benzothiophener
DK0970073T3 (da) Fremgangsmåde til fremstilling af eprosartan
DK1308454T3 (da) Fremgangsmåde til fremstilling af platinforbindelse
DK1023292T3 (da) Fremgangsmåde til syntese af chlorpurinintermediater