DK0912576T3 - Fremgangsmåde til syntese af carbapenem-antibiotika - Google Patents

Fremgangsmåde til syntese af carbapenem-antibiotika

Info

Publication number
DK0912576T3
DK0912576T3 DK97934060T DK97934060T DK0912576T3 DK 0912576 T3 DK0912576 T3 DK 0912576T3 DK 97934060 T DK97934060 T DK 97934060T DK 97934060 T DK97934060 T DK 97934060T DK 0912576 T3 DK0912576 T3 DK 0912576T3
Authority
DK
Denmark
Prior art keywords
synthesis
carbapenem antibiotics
carbapenem
antibiotics
Prior art date
Application number
DK97934060T
Other languages
English (en)
Inventor
John M Williams
Ronald B Jobson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617417.2A external-priority patent/GB9617417D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0912576T3 publication Critical patent/DK0912576T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
DK97934060T 1996-07-12 1997-07-08 Fremgangsmåde til syntese af carbapenem-antibiotika DK0912576T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2164996P 1996-07-12 1996-07-12
GBGB9617417.2A GB9617417D0 (en) 1996-08-20 1996-08-20 Process for synthesizing carbapenem antibodies
PCT/US1997/011844 WO1998002439A1 (en) 1996-07-12 1997-07-08 Process for synthesizing carbapenem antibiotics

Publications (1)

Publication Number Publication Date
DK0912576T3 true DK0912576T3 (da) 2002-03-25

Family

ID=26309896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97934060T DK0912576T3 (da) 1996-07-12 1997-07-08 Fremgangsmåde til syntese af carbapenem-antibiotika

Country Status (18)

Country Link
EP (1) EP0912576B1 (da)
CN (1) CN1085210C (da)
AR (1) AR008255A1 (da)
AT (1) ATE210664T1 (da)
AU (1) AU3720997A (da)
BR (1) BR9710360A (da)
CY (1) CY2310B1 (da)
CZ (1) CZ9199A3 (da)
DE (1) DE69709113T2 (da)
DK (1) DK0912576T3 (da)
EA (1) EA001152B1 (da)
ES (1) ES2167762T3 (da)
HK (1) HK1017356A1 (da)
PT (1) PT912576E (da)
SK (1) SK283298B6 (da)
TW (1) TW513430B (da)
UA (1) UA54444C2 (da)
WO (1) WO1998002439A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101172962B (zh) * 2002-11-13 2010-09-08 株式会社钟化 经口给药用碳青霉素烯化合物的合成中间体
PT1926732E (pt) 2005-09-05 2013-12-27 Ranbaxy Lab Ltd Processo para a preparação de compostos de carbapenem
CN101357920B (zh) * 2007-06-22 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺基三嗪的培南化合物
CN101367807B (zh) * 2007-06-28 2011-01-12 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物
CN101367806B (zh) * 2007-06-28 2010-11-17 山东轩竹医药科技有限公司 甲酰苯胺取代的巯基吡咯烷碳青霉烯类化合物
CN101343272B (zh) * 2007-07-13 2011-02-09 山东轩竹医药科技有限公司 含有环己烷的碳青霉烯化合物
CN101362757A (zh) * 2007-08-09 2009-02-11 山东轩竹医药科技有限公司 磺酰基取代的碳青霉烯类化合物
CN101362763B (zh) * 2007-08-12 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷的碳青霉烯衍生物
CN101412719B (zh) * 2007-08-30 2010-11-17 山东轩竹医药科技有限公司 碳代青霉烯类衍生物
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101694506B1 (ko) * 2009-04-30 2017-01-10 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 에르타페넴의 중간체, 이를 포함하는 조성물 및 이의 제조 방법
CN102260264A (zh) * 2010-05-25 2011-11-30 浙江海翔药业股份有限公司 一种非钯体系制备厄他培南的方法
CN104703986A (zh) 2012-10-12 2015-06-10 桑多斯股份公司 厄他培南中间体的制备
CN106565579A (zh) * 2016-06-26 2017-04-19 宁夏海诚电化信息科技有限公司 一种尔它培南侧链生产工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds

Also Published As

Publication number Publication date
EP0912576A1 (en) 1999-05-06
DE69709113D1 (de) 2002-01-24
HK1017356A1 (en) 1999-11-19
EA001152B1 (ru) 2000-10-30
PT912576E (pt) 2002-05-31
AR008255A1 (es) 1999-12-29
CY2310B1 (en) 2003-11-14
ATE210664T1 (de) 2001-12-15
EP0912576B1 (en) 2001-12-12
UA54444C2 (uk) 2003-03-17
ES2167762T3 (es) 2002-05-16
WO1998002439A1 (en) 1998-01-22
CN1085210C (zh) 2002-05-22
CN1225636A (zh) 1999-08-11
SK283298B6 (sk) 2003-05-02
EA199900099A1 (ru) 1999-06-24
BR9710360A (pt) 1999-08-17
SK3299A3 (en) 1999-07-12
TW513430B (en) 2002-12-11
DE69709113T2 (de) 2002-07-11
CZ9199A3 (cs) 1999-06-16
AU3720997A (en) 1998-02-09

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