EA199900099A1 - Способ получения карбапенемовых антибиотиков - Google Patents

Способ получения карбапенемовых антибиотиков

Info

Publication number
EA199900099A1
EA199900099A1 EA199900099A EA199900099A EA199900099A1 EA 199900099 A1 EA199900099 A1 EA 199900099A1 EA 199900099 A EA199900099 A EA 199900099A EA 199900099 A EA199900099 A EA 199900099A EA 199900099 A1 EA199900099 A1 EA 199900099A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
aryl
ester
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
EA199900099A
Other languages
English (en)
Other versions
EA001152B1 (ru
Inventor
Джон М. Вилльямс
Рональд Б. Джобсон
Original Assignee
Мерк Энд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617417.2A external-priority patent/GB9617417D0/en
Application filed by Мерк Энд Ко., Инк. filed Critical Мерк Энд Ко., Инк.
Publication of EA199900099A1 publication Critical patent/EA199900099A1/ru
Publication of EA001152B1 publication Critical patent/EA001152B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Предложен способ получения соединения формулы (I) или его фармацевтически приемлемой соли или сложного эфира,где каждый Р независимо обозначает Н или защитную группу и Rи Rнезависимо друг от друга обозначают Н, Cалкил, арил или гетероарил или замещенный Cалкил, арил или гетероарил, включающий взаимодействие соединений (II) или его фармацевтически приемлемой соли или сложного эфира и (III) или его фармацевтически приемлемой соли или сложного эфира, где Х обозначает ОР(O)(OR)или OSOR, где R обозначает Cалкил, арил или перфтор Cалкил, в присутствии амина, выбранного из группы, состоящей из диизопропиламина (ДИПА), дициклогексиламина (ДЦГА), 2,2,6,6-тетраметилпиперидина (ТМП), 1,1,3,3-тетраметилгуанидина (ТМГ), 1,8-диазабицикло[4.3.0]ундец-7-ена (ДБУ) и 1,5-диазабицикло[4.3.0]нон-5-ена (ДБН), с получением соединения формулы (I).Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199900099A 1996-07-12 1997-07-08 Способ получения карбапенемовых антибиотиков EA001152B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2164996P 1996-07-12 1996-07-12
GBGB9617417.2A GB9617417D0 (en) 1996-08-20 1996-08-20 Process for synthesizing carbapenem antibodies
PCT/US1997/011844 WO1998002439A1 (en) 1996-07-12 1997-07-08 Process for synthesizing carbapenem antibiotics

Publications (2)

Publication Number Publication Date
EA199900099A1 true EA199900099A1 (ru) 1999-06-24
EA001152B1 EA001152B1 (ru) 2000-10-30

Family

ID=26309896

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199900099A EA001152B1 (ru) 1996-07-12 1997-07-08 Способ получения карбапенемовых антибиотиков

Country Status (18)

Country Link
EP (1) EP0912576B1 (ru)
CN (1) CN1085210C (ru)
AR (1) AR008255A1 (ru)
AT (1) ATE210664T1 (ru)
AU (1) AU3720997A (ru)
BR (1) BR9710360A (ru)
CY (1) CY2310B1 (ru)
CZ (1) CZ9199A3 (ru)
DE (1) DE69709113T2 (ru)
DK (1) DK0912576T3 (ru)
EA (1) EA001152B1 (ru)
ES (1) ES2167762T3 (ru)
HK (1) HK1017356A1 (ru)
PT (1) PT912576E (ru)
SK (1) SK283298B6 (ru)
TW (1) TW513430B (ru)
UA (1) UA54444C2 (ru)
WO (1) WO1998002439A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1582526A4 (en) * 2002-11-13 2008-08-06 Kaneka Corp NOVEL INTERMEDIATE FOR CARBAPENEM COMPOUND FOR ORAL ADMINISTRATION AND METHOD OF PRODUCING THE SAME
SI1926732T1 (sl) 2005-09-05 2014-02-28 Ranbaxy Laboratories Limited Postopek za pripravo karbapenskih spojin
CN101357920B (zh) * 2007-06-22 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺基三嗪的培南化合物
CN101367807B (zh) * 2007-06-28 2011-01-12 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物
CN101367806B (zh) * 2007-06-28 2010-11-17 山东轩竹医药科技有限公司 甲酰苯胺取代的巯基吡咯烷碳青霉烯类化合物
CN101343272B (zh) * 2007-07-13 2011-02-09 山东轩竹医药科技有限公司 含有环己烷的碳青霉烯化合物
CN101362757A (zh) * 2007-08-09 2009-02-11 山东轩竹医药科技有限公司 磺酰基取代的碳青霉烯类化合物
CN101362763B (zh) * 2007-08-12 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷的碳青霉烯衍生物
CN101412719B (zh) * 2007-08-30 2010-11-17 山东轩竹医药科技有限公司 碳代青霉烯类衍生物
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
WO2010124531A1 (zh) 2009-04-30 2010-11-04 石药集团中奇制药技术（石家庄）有限公司 一种厄他培南中间体、含其的组合物及其制备方法
CN102260264A (zh) * 2010-05-25 2011-11-30 浙江海翔药业股份有限公司 一种非钯体系制备厄他培南的方法
IN2015DN02513A (ru) 2012-10-12 2015-09-11 Sandoz Ag
CN106565579A (zh) * 2016-06-26 2017-04-19 宁夏海诚电化信息科技有限公司 一种尔它培南侧链生产工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds

Also Published As

Publication number Publication date
DE69709113D1 (de) 2002-01-24
UA54444C2 (ru) 2003-03-17
BR9710360A (pt) 1999-08-17
CY2310B1 (en) 2003-11-14
EA001152B1 (ru) 2000-10-30
HK1017356A1 (en) 1999-11-19
EP0912576A1 (en) 1999-05-06
DK0912576T3 (da) 2002-03-25
WO1998002439A1 (en) 1998-01-22
EP0912576B1 (en) 2001-12-12
SK283298B6 (sk) 2003-05-02
DE69709113T2 (de) 2002-07-11
CZ9199A3 (cs) 1999-06-16
PT912576E (pt) 2002-05-31
SK3299A3 (en) 1999-07-12
ATE210664T1 (de) 2001-12-15
AU3720997A (en) 1998-02-09
ES2167762T3 (es) 2002-05-16
CN1085210C (zh) 2002-05-22
CN1225636A (zh) 1999-08-11
TW513430B (en) 2002-12-11
AR008255A1 (es) 1999-12-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU