CY2310B1 - Process for synthesizing carbapenem antibiotics. - Google Patents

Process for synthesizing carbapenem antibiotics.

Info

Publication number
CY2310B1
CY2310B1 CY0300002A CY0300002A CY2310B1 CY 2310 B1 CY2310 B1 CY 2310B1 CY 0300002 A CY0300002 A CY 0300002A CY 0300002 A CY0300002 A CY 0300002A CY 2310 B1 CY2310 B1 CY 2310B1
Authority
CY
Cyprus
Prior art keywords
carbapenem antibiotics
synthesizing carbapenem
synthesizing
antibiotics
carbapenem
Prior art date
Application number
CY0300002A
Other languages
English (en)
Inventor
John M Williams
Ronald B Jobson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9617417.2A external-priority patent/GB9617417D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of CY2310B1 publication Critical patent/CY2310B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CY0300002A 1996-07-12 2003-01-14 Process for synthesizing carbapenem antibiotics. CY2310B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2164996P 1996-07-12 1996-07-12
GBGB9617417.2A GB9617417D0 (en) 1996-08-20 1996-08-20 Process for synthesizing carbapenem antibodies

Publications (1)

Publication Number Publication Date
CY2310B1 true CY2310B1 (en) 2003-11-14

Family

ID=26309896

Family Applications (1)

Application Number Title Priority Date Filing Date
CY0300002A CY2310B1 (en) 1996-07-12 2003-01-14 Process for synthesizing carbapenem antibiotics.

Country Status (18)

Country Link
EP (1) EP0912576B1 (xx)
CN (1) CN1085210C (xx)
AR (1) AR008255A1 (xx)
AT (1) ATE210664T1 (xx)
AU (1) AU3720997A (xx)
BR (1) BR9710360A (xx)
CY (1) CY2310B1 (xx)
CZ (1) CZ9199A3 (xx)
DE (1) DE69709113T2 (xx)
DK (1) DK0912576T3 (xx)
EA (1) EA001152B1 (xx)
ES (1) ES2167762T3 (xx)
HK (1) HK1017356A1 (xx)
PT (1) PT912576E (xx)
SK (1) SK283298B6 (xx)
TW (1) TW513430B (xx)
UA (1) UA54444C2 (xx)
WO (1) WO1998002439A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7538212B2 (en) * 2002-11-13 2009-05-26 Kaneka Corporation Intermediate for carbapenem compound for oral administration and process for producing the same
EP1926732B1 (en) 2005-09-05 2013-11-06 Ranbaxy Laboratories Limited A process for the preparation of carbapenem compounds
CN101357920B (zh) * 2007-06-22 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷甲酰胺基三嗪的培南化合物
CN101367807B (zh) * 2007-06-28 2011-01-12 山东轩竹医药科技有限公司 被巯基吡咯烷甲酰胺基吡啶取代的培南衍生物
CN101367806B (zh) * 2007-06-28 2010-11-17 山东轩竹医药科技有限公司 甲酰苯胺取代的巯基吡咯烷碳青霉烯类化合物
CN101343272B (zh) * 2007-07-13 2011-02-09 山东轩竹医药科技有限公司 含有环己烷的碳青霉烯化合物
CN101362757A (zh) * 2007-08-09 2009-02-11 山东轩竹医药科技有限公司 磺酰基取代的碳青霉烯类化合物
CN101362763B (zh) * 2007-08-12 2011-01-12 山东轩竹医药科技有限公司 含有巯基吡咯烷的碳青霉烯衍生物
CN101412719B (zh) * 2007-08-30 2010-11-17 山东轩竹医药科技有限公司 碳代青霉烯类衍生物
US8097719B2 (en) * 2008-07-15 2012-01-17 Genesen Labs Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
CN101875665B (zh) 2009-04-30 2013-02-06 石药集团中奇制药技术（石家庄）有限公司 一种厄他培南中间体、含其的组合物及其制备方法
CN102260264A (zh) * 2010-05-25 2011-11-30 浙江海翔药业股份有限公司 一种非钯体系制备厄他培南的方法
JP2015533142A (ja) 2012-10-12 2015-11-19 サンド・アクチエンゲゼルシヤフト エルタペネム中間体の製造
CN106565579A (zh) * 2016-06-26 2017-04-19 宁夏海诚电化信息科技有限公司 一种尔它培南侧链生产工艺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9202298D0 (en) * 1992-02-04 1992-03-18 Ici Plc Antibiotic compounds

Also Published As

Publication number Publication date
SK3299A3 (en) 1999-07-12
UA54444C2 (uk) 2003-03-17
ATE210664T1 (de) 2001-12-15
EA199900099A1 (ru) 1999-06-24
AU3720997A (en) 1998-02-09
HK1017356A1 (en) 1999-11-19
TW513430B (en) 2002-12-11
SK283298B6 (sk) 2003-05-02
EA001152B1 (ru) 2000-10-30
CZ9199A3 (cs) 1999-06-16
EP0912576B1 (en) 2001-12-12
PT912576E (pt) 2002-05-31
DK0912576T3 (da) 2002-03-25
DE69709113D1 (de) 2002-01-24
CN1085210C (zh) 2002-05-22
CN1225636A (zh) 1999-08-11
BR9710360A (pt) 1999-08-17
DE69709113T2 (de) 2002-07-11
AR008255A1 (es) 1999-12-29
ES2167762T3 (es) 2002-05-16
EP0912576A1 (en) 1999-05-06
WO1998002439A1 (en) 1998-01-22

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