JP2009542264A5 - - Google Patents
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- Publication number
- JP2009542264A5 JP2009542264A5 JP2009507759A JP2009507759A JP2009542264A5 JP 2009542264 A5 JP2009542264 A5 JP 2009542264A5 JP 2009507759 A JP2009507759 A JP 2009507759A JP 2009507759 A JP2009507759 A JP 2009507759A JP 2009542264 A5 JP2009542264 A5 JP 2009542264A5
- Authority
- JP
- Japan
- Prior art keywords
- cross
- precursor
- linking agent
- molecular weight
- fluid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000003431 cross linking reagent Substances 0.000 claims 7
- 239000002243 precursor Substances 0.000 claims 6
- 239000013060 biological fluid Substances 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 3
- 239000004971 Cross linker Substances 0.000 claims 2
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 210000002381 plasma Anatomy 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- GVJXGCIPWAVXJP-UHFFFAOYSA-N 2,5-dioxo-1-oxoniopyrrolidine-3-sulfonate Chemical compound ON1C(=O)CC(S(O)(=O)=O)C1=O GVJXGCIPWAVXJP-UHFFFAOYSA-N 0.000 claims 1
- XDGRAWWEIOPNRC-UHFFFAOYSA-N 3-hydroxy-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound OS(=O)(=O)C1(O)CC(=O)NC1=O XDGRAWWEIOPNRC-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 210000003567 ascitic fluid Anatomy 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 238000004132 cross linking Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012039 electrophile Substances 0.000 claims 1
- 150000002118 epoxides Chemical class 0.000 claims 1
- 239000012530 fluid Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000155 melt Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000000467 secondary amino group Chemical class [H]N([*:1])[*:2] 0.000 claims 1
- 210000000582 semen Anatomy 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 125000001302 tertiary amino group Chemical group 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79438406P | 2006-04-24 | 2006-04-24 | |
| US60/794,384 | 2006-04-24 | ||
| PCT/US2007/009934 WO2007127198A2 (en) | 2006-04-24 | 2007-04-24 | Protein crosslinkers, crosslinking methods and applications thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009542264A JP2009542264A (ja) | 2009-12-03 |
| JP2009542264A5 true JP2009542264A5 (enExample) | 2010-06-17 |
| JP6075930B2 JP6075930B2 (ja) | 2017-02-08 |
Family
ID=38656138
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507759A Active JP6075930B2 (ja) | 2006-04-24 | 2007-04-24 | タンパク質架橋剤、架橋方法及びその用途 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7597882B2 (enExample) |
| EP (1) | EP2023941B1 (enExample) |
| JP (1) | JP6075930B2 (enExample) |
| AU (1) | AU2007243483B2 (enExample) |
| CA (1) | CA2650473C (enExample) |
| WO (1) | WO2007127198A2 (enExample) |
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2007
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- 2007-04-24 CA CA2650473A patent/CA2650473C/en active Active
- 2007-04-24 AU AU2007243483A patent/AU2007243483B2/en active Active
- 2007-04-24 US US11/789,459 patent/US7597882B2/en active Active
- 2007-04-24 WO PCT/US2007/009934 patent/WO2007127198A2/en not_active Ceased
- 2007-04-24 EP EP07755963.1A patent/EP2023941B1/en active Active
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2009
- 2009-08-24 US US12/546,231 patent/US9498557B2/en active Active
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