JP6075930B2 - タンパク質架橋剤、架橋方法及びその用途 - Google Patents

タンパク質架橋剤、架橋方法及びその用途 Download PDF

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JP6075930B2
JP6075930B2 JP2009507759A JP2009507759A JP6075930B2 JP 6075930 B2 JP6075930 B2 JP 6075930B2 JP 2009507759 A JP2009507759 A JP 2009507759A JP 2009507759 A JP2009507759 A JP 2009507759A JP 6075930 B2 JP6075930 B2 JP 6075930B2
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cross
solution
blood
linking
hydroxysuccinimide
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JP2009542264A (ja
JP2009542264A5 (enExample
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ピー．パトハク チャンドラスヘクハル
ピー．パトハク チャンドラスヘクハル
エス．サウフネイ アマルプレエト
エス．サウフネイ アマルプレエト
エイチ．ドレヘル ジャメス
エイチ．ドレヘル ジャメス
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0005—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/108—Specific proteins or polypeptides not covered by groups A61L24/102 - A61L24/106
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08H—DERIVATIVES OF NATURAL MACROMOLECULAR COMPOUNDS
    • C08H1/00—Macromolecular products derived from proteins
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L89/00—Compositions of proteins; Compositions of derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2009507759A 2006-04-24 2007-04-24 タンパク質架橋剤、架橋方法及びその用途 Active JP6075930B2 (ja)

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US79438406P 2006-04-24 2006-04-24
US60/794,384 2006-04-24
PCT/US2007/009934 WO2007127198A2 (en) 2006-04-24 2007-04-24 Protein crosslinkers, crosslinking methods and applications thereof

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JP2009542264A JP2009542264A (ja) 2009-12-03
JP2009542264A5 JP2009542264A5 (enExample) 2010-06-17
JP6075930B2 true JP6075930B2 (ja) 2017-02-08

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US (2) US7597882B2 (enExample)
EP (1) EP2023941B1 (enExample)
JP (1) JP6075930B2 (enExample)
AU (1) AU2007243483B2 (enExample)
CA (1) CA2650473C (enExample)
WO (1) WO2007127198A2 (enExample)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288608B2 (en) 2001-10-10 2007-10-30 Regents Of The University Of Colorado Degradable thiol-ene polymers
EP1796693A2 (en) * 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantable tissue compositions and method
WO2007088402A2 (en) * 2006-02-03 2007-08-09 Tissuemed Limited Tissue-adhesive materials
US8377091B2 (en) 2006-06-15 2013-02-19 Microvention, Inc. Embolization device constructed from expansile polymer
US10278947B2 (en) * 2007-02-28 2019-05-07 Orthopeutics, L.P. Crosslinker enhanced repair of connective tissues
WO2011150218A1 (en) * 2010-05-27 2011-12-01 Hedman Thomas P Crosslinker enhanced repair of knee meniscus
US9125807B2 (en) 2007-07-09 2015-09-08 Incept Llc Adhesive hydrogels for ophthalmic drug delivery
US7923486B2 (en) * 2007-10-04 2011-04-12 Board Of Regents, The University Of Texas System Bio-polymer and scaffold-sheet method for tissue engineering
CN101903051B (zh) 2007-12-21 2013-07-31 微温森公司 用于生物医药用途的水凝胶细丝
EP2145634A1 (de) 2008-07-17 2010-01-20 Bayer MaterialScience AG Medizinische Klebstoffe zur Stillung schwerwiegender Blutungen und Abdichtung von Leckagen
US8198248B2 (en) * 2008-08-15 2012-06-12 Orthopeutics, Lp Formulations for nonsurgical exogenous crosslink therapy
US20100040593A1 (en) * 2008-08-15 2010-02-18 Orthopeutics, Lp Formulations for nonsurgical exogenous crosslink therapy
US8283322B2 (en) * 2008-08-15 2012-10-09 Orthopeutics, Lp Formulations for nonsurgical exogenous crosslink therapy
US8586707B2 (en) * 2008-09-16 2013-11-19 The Research Foundation Of State University Of New York Stapled peptides and method of synthesis
US8859706B2 (en) 2008-11-28 2014-10-14 Zetascience Gmbh Bioactive hydrogel
EP2396070B1 (en) 2009-02-12 2024-12-04 Incept Llc Drug delivery through hydrogel plugs
BRPI1014645B1 (pt) 2009-04-30 2020-07-07 Technip France método e sistema para compartilhar linhas de amarração
US10639396B2 (en) 2015-06-11 2020-05-05 Microvention, Inc. Polymers
US9463004B2 (en) 2009-05-04 2016-10-11 Incept, Llc. Biomaterials for track and puncture closure
US9271925B2 (en) 2013-03-11 2016-03-01 Bioinspire Technologies, Inc. Multi-layer biodegradable device having adjustable drug release profile
WO2011035020A1 (en) * 2009-09-18 2011-03-24 Bioinspire Technologies, Inc. Free-standing biodegradable patch
US20110081701A1 (en) * 2009-10-02 2011-04-07 Timothy Sargeant Surgical compositions
AU2010313530B2 (en) 2009-10-26 2015-12-17 Microvention, Inc. Embolization device constructed from expansile polymer
AU2010319496A1 (en) 2009-11-13 2012-05-17 Icx-Agentase Dynamic thermoresponsive nanoparticles for stabilization of enzymes at high temperatures
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
JP5279745B2 (ja) * 2010-02-24 2013-09-04 株式会社東芝 マスクレイアウト作成方法、マスクレイアウト作成装置、リソグラフィ用マスクの製造方法、半導体装置の製造方法、およびコンピュータが実行可能なプログラム
SA111320355B1 (ar) 2010-04-07 2015-01-08 Baxter Heathcare S A إسفنجة لايقاف النزف
JPWO2012035598A1 (ja) * 2010-09-13 2014-01-20 株式会社グツドマン 医療用材料、乾燥体及びそれらの製造方法
US8961501B2 (en) 2010-09-17 2015-02-24 Incept, Llc Method for applying flowable hydrogels to a cornea
US20140038826A1 (en) 2011-01-28 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Covalently cross linked hydrogels and methods of making and using same
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
JP5808480B2 (ja) * 2011-05-09 2015-11-10 ワシントン ステート ユニバーシティ リサーチ ファウンデーション 可撓固体導体
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US9988433B2 (en) 2013-03-14 2018-06-05 Mosaic Biosciences, Inc. Covalent modification of biological macromolecules
WO2013116791A1 (en) * 2012-02-02 2013-08-08 Mosaic Biosciences, Inc. Biomaterials for delivery of blood extracts and methods of using same
US9011884B2 (en) 2012-04-18 2015-04-21 Microvention, Inc. Embolic devices
KR102133611B1 (ko) 2012-06-14 2020-07-13 마이크로벤션, 인코포레이티드 중합체 치료 조성물
WO2014062696A1 (en) 2012-10-15 2014-04-24 Microvention, Inc. Polymeric treatment compositions
US10842969B2 (en) 2013-10-25 2020-11-24 Mercator Medsystems, Inc. Systems and methods of treating malacia by local delivery of hydrogel to augment tissue
CN104649926B (zh) * 2013-11-25 2018-08-17 刘现梅 一种n,n’-癸二酰基二天门冬氨酸及其制备方法
WO2015153996A1 (en) 2014-04-03 2015-10-08 Micro Vention, Inc. Embolic devices
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
CN110433326A (zh) 2014-04-29 2019-11-12 微仙美国有限公司 包含活性剂的聚合物
WO2016065245A1 (en) * 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
JP2018507908A (ja) 2015-02-09 2018-03-22 モザイク バイオサイエンシズ，インコーポレイティド 分解性チオール−エンポリマー及びそれを製造する方法
CN107921237A (zh) 2015-04-27 2018-04-17 反射医学公司 交感神经心肺神经调节系统和方法
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
WO2019074965A1 (en) 2017-10-09 2019-04-18 Microvention, Inc. EMBOLIC RADIOACTIVE LIQUID
US10980913B2 (en) 2018-03-05 2021-04-20 Ethicon Llc Sealant foam compositions for lung applications
US20220042982A1 (en) * 2018-06-12 2022-02-10 Arizona Board Of Regents On Behalf Of Arizona State University Adaptation of nappa for surface plasmon resonance imaging analyses
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
RU2699045C1 (ru) * 2018-12-17 2019-09-03 Федеральное государственное бюджетное учреждение науки Институт химической биологии и фундаментальной медицины Сибирского отделения Российской академии наук (ИХБФМ СО РАН) Способ модификации поверхности биоразлагаемых полимерных материалов
BR102020000922A2 (pt) 2019-01-24 2021-11-30 Euroimmun Medizinische Labordiagnostika Ag Detecção sorológica de anticorpos de plasmodium
CN109942450A (zh) * 2019-03-27 2019-06-28 南京华狮新材料有限公司 一种氨基酸型螯合剂及其制备方法和应用
CN111378069B (zh) * 2020-02-14 2022-05-06 华侨大学 一种抗菌可降解医用组织粘合剂的制备方法
CN111777775B (zh) * 2020-07-01 2023-03-31 宁波艾捷康宁生物科技有限公司 一种酰胺型交联聚合物及其制备方法和其在生物蛋白质沉淀中的用途
US12161777B2 (en) 2020-07-02 2024-12-10 Davol Inc. Flowable hemostatic suspension
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN116744984A (zh) 2020-12-28 2023-09-12 达沃有限公司 包含蛋白质和多官能化改性的基于聚乙二醇的交联剂的反应性干粉状止血材料
CN116549705A (zh) * 2023-05-29 2023-08-08 华侨大学 一种丙烯酸基共聚物功能敷料的制备方法

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175177A (en) 1978-02-24 1979-11-20 Union Carbide Corporation Crosslinkable copolymer of a lactone and a polyfunctional acrylate
AT366916B (de) 1980-04-02 1982-05-25 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen
AT379311B (de) 1984-03-29 1985-12-27 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
AT382783B (de) 1985-06-20 1987-04-10 Immuno Ag Vorrichtung zur applikation eines gewebeklebstoffes
DE3722904A1 (de) 1987-01-09 1988-07-21 Harald Maslanka Injektionseinrichtung mit doppelkanuele fuer ein endoskop
US4978336A (en) 1987-09-29 1990-12-18 Hemaedics, Inc. Biological syringe system
US4874368A (en) 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US4902281A (en) 1988-08-16 1990-02-20 Corus Medical Corporation Fibrinogen dispensing kit
US5936035A (en) 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US5643464A (en) 1988-11-21 1997-07-01 Collagen Corporation Process for preparing a sterile, dry crosslinking agent
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5527856A (en) 1988-11-21 1996-06-18 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5800541A (en) 1988-11-21 1998-09-01 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5565519A (en) 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5122614A (en) 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
DK469989D0 (da) 1989-09-22 1989-09-22 Bukh Meditec Farmaceutisk praeparat
US5116315A (en) 1989-10-03 1992-05-26 Hemaedics, Inc. Biological syringe system
US5219328A (en) 1990-01-03 1993-06-15 Cryolife, Inc. Fibrin sealant delivery method
US5219564A (en) 1990-07-06 1993-06-15 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
US5626863A (en) 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
DE69217457T2 (de) * 1991-11-23 1997-09-04 Yoshitaka Aoyama Einrichtung zum Feststellen von Teilen, verbunden mit einem Zuführstab einer Teile-Zuführeinheit
BR9306038A (pt) 1992-02-28 1998-01-13 Univ Texas Hidrogéis biodegradáveis fotopolimerizáveis como materiais de contato de tecidos e condutores de liberação controlada
US5573934A (en) 1992-04-20 1996-11-12 Board Of Regents, The University Of Texas System Gels for encapsulation of biological materials
BE1005718A3 (fr) * 1992-03-10 1993-12-28 Solvay Procede pour la fabrication d'une poudre microspheroidale a faible dispersite, poudre microspheroidale a faible dispersite ainsi obtenue, catalyseurs pour la polymerisation d'alpha-olefines et procede de polymerisation d'alpha-olefines.
US5540707A (en) 1992-11-13 1996-07-30 Scimed Life Systems, Inc. Expandable intravascular occlusion material removal devices and methods of use
US5800373A (en) 1995-03-23 1998-09-01 Focal, Inc. Initiator priming for improved adherence of gels to substrates
ES2119201T3 (es) 1993-04-28 1998-10-01 Focal Inc Aparato, producto y uso relacionados con la fototermoconformacion intraluminal.
EP0712635B1 (en) 1994-05-13 2003-05-02 Kuraray Co., Ltd. Medical polymer gel
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
CA2165728A1 (en) 1995-03-14 1996-09-15 Woonza M. Rhee Use of hydrophobic crosslinking agents to prepare crosslinked biomaterial compositions
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US6201065B1 (en) 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
EP1704878B1 (en) 1995-12-18 2013-04-10 AngioDevice International GmbH Crosslinked polymer compositions and methods for their use
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US5935139A (en) 1996-05-03 1999-08-10 Boston Scientific Corporation System for immobilizing or manipulating an object in a tract
US6800080B1 (en) 1996-05-03 2004-10-05 Scimed Life Systems, Inc. Medical retrieval device
US6050972A (en) 1996-05-20 2000-04-18 Percusurge, Inc. Guidewire inflation system
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US20020064546A1 (en) 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
WO1998012274A1 (en) * 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
WO1998035631A1 (en) 1997-02-14 1998-08-20 Pathak Chandrashekar Biocompatible polymers and methods for their use
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US6065645A (en) 1997-04-01 2000-05-23 Discus Dental Impressions, Inc. Double-barreled syringe with detachable locking mixing tip
US6153211A (en) 1997-07-18 2000-11-28 Infimed, Inc. Biodegradable macromers for the controlled release of biologically active substances
EP1002024B1 (en) 1997-08-05 2004-04-14 Sericol Limited An ink jet ink
US6162241A (en) 1997-08-06 2000-12-19 Focal, Inc. Hemostatic tissue sealants
US6068852A (en) 1997-10-11 2000-05-30 Polytherapeutics, Inc. Polymeric composition for sealing and shielding animal skin
ES2211033T3 (es) 1998-01-07 2004-07-01 Debio Recherche Pharmaceutique S.A. Acrilatos de polietilenglicol heterobifuncionales degradables y geles y conjugados derivados de dichos acrilatos.
US6875193B1 (en) 1998-02-06 2005-04-05 Possis Medical, Inc. Rapid exchange fluid jet thrombectomy device and method
US6156531A (en) 1998-07-20 2000-12-05 Sulzer Carbomedics Inc. Cross-linking tissue with a compound having a C8 to C40 aliphatic chain
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
AU5560899A (en) 1998-08-14 2000-03-06 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6703047B2 (en) * 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
ATE324831T1 (de) 1998-08-26 2006-06-15 Neomend Inc Kit zur in-situ-erzeugung chemisch verbundener mechanischer barrieren oder abdeckstrukturen für eine punktionsstelle in einem blutgefäss
US6458147B1 (en) 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
US7279001B2 (en) 1998-11-06 2007-10-09 Neomend, Inc. Systems, methods, and compositions for achieving closure of vascular puncture sites
AU2707500A (en) * 1998-12-04 2000-06-26 Incept Llc Biocompatible crosslinked polymers
CA2358565A1 (en) * 1999-01-22 2000-07-27 Peter S. Dardi Medical adhesives
US6958212B1 (en) * 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
JP2000288079A (ja) * 1999-04-07 2000-10-17 Toyobo Co Ltd 生体組織用接着剤
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6132986A (en) 1999-04-23 2000-10-17 Sulzer Carbomedics Inc. Tissue crosslinking for bioprostheses using activated difunctional or polyfunctional acids
US6371970B1 (en) 1999-07-30 2002-04-16 Incept Llc Vascular filter having articulation region and methods of use in the ascending aorta
WO2001016210A1 (en) 1999-08-27 2001-03-08 Cohesion Technologies, Inc. Compositions that form interpenetrating polymer networks for use as high strength medical sealants
US6461857B1 (en) * 2000-07-19 2002-10-08 Arch Personal Care Products, L.P. Producing water-soluble yeast extract by adding peroxide to growing yeast cells
US20020106406A1 (en) 2000-12-08 2002-08-08 Mchugh Anthony J. Crystallizable/non-crystallizable polymer composites
US20020111532A1 (en) 2000-12-19 2002-08-15 Pathak Chandrashekhar P. Tris(hydroxymethyl)phosphino compounds as tissue crosslinking agents
US6596471B2 (en) 2000-12-21 2003-07-22 Carbomedics Inc. Method of cross-linking tissue with a bis-maleimide compound
US6673851B2 (en) * 2001-10-12 2004-01-06 Ashland Inc. Self-photoinitiating multifunctional acrylates
US6846851B2 (en) 2003-04-15 2005-01-25 Gregory Nakhmanovich Water-based inkjet inks containing an ultraviolet curable humectant
JP4397015B2 (ja) 2003-06-06 2010-01-13 マクロテック株式会社 ゲル化組成物
NZ550970A (en) * 2004-05-27 2010-01-29 Univ Pittsburgh Medical adhesive and methods of tissue adhesion
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
EP1796693A2 (en) 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantable tissue compositions and method
WO2006034128A2 (en) * 2004-09-17 2006-03-30 Angiotech Biomaterials Corporation Multifunctional compounds for forming crosslinked biomaterials and methods of preparation and use
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device

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US9498557B2 (en) 2016-11-22
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