JP2009541415A5 - - Google Patents
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- Publication number
- JP2009541415A5 JP2009541415A5 JP2009517107A JP2009517107A JP2009541415A5 JP 2009541415 A5 JP2009541415 A5 JP 2009541415A5 JP 2009517107 A JP2009517107 A JP 2009517107A JP 2009517107 A JP2009517107 A JP 2009517107A JP 2009541415 A5 JP2009541415 A5 JP 2009541415A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- tetrazol
- hetero
- halo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81729806P | 2006-06-29 | 2006-06-29 | |
| US60/817,298 | 2006-06-29 | ||
| PCT/EP2007/055997 WO2008000645A1 (en) | 2006-06-29 | 2007-06-18 | Tetrazole-substituted arylamides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012134357A Division JP5456846B2 (ja) | 2006-06-29 | 2012-06-14 | テトラゾール置換アリールアミド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009541415A JP2009541415A (ja) | 2009-11-26 |
| JP2009541415A5 true JP2009541415A5 (OSRAM) | 2012-06-07 |
| JP5021734B2 JP5021734B2 (ja) | 2012-09-12 |
Family
ID=38462418
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517107A Active JP5021734B2 (ja) | 2006-06-29 | 2007-06-18 | テトラゾール置換アリールアミド |
| JP2012134357A Active JP5456846B2 (ja) | 2006-06-29 | 2012-06-14 | テトラゾール置換アリールアミド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012134357A Active JP5456846B2 (ja) | 2006-06-29 | 2012-06-14 | テトラゾール置換アリールアミド |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US7595405B2 (OSRAM) |
| EP (2) | EP2592070B1 (OSRAM) |
| JP (2) | JP5021734B2 (OSRAM) |
| KR (1) | KR101103143B1 (OSRAM) |
| CN (2) | CN103159692B (OSRAM) |
| AR (1) | AR061667A1 (OSRAM) |
| AU (1) | AU2007263809B2 (OSRAM) |
| BR (2) | BR122019017036B8 (OSRAM) |
| CA (1) | CA2654915C (OSRAM) |
| CL (1) | CL2007001887A1 (OSRAM) |
| ES (2) | ES2604542T3 (OSRAM) |
| IL (2) | IL195786A (OSRAM) |
| MX (1) | MX2008016423A (OSRAM) |
| TW (1) | TWI334414B (OSRAM) |
| WO (1) | WO2008000645A1 (OSRAM) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101165936B1 (ko) * | 2006-11-09 | 2012-07-19 | 에프. 호프만-라 로슈 아게 | 티아졸 및 옥사졸-치환된 아릴아마이드 |
| US8501933B2 (en) | 2006-11-09 | 2013-08-06 | Roche Palo Alto Llc | Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists |
| MX2010003156A (es) * | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de aril amida substituida con tetrazol y usos de los mismos. |
| CA2703915C (en) * | 2007-10-31 | 2015-02-24 | Merck Sharp & Dohme Corp. | P2x3 receptor antagonists for treatment of pain |
| US8247401B2 (en) * | 2007-10-31 | 2012-08-21 | Merck Sharp & Dohme Corp. | P2X3 receptor antagonists for treatment of pain |
| AU2008337665B2 (en) * | 2007-12-17 | 2014-01-16 | F. Hoffmann-La Roche Ag | Tetrazole-substituted arylamide derivatives and their use as P2x3 and/or P2x2/3 purinergic receptor antagonists |
| AU2013273626B2 (en) * | 2007-12-17 | 2016-04-28 | F.Hoffmann-La Roche Ag | Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists |
| ES2570628T3 (es) * | 2007-12-17 | 2016-05-19 | Hoffmann La Roche | Nuevas arilamidas con sustitución imidazol |
| KR101284510B1 (ko) * | 2007-12-17 | 2013-07-23 | 에프. 호프만-라 로슈 아게 | 트리아졸 치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 용도 |
| PL2234976T3 (pl) * | 2007-12-17 | 2013-09-30 | Hoffmann La Roche | Nowe aryloamidy podstawione pirazolem |
| US8946439B2 (en) | 2008-02-29 | 2015-02-03 | Evotec Ag | Amide compounds, compositions and uses thereof |
| US20110237578A1 (en) * | 2008-09-18 | 2011-09-29 | Zhi-Liang Wei | Amide compounds, compositions and uses thereof |
| US8598209B2 (en) * | 2008-10-31 | 2013-12-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| BRPI0922645A2 (pt) * | 2008-12-16 | 2019-09-24 | Hoffmann La Roche | "arilamidas tiadiazol substituídas". |
| ES2660892T3 (es) | 2009-03-23 | 2018-03-26 | Merck Sharp & Dohme Corp. | Antagonistas del receptor P2X3 para el tratamiento del dolor |
| JP2012521428A (ja) | 2009-03-23 | 2012-09-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 疼痛治療用のｐ２ｘ３受容体アンタゴニスト |
| US8946231B2 (en) | 2009-03-23 | 2015-02-03 | Merck Sharp & Dohme Corp. | P2X3, receptor antagonists for treatment of pain |
| EP2246259B1 (en) | 2009-04-29 | 2012-12-12 | Eurocopter Deutschland GmbH | Rotor wing with integrated tension-torque-transmission element and method for its production |
| JP5685203B2 (ja) | 2009-05-29 | 2015-03-18 | ラクオリア創薬株式会社 | カルシウムチャネル遮断薬またはナトリウムチャネル遮断薬としてのアリール置換カルボキサミド誘導体 |
| TW201103904A (en) * | 2009-06-11 | 2011-02-01 | Hoffmann La Roche | Janus kinase inhibitor compounds and methods |
| CA2754654A1 (en) * | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Novel oxazolone and pyrrolidinone-substituted arylamides |
| ES2450891T3 (es) * | 2009-06-22 | 2014-03-25 | F. Hoffmann-La Roche Ag | Bifenilamidas útiles como moduladores de receptores P2X3 y/o P2X2/3 |
| CA2761921A1 (en) | 2009-06-22 | 2010-12-29 | F. Hoffmann-La Roche Ag | Indole, indazole and benzimidazole arylamides |
| KR20130087002A (ko) * | 2010-06-04 | 2013-08-05 | 알바니 몰레큘라 리써치, 인크. | 글리신 수송체-1 저해제, 그의 제조 방법 및 그의 용도 |
| WO2014117274A1 (en) * | 2013-01-31 | 2014-08-07 | Neomed Institute | Imidazopyridine compounds and uses thereof |
| US10183937B2 (en) | 2014-12-09 | 2019-01-22 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides |
| JP6544665B2 (ja) | 2014-12-09 | 2019-07-17 | バイエル アクチェンゲゼルシャフトＢａｙｅｒ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | １，３−チアゾール−２−イル置換ベンズアミド |
| CN107207449B (zh) * | 2015-04-23 | 2020-11-10 | 豪夫迈·罗氏有限公司 | 用于治疗精神障碍的四唑衍生物 |
| EP3303299B1 (en) * | 2015-06-04 | 2019-04-24 | H. Hoffnabb-La Roche Ag | Imidazole derivatives |
| WO2017060202A1 (en) * | 2015-10-06 | 2017-04-13 | F. Hoffmann-La Roche Ag | Triazole derivatives |
| EP3411365B1 (en) | 2016-02-02 | 2019-11-20 | H. Hoffnabb-La Roche Ag | Pyrazol-pyridine derivatives as eaat3 inhibitors |
| TWI679197B (zh) * | 2016-05-05 | 2019-12-11 | 瑞士商伊蘭科動物健康公司 | 雜芳基-1,2,4-三唑及雜芳基-三唑化合物 |
| EP3464246B1 (en) * | 2016-05-27 | 2020-07-08 | H. Hoffnabb-La Roche Ag | Pyrazol compounds as eaat3 inhibitors |
| EP3526201B1 (en) | 2016-10-14 | 2020-11-18 | H. Hoffnabb-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
| TWI741040B (zh) * | 2016-10-20 | 2021-10-01 | 德商拜耳作物科學公司 | 製備3-烷基硫基-2-氯-n-(1-烷基-1h-四唑-5-基)-4-三氟甲基苯甲醯胺之方法 |
| RU2650780C1 (ru) | 2016-12-06 | 2018-04-17 | Общество с ограниченной ответственностью "Анальгетики будущего" | Пептидный модулятор пуринергических рецепторов |
| WO2020239953A1 (en) | 2019-05-31 | 2020-12-03 | Chiesi Farmaceutici S.P.A. | Pyridopyrimidines derivatives as p2x3 inhibitors |
| GEP20257823B (en) | 2019-05-31 | 2025-11-10 | Chiesi Farm Spa | Amino quinazoline derivatives as p2x3 inhibitors |
| CN116601149A (zh) | 2020-11-27 | 2023-08-15 | 奇斯药制品公司 | 作为p2x3抑制剂的氨基喹唑啉衍生物 |
| KR20230113289A (ko) | 2020-11-27 | 2023-07-28 | 키에시 파르마슈티시 엣스. 피. 에이. | P2x3 억제제로서 프탈라진 유도체 |
| AU2021386684A1 (en) | 2020-11-27 | 2023-05-25 | Chiesi Farmaceutici S.P.A. | (aza)quinoline 4-amines derivatives as p2x3 inhibitors |
| AR131715A1 (es) * | 2023-01-30 | 2025-04-23 | Eurofarma Laboratorios S A | AMIDAS BLOQUEADORAS DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y KITS |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL109570A0 (en) * | 1993-05-17 | 1994-08-26 | Fujisawa Pharmaceutical Co | Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof |
| JPH10501122A (ja) * | 1994-05-27 | 1998-02-03 | グラクソ、グループ、リミテッド | Ｐ▲下２ｘ▼レセプター（プリノセプターファミリー） |
| US6133434A (en) * | 1997-04-28 | 2000-10-17 | Glaxo Group Limited | Purinergic receptor |
| JP2000281664A (ja) * | 1999-03-30 | 2000-10-10 | Otsuka Pharmaceut Co Ltd | チアゾール誘導体 |
| ES2250126T3 (es) | 1999-06-30 | 2006-04-16 | H. Lundbeck A/S | Antagonistas selectivos del npy(y5). |
| AU2001268711A1 (en) | 2000-06-23 | 2002-01-08 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
| DE10055713A1 (de) | 2000-11-10 | 2002-05-23 | Dingwei Tim Yu | Neue Klasse von Antifungimitteln |
| PA8557501A1 (es) * | 2001-11-12 | 2003-06-30 | Pfizer Prod Inc | Benzamida, heteroarilamida y amidas inversas |
| TW200304374A (en) * | 2001-11-30 | 2003-10-01 | Smithkline Beecham Plc | Novel compounds |
| US20030236439A1 (en) | 2002-01-30 | 2003-12-25 | Gregory Agoston | Non-steroidal analogs of 2-methoxyestradiol |
| CA2480856A1 (en) * | 2002-04-05 | 2003-10-23 | Merck & Co., Inc. | Substituted aryl amides |
| US7078423B2 (en) * | 2002-07-18 | 2006-07-18 | Inotek Pharmaceuticals Corporation | 5-Aryltetrazole compounds, compositions thereof, and uses therefor |
| CA2466288A1 (en) | 2002-07-18 | 2004-01-29 | Sri International | Methods of treating conditions associated with an edg-1 receptor |
| DE10312963A1 (de) * | 2003-03-24 | 2004-10-07 | Aventis Pharma Deutschland Gmbh | Substituierte 4-Phenyltetrahydroisochinoline, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament |
| AU2004232936B2 (en) | 2003-04-18 | 2008-10-30 | Merck & Co., Inc. | Biaryl substituted thiazoles, oxazoles and imidazoles as sodium channel blockers |
| AU2005259835B2 (en) * | 2004-07-02 | 2011-07-07 | The Walter And Eliza Hall Institute Of Medical Research | Alpha-helical mimetics |
| WO2007020194A1 (en) * | 2005-08-15 | 2007-02-22 | F. Hoffmann-La Roche Ag | Piperidine and piperazine derivatives as p2x3 antagonists |
-
2007
- 2007-06-18 EP EP12194476.3A patent/EP2592070B1/en active Active
- 2007-06-18 CN CN201310005567.3A patent/CN103159692B/zh active Active
- 2007-06-18 BR BR122019017036A patent/BR122019017036B8/pt active IP Right Grant
- 2007-06-18 ES ES07730213.1T patent/ES2604542T3/es active Active
- 2007-06-18 ES ES12194476.3T patent/ES2596706T3/es active Active
- 2007-06-18 CA CA2654915A patent/CA2654915C/en active Active
- 2007-06-18 BR BRPI0714315A patent/BRPI0714315B8/pt active IP Right Grant
- 2007-06-18 CN CN2007800241415A patent/CN101479250B/zh active Active
- 2007-06-18 JP JP2009517107A patent/JP5021734B2/ja active Active
- 2007-06-18 MX MX2008016423A patent/MX2008016423A/es active IP Right Grant
- 2007-06-18 EP EP07730213.1A patent/EP2038264B1/en active Active
- 2007-06-18 WO PCT/EP2007/055997 patent/WO2008000645A1/en not_active Ceased
- 2007-06-18 AU AU2007263809A patent/AU2007263809B2/en not_active Ceased
- 2007-06-18 KR KR1020087031545A patent/KR101103143B1/ko active Active
- 2007-06-26 TW TW096122982A patent/TWI334414B/zh not_active IP Right Cessation
- 2007-06-27 AR ARP070102859A patent/AR061667A1/es not_active Application Discontinuation
- 2007-06-27 CL CL200701887A patent/CL2007001887A1/es unknown
- 2007-06-28 US US11/823,808 patent/US7595405B2/en active Active
-
2008
- 2008-12-08 IL IL195786A patent/IL195786A/en not_active IP Right Cessation
-
2009
- 2009-08-18 US US12/583,325 patent/US8193368B2/en active Active
-
2012
- 2012-05-02 US US13/462,115 patent/US8846945B2/en active Active
- 2012-06-14 JP JP2012134357A patent/JP5456846B2/ja active Active
-
2014
- 2014-01-09 US US14/151,680 patent/US9593128B2/en active Active
- 2014-12-28 IL IL236492A patent/IL236492A0/en unknown
-
2017
- 2017-02-01 US US15/422,121 patent/US10201525B2/en active Active
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