JP2009540274A5 - - Google Patents
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- JP2009540274A5 JP2009540274A5 JP2009513584A JP2009513584A JP2009540274A5 JP 2009540274 A5 JP2009540274 A5 JP 2009540274A5 JP 2009513584 A JP2009513584 A JP 2009513584A JP 2009513584 A JP2009513584 A JP 2009513584A JP 2009540274 A5 JP2009540274 A5 JP 2009540274A5
- Authority
- JP
- Japan
- Prior art keywords
- analyte
- sample
- whole blood
- membrane
- treated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 11
- 239000000523 sample Substances 0.000 claims 7
- 210000004369 blood Anatomy 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 6
- 239000012491 analyte Substances 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 4
- 210000003743 erythrocyte Anatomy 0.000 claims 3
- 239000012528 membrane Substances 0.000 claims 3
- 150000001450 anions Chemical class 0.000 claims 2
- 150000001768 cations Chemical class 0.000 claims 2
- 238000013375 chromatographic separation Methods 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 239000011148 porous material Substances 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- 206010018910 Haemolysis Diseases 0.000 claims 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000004440 column chromatography Methods 0.000 claims 1
- 239000000470 constituent Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 230000008588 hemolysis Effects 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 229940124589 immunosuppressive drug Drugs 0.000 claims 1
- 238000004811 liquid chromatography Methods 0.000 claims 1
- 238000004949 mass spectrometry Methods 0.000 claims 1
- UZZYXUGECOQHPU-UHFFFAOYSA-M n-octyl sulfate Chemical compound CCCCCCCCOS([O-])(=O)=O UZZYXUGECOQHPU-UHFFFAOYSA-M 0.000 claims 1
- 229940067739 octyl sulfate Drugs 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- UZZYXUGECOQHPU-UHFFFAOYSA-N sulfuric acid monooctyl ester Natural products CCCCCCCCOS(O)(=O)=O UZZYXUGECOQHPU-UHFFFAOYSA-N 0.000 claims 1
- -1 tetrafluoroborate Chemical compound 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06011604 | 2006-06-06 | ||
| EP06011604.3 | 2006-06-06 | ||
| PCT/EP2007/004923 WO2007140961A1 (en) | 2006-06-06 | 2007-06-04 | Differential hemolysis of a whole blood sample |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009540274A JP2009540274A (ja) | 2009-11-19 |
| JP2009540274A5 true JP2009540274A5 (https=) | 2010-05-20 |
| JP5156738B2 JP5156738B2 (ja) | 2013-03-06 |
Family
ID=37081679
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009513584A Active JP5156738B2 (ja) | 2006-06-06 | 2007-06-04 | 全血試料の特異的溶血 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7951598B2 (https=) |
| EP (1) | EP2032979B1 (https=) |
| JP (1) | JP5156738B2 (https=) |
| CN (1) | CN101467036B (https=) |
| CA (1) | CA2649633C (https=) |
| ES (1) | ES2690319T3 (https=) |
| WO (1) | WO2007140961A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7952067B2 (en) * | 2008-10-06 | 2011-05-31 | Quest Diagnostics Investments Incorporated | Methods for detecting vitamin C by mass spectrometry |
| US9371509B2 (en) * | 2009-09-02 | 2016-06-21 | Roche Diagnostics Operations, Inc. | Reagents for lysis of bacterial cells |
| JP5249905B2 (ja) * | 2009-10-29 | 2013-07-31 | 株式会社日立ハイテクノロジーズ | 臨床検査システム及び臨床検査法方法 |
| US20110217777A1 (en) * | 2010-03-02 | 2011-09-08 | Teixeira Rodrigo E | Process for the Extraction of Lipids from Microalgae Using Ionic Liquids |
| EP2567395B1 (en) * | 2010-05-07 | 2019-12-18 | UT-Battelle, LLC | System and method for extracting a sample from a surface |
| JP5452383B2 (ja) * | 2010-06-15 | 2014-03-26 | 株式会社日立ハイテクノロジーズ | 生体試料前処理方法及び装置 |
| CN103124793B (zh) * | 2010-08-11 | 2014-12-31 | 协和梅迪克斯株式会社 | 糖化血红蛋白的测定方法 |
| US8486703B2 (en) | 2010-09-30 | 2013-07-16 | Ut-Battelle, Llc | Surface sampling concentration and reaction probe |
| US8519330B2 (en) | 2010-10-01 | 2013-08-27 | Ut-Battelle, Llc | Systems and methods for laser assisted sample transfer to solution for chemical analysis |
| US8637813B2 (en) | 2010-10-01 | 2014-01-28 | Ut-Battelle, Llc | System and method for laser assisted sample transfer to solution for chemical analysis |
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| WO2012054639A2 (en) | 2010-10-22 | 2012-04-26 | T2 Biosystems, Inc. | Nmr systems and methods for the rapid detection of analytes |
| US9891149B2 (en) | 2011-08-08 | 2018-02-13 | Thermo Fisher Scientific Oy | Method and apparatus for automated analysis |
| FI20115785A0 (fi) | 2011-08-08 | 2011-08-08 | Thermo Fisher Scientific Oy | Menetelmä ja laite automaattiseen analyysiin |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| JP6694509B2 (ja) * | 2015-12-18 | 2020-05-13 | エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト | 自動化された臨床診断システムおよび方法 |
| WO2017127731A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
| CN107561170B (zh) * | 2016-07-02 | 2021-07-30 | 山东新时代药业有限公司 | 一种坦西莫司中间体的分析检测方法 |
| CN106770747A (zh) * | 2016-12-09 | 2017-05-31 | 广州迈达康医药科技有限公司 | 一种他克莫司制剂评价方法 |
| JP7376361B2 (ja) * | 2017-03-07 | 2023-11-08 | エフ. ホフマン-ラ ロシュ アーゲー | 免疫調節マクロライドのための安定な配合物 |
| WO2022051443A1 (en) * | 2020-09-03 | 2022-03-10 | Bio-Rad Laboratories, Inc. | Preparation of nucleated rbc (nrbc) analogs for use as reference hematology controls in automated hematology analyzers |
| CN113325171B (zh) * | 2021-08-02 | 2021-12-21 | 天津康博尔生物基因技术有限公司 | 检测人体红细胞叶酸含量的试剂盒、检测方法及用途 |
| CN113776903A (zh) * | 2021-08-27 | 2021-12-10 | 深圳市希莱恒医用电子有限公司 | 一种前处理试剂的制备方法、前处理试剂及前处理方法 |
| WO2025119902A1 (en) * | 2023-12-04 | 2025-06-12 | F. Hoffmann-La Roche Ag | Hemoglobin determination methods and systems |
| WO2026052704A1 (en) | 2024-09-05 | 2026-03-12 | Roche Diagnostics Gmbh | Extraction of macrocyclic analytes |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2410033C2 (de) | 1974-03-02 | 1975-09-11 | Merck Patent Gmbh, 6100 Darmstadt | Isolierung von in lipophilen Lösungsmitteln löslichen Inhaltstoffen wäßriger Lösungen |
| US4286963A (en) * | 1979-11-23 | 1981-09-01 | Coulter Electronics, Inc. | Differential lymphoid-myeloid determination of leukocytes in whole blood |
| US4529705A (en) * | 1983-06-06 | 1985-07-16 | Coulter Electronics, Inc. | Reagent for combined diluting and lysing whole blood |
| US4751179A (en) | 1984-05-31 | 1988-06-14 | Coulter Electronics, Inc. | Method and reagents for differential determination of four populations of leukocytes in blood |
| CA1339952C (en) * | 1984-10-29 | 1998-07-14 | William J. Knowles | Immunoassays for denatured protein analytes, particularly hb alc, and monoclonal antibodies thereto |
| DE3446826A1 (de) | 1984-12-21 | 1986-06-26 | Günter Horst 7927 Sontheim Röhm | Backenspannfutter fuer drehmaschinen zur bearbeitung von werkstuecken unter mehreren bearbeitungsachsen |
| IL85532A (en) | 1987-03-13 | 1992-03-29 | Coulter Electronics | Method and lytic reagent system for isolation,identification and/or analysis of leukocytes from whole blood samples |
| US5292663A (en) | 1987-11-30 | 1994-03-08 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Method of treating blood containing labile glycosylated hemoglobin A1C |
| JPH0774799B2 (ja) * | 1988-04-28 | 1995-08-09 | 積水化学工業株式会社 | 血中成分の測定法 |
| US5316951A (en) | 1991-06-07 | 1994-05-31 | Carver Jr Edward L | Method for the improved determination of white blood cell subpopulations |
| DE4300412A1 (de) * | 1993-01-09 | 1994-07-14 | Behringwerke Ag | Hydrophobe Adsorbentien und ihre Verwendung zur Absorption von Lipoproteinen |
| US6043032A (en) * | 1993-09-22 | 2000-03-28 | Tosoh Corporation | Method of extracting nucleic acids and method of detecting specified nucleic acid sequences |
| US5416026A (en) * | 1993-10-04 | 1995-05-16 | I-Stat Corporation | Method for detecting the change in an analyte due to hemolysis in a fluid sample |
| US5506103A (en) * | 1993-11-16 | 1996-04-09 | Hybridon, Inc. | Method for detecting charged oligonucleotides in biological fluids |
| US5817518A (en) | 1995-12-18 | 1998-10-06 | Coulter International Corp. | Reagent and method for differential determination of leukocytes in blood |
| DE69625581T2 (de) | 1996-03-07 | 2003-09-25 | Coulter International Corp., Miami | Cyanidfreies Reagenz und Verfahren zur Bestimmung von Hämoglobin und Leukozytendifferenzierung |
| US6451609B1 (en) | 1996-05-30 | 2002-09-17 | The Cleveland Clinic Foundation | Method of detecting gynecological carcinomas |
| US5882934A (en) | 1997-01-21 | 1999-03-16 | Coulter International Corp. | Composition and method for hemoglobin and cell analysis |
| JPH10248828A (ja) | 1997-03-10 | 1998-09-22 | Nissho Corp | 溶血管 |
| JPH1123547A (ja) * | 1997-07-09 | 1999-01-29 | Tokuyama Sekisui Ind Corp | 液体クロマトグラフ用サンプリングループ及び液体クロマトグラフ |
| US5935857A (en) | 1997-08-01 | 1999-08-10 | Coulter International Corp. | Blood diluent |
| US5874310A (en) | 1997-11-21 | 1999-02-23 | Coulter International Corp. | Method for differentiation of nucleated red blood cells |
| WO1999064480A1 (en) | 1998-06-12 | 1999-12-16 | Waters Investments Limited | Novel ion exchange porous resins for solid phase extraction and chromatography |
| JP3315657B2 (ja) * | 1998-06-22 | 2002-08-19 | 積水化学工業株式会社 | 液体クロマトグラフィー用フィルター、液体クロマトグラフィー用カラム及びヘモグロビン類の測定方法 |
| WO1999067647A1 (en) | 1998-06-24 | 1999-12-29 | Chen & Chen, Llc | Multi-layer testing column |
| JP3429709B2 (ja) * | 1998-08-07 | 2003-07-22 | 積水化学工業株式会社 | 安定型ヘモグロビンA1cの測定方法 |
| EP1103812B1 (en) * | 1998-08-07 | 2015-11-18 | Sekisui Chemical Co., Ltd. | Method for determining hemoglobins |
| JP4391733B2 (ja) * | 1998-08-07 | 2009-12-24 | 積水化学工業株式会社 | ヘモグロビン類の測定方法 |
| JP3429679B2 (ja) * | 1998-08-07 | 2003-07-22 | 積水化学工業株式会社 | 安定型ヘモグロビンA1cの測定方法 |
| DE19937187A1 (de) | 1999-08-06 | 2001-03-01 | Qiagen Gmbh | Automatisierte Proteinreinigung im Multiwellformat durch Vakuumfiltration |
| EP1404875A1 (en) * | 2001-06-08 | 2004-04-07 | ChemoMetec A/S | A method and a system for counting cells from a plurality of species |
| JP2003207497A (ja) * | 2002-01-10 | 2003-07-25 | Sekisui Chem Co Ltd | 溶離液と溶血試薬及びヘモグロビン類の測定方法 |
| US6723236B2 (en) | 2002-03-19 | 2004-04-20 | Waters Investments Limited | Device for solid phase extraction and method for purifying samples prior to analysis |
-
2007
- 2007-06-04 CN CN2007800212732A patent/CN101467036B/zh active Active
- 2007-06-04 ES ES07725792.1T patent/ES2690319T3/es active Active
- 2007-06-04 JP JP2009513584A patent/JP5156738B2/ja active Active
- 2007-06-04 EP EP07725792.1A patent/EP2032979B1/en active Active
- 2007-06-04 CA CA2649633A patent/CA2649633C/en active Active
- 2007-06-04 WO PCT/EP2007/004923 patent/WO2007140961A1/en not_active Ceased
-
2008
- 2008-12-05 US US12/328,890 patent/US7951598B2/en active Active
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