JP2009540012A5 - - Google Patents

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Publication number
JP2009540012A5
JP2009540012A5 JP2009515619A JP2009515619A JP2009540012A5 JP 2009540012 A5 JP2009540012 A5 JP 2009540012A5 JP 2009515619 A JP2009515619 A JP 2009515619A JP 2009515619 A JP2009515619 A JP 2009515619A JP 2009540012 A5 JP2009540012 A5 JP 2009540012A5
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JP
Japan
Prior art keywords
diamine
pyrimidine
dimethylamino
propyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009515619A
Other languages
English (en)
Japanese (ja)
Other versions
JP5306190B2 (ja
JP2009540012A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/071073 external-priority patent/WO2007146977A1/en
Publication of JP2009540012A publication Critical patent/JP2009540012A/ja
Publication of JP2009540012A5 publication Critical patent/JP2009540012A5/ja
Application granted granted Critical
Publication of JP5306190B2 publication Critical patent/JP5306190B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009515619A 2006-06-15 2007-06-13 ２−アニリノ−４−アミノアルキレンアミノピリミジン Expired - Fee Related JP5306190B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US81387506P 2006-06-15 2006-06-15
US60/813,875 2006-06-15
PCT/US2007/071073 WO2007146977A1 (en) 2006-06-15 2007-06-13 2-anilino-4-aminoalkyleneaminopyrimidines

Publications (3)

Publication Number Publication Date
JP2009540012A JP2009540012A (ja) 2009-11-19
JP2009540012A5 true JP2009540012A5 (enExample) 2010-07-29
JP5306190B2 JP5306190B2 (ja) 2013-10-02

Family

ID=38611102

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009515619A Expired - Fee Related JP5306190B2 (ja) 2006-06-15 2007-06-13 ２−アニリノ−４−アミノアルキレンアミノピリミジン

Country Status (15)

Country Link
US (2) US20070293525A1 (enExample)
EP (1) EP2032543A1 (enExample)
JP (1) JP5306190B2 (enExample)
KR (1) KR20090023698A (enExample)
CN (1) CN101506176A (enExample)
AR (1) AR062822A1 (enExample)
AU (1) AU2007257701A1 (enExample)
CA (1) CA2655315A1 (enExample)
CL (1) CL2007001748A1 (enExample)
IL (1) IL195865A0 (enExample)
MX (1) MX2008016007A (enExample)
RU (1) RU2008152193A (enExample)
TW (1) TW200815368A (enExample)
WO (1) WO2007146977A1 (enExample)
ZA (1) ZA200809945B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007146981A2 (en) 2006-06-15 2007-12-21 Boehringer Ingelheim International Gmbh 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha
ES2610880T3 (es) 2008-02-22 2017-05-03 Rigel Pharmaceuticals, Inc. Uso de 2,4-pirimidinadiaminas para el tratamiento de la aterosclerosis
US20120301463A1 (en) 2009-09-30 2012-11-29 President And Fellows Of Harvard College Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products
WO2011075560A1 (en) * 2009-12-17 2011-06-23 Merck Sharp & Dohme Corp. Aminopyrimidines as syk inhibitors
MX2012014158A (es) 2010-06-04 2013-02-07 Hoffmann La Roche Derivados de aminopirimidina como moduladores de proteina cinasa rica repeticiones leucina 2 (lrrk2).
ES2653967T3 (es) 2010-11-10 2018-02-09 Genentech, Inc. Derivados de pirazol aminopirimidina como moduladores de LRRK2
KR101664106B1 (ko) * 2014-09-11 2016-10-10 한국화학연구원 폴리믹신 b 화합물을 포함하는 심혈관 질환의 예방 및 치료용 약학적 조성물
EP3313993A4 (en) 2015-06-29 2019-06-19 Regents of the University of Minnesota ANTI-APOBEC3 ANTIBODIES AND METHOD OF PREPARATION AND USE
KR101876514B1 (ko) * 2016-11-08 2018-07-10 한국화학연구원 신규한 피리미딘화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 암 및 염증질환의 예방 또는 치료용 약학적 조성물
CN109516959A (zh) * 2018-12-03 2019-03-26 陕西师范大学 2-芳氨基-4-取代嘧啶类衍生物及其在制备抗肿瘤药物中的应用

Family Cites Families (31)

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GB592928A (en) 1943-06-11 1947-10-03 Francis Henry Swinden Curd New pyrimidine compounds
US2437683A (en) * 1948-03-16 Pyrimedine compounds and method of
US2443305A (en) * 1948-06-15 Pyrimidine derivatives
DE833651C (de) 1943-11-02 1952-03-10 Ici Ltd Verfahren zur Herstellung von neuen Pyrimidinabkoemmlingen
GB587550A (en) 1944-09-25 1947-04-29 Francis Henry Swinden Curd New pyrimidine compounds
US3445467A (en) * 1964-05-25 1969-05-20 Ciba Geigy Corp Biphenyl diphenylalkane and diphenylether compounds,amino - substituted on the phenyl rings
FR2244520B1 (enExample) 1973-07-06 1977-02-04 Ugine Kuhlmann
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
DK0945443T3 (da) 1998-03-27 2003-06-02 Janssen Pharmaceutica Nv HIV-hæmmende pyrimidinderivater
EP0945442A1 (en) 1998-03-27 1999-09-29 Janssen Pharmaceutica N.V. Trisubstituted pyrimidine derivatives
AU5438299A (en) * 1998-08-29 2000-03-21 Astrazeneca Ab Pyrimidine compounds
EE200100502A (et) 1999-03-26 2002-12-16 Astrazeneca Ab Ühendid
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
IL159120A0 (en) * 2001-05-29 2004-05-12 Schering Ag Cdk inhibiting pyrimidines, production thereof and their use as medicaments
US6939874B2 (en) 2001-08-22 2005-09-06 Amgen Inc. Substituted pyrimidinyl derivatives and methods of use
US7115617B2 (en) 2001-08-22 2006-10-03 Amgen Inc. Amino-substituted pyrimidinyl derivatives and methods of use
WO2003026666A1 (en) 2001-09-26 2003-04-03 Bayer Pharmaceuticals Corporation 2-phenylamino-4- (5-pyrazolylamino)-pyrimidine derivatives as kinase inhibitors, in particular, as src kinase inhibitors
WO2003032994A2 (de) 2001-10-17 2003-04-24 Boehringer Ingelheim Pharma Gmbh & Co. Kg 5-substituierte 4-amino-2-phenylamino-pyrimidinderivate und ihre verwendung als beta-amyloid modulatoren
ES2314106T3 (es) 2001-10-17 2009-03-16 BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG Derivados de pirimidina, agentes farmaceuticos que contiene dichos compuestos, uso y metodo para su obtencion.
CA2463822A1 (en) 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors)
SE0104140D0 (sv) * 2001-12-07 2001-12-07 Astrazeneca Ab Novel Compounds
AR039540A1 (es) 2002-05-13 2005-02-23 Tibotec Pharm Ltd Compuestos microbicidas con contenido de pirimidina o triazina
WO2004048343A1 (en) * 2002-11-28 2004-06-10 Schering Aktiengesellschaft Chk-, pdk- and akt-inhibitory pyrimidines, their production and use as pharmaceutical agents
AU2003288994A1 (en) * 2002-12-10 2004-06-30 Ono Pharmaceutical Co., Ltd. Nitrogen-containing heterocyclic compounds and medicinal use thereof
WO2005003103A2 (en) 2003-06-30 2005-01-13 Astrazeneca Ab 2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases
US7122542B2 (en) 2003-07-30 2006-10-17 Rigel Pharmaceuticals, Inc. Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
DK1663242T3 (da) 2003-08-07 2011-08-01 Rigel Pharmaceuticals Inc 2,4-Pyrimidindiamin-forbindelser og anvendelse som antiproliferative midler
US20050209231A1 (en) * 2004-01-16 2005-09-22 Xu Wu Compositions and methods for inducing cardiomyogenesis
US8211929B2 (en) 2004-12-30 2012-07-03 Exelixis, Inc. Pyrimidine derivatives as kinase modulators and method of use
DE102005016634A1 (de) 2005-04-12 2006-10-19 Merck Patent Gmbh Neuartige Aza-Hetercyclen als Kinase-Inhibitoren
WO2007146981A2 (en) * 2006-06-15 2007-12-21 Boehringer Ingelheim International Gmbh 2-anilino-4-(heterocyclic)amino-pyrimidines as inhibitors of protein kinase c-alpha

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