JP2009539870A5 - - Google Patents
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- Publication number
- JP2009539870A5 JP2009539870A5 JP2009514512A JP2009514512A JP2009539870A5 JP 2009539870 A5 JP2009539870 A5 JP 2009539870A5 JP 2009514512 A JP2009514512 A JP 2009514512A JP 2009514512 A JP2009514512 A JP 2009514512A JP 2009539870 A5 JP2009539870 A5 JP 2009539870A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- dll4
- antibody
- effective amount
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81135706P | 2006-06-06 | 2006-06-06 | |
| US86676706P | 2006-11-21 | 2006-11-21 | |
| PCT/US2007/070516 WO2007143689A2 (en) | 2006-06-06 | 2007-06-06 | Compositions and methods for modulating vascular development |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009539870A JP2009539870A (ja) | 2009-11-19 |
| JP2009539870A5 true JP2009539870A5 (enExample) | 2011-06-30 |
Family
ID=38626647
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009514512A Pending JP2009539870A (ja) | 2006-06-06 | 2007-06-06 | 血管発生の調節ための組成物および方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20080014196A1 (enExample) |
| EP (1) | EP2029159A2 (enExample) |
| JP (1) | JP2009539870A (enExample) |
| KR (1) | KR20090016762A (enExample) |
| AR (1) | AR061245A1 (enExample) |
| AU (1) | AU2007256617A1 (enExample) |
| BR (1) | BRPI0710411A2 (enExample) |
| CA (1) | CA2654304A1 (enExample) |
| CL (1) | CL2007001624A1 (enExample) |
| CR (1) | CR10529A (enExample) |
| EC (1) | ECSP099032A (enExample) |
| IL (1) | IL194788A0 (enExample) |
| MA (1) | MA30536B1 (enExample) |
| MX (1) | MX2008015532A (enExample) |
| NO (1) | NO20090046L (enExample) |
| RU (1) | RU2008152435A (enExample) |
| SG (1) | SG172687A1 (enExample) |
| TW (1) | TW200817435A (enExample) |
| WO (1) | WO2007143689A2 (enExample) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6984522B2 (en) * | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| US8048418B2 (en) | 2004-10-29 | 2011-11-01 | Regeneron Pharmaceuticals, Inc. | Therapeutic methods for inhibiting tumor growth with combination of Dll4 antagonists and VEGF antagonists |
| US7906116B2 (en) * | 2005-09-01 | 2011-03-15 | Parkash Gill | Methods for using and identifying modulators of Delta-like 4 |
| JP5489465B2 (ja) * | 2005-12-16 | 2014-05-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Dll4アンタゴニストによって腫瘍増殖を阻害する治療方法 |
| WO2011053822A2 (en) | 2009-11-01 | 2011-05-05 | The Brigham And Women's Hospital, Inc. | Notch inhibition in the treatment and prevention of obesity and metabolic syndrome |
| US9567396B2 (en) | 2006-03-07 | 2017-02-14 | Evonik Degussa Gmbh | Notch inhibition in the prevention of vein graft failure |
| RS52685B (sr) * | 2006-08-07 | 2013-08-30 | Regeneron Pharmaceuticals, Inc. | Korišćenje antagonista dii4 u ishemijskom oštećenju ili vaskularnoj insuficijenciji |
| CA2664738C (en) * | 2006-09-29 | 2017-03-07 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| NO347649B1 (no) | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| WO2008092002A2 (en) | 2007-01-24 | 2008-07-31 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| US20100119526A1 (en) * | 2007-01-26 | 2010-05-13 | Bioinvent International Ab | DLL4 Signaling Inhibitors and Uses Thereof |
| GB0709333D0 (en) * | 2007-05-15 | 2007-06-20 | Smart Targeting Ltd | Binding protein |
| CL2008003302A1 (es) | 2007-11-09 | 2009-03-06 | Genentech Inc | Uso de una proteina de funsion kinasa 1 similar al receptor de activina (alk-1) y fc (alk1.fc) porque sirve para preparar un medicamento contra tumor,cancer o desordenes proliferativos. |
| WO2009124931A2 (en) * | 2008-04-07 | 2009-10-15 | Ablynx Nv | Amino acid sequences directed against the notch pathways and uses thereof |
| JP5646457B2 (ja) * | 2008-04-29 | 2014-12-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
| US20100260668A1 (en) * | 2008-04-29 | 2010-10-14 | Abbott Laboratories | Dual Variable Domain Immunoglobulins and Uses Thereof |
| US8258111B2 (en) | 2008-05-08 | 2012-09-04 | The Johns Hopkins University | Compositions and methods related to miRNA modulation of neovascularization or angiogenesis |
| JP2011523853A (ja) * | 2008-06-03 | 2011-08-25 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリン及びその使用 |
| AR072000A1 (es) * | 2008-06-03 | 2010-07-28 | Abbott Lab | Proteinas de union multivalentes con capacidad de unir dos o mas antigenos y usos de la misma |
| EP2307051B1 (en) | 2008-07-08 | 2015-02-11 | OncoMed Pharmaceuticals, Inc. | Notch-binding agents and antagonists and methods of use thereof |
| BRPI0915448A2 (pt) * | 2008-07-08 | 2015-11-10 | Abbott Lab | imunoglobulinas de domínio variável duplo para prostaglandina e2 e usos das mesmas |
| EP2344536A1 (en) * | 2008-09-19 | 2011-07-20 | MedImmune, LLC | Antibodies directed to dll4 and uses thereof |
| DK2356270T3 (da) | 2008-11-07 | 2016-12-12 | Fabrus Llc | Kombinatoriske antistofbiblioteker og anvendelser deraf |
| CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
| TWI513465B (zh) * | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以dll4拮抗劑與化學治療劑治療癌症之方法 |
| UY32808A (es) * | 2009-07-29 | 2011-02-28 | Abbott Lab | Inmunoglobulinas como dominio variable dual y usos de las mismas |
| MX336152B (es) * | 2009-08-29 | 2016-01-08 | Abbvie Inc | Proteinas terapeutico de union a dll4. |
| KR20120060877A (ko) * | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| UY32920A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moleculas de unión biespecíficas para la terapia anti-angiogénesis |
| UY32917A (es) | 2009-10-02 | 2011-04-29 | Boehringer Ingelheim Int | Moléculas de unión a dll-4 |
| TW201119676A (en) * | 2009-10-15 | 2011-06-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| US8883145B2 (en) | 2009-10-16 | 2014-11-11 | Oncomed Pharmaceuticals, Inc. | Methods of treatment with DLL4 antagonists and an anti-hypertensive agent |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| CA2782299A1 (en) * | 2009-12-01 | 2011-06-09 | Oncomed Pharmaceuticals, Inc. | Methods for treating cancers comprising k-ras mutations |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Wnt拮抗劑及治療和篩選方法 |
| WO2011088215A2 (en) | 2010-01-13 | 2011-07-21 | Oncomed Pharmaceuticals, Inc. | Notch1 binding agents and methods of use thereof |
| JO3183B1 (ar) | 2010-01-29 | 2018-03-08 | Regeneron Pharma | طرق لمعالجة أمراض المناعة الذاتية مضادات dll4 |
| EP3072904A1 (en) | 2010-03-02 | 2016-09-28 | Abbvie Inc. | Therapeutic dll4 binding proteins |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| SG187938A1 (en) | 2010-08-26 | 2013-04-30 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
| US20120225081A1 (en) | 2010-09-03 | 2012-09-06 | Boehringer Ingelheim International Gmbh | Vegf-binding molecules |
| US8551479B2 (en) | 2010-09-10 | 2013-10-08 | Oncomed Pharmaceuticals, Inc. | Methods for treating melanoma |
| KR101330184B1 (ko) * | 2010-10-15 | 2013-11-15 | 성균관대학교산학협력단 | 감마-세크레타제 저해제를 유효성분으로 함유하는 류마티스성 관절염의 예방 또는 치료용 조성물 |
| US20130078247A1 (en) * | 2011-04-01 | 2013-03-28 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to dii4 and ang2 |
| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| JP6170496B2 (ja) | 2011-09-23 | 2017-07-26 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Vegf/dll4結合剤およびその使用 |
| CN104159920A (zh) | 2011-12-30 | 2014-11-19 | 艾伯维公司 | 针对il-13和/或il-17的双重可变结构域免疫球蛋白 |
| US9434786B2 (en) | 2012-02-10 | 2016-09-06 | University Of Maryland, Baltimore | Chemoenzymatic glycoengineering of antibodies and Fc fragments thereof |
| HUE044263T2 (hu) | 2012-03-30 | 2019-10-28 | Boehringer Ingelheim Int | ANG2-kötõ molekulák |
| WO2013169939A2 (en) | 2012-05-08 | 2013-11-14 | Aeromics, Llc | New methods |
| WO2014049100A1 (en) * | 2012-09-28 | 2014-04-03 | Boehringer Ingelheim International Gmbh | Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents |
| JP2015532272A (ja) | 2012-09-28 | 2015-11-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 二重アンジオポエチン−2/Dll4結合剤および抗VEGF−R剤を含む薬学的組み合わせ |
| JP6371294B2 (ja) | 2012-10-31 | 2018-08-08 | オンコメッド ファーマシューティカルズ インコーポレイテッド | Dll4アンタゴニストによる処置の方法およびモニタリング |
| MY171664A (en) | 2012-11-01 | 2019-10-22 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulins and uses thereof |
| AR093445A1 (es) | 2012-11-14 | 2015-06-10 | Regeneron Pharma | Metodos para tratar el cancer de ovario con antagonistas de dll4 |
| JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質 |
| CA2929821A1 (en) | 2013-11-06 | 2015-05-14 | Aeromics, Inc. | 2-{[3,5-bis(trifluoromethyl)phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate formulations and kits |
| WO2016070051A2 (en) | 2014-10-31 | 2016-05-06 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| EP3353204B1 (en) | 2015-09-23 | 2023-10-18 | Mereo BioPharma 5, Inc. | Bi-specific anti-vegf/dll4 antibody for use in treating platinum-resistant ovarian cancer |
| US11026996B2 (en) * | 2016-05-25 | 2021-06-08 | The Trustees Of Columbia University In The City Of New York | Human Notch1 based fusion proteins as decoy inhibitors of jagged-notch signaling and DLL-notch signaling |
| WO2020023807A1 (en) * | 2018-07-26 | 2020-01-30 | The Regents Of The University Of California | Treatment of vascular occlusion by activation of notch signaling |
| US20220185875A1 (en) | 2019-03-18 | 2022-06-16 | Jiangsu Hengrui Medicine Co., Ltd. | Bispecific antibody specifically bound to vegf and ang2 |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| AU600575B2 (en) * | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US4975278A (en) * | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
| GB8823869D0 (en) * | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) * | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| US5633425A (en) * | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5661016A (en) * | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ES2108048T3 (es) * | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5625126A (en) * | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| US20030206899A1 (en) * | 1991-03-29 | 2003-11-06 | Genentech, Inc. | Vascular endothelial cell growth factor antagonists |
| US6582959B2 (en) * | 1991-03-29 | 2003-06-24 | Genentech, Inc. | Antibodies to vascular endothelial cell growth factor |
| EP0940468A1 (en) * | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| US5545007A (en) * | 1994-11-25 | 1996-08-13 | United Technologies Corp. | Engine blade clearance control system with piezoelectric actuator |
| US6121045A (en) * | 1997-04-04 | 2000-09-19 | Millennium Biotherapeutics, Inc. | Human Delta3 nucleic acid molecules |
| US20060122373A1 (en) * | 1997-04-04 | 2006-06-08 | Millennium Pharmaceuticals, Inc. | Delta3, FTHMA-070, Tango85, Tango77, SPOIL,NEOKINE, Tango129 and integrin alpha subunit protein and nucleic acid molecules and uses thereof |
| US6884879B1 (en) * | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| US20020032315A1 (en) * | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| KR100870353B1 (ko) * | 1997-04-07 | 2008-11-25 | 제넨테크, 인크. | 항-vegf 항체 |
| EP1004669B1 (en) * | 1997-05-14 | 2007-04-18 | Asahi Kasei Kabushiki Kaisha | Novel differentiation inhibitor |
| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| ES2434961T5 (es) * | 1998-04-20 | 2018-01-18 | Roche Glycart Ag | Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1176195B1 (en) * | 1999-04-09 | 2013-05-22 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
| US6703020B1 (en) * | 1999-04-28 | 2004-03-09 | Board Of Regents, The University Of Texas System | Antibody conjugate methods for selectively inhibiting VEGF |
| WO2001097850A2 (en) * | 2000-06-23 | 2001-12-27 | Schering Aktiengesellschaft | Combinations and compositions which interfere with vegf/vegf and angiopoietin/tie receptor function and their use (ii) |
| US6946292B2 (en) * | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US7064191B2 (en) * | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US20030157108A1 (en) * | 2001-10-25 | 2003-08-21 | Genentech, Inc. | Glycoprotein compositions |
| US20040093621A1 (en) * | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
| US20040132140A1 (en) * | 2002-04-09 | 2004-07-08 | Kyowa Hakko Kogyo Co., Ltd. | Production process for antibody composition |
| AU2003236018A1 (en) * | 2002-04-09 | 2003-10-20 | Kyowa Hakko Kirin Co., Ltd. | METHOD OF ENHANCING ACTIVITY OF ANTIBODY COMPOSITION OF BINDING TO FcGamma RECEPTOR IIIa |
| CN102911987B (zh) * | 2002-04-09 | 2015-09-30 | 协和发酵麒麟株式会社 | 基因组被修饰的细胞 |
| WO2003084569A1 (en) * | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Drug containing antibody composition |
| JP4628679B2 (ja) * | 2002-04-09 | 2011-02-09 | 協和発酵キリン株式会社 | Gdp−フコースの輸送に関与する蛋白質の活性が低下または欠失した細胞 |
| US20050031613A1 (en) * | 2002-04-09 | 2005-02-10 | Kazuyasu Nakamura | Therapeutic agent for patients having human FcgammaRIIIa |
| US7361740B2 (en) * | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
| KR20160014775A (ko) * | 2003-05-30 | 2016-02-11 | 제넨테크, 인크. | 항-vegf 항체를 사용한 치료 |
| US20070134759A1 (en) * | 2003-10-09 | 2007-06-14 | Harue Nishiya | Process for producing antibody composition by using rna inhibiting the function of alpha1,6-fucosyltransferase |
| ES2672640T3 (es) * | 2003-11-05 | 2018-06-15 | Roche Glycart Ag | Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas |
| US20060134121A1 (en) * | 2004-10-29 | 2006-06-22 | Gavin Thurston | DII4 antagonists, assays, and therapeutic methods thereof |
| AU2006287228B2 (en) * | 2005-09-01 | 2012-12-13 | Alora Biopharma, Inc. | Methods for using and identifying modulators of Delta-like 4 |
| JP5489465B2 (ja) * | 2005-12-16 | 2014-05-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Dll4アンタゴニストによって腫瘍増殖を阻害する治療方法 |
-
2007
- 2007-06-06 KR KR1020097000079A patent/KR20090016762A/ko not_active Withdrawn
- 2007-06-06 BR BRPI0710411-1A patent/BRPI0710411A2/pt not_active IP Right Cessation
- 2007-06-06 US US11/759,093 patent/US20080014196A1/en not_active Abandoned
- 2007-06-06 AU AU2007256617A patent/AU2007256617A1/en not_active Abandoned
- 2007-06-06 TW TW096120337A patent/TW200817435A/zh unknown
- 2007-06-06 MX MX2008015532A patent/MX2008015532A/es unknown
- 2007-06-06 SG SG2011041456A patent/SG172687A1/en unknown
- 2007-06-06 JP JP2009514512A patent/JP2009539870A/ja active Pending
- 2007-06-06 CA CA002654304A patent/CA2654304A1/en not_active Abandoned
- 2007-06-06 RU RU2008152435/15A patent/RU2008152435A/ru not_active Application Discontinuation
- 2007-06-06 EP EP07798174A patent/EP2029159A2/en not_active Withdrawn
- 2007-06-06 AR ARP070102434A patent/AR061245A1/es not_active Application Discontinuation
- 2007-06-06 CL CL2007001624A patent/CL2007001624A1/es unknown
- 2007-06-06 WO PCT/US2007/070516 patent/WO2007143689A2/en not_active Ceased
-
2008
- 2008-10-22 IL IL194788A patent/IL194788A0/en unknown
- 2008-12-18 CR CR10529A patent/CR10529A/es not_active Application Discontinuation
- 2008-12-26 MA MA31521A patent/MA30536B1/fr unknown
-
2009
- 2009-01-05 NO NO20090046A patent/NO20090046L/no not_active Application Discontinuation
- 2009-01-06 EC EC2009009032A patent/ECSP099032A/es unknown
- 2009-07-02 US US12/497,405 patent/US20100129356A1/en not_active Abandoned
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