JP2009538896A5 - - Google Patents
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- Publication number
- JP2009538896A5 JP2009538896A5 JP2009512681A JP2009512681A JP2009538896A5 JP 2009538896 A5 JP2009538896 A5 JP 2009538896A5 JP 2009512681 A JP2009512681 A JP 2009512681A JP 2009512681 A JP2009512681 A JP 2009512681A JP 2009538896 A5 JP2009538896 A5 JP 2009538896A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- methyl
- dihydropyridazin
- fluorobenzoyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0610680.1 | 2006-05-31 | ||
| GBGB0610680.1A GB0610680D0 (en) | 2006-05-31 | 2006-05-31 | Therapeutic compounds |
| PCT/GB2007/050295 WO2007138351A2 (en) | 2006-05-31 | 2007-05-25 | Pyridinone and pyridazinone derivatives as inhibitors of poly(adp-ribose)polymerase (parp) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009538896A JP2009538896A (ja) | 2009-11-12 |
| JP2009538896A5 true JP2009538896A5 (cg-RX-API-DMAC7.html) | 2013-08-22 |
| JP5351755B2 JP5351755B2 (ja) | 2013-11-27 |
Family
ID=36694627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009512681A Active JP5351755B2 (ja) | 2006-05-31 | 2007-05-25 | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）インヒビターとしてのピリジノン及びピリダジノン誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8188084B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2029551B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5351755B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101529891B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103420988A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007266836B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0711741B8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2653529C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2702781T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0610680D0 (cg-RX-API-DMAC7.html) |
| IL (1) | IL195113A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008015014A (cg-RX-API-DMAC7.html) |
| NO (1) | NO343950B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ572815A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007138351A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA200809238B (cg-RX-API-DMAC7.html) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0622195D0 (en) * | 2006-11-08 | 2006-12-20 | Angeletti P Ist Richerche Bio | Therapeutic agents |
| MX2010005070A (es) * | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
| DE102008019907A1 (de) * | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| JP5654001B2 (ja) * | 2009-04-29 | 2015-01-14 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | Ｐ２Ｘ７調節因子としての５，６，７，８−テトラヒドロ［１，２，４］トリアゾロ［４，３−ａ］ピラジン誘導体 |
| GB0907515D0 (en) * | 2009-04-30 | 2009-06-10 | Glaxo Group Ltd | Compounds |
| US10065960B2 (en) | 2010-04-02 | 2018-09-04 | Ogeda Sa | NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders |
| SI2552920T1 (sl) * | 2010-04-02 | 2017-07-31 | Ogeda Sa | Nove nk-3 receptor selektivne antagonist spojine, farmacevtski sestavki in postopki za uporabo pri nk-3 receptor posredovanih motnjah |
| AU2011251622A1 (en) | 2010-05-10 | 2012-12-20 | Radikal Therapeutics Inc. | Lipoic acid and nitroxide derivatives and uses thereof |
| CN102372716A (zh) * | 2010-08-09 | 2012-03-14 | 江苏恒瑞医药股份有限公司 | 酞嗪酮类衍生物、其制备方法及其在医药上的应用 |
| JP5960253B2 (ja) | 2011-05-31 | 2016-08-02 | ニューゲン セラピューティクス， インコーポレイテッド | ポリ（ａｄｐ−リボース）ポリメラーゼの三環系阻害剤 |
| CN105175421B (zh) | 2011-10-03 | 2018-07-13 | 欧歌达有限公司 | 用于合成选择性nk-3受体拮抗剂的中间体化合物及其用途 |
| CN103570725B (zh) * | 2012-08-01 | 2017-03-22 | 中国科学院上海药物研究所 | 哌嗪并三唑类化合物及其制备方法和用途 |
| CN103833756B (zh) * | 2012-11-26 | 2016-12-21 | 中国科学院上海药物研究所 | 一类哒嗪酮类化合物及其制备方法和用途 |
| ES2469990B1 (es) * | 2012-12-19 | 2015-01-26 | Universidade De Vigo | Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica |
| WO2014102817A1 (en) | 2012-12-31 | 2014-07-03 | Cadila Healthcare Limited | Substituted phthalazin-1 (2h)-one derivatives as selective inhibitors of poly (adp-ribose) polymerase-1 |
| MY174269A (en) * | 2013-03-13 | 2020-04-01 | Chugai Pharmaceutical Co Ltd | Dihydropyridazine-3,5-dione derivative |
| RU2737434C2 (ru) | 2013-03-13 | 2020-11-30 | Форма Терапьютикс, Инк. | Новые соединения и композиции для ингибирования fasn |
| JP6316932B2 (ja) | 2013-03-29 | 2018-04-25 | オゲダ エス．エー． | 選択的ＮＫ−３受容体拮抗薬としての新規なＮ−アシル−（３位置換）−（８位置換）−５，６−ジヒドロ−［１，２，４］トリアゾロ［４，３−ａ］ピラジン、医薬組成物、ＮＫ−３受容体媒介性障害における使用方法 |
| ES2721018T3 (es) | 2013-03-29 | 2019-07-26 | Ogeda S A | N-Acil-(3-sustituido)-(8-metil)-5,6-dihidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor NK-3, composición farmacéutica, métodos para su uso en trastornos mediados por el receptor de NK-3 |
| US10183948B2 (en) | 2013-03-29 | 2019-01-22 | Ogeda Sa | N-acyl-(3-substituted)-(8-substituted)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazines as selective NK-3 receptor antagonists |
| ES2711143T3 (es) | 2013-03-29 | 2019-04-30 | Ogeda Sa | N-acil-(3-sustituido)-5,6,7,8-tetrahidro-[1,2,4]triazolo[4,3-a]pirazinas como antagonistas selectivos del receptor de NK-3, composición farmacéutica, métodos para su uso en los trastornos mediados por el receptor de NK-3 |
| KR101670126B1 (ko) | 2013-09-13 | 2016-10-27 | 일동제약(주) | 신규 프탈라지논 유도체 및 그 제조방법 |
| ES2544869B2 (es) * | 2014-03-04 | 2016-01-18 | Universidade De Vigo | Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa |
| US10472664B2 (en) | 2014-10-03 | 2019-11-12 | Institute For Cancer Research | Screening assay for identification of poly(ADP-ribose) polymerase 1 inhibitors |
| US10550108B2 (en) | 2014-10-03 | 2020-02-04 | Institute For Cancer Research | Poly(ADP-ribose) polymerase 1 inhibitors structurally unrelated to NAD |
| JP6871169B2 (ja) | 2015-03-02 | 2021-05-12 | シナイ ヘルス システム | 相同組換え因子 |
| CA2993270C (en) | 2015-07-23 | 2019-07-16 | Institut Curie | Use of a combination of dbait molecule and parp inhibitors to treat cancer |
| CN106749261A (zh) * | 2015-11-23 | 2017-05-31 | 中国科学院上海药物研究所 | 一类取代三唑并哌嗪类parp抑制剂及其制备方法和用途 |
| WO2018162439A1 (en) | 2017-03-08 | 2018-09-13 | Onxeo | New predictive biomarker for the sensitivity to a treatment of cancer with a dbait molecule |
| ES2788856T3 (es) | 2017-03-20 | 2020-10-23 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| CN109232575B (zh) * | 2017-07-10 | 2022-01-25 | 中国科学院上海药物研究所 | 吡咯[1,2-b]哒嗪类化合物或其可药用盐及它们的用途 |
| CN111819282A (zh) | 2018-03-13 | 2020-10-23 | 欧恩科斯欧公司 | 对抗癌症治疗中获得性耐药性的Dbait分子 |
| TWI877697B (zh) | 2018-04-30 | 2025-03-21 | 美商律幫治療股份有限公司 | 作為parp7抑制劑的嗒酮 |
| WO2020061378A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| TWI767148B (zh) | 2018-10-10 | 2022-06-11 | 美商弗瑪治療公司 | 抑制脂肪酸合成酶(fasn) |
| US10793554B2 (en) | 2018-10-29 | 2020-10-06 | Forma Therapeutics, Inc. | Solid forms of 4-(2-fluoro-4-(1-methyl-1H-benzo[d]imidazol-5-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone |
| US12371421B2 (en) | 2019-04-29 | 2025-07-29 | Ribon Therapeutics, Inc. | Solid forms of a PARP7 inhibitor |
| MA57202B1 (fr) | 2019-09-19 | 2025-09-30 | Novo Nordisk Health Care Ag | Compositions d'activation de la pyruvate kinase r (pkr) |
| US11691969B2 (en) | 2019-10-30 | 2023-07-04 | Ribon Therapeutics, Inc. | Pyridazinones as PARP7 inhibtors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
| EP4139298A4 (en) | 2020-04-21 | 2024-05-22 | Idience Co., Ltd. | Process for preparing a phthalazinone derivative and intermediates thereof |
| IL297464A (en) | 2020-04-21 | 2022-12-01 | Idience Co Ltd | Crystalline forms of phthalazinone compound |
| US12059419B2 (en) | 2020-10-16 | 2024-08-13 | Idience Co., Ltd. | Pharmaceutical composition comprising phthalazinone derivatives |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| TW202302602A (zh) * | 2021-04-23 | 2023-01-16 | 大陸商四川海思科製藥有限公司 | 並環雜環衍生物及其在醫藥上的應用 |
| CN115477640A (zh) * | 2021-05-31 | 2022-12-16 | 由理生物医药（上海）有限公司 | 作为parp7抑制剂的哒嗪酮类化合物 |
| AU2022375782A1 (en) * | 2021-10-28 | 2024-05-02 | Gilead Sciences, Inc. | Pyridizin-3(2h)-one derivatives |
| CN115745971B (zh) * | 2021-12-20 | 2024-07-30 | 北京华森英诺生物科技有限公司 | Parp7抑制剂及其应用 |
| AU2022451580B2 (en) * | 2022-04-01 | 2024-11-07 | Novostar Pharmaceuticals, Ltd. | Parp7 inhibitor and use thereof |
| AU2024265078A1 (en) | 2023-05-04 | 2025-12-11 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| WO2024261243A1 (en) | 2023-06-21 | 2024-12-26 | Hemispherian As | Combination comprising a deoxycytidine derivative and a parp inhibitor for use in a method of treating hr proficient cancer |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025217307A1 (en) | 2024-04-09 | 2025-10-16 | Revolution Medicines, Inc. | Methods for predicting response to a ras(on) inhibitor and combination therapies |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
| CA2205757C (en) * | 1996-05-30 | 2006-01-24 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives and their use as inhibitors of prostaglandin g/h synthase i and ii(cox i and ii) |
| AU9578901A (en) | 2000-10-30 | 2002-05-15 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US6664269B2 (en) | 2001-05-08 | 2003-12-16 | Maybridge Plc | Isoquinolinone derivatives |
| WO2003011293A2 (en) * | 2001-08-02 | 2003-02-13 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
| WO2003017369A1 (en) | 2001-08-14 | 2003-02-27 | Transchip, Inc. | A pixel sensor with charge evacuation element and systems and methods for using such |
| DE60335359D1 (de) | 2002-04-30 | 2011-01-27 | Kudos Pharm Ltd | Phthalazinonderivate |
| NZ542680A (en) | 2003-03-12 | 2008-08-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| BRPI0408704A (pt) * | 2003-03-24 | 2006-03-07 | Hoffmann La Roche | benzil-piridazinonas como inibidores de transcriptase reversa |
| CA2559552A1 (en) * | 2004-03-23 | 2005-09-29 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinone derivatives as non-nucleoside reverse transcriptase inhibitors |
| PE20060285A1 (es) | 2004-03-30 | 2006-05-08 | Aventis Pharma Inc | Piridonas sustituidas como inhibidores de pol(adp-ribosa)-polimerasa (parp) |
| EP1737827A1 (en) * | 2004-04-15 | 2007-01-03 | F.Hoffmann-La Roche Ag | Process for preparing pyridazinone compounds |
| WO2006021801A1 (en) | 2004-08-26 | 2006-03-02 | Kudos Pharmaceuticals Limited | 4-heteroarylmethyl substituted phthalazinone derivatives |
| KR100965006B1 (ko) * | 2005-07-21 | 2010-06-21 | 에프. 호프만-라 로슈 아게 | 갑상선 호르몬 수용체 작용제로서 피리다진온 유도체 |
| DE602006004473D1 (de) * | 2005-09-30 | 2009-02-05 | Hoffmann La Roche | Nnrt-inhibitoren |
| JP4611441B2 (ja) * | 2006-04-03 | 2011-01-12 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー | ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール及びベンゾトリアゾール誘導体 |
| US7834015B2 (en) * | 2006-05-31 | 2010-11-16 | Instituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP) |
| MX347085B (es) * | 2006-12-28 | 2017-04-06 | Abbott Laboratories * | Inhibidores de la poli (adp-ribosa) polimerasa. |
| US8466150B2 (en) * | 2006-12-28 | 2013-06-18 | Abbott Laboratories | Inhibitors of poly(ADP-ribose)polymerase |
| US20080280910A1 (en) | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
| TW200900396A (en) | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
| US20090023727A1 (en) | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
| WO2011055270A1 (en) * | 2009-11-04 | 2011-05-12 | Wyeth Llc | Indole based receptor crth2 antagonists |
-
2006
- 2006-05-31 GB GBGB0610680.1A patent/GB0610680D0/en not_active Ceased
-
2007
- 2007-05-25 ES ES07733716T patent/ES2702781T3/es active Active
- 2007-05-25 JP JP2009512681A patent/JP5351755B2/ja active Active
- 2007-05-25 CA CA2653529A patent/CA2653529C/en active Active
- 2007-05-25 EP EP07733716.0A patent/EP2029551B1/en active Active
- 2007-05-25 KR KR1020087029132A patent/KR101529891B1/ko active Active
- 2007-05-25 US US12/227,513 patent/US8188084B2/en active Active
- 2007-05-25 AU AU2007266836A patent/AU2007266836B2/en active Active
- 2007-05-25 CN CN2013103167261A patent/CN103420988A/zh active Pending
- 2007-05-25 BR BRPI0711741A patent/BRPI0711741B8/pt active IP Right Grant
- 2007-05-25 CN CNA2007800201367A patent/CN101501006A/zh active Pending
- 2007-05-25 WO PCT/GB2007/050295 patent/WO2007138351A2/en not_active Ceased
- 2007-05-25 NZ NZ572815A patent/NZ572815A/en unknown
- 2007-05-25 MX MX2008015014A patent/MX2008015014A/es active IP Right Grant
-
2008
- 2008-10-27 ZA ZA200809238A patent/ZA200809238B/xx unknown
- 2008-11-04 IL IL195113A patent/IL195113A/en active IP Right Grant
- 2008-12-29 NO NO20085397A patent/NO343950B1/no unknown
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