AU2007266836B2 - Pyridinone and pyridazinone derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP) - Google Patents

Pyridinone and pyridazinone derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP) Download PDF

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AU2007266836B2
AU2007266836B2 AU2007266836A AU2007266836A AU2007266836B2 AU 2007266836 B2 AU2007266836 B2 AU 2007266836B2 AU 2007266836 A AU2007266836 A AU 2007266836A AU 2007266836 A AU2007266836 A AU 2007266836A AU 2007266836 B2 AU2007266836 B2 AU 2007266836B2
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oxo
methyl
dihydropyridazin
trifluoroacetate
fluorobenzoyl
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AU2007266836A1 (en
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Federica Ferrigno
Philip Jones
Olaf Kinzel
Laura Llauger Bufi
Giovanna Pescatore
Carsten Schultz-Fademrecht
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MSD Italia SRL
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A—HUMAN NECESSITIES
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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AU2007266836A 2006-05-31 2007-05-25 Pyridinone and pyridazinone derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP) Active AU2007266836B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0610680.1 2006-05-31
GBGB0610680.1A GB0610680D0 (en) 2006-05-31 2006-05-31 Therapeutic compounds
PCT/GB2007/050295 WO2007138351A2 (en) 2006-05-31 2007-05-25 Pyridinone and pyridazinone derivatives as inhibitors of poly(adp-ribose)polymerase (parp)

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AU2007266836A1 AU2007266836A1 (en) 2007-12-06
AU2007266836B2 true AU2007266836B2 (en) 2013-09-26

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US (1) US8188084B2 (cg-RX-API-DMAC7.html)
EP (1) EP2029551B1 (cg-RX-API-DMAC7.html)
JP (1) JP5351755B2 (cg-RX-API-DMAC7.html)
KR (1) KR101529891B1 (cg-RX-API-DMAC7.html)
CN (2) CN103420988A (cg-RX-API-DMAC7.html)
AU (1) AU2007266836B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0711741B8 (cg-RX-API-DMAC7.html)
CA (1) CA2653529C (cg-RX-API-DMAC7.html)
ES (1) ES2702781T3 (cg-RX-API-DMAC7.html)
GB (1) GB0610680D0 (cg-RX-API-DMAC7.html)
IL (1) IL195113A (cg-RX-API-DMAC7.html)
MX (1) MX2008015014A (cg-RX-API-DMAC7.html)
NO (1) NO343950B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ572815A (cg-RX-API-DMAC7.html)
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ES2524787T3 (es) * 2007-11-15 2014-12-12 Msd Italia S.R.L. Derivados de piridazinona como inhibidores de PARP
DE102008019907A1 (de) * 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
EP2424869B1 (en) * 2009-04-29 2016-06-22 Glaxo Group Limited 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS
GB0907515D0 (en) * 2009-04-30 2009-06-10 Glaxo Group Ltd Compounds
PT2552920T (pt) * 2010-04-02 2017-06-07 Ogeda Sa Compostos antagonistas seletivos de recetor de nk-3 inovadores, composições farmacêuticas e métodos para utilização em distúrbios mediados por recetores de nk-3
US10065960B2 (en) 2010-04-02 2018-09-04 Ogeda Sa NK-3 receptor selective antagonist compounds, pharmaceutical composition and methods for use in NK-3 receptors mediated disorders
CA2798697A1 (en) 2010-05-10 2011-11-17 Radikal Therapeutics Inc. Lipoic acid and nitroxide derivatives and uses thereof
CN102372716A (zh) * 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 酞嗪酮类衍生物、其制备方法及其在医药上的应用
WO2012166983A1 (en) 2011-05-31 2012-12-06 Newgen Therapeutics, Inc. Tricyclic inhibitors of poly(adp-ribose)polymerase
EP3029042A1 (en) 2011-10-03 2016-06-08 Euroscreen S.A. Novel chiral n-acyl-5,6,7,(8-substituted)-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazines as selective nk-3 receptor antagonists, pharmaceutical composition, methods for use in nk-3 receptor mediated disorders and chiral synthesis thereof
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