JP2009538120A - 四量体化ポリペプチドおよび使用方法 - Google Patents

四量体化ポリペプチドおよび使用方法 Download PDF

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JP2009538120A
JP2009538120A JP2009505633A JP2009505633A JP2009538120A JP 2009538120 A JP2009538120 A JP 2009538120A JP 2009505633 A JP2009505633 A JP 2009505633A JP 2009505633 A JP2009505633 A JP 2009505633A JP 2009538120 A JP2009538120 A JP 2009538120A
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protein
vasp
cells
heterologous
fusion protein
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Japanese (ja)
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JP2009538120A5 (https=
Inventor
ジェームス ダブリュ. ウェスト
キャメロン エス. ブラント
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ザイモジェネティクス, インコーポレイテッド
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70532B7 molecules, e.g. CD80, CD86
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2009505633A 2006-04-13 2007-04-13 四量体化ポリペプチドおよび使用方法 Withdrawn JP2009538120A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79162606P 2006-04-13 2006-04-13
PCT/US2007/066607 WO2007124283A2 (en) 2006-04-13 2007-04-13 Tetramerizing polypeptides and methods of use

Publications (2)

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JP2009538120A true JP2009538120A (ja) 2009-11-05
JP2009538120A5 JP2009538120A5 (https=) 2009-12-17

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ID=38617337

Family Applications (1)

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JP2009505633A Withdrawn JP2009538120A (ja) 2006-04-13 2007-04-13 四量体化ポリペプチドおよび使用方法

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US (1) US20070254339A1 (https=)
EP (1) EP2004682A2 (https=)
JP (1) JP2009538120A (https=)
AU (1) AU2007240491A1 (https=)
CA (1) CA2648915A1 (https=)
IL (1) IL194161A0 (https=)
WO (1) WO2007124283A2 (https=)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013531982A (ja) * 2010-06-09 2013-08-15 ザイモジェネティクス, インコーポレイテッド 二量体vstm3融合タンパク質および関連組成物および方法
JP2018530337A (ja) * 2015-10-10 2018-10-18 グアンジョウ インスティテュート オブ バイオメディスン アンド ヘルス,チャイニーズ アカデミー オブ サイエンスィズ 高親和力の可溶性pdl−1分子
JP2020516251A (ja) * 2017-04-06 2020-06-11 ウニヴェルズィテート シュトゥットガルト 結合および生物活性を改善した腫瘍壊死因子受容体(tnfr)結合タンパク質複合体
US12173046B2 (en) 2019-06-24 2024-12-24 Universitat Stuttgart TNFR2 agonists with improved stability

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040121370A1 (en) 2002-09-11 2004-06-24 Genentech, Inc. Novel composition and methods for the treatment of immune related diseases
EP1997887B1 (en) 2006-03-03 2013-09-04 Ono Pharmaceutical Co., Ltd. Multimer of extracellular domain of cell surface functional molecule
US20070243584A1 (en) * 2006-04-13 2007-10-18 West James W Tetramerizing polypeptides and methods of use
KR101662622B1 (ko) 2007-10-04 2016-10-05 지모제넥틱스, 인코포레이티드 B7 패밀리 구성원 zB7H6 및 관련된 조성물 및 방법
EP3208612B1 (en) 2008-04-09 2019-09-18 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
CA2916681A1 (en) 2013-07-16 2015-01-22 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonists and tigit inhibitors
US10227408B2 (en) 2015-02-19 2019-03-12 Compugen Ltd. Anti-PVRIG antibodies and methods of use
EP3978929A1 (en) 2015-02-19 2022-04-06 Compugen Ltd. Pvrig polypeptides and methods of treatment
CA2994858C (en) 2015-09-25 2024-01-23 Genentech, Inc. Anti-tigit antibodies and methods of use
WO2017152088A1 (en) 2016-03-04 2017-09-08 JN Biosciences, LLC Antibodies to tigit
CN110088132B (zh) 2016-08-17 2020-10-27 康姆普根有限公司 抗tigit抗体,抗pvrig抗体及其组合
CN110799213A (zh) 2017-06-01 2020-02-14 康姆普根有限公司 三联组合抗体疗法
JP2021534196A (ja) 2018-08-23 2021-12-09 シージェン インコーポレイテッド 抗tigit抗体
BR112022024221A2 (pt) 2020-06-02 2022-12-20 Arcus Biosciences Inc Anticorpos para tigit

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6803192B1 (en) * 1999-11-30 2004-10-12 Mayo Foundation For Medical Education And Research B7-H1, a novel immunoregulatory molecule
US20020107363A1 (en) * 2000-09-20 2002-08-08 Amgen, Inc. B7-Like molecules and uses thereof
PL368972A1 (en) * 2001-08-29 2005-04-04 Genentech, Inc. Bv8 nucleic acids and polypeptides with mitogenic activity
US7193069B2 (en) * 2002-03-22 2007-03-20 Research Association For Biotechnology Full-length cDNA
US20040121370A1 (en) * 2002-09-11 2004-06-24 Genentech, Inc. Novel composition and methods for the treatment of immune related diseases
EP3214095B1 (en) * 2005-05-12 2019-12-11 ZymoGenetics, Inc. Compositions and methods for modulating immune responses

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013531982A (ja) * 2010-06-09 2013-08-15 ザイモジェネティクス, インコーポレイテッド 二量体vstm3融合タンパク質および関連組成物および方法
JP2018530337A (ja) * 2015-10-10 2018-10-18 グアンジョウ インスティテュート オブ バイオメディスン アンド ヘルス,チャイニーズ アカデミー オブ サイエンスィズ 高親和力の可溶性pdl−1分子
JP2020516251A (ja) * 2017-04-06 2020-06-11 ウニヴェルズィテート シュトゥットガルト 結合および生物活性を改善した腫瘍壊死因子受容体(tnfr)結合タンパク質複合体
JP7370580B2 (ja) 2017-04-06 2023-10-30 ウニヴェルズィテート シュトゥットガルト 結合および生物活性を改善した腫瘍壊死因子受容体(tnfr)結合タンパク質複合体
US12173046B2 (en) 2019-06-24 2024-12-24 Universitat Stuttgart TNFR2 agonists with improved stability

Also Published As

Publication number Publication date
WO2007124283A3 (en) 2008-01-17
CA2648915A1 (en) 2007-11-01
US20070254339A1 (en) 2007-11-01
IL194161A0 (en) 2011-08-01
EP2004682A2 (en) 2008-12-24
WO2007124283A2 (en) 2007-11-01
AU2007240491A1 (en) 2007-11-01

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