JP2009537612A5 - - Google Patents

Info

Publication number

JP2009537612A5

JP2009537612A5 JP2009511534A JP2009511534A JP2009537612A5 JP 2009537612 A5 JP2009537612 A5 JP 2009537612A5 JP 2009511534 A JP2009511534 A JP 2009511534A JP 2009511534 A JP2009511534 A JP 2009511534A JP 2009537612 A5 JP2009537612 A5 JP 2009537612A5

Authority

JP

Japan

Prior art keywords

proinsulin

nucleotide sequence

compound

seq

activity

Prior art date

2007-05-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 108010076181 Proinsulin Proteins 0.000 claims 31
• 239000002773 nucleotide Substances 0.000 claims 25
• 125000003729 nucleotide group Chemical group 0.000 claims 25
• 150000001875 compounds Chemical class 0.000 claims 22
• 230000000694 effects Effects 0.000 claims 13
• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 230000001939 inductive effect Effects 0.000 claims 10
• 108090000623 proteins and genes Proteins 0.000 claims 7
• 239000013604 expression vector Substances 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 210000003527 eukaryotic cell Anatomy 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 210000001519 tissue Anatomy 0.000 claims 4
• 230000004770 neurodegeneration Effects 0.000 claims 3
• 208000015122 neurodegenerative disease Diseases 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 102000004169 proteins and genes Human genes 0.000 claims 3
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
• 238000003782 apoptosis assay Methods 0.000 claims 2
• 230000001684 chronic effect Effects 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 210000005260 human cell Anatomy 0.000 claims 2
• 210000003205 muscle Anatomy 0.000 claims 2
• 230000000626 neurodegenerative effect Effects 0.000 claims 2
• 230000004112 neuroprotection Effects 0.000 claims 2
• 230000000324 neuroprotective effect Effects 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 230000005522 programmed cell death Effects 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 1
• 208000031277 Amaurotic familial idiocy Diseases 0.000 claims 1
• 208000010412 Glaucoma Diseases 0.000 claims 1
• 208000023105 Huntington disease Diseases 0.000 claims 1
• 208000009829 Lewy Body Disease Diseases 0.000 claims 1
• 201000002832 Lewy body dementia Diseases 0.000 claims 1
• 208000018737 Parkinson disease Diseases 0.000 claims 1
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims 1
• 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
• 201000004810 Vascular dementia Diseases 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 208000002780 macular degeneration Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229940126601 medicinal product Drugs 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 208000020431 spinal cord injury Diseases 0.000 claims 1