MX9700198A - Compuestos peptidos de proinsulina para detectar y tratar diabetes tipo 1. - Google Patents
Compuestos peptidos de proinsulina para detectar y tratar diabetes tipo 1.Info
- Publication number
- MX9700198A MX9700198A MX9700198A MX9700198A MX9700198A MX 9700198 A MX9700198 A MX 9700198A MX 9700198 A MX9700198 A MX 9700198A MX 9700198 A MX9700198 A MX 9700198A MX 9700198 A MX9700198 A MX 9700198A
- Authority
- MX
- Mexico
- Prior art keywords
- proinsulin
- diabetes
- peptide compounds
- proinsulin peptide
- type
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physiology (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
Abstract
Se describen compuestos péptidos de proinsulina que modulan una respuesta inmunologica mediante las células T de sujetos diabéticos Tipo I. Los compuestos péptidos de proinsulina de la invencion se derivan de preferencia a partir de una region de proinsulina que abarca la union entre la cadena B y el péptido C de la proinsulina. También se describen composiciones farmacéuticas que comprenden los compuestos péptidos de proinsulina. Se puede usar una respuesta inmunologica a un compuesto péptido de proinsulina de la invencion, como un indicador de diabetes tipo I en un sujeto. De conformidad, la invencion proporciona ensayos de diagnostico para diabetes Tipo I usando los compuestos péptidos de proinsulina. También se describen métodos para la inhibicion del desarrollo o progreso de la diabetes Tipo I en un sujeto, mediante la administracion de un compuesto péptido de proinsulina.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27222094A | 1994-07-08 | 1994-07-08 | |
US47270495A | 1995-06-06 | 1995-06-06 | |
PCT/US1995/008596 WO1996001846A1 (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9700198A true MX9700198A (es) | 1997-04-30 |
Family
ID=26955374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9700198A MX9700198A (es) | 1994-07-08 | 1995-07-07 | Compuestos peptidos de proinsulina para detectar y tratar diabetes tipo 1. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20030220229A1 (es) |
EP (1) | EP0788512B1 (es) |
JP (1) | JPH10505821A (es) |
CN (1) | CN1157621A (es) |
AT (1) | ATE178074T1 (es) |
AU (1) | AU3094795A (es) |
CA (1) | CA2194548A1 (es) |
DE (1) | DE69508605T2 (es) |
DK (1) | DK0788512T3 (es) |
ES (1) | ES2130629T3 (es) |
MX (1) | MX9700198A (es) |
WO (1) | WO1996001846A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996026218A1 (en) | 1995-02-20 | 1996-08-29 | Amrad Operations Pty. Ltd. | Immunoreactive and immunotherapeutic molecules which interact in subjects with insulin-dependent diabetes mellitus (iddm) |
SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
AUPO269996A0 (en) * | 1996-10-01 | 1996-10-24 | Walter And Eliza Hall Institute Of Medical Research, The | A method of prophylaxis and treatment |
US7509406B2 (en) * | 2004-09-30 | 2009-03-24 | Microsoft Corporation | Managing terminal services accounts and sessions for online utilization of a hosted application |
ES2331342B1 (es) * | 2006-05-22 | 2010-10-13 | Consejo Superior Investg.Cientificas | Uso de la proinsulina para la elaboracion de una composicion farmaceutica neuroprotectora, composicion terapeutica que la contiene y sus aplicaciones. |
CN103630692B (zh) * | 2013-06-02 | 2015-05-06 | 马鞍山国声生物技术有限公司 | 快速检测尿液c肽的胶体金免疫层析试剂盒及其检测方法 |
CN111239415B (zh) * | 2013-10-17 | 2024-03-26 | 综合医院公司 | 鉴定响应于用于自身免疫性疾病的治疗的受试者的方法以及用于治疗该疾病的组合物 |
GB2559499A (en) * | 2014-02-25 | 2018-08-08 | Orban Tihamer | Immunomodulatory therapy for type 1 diabetes mellitus autoimmunity |
GB2523399B (en) | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5210872B2 (es) * | 1973-07-14 | 1977-03-26 | ||
US4308181A (en) * | 1980-12-08 | 1981-12-29 | American Home Products Corporation | Polypeptide compositions |
US4652548A (en) * | 1981-08-27 | 1987-03-24 | Eli Lilly And Company | Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
NL9001083A (nl) * | 1990-05-04 | 1991-12-02 | Rijksuniversiteit | Beta-cel antigeen. |
EP0543945B1 (en) * | 1990-08-17 | 1996-10-16 | The University Of Florida | Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus |
-
1995
- 1995-07-07 CN CN95194541A patent/CN1157621A/zh active Pending
- 1995-07-07 CA CA002194548A patent/CA2194548A1/en not_active Abandoned
- 1995-07-07 AU AU30947/95A patent/AU3094795A/en not_active Abandoned
- 1995-07-07 EP EP95926642A patent/EP0788512B1/en not_active Revoked
- 1995-07-07 DK DK95926642T patent/DK0788512T3/da active
- 1995-07-07 WO PCT/US1995/008596 patent/WO1996001846A1/en active IP Right Grant
- 1995-07-07 MX MX9700198A patent/MX9700198A/es not_active IP Right Cessation
- 1995-07-07 DE DE69508605T patent/DE69508605T2/de not_active Expired - Fee Related
- 1995-07-07 AT AT95926642T patent/ATE178074T1/de not_active IP Right Cessation
- 1995-07-07 ES ES95926642T patent/ES2130629T3/es not_active Expired - Lifetime
- 1995-07-07 JP JP8504435A patent/JPH10505821A/ja not_active Ceased
-
2003
- 2003-01-16 US US10/346,563 patent/US20030220229A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69508605T2 (de) | 1999-07-22 |
EP0788512A1 (en) | 1997-08-13 |
CN1157621A (zh) | 1997-08-20 |
AU3094795A (en) | 1996-02-09 |
ATE178074T1 (de) | 1999-04-15 |
JPH10505821A (ja) | 1998-06-09 |
DK0788512T3 (da) | 1999-10-11 |
CA2194548A1 (en) | 1996-01-25 |
EP0788512B1 (en) | 1999-03-24 |
DE69508605D1 (de) | 1999-04-29 |
WO1996001846A1 (en) | 1996-01-25 |
US20030220229A1 (en) | 2003-11-27 |
ES2130629T3 (es) | 1999-07-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |