ES2130629T3 - Compuestos peptidicos de proinsulina para detectar y tratar la diabetes tipo i. - Google Patents
Compuestos peptidicos de proinsulina para detectar y tratar la diabetes tipo i.Info
- Publication number
- ES2130629T3 ES2130629T3 ES95926642T ES95926642T ES2130629T3 ES 2130629 T3 ES2130629 T3 ES 2130629T3 ES 95926642 T ES95926642 T ES 95926642T ES 95926642 T ES95926642 T ES 95926642T ES 2130629 T3 ES2130629 T3 ES 2130629T3
- Authority
- ES
- Spain
- Prior art keywords
- proinsulin
- diabetes
- compounds
- type
- peptidic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/62—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Obesity (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physiology (AREA)
- Emergency Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
Abstract
SE DESCRIBEN COMPUESTOS DE PEPTIDO DE PROINSULINA, QUE MODULAN LA RESPUESTA INMUNOLOGICA MEDIADA POR CELULAS T, DE SUJETOS DIABETICOS DE TIPO I. LOS COMPUESTOS DE LA INVENCION, SE DERIVAN PREFERIBLEMENTE DE UNA REGION DE LA PROINSULINA, QUE SE EXTIENDE DESDE LA UNION ENTRE LA CADENA B Y EL PEPTIDO C DE LA PROINSULINA. SE DESCRIBEN ASIMISMO, COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN DICHOS COMPUESTOS DE PEPTIDO DE PROINSULINA. LA RESPUESTA INMUNOLOGICA INDUCIDA POR UN COMPUESTO DE PEPTIDO DE PROINSULINA, SE PUEDE UTILIZAR COMO INDICADOR DE LA DIABETES TIPO I EN UN SUJETO. CONSECUENTEMENTE, LA INVENCION PROPORCIONA ENSAYOS DIAGNOSTICOS PARA LA DIABETES TIPO I, UTILIZANDO DICHOS COMPUESTOS. TAMBIEN SE INCLUYEN METODOS PARA INHIBIR EL DESARROLLO O PROGRESION DE LA DIABETES TIPO I EN UN SUJETO, MEDIANTE LA ADMINISTRACION DE UN COMPUESTO DE PEPTIDO DE PROINSULINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27222094A | 1994-07-08 | 1994-07-08 | |
US47270495A | 1995-06-06 | 1995-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2130629T3 true ES2130629T3 (es) | 1999-07-01 |
Family
ID=26955374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95926642T Expired - Lifetime ES2130629T3 (es) | 1994-07-08 | 1995-07-07 | Compuestos peptidicos de proinsulina para detectar y tratar la diabetes tipo i. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20030220229A1 (es) |
EP (1) | EP0788512B1 (es) |
JP (1) | JPH10505821A (es) |
CN (1) | CN1157621A (es) |
AT (1) | ATE178074T1 (es) |
AU (1) | AU3094795A (es) |
CA (1) | CA2194548A1 (es) |
DE (1) | DE69508605T2 (es) |
DK (1) | DK0788512T3 (es) |
ES (1) | ES2130629T3 (es) |
MX (1) | MX9700198A (es) |
WO (1) | WO1996001846A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69637130T2 (de) | 1995-02-20 | 2008-02-21 | The Walter And Eliza Hall Institute Of Medical Research, Parkville | Immunoreaktive und immunotherapeutische moleküle welche in individuen mit insulin-abhängiger diabetes mellitus interagieren |
SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
AUPO269996A0 (en) * | 1996-10-01 | 1996-10-24 | Walter And Eliza Hall Institute Of Medical Research, The | A method of prophylaxis and treatment |
US7509406B2 (en) * | 2004-09-30 | 2009-03-24 | Microsoft Corporation | Managing terminal services accounts and sessions for online utilization of a hosted application |
ES2331342B1 (es) * | 2006-05-22 | 2010-10-13 | Consejo Superior Investg.Cientificas | Uso de la proinsulina para la elaboracion de una composicion farmaceutica neuroprotectora, composicion terapeutica que la contiene y sus aplicaciones. |
CN103630692B (zh) * | 2013-06-02 | 2015-05-06 | 马鞍山国声生物技术有限公司 | 快速检测尿液c肽的胶体金免疫层析试剂盒及其检测方法 |
JP6560200B2 (ja) * | 2013-10-17 | 2019-08-14 | ザ ジェネラル ホスピタル コーポレイション | 自己免疫疾患の治療に応答性の対象を同定する方法およびそれを治療するための組成物 |
GB2559499A (en) * | 2014-02-25 | 2018-08-08 | Orban Tihamer | Immunomodulatory therapy for type 1 diabetes mellitus autoimmunity |
GB2523399B (en) * | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5210872B2 (es) * | 1973-07-14 | 1977-03-26 | ||
US4308181A (en) * | 1980-12-08 | 1981-12-29 | American Home Products Corporation | Polypeptide compositions |
US4652548A (en) * | 1981-08-27 | 1987-03-24 | Eli Lilly And Company | Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin |
US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
NL9001083A (nl) * | 1990-05-04 | 1991-12-02 | Rijksuniversiteit | Beta-cel antigeen. |
ATE144326T1 (de) * | 1990-08-17 | 1996-11-15 | Univ Florida | Verfahren und komposition zum frühnachweiss und behandlung insulinabhängiger diabetes |
-
1995
- 1995-07-07 WO PCT/US1995/008596 patent/WO1996001846A1/en active IP Right Grant
- 1995-07-07 DK DK95926642T patent/DK0788512T3/da active
- 1995-07-07 ES ES95926642T patent/ES2130629T3/es not_active Expired - Lifetime
- 1995-07-07 CA CA002194548A patent/CA2194548A1/en not_active Abandoned
- 1995-07-07 CN CN95194541A patent/CN1157621A/zh active Pending
- 1995-07-07 DE DE69508605T patent/DE69508605T2/de not_active Expired - Fee Related
- 1995-07-07 AT AT95926642T patent/ATE178074T1/de not_active IP Right Cessation
- 1995-07-07 JP JP8504435A patent/JPH10505821A/ja not_active Ceased
- 1995-07-07 AU AU30947/95A patent/AU3094795A/en not_active Abandoned
- 1995-07-07 EP EP95926642A patent/EP0788512B1/en not_active Revoked
- 1995-07-07 MX MX9700198A patent/MX9700198A/es not_active IP Right Cessation
-
2003
- 2003-01-16 US US10/346,563 patent/US20030220229A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU3094795A (en) | 1996-02-09 |
US20030220229A1 (en) | 2003-11-27 |
EP0788512B1 (en) | 1999-03-24 |
EP0788512A1 (en) | 1997-08-13 |
DK0788512T3 (da) | 1999-10-11 |
CN1157621A (zh) | 1997-08-20 |
JPH10505821A (ja) | 1998-06-09 |
DE69508605D1 (de) | 1999-04-29 |
ATE178074T1 (de) | 1999-04-15 |
WO1996001846A1 (en) | 1996-01-25 |
DE69508605T2 (de) | 1999-07-22 |
CA2194548A1 (en) | 1996-01-25 |
MX9700198A (es) | 1997-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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