ES8707547A1 - Procedimiento para preparar un oligopeptidil-argininol u-homoargininol o derivado de estos - Google Patents
Procedimiento para preparar un oligopeptidil-argininol u-homoargininol o derivado de estosInfo
- Publication number
- ES8707547A1 ES8707547A1 ES552086A ES552086A ES8707547A1 ES 8707547 A1 ES8707547 A1 ES 8707547A1 ES 552086 A ES552086 A ES 552086A ES 552086 A ES552086 A ES 552086A ES 8707547 A1 ES8707547 A1 ES 8707547A1
- Authority
- ES
- Spain
- Prior art keywords
- residue
- derivatives
- preparation
- agents containing
- oligopeptidylargininol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEIDMIENTO PARA LA PREPARACION DE UN OLIGOPEPDITIL-ARGINOL U -HOMOARGININOL O UN DEROVADO DE ESTOS, DE FORMULA GENERAL (I). CONSISTE EN HACER REACCIONAR ENTRE SI DERIVADOS CONOCIDOS Y EVENTUALMENTE ACTIVADOS DE PORCIONES MOLECULARES CONOCIDAS DE UN COMPUESTO DE FORMULA GENERAL (I), PARA LO CUAL LOS DISTINTOS REACCIONANTES PUEDEN PRESENTARSE EN UN EXCESO DE HASTA 10 VECES MOLAR CON RESPECTO AL OTRO REACCIONANTE. DICHOS REACCIONANTES SE DISUELVEN EN UN DISOLVENTE QUE NO PERTURBE LA REACCION DESEADA Y SE AJUSTAN A UN PH COMPRENDIDO DENTRO DEL INTERVALO DE 4,0 A 8,5, EFECTUANDOSE LA REACCION A UNA TEMPERATURA QUE SE CARACTERIZA POR EL PUNTO DE FUSION O DE EBULLICION DEL DISOLVENTE CORRESPONDIENTE. DE APLICACION COMO AGENTES FARMACEUTICOS ALTAMENTE INHIBIDORES DE TROMBINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19853505555 DE3505555A1 (de) | 1985-02-18 | 1985-02-18 | Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8707547A1 true ES8707547A1 (es) | 1987-08-01 |
ES552086A0 ES552086A0 (es) | 1987-08-01 |
Family
ID=6262841
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES552086A Expired ES8707547A1 (es) | 1985-02-18 | 1986-02-17 | Procedimiento para preparar un oligopeptidil-argininol u-homoargininol o derivado de estos |
Country Status (7)
Country | Link |
---|---|
US (1) | US4713369A (es) |
EP (1) | EP0192135A3 (es) |
JP (1) | JPS61189298A (es) |
AU (1) | AU589159B2 (es) |
CA (1) | CA1269200A (es) |
DE (1) | DE3505555A1 (es) |
ES (1) | ES8707547A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH075634B2 (ja) * | 1987-10-30 | 1995-01-25 | 日東紡績株式会社 | トリペプチド類及びこれを含有する抗プラスミン剤 |
US4929602A (en) * | 1987-11-25 | 1990-05-29 | Scripps Clinic And Research Foundation | Method of inhibiting platelet dependent arterial thrombosis |
US5023236A (en) * | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
EP0436654A1 (en) | 1988-09-30 | 1991-07-17 | The University Of Vermont And State Agricultural College | Immunoassays for catalytically-active, serine proteases |
US4994367A (en) * | 1988-10-07 | 1991-02-19 | East Carolina University | Extended shelf life platelet preparations and process for preparing the same |
US5391705A (en) * | 1991-03-15 | 1995-02-21 | Merrell Dow Pharmaceuticals Inc. | Polyfluorinated tripeptide thrombin inhibitors |
SE9102462D0 (sv) * | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
SE9103612D0 (sv) * | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
KR100244418B1 (ko) * | 1992-06-18 | 2000-02-01 | 슈테펜엘.네스비트 | 트롬빈 억제제 |
ATE174036T1 (de) * | 1993-03-29 | 1998-12-15 | Du Pont Merck Pharma | Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern |
SE9301916D0 (sv) * | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
US6984627B1 (en) | 1993-06-03 | 2006-01-10 | Astrazeneca Ab | Peptide derivatives |
US5783563A (en) * | 1993-06-03 | 1998-07-21 | Astra Aktiebolag | Method for treatment or prophylaxis of venous thrombosis |
GB9318637D0 (en) * | 1993-09-08 | 1993-10-27 | Ferring Res Ltd | Enzyme inhibitors |
US5821267A (en) * | 1993-10-21 | 1998-10-13 | G.D. Searle & Co. | Amidino derivatives useful as nitric oxide synthase inhibitors |
WO1995024382A1 (en) * | 1994-03-10 | 1995-09-14 | G.D. Searle & Co. | L-n6-(1-iminoethyl)lysine derivatives useful as nitric oxide synthase inhibitors |
DE4436772A1 (de) * | 1994-10-14 | 1996-04-18 | Boehringer Mannheim Gmbh | Neues Dipeptid-Derivat, Verfahren zu seiner Herstellung sowie diese Verbindung enthaltende Arzneimittel |
US5684008A (en) | 1994-11-09 | 1997-11-04 | G. D. Searle & Co. | Aminotetrazole derivatives useful as nitric oxide synthase inhibitors |
SE9404196D0 (sv) * | 1994-12-02 | 1994-12-02 | Astra Ab | New antithrombotic formulation |
US5612369A (en) * | 1995-06-07 | 1997-03-18 | 3-Dimensional Pharmaceuticals, Inc. | Thrombin inhibitors |
US5830917A (en) * | 1995-09-11 | 1998-11-03 | G. D. Searle & Co. | L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors |
US6069232A (en) * | 1995-10-02 | 2000-05-30 | Hoechst Marion Roussel, Inc. | Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors |
TW541316B (en) | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
DE19549118C2 (de) * | 1995-12-29 | 2000-07-13 | Thomas W Stief | Hämostaseaktivierungs-Inhibitor und Verfahren zum Hemmen der Hämostaseaktivierung in Blut oder anderen biologischen Flüssigkeiten |
US5981511A (en) * | 1996-03-06 | 1999-11-09 | G.D. Searle & Co. | Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors |
FR3015515B1 (fr) | 2013-12-19 | 2016-02-05 | IFP Energies Nouvelles | Procede de pretraitement d'huiles vegetales par catalyse heterogene de l'esterification des acides gras |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4318904A (en) * | 1980-04-25 | 1982-03-09 | Research Corporation | Peptide affinity labels for thrombin and other trypsin-like proteases |
JPS56158753A (en) * | 1980-05-08 | 1981-12-07 | Otsuka Pharmaceut Factory Inc | Kyotorphin derivative |
HU184368B (en) * | 1981-01-13 | 1984-08-28 | Gyogyszerkutato Intezet | Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate |
JPS60214768A (ja) * | 1984-04-07 | 1985-10-28 | Fujisawa Pharmaceut Co Ltd | オリゴペプチド化合物 |
-
1985
- 1985-02-18 DE DE19853505555 patent/DE3505555A1/de not_active Ceased
-
1986
- 1986-02-07 EP EP86101588A patent/EP0192135A3/de not_active Withdrawn
- 1986-02-14 US US06/829,482 patent/US4713369A/en not_active Expired - Fee Related
- 1986-02-17 AU AU53727/86A patent/AU589159B2/en not_active Ceased
- 1986-02-17 JP JP61031025A patent/JPS61189298A/ja active Pending
- 1986-02-17 ES ES552086A patent/ES8707547A1/es not_active Expired
- 1986-02-17 CA CA000502027A patent/CA1269200A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE3505555A1 (de) | 1986-09-11 |
EP0192135A3 (de) | 1988-08-31 |
AU589159B2 (en) | 1989-10-05 |
US4713369A (en) | 1987-12-15 |
JPS61189298A (ja) | 1986-08-22 |
EP0192135A2 (de) | 1986-08-27 |
CA1269200A (en) | 1990-05-15 |
ES552086A0 (es) | 1987-08-01 |
AU5372786A (en) | 1986-08-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES8707547A1 (es) | Procedimiento para preparar un oligopeptidil-argininol u-homoargininol o derivado de estos | |
ES8708237A1 (es) | Procedimiento para la preparacion de nuevos aldehidos pep- tidos | |
IL127352A (en) | Pyridyl alkene- and pyridyl alkine-acid amides and pharmaceutical compositions containing them | |
ATE137763T1 (de) | Peptid-verbindungen, deren verfahren zur herstellung und sie enthaltende pharmazeutische zusammensetzung | |
HK1013283A1 (en) | Nitrato amino acid disulphides for use in the therapy of disorders of the cardiovasculary system | |
IL104716A (en) | 7-1-oxo-2- (substituted mercapto)-3- phenylpropyl) amino| octahydro-6-pyrido £2, 1-a| benzazepine- 4-carboxylic acid derivatives and analogs, their preparation and pharmaceutical compositions containing them for inhibiting enkephalinase and ace | |
BR9713465A (pt) | Inibidores metalotprotease de amina cìclica sibstituìda | |
YU31399A (sh) | Inhibitori sintaze azot-monoksida | |
MY133647A (en) | Substituted quinoline-2-carboxamides, their preparation and their use as pharmaceuticals, and intermediates | |
PT80303B (pt) | Processo para a preparacao de composicoes para a higiene bucal | |
MY103850A (en) | Phenol substituted gem-diphosphonate derivatives, process for their preparation and pharmaceutical compositions containing them. | |
MX9503529A (es) | Derivados de glicinamida, procedimiento para su preparacion y medicamentos que los contienen. | |
UA35574C2 (uk) | Похідні заміщеної гетероциклом фенілциклогексанкарбонової кислоти, суміші їх ізомерів або окремі ізомери та їх солі | |
ES8601108A1 (es) | Procedimiento para la obtencion de eglinas b o c modificadas | |
ES8307744A1 (es) | Un metodo para la preparacion de nuevos derivados de sales de metales alcalinos de acidos 2-pirrolidon-4-carboxilicos. | |
ES8800272A1 (es) | Un procedimiento para la preparacion de polipeptidos. | |
EP0460062A4 (en) | Method for the synthesis of huperzine a and analogs thereof and compounds useful therein | |
JO1406B1 (en) | Chemical compounds | |
UA35607C2 (uk) | Похідні оксазолідинонкарбонової кислоти, спосіб їх одержання, фармацевтична композиція і спосіб її одержання | |
ES8106891A1 (es) | Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas | |
EP0384341A3 (en) | New proline derivatives | |
ATE48001T1 (de) | Cephemverbindungen, verfahren zu ihrer herstellung und ihre pharmazeutischen praeparate. | |
LTIP610A (en) | Inhibitors of cells proliferation, pharmaceutical composition and method for preparation of compounds | |
ATE83242T1 (de) | Cysteinreiche, gamma-glutaminsaeure und betaalanin-einheitenaufweisende peptide, verfahren zu deren herstellung und ihre verwendung. | |
ZA9710960B (en) | Substituted tetrahydropyridine compounds, process for preparing them and pharmaceutical compositions containing them. |