JP2009535295A - キナーゼ阻害剤として有用なピロロトリアジンアニリンプロドラッグ化合物 - Google Patents

キナーゼ阻害剤として有用なピロロトリアジンアニリンプロドラッグ化合物 Download PDF

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JP2009535295A
JP2009535295A JP2008558486A JP2008558486A JP2009535295A JP 2009535295 A JP2009535295 A JP 2009535295A JP 2008558486 A JP2008558486 A JP 2008558486A JP 2008558486 A JP2008558486 A JP 2008558486A JP 2009535295 A JP2009535295 A JP 2009535295A
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optionally substituted
compound
alkyl
methyl
hydrogen
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JP2009535295A5 (enExample
Inventor
リュー・チュンジャン
カテリナ・レフテリス
ビベカナンダ・エム・ブルドゥラ
ジェイムズ・リン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • AIDS & HIV (AREA)
JP2008558486A 2006-03-07 2007-03-05 キナーゼ阻害剤として有用なピロロトリアジンアニリンプロドラッグ化合物 Pending JP2009535295A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77985106P 2006-03-07 2006-03-07
PCT/US2007/063250 WO2007103839A2 (en) 2006-03-07 2007-03-05 Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors

Publications (2)

Publication Number Publication Date
JP2009535295A true JP2009535295A (ja) 2009-10-01
JP2009535295A5 JP2009535295A5 (enExample) 2010-02-25

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ID=38475749

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008558486A Pending JP2009535295A (ja) 2006-03-07 2007-03-05 キナーゼ阻害剤として有用なピロロトリアジンアニリンプロドラッグ化合物

Country Status (17)

Country Link
US (2) US7572795B2 (enExample)
EP (1) EP2001886A2 (enExample)
JP (1) JP2009535295A (enExample)
KR (1) KR20080107408A (enExample)
CN (1) CN101395158A (enExample)
AR (1) AR059778A1 (enExample)
AU (1) AU2007223342A1 (enExample)
BR (1) BRPI0708644A2 (enExample)
CA (1) CA2645031A1 (enExample)
EA (1) EA200801945A1 (enExample)
IL (1) IL193653A0 (enExample)
MX (1) MX2008011136A (enExample)
NO (1) NO20083717L (enExample)
PE (1) PE20080139A1 (enExample)
TW (1) TW200804390A (enExample)
WO (1) WO2007103839A2 (enExample)
ZA (1) ZA200807459B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019515947A (ja) * 2016-04-04 2019-06-13 ケモセントリックス，インコーポレイティド 可溶性Ｃ５ａＲアンタゴニスト

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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HRP20040988A2 (en) * 2002-04-23 2005-06-30 Bristol-Myers Squibb Company A Delaware (Usa) Corp Pyrrolo-triazine aniline compounds useful as kinas
EA200801945A1 (ru) * 2006-03-07 2009-02-27 Бристол-Маерс Сквибб Компани Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы
WO2009158446A2 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, method of preparation and use thereof
WO2009158450A1 (en) * 2008-06-25 2009-12-30 Bristol-Myers Squibb Company Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, preparation and use thereof
RU2554347C2 (ru) 2008-08-19 2015-06-27 Ксенопорт, Инк. Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения
TW201035100A (en) 2008-12-19 2010-10-01 Cephalon Inc Pyrrolotriazines as ALK and JAK2 inhibitors
AU2010266040B2 (en) * 2009-06-25 2015-01-15 Alkermes Pharma Ireland Limited Prodrugs of NH-acidic compounds
CN102596921B (zh) * 2009-09-29 2015-04-29 葛兰素集团有限公司 新化合物
JP5752691B2 (ja) 2009-09-29 2015-07-22 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 新規化合物
CN102918045A (zh) 2010-03-31 2013-02-06 百时美施贵宝公司 作为蛋白激酶抑制剂的取代的吡咯并三嗪
WO2012031057A1 (en) 2010-09-01 2012-03-08 Bristol-Myers Squibb Company Bms- 582949 for the treatment of resistant rheumatic disease
CN102153558B (zh) * 2011-02-23 2012-11-21 扬州永济医药新技术有限公司 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法
US8901305B2 (en) * 2012-07-31 2014-12-02 Bristol-Myers Squibb Company Aryl lactam kinase inhibitors
AU2013305684B2 (en) 2012-08-22 2016-11-24 Xenoport, Inc. Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof
US9050345B2 (en) 2013-03-11 2015-06-09 Bristol-Myers Squibb Company Pyrrolotriazines as potassium ion channel inhibitors
WO2014160633A1 (en) 2013-03-24 2014-10-02 Xenoport, Inc. Pharmaceutical compositions of dimethyl fumarate
US9302977B2 (en) 2013-06-07 2016-04-05 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
WO2015035184A1 (en) 2013-09-06 2015-03-12 Xenoport, Inc. Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use
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