KR20080107408A - 키나제 억제제로서 유용한 피롤로트리아진 아닐린 전구약물화합물 - Google Patents
키나제 억제제로서 유용한 피롤로트리아진 아닐린 전구약물화합물 Download PDFInfo
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- KR20080107408A KR20080107408A KR1020087021851A KR20087021851A KR20080107408A KR 20080107408 A KR20080107408 A KR 20080107408A KR 1020087021851 A KR1020087021851 A KR 1020087021851A KR 20087021851 A KR20087021851 A KR 20087021851A KR 20080107408 A KR20080107408 A KR 20080107408A
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- optionally substituted
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| EA200801945A1 (ru) * | 2006-03-07 | 2009-02-27 | Бристол-Маерс Сквибб Компани | Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы |
| WO2009158446A2 (en) * | 2008-06-25 | 2009-12-30 | Bristol-Myers Squibb Company | Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, method of preparation and use thereof |
| WO2009158450A1 (en) * | 2008-06-25 | 2009-12-30 | Bristol-Myers Squibb Company | Crystalline forms of ((((4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl)carbonyl)(propyl)carbamoyl)oxy)methyl (4-(phosphonooxy)phenyl)acetate, preparation and use thereof |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| TW201035100A (en) | 2008-12-19 | 2010-10-01 | Cephalon Inc | Pyrrolotriazines as ALK and JAK2 inhibitors |
| AU2010266040B2 (en) * | 2009-06-25 | 2015-01-15 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds |
| CN102596921B (zh) * | 2009-09-29 | 2015-04-29 | 葛兰素集团有限公司 | 新化合物 |
| JP5752691B2 (ja) | 2009-09-29 | 2015-07-22 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | 新規化合物 |
| CN102918045A (zh) | 2010-03-31 | 2013-02-06 | 百时美施贵宝公司 | 作为蛋白激酶抑制剂的取代的吡咯并三嗪 |
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| CN102153558B (zh) * | 2011-02-23 | 2012-11-21 | 扬州永济医药新技术有限公司 | 多靶点抗肿瘤抑制剂2-氨吡咯-三嗪的衍生物及其合成方法 |
| US8901305B2 (en) * | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
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- 2007-03-05 WO PCT/US2007/063250 patent/WO2007103839A2/en not_active Ceased
- 2007-03-05 CN CNA2007800079168A patent/CN101395158A/zh active Pending
- 2007-03-05 EP EP07757860A patent/EP2001886A2/en not_active Withdrawn
- 2007-03-05 JP JP2008558486A patent/JP2009535295A/ja active Pending
- 2007-03-05 CA CA002645031A patent/CA2645031A1/en not_active Abandoned
- 2007-03-05 KR KR1020087021851A patent/KR20080107408A/ko not_active Withdrawn
- 2007-03-05 AU AU2007223342A patent/AU2007223342A1/en not_active Abandoned
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- 2007-03-07 AR ARP070100944A patent/AR059778A1/es unknown
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| BRPI0708644A2 (pt) | 2011-06-07 |
| CN101395158A (zh) | 2009-03-25 |
| EP2001886A2 (en) | 2008-12-17 |
| WO2007103839A2 (en) | 2007-09-13 |
| PE20080139A1 (es) | 2008-03-10 |
| US7572795B2 (en) | 2009-08-11 |
| US20070213300A1 (en) | 2007-09-13 |
| AU2007223342A1 (en) | 2007-09-13 |
| IL193653A0 (en) | 2009-08-03 |
| CA2645031A1 (en) | 2007-09-13 |
| TW200804390A (en) | 2008-01-16 |
| MX2008011136A (es) | 2008-09-08 |
| WO2007103839A3 (en) | 2008-06-05 |
| AR059778A1 (es) | 2008-04-30 |
| JP2009535295A (ja) | 2009-10-01 |
| EA200801945A1 (ru) | 2009-02-27 |
| ZA200807459B (en) | 2009-11-25 |
| NO20083717L (no) | 2008-10-06 |
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