BRPI0708644A2 - compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase - Google Patents
compostos de pró-fármaco de anilina de pirrolotriazina úteis como inibidores de cinase Download PDFInfo
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- BRPI0708644A2 BRPI0708644A2 BRPI0708644-0A BRPI0708644A BRPI0708644A2 BR PI0708644 A2 BRPI0708644 A2 BR PI0708644A2 BR PI0708644 A BRPI0708644 A BR PI0708644A BR PI0708644 A2 BRPI0708644 A2 BR PI0708644A2
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| EA200801945A1 (ru) * | 2006-03-07 | 2009-02-27 | Бристол-Маерс Сквибб Компани | Пирролотриазинанилиновые пролекарственные соединения, полезные в качестве ингибиторов киназы |
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| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| TW201035100A (en) | 2008-12-19 | 2010-10-01 | Cephalon Inc | Pyrrolotriazines as ALK and JAK2 inhibitors |
| AU2010266040B2 (en) * | 2009-06-25 | 2015-01-15 | Alkermes Pharma Ireland Limited | Prodrugs of NH-acidic compounds |
| CN102596921B (zh) * | 2009-09-29 | 2015-04-29 | 葛兰素集团有限公司 | 新化合物 |
| JP5752691B2 (ja) | 2009-09-29 | 2015-07-22 | グラクソ グループ リミテッドGlaxo Group Limited | 新規化合物 |
| CN102918045A (zh) | 2010-03-31 | 2013-02-06 | 百时美施贵宝公司 | 作为蛋白激酶抑制剂的取代的吡咯并三嗪 |
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| US8901305B2 (en) * | 2012-07-31 | 2014-12-02 | Bristol-Myers Squibb Company | Aryl lactam kinase inhibitors |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US9050345B2 (en) | 2013-03-11 | 2015-06-09 | Bristol-Myers Squibb Company | Pyrrolotriazines as potassium ion channel inhibitors |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| WO2015035184A1 (en) | 2013-09-06 | 2015-03-12 | Xenoport, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| MA41136A (fr) * | 2014-12-09 | 2017-10-17 | Bayer Pharma AG | Composés pour le traitement d'un cancer |
| WO2017070135A1 (en) * | 2015-10-20 | 2017-04-27 | Bristol-Myers Squibb Company | Prodrugs of 2-(4-(3-((4-amino-7-cyano-imidazo[2,1-f][1,2,4]triazin-2-yl)amino)phenyl)piperaz in-1-yl)propanamide derivatives as ck2 inhibitors for the treatment of cancer |
| NZ747259A (en) * | 2016-04-04 | 2022-11-25 | Chemocentryx Inc | Soluble c5ar antagonists |
| PT3691620T (pt) | 2017-10-05 | 2022-10-06 | Fulcrum Therapeutics Inc | Os inibidores da quinase p38 reduzem a expressão de dux4 e genes a jusante para o tratamento de fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
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| CN110590839B (zh) * | 2018-06-13 | 2022-04-05 | 四川海思科制药有限公司 | 一种乐伐替尼衍生物及制备方法和用途 |
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| US3629301A (en) | 1969-10-24 | 1971-12-21 | Du Pont | 3 3-difluoro-2-substituted steroids and their preparation |
| US4200750A (en) | 1977-01-07 | 1980-04-29 | Westwood Pharmaceuticals Inc. | 4-Substituted imidazo [1,2-a]quinoxalines |
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| US5977103A (en) * | 1996-01-11 | 1999-11-02 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US5945418A (en) * | 1996-12-18 | 1999-08-31 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| US6147080A (en) * | 1996-12-18 | 2000-11-14 | Vertex Pharmaceuticals Incorporated | Inhibitors of p38 |
| RU2249591C2 (ru) * | 1997-05-22 | 2005-04-10 | Дж.Д. Серл Энд Ко. | 3(5)-гетероарилзамещенные пиразолы в качестве ингибиторов киназы p38 |
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| ATE418546T1 (de) | 2002-04-23 | 2009-01-15 | Bristol Myers Squibb Co | Als kinase inhibitoren geeignete arylketonpyrrolotriazin-verbindungen |
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- 2007-03-05 AU AU2007223342A patent/AU2007223342A1/en not_active Abandoned
- 2007-03-05 MX MX2008011136A patent/MX2008011136A/es not_active Application Discontinuation
- 2007-03-05 BR BRPI0708644-0A patent/BRPI0708644A2/pt not_active IP Right Cessation
- 2007-03-06 US US11/682,331 patent/US7572795B2/en active Active
- 2007-03-06 PE PE2007000242A patent/PE20080139A1/es not_active Application Discontinuation
- 2007-03-07 AR ARP070100944A patent/AR059778A1/es unknown
- 2007-03-07 TW TW096107889A patent/TW200804390A/zh unknown
-
2008
- 2008-08-24 IL IL193653A patent/IL193653A0/en unknown
- 2008-08-29 ZA ZA200807459A patent/ZA200807459B/xx unknown
- 2008-08-29 NO NO20083717A patent/NO20083717L/no not_active Application Discontinuation
-
2009
- 2009-02-12 US US12/370,081 patent/US20090156555A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20090156555A1 (en) | 2009-06-18 |
| CN101395158A (zh) | 2009-03-25 |
| EP2001886A2 (en) | 2008-12-17 |
| WO2007103839A2 (en) | 2007-09-13 |
| PE20080139A1 (es) | 2008-03-10 |
| US7572795B2 (en) | 2009-08-11 |
| US20070213300A1 (en) | 2007-09-13 |
| AU2007223342A1 (en) | 2007-09-13 |
| IL193653A0 (en) | 2009-08-03 |
| CA2645031A1 (en) | 2007-09-13 |
| TW200804390A (en) | 2008-01-16 |
| MX2008011136A (es) | 2008-09-08 |
| WO2007103839A3 (en) | 2008-06-05 |
| AR059778A1 (es) | 2008-04-30 |
| JP2009535295A (ja) | 2009-10-01 |
| EA200801945A1 (ru) | 2009-02-27 |
| ZA200807459B (en) | 2009-11-25 |
| NO20083717L (no) | 2008-10-06 |
| KR20080107408A (ko) | 2008-12-10 |
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