JP2009534667A5 - - Google Patents
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- Publication number
- JP2009534667A5 JP2009534667A5 JP2009506738A JP2009506738A JP2009534667A5 JP 2009534667 A5 JP2009534667 A5 JP 2009534667A5 JP 2009506738 A JP2009506738 A JP 2009506738A JP 2009506738 A JP2009506738 A JP 2009506738A JP 2009534667 A5 JP2009534667 A5 JP 2009534667A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- cancer cells
- immunoassay
- blood
- detecting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004169 proteins and genes Human genes 0.000 claims description 32
- 108090000623 proteins and genes Proteins 0.000 claims description 32
- 206010028980 Neoplasm Diseases 0.000 claims description 29
- 201000011510 cancer Diseases 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 27
- 238000003018 immunoassay Methods 0.000 claims description 26
- 239000008280 blood Substances 0.000 claims description 22
- 210000004369 blood Anatomy 0.000 claims description 22
- 238000001514 detection method Methods 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 102000001301 EGF receptor Human genes 0.000 claims description 4
- 108060006698 EGF receptor Proteins 0.000 claims description 4
- 230000035945 sensitivity Effects 0.000 claims description 4
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims description 2
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims description 2
- 102000000505 Ribonucleotide Reductases Human genes 0.000 claims description 2
- 108010041388 Ribonucleotide Reductases Proteins 0.000 claims description 2
- 108010022394 Threonine synthase Proteins 0.000 claims description 2
- 102000005497 Thymidylate Synthase Human genes 0.000 claims description 2
- 102000004243 Tubulin Human genes 0.000 claims description 2
- 108090000704 Tubulin Proteins 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 208000036815 beta tubulin Diseases 0.000 claims description 2
- 229960005395 cetuximab Drugs 0.000 claims description 2
- 229960001433 erlotinib Drugs 0.000 claims description 2
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims description 2
- 230000006846 excision repair Effects 0.000 claims description 2
- 238000002875 fluorescence polarization Methods 0.000 claims description 2
- 229960002584 gefitinib Drugs 0.000 claims description 2
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims description 2
- 229960001972 panitumumab Drugs 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 3
- 239000012530 fluid Substances 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 14
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 1
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74501606P | 2006-04-18 | 2006-04-18 | |
| US60/745,016 | 2006-04-18 | ||
| PCT/US2007/066857 WO2007121465A2 (en) | 2006-04-18 | 2007-04-18 | Detection of proteins from circulating neoplastic cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009534667A JP2009534667A (ja) | 2009-09-24 |
| JP2009534667A5 true JP2009534667A5 (enExample) | 2010-04-30 |
| JP5025724B2 JP5025724B2 (ja) | 2012-09-12 |
Family
ID=38610457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009506738A Expired - Fee Related JP5025724B2 (ja) | 2006-04-18 | 2007-04-18 | 循環腫瘍性細胞からのタンパク質の検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8012480B2 (enExample) |
| EP (1) | EP2008102A4 (enExample) |
| JP (1) | JP5025724B2 (enExample) |
| CA (1) | CA2647843A1 (enExample) |
| MX (1) | MX2008013332A (enExample) |
| WO (1) | WO2007121465A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4798801B2 (ja) * | 2004-10-06 | 2011-10-19 | ウェルスタット バイオロジクス コーポレイション | 循環する癌細胞におけるＨｅｒ−２／ｎｅｕタンパク質のレベルの上昇の検出および処置 |
| JP2010525326A (ja) * | 2007-04-19 | 2010-07-22 | ウェルスタット バイオロジックス コーポレイション | 分離されていない循環癌細胞由来のＨｅｒ−２／ｎｅｕタンパク質の上昇したレベルの検出および治療 |
| US11072655B2 (en) | 2008-01-15 | 2021-07-27 | The Board Of Trustees Of The Leland Stanford Junior University | Markers of acute myeloid leukemia stem cells |
| PT3056515T (pt) | 2008-01-15 | 2019-07-19 | Univ Leland Stanford Junior | Métodos para manipulação da fagocitose mediada por cd47 |
| PT4160212T (pt) | 2008-01-15 | 2024-06-25 | Univ Leland Stanford Junior | Marcadores de células estaminais de leucemia mielóide aguda |
| US20120093733A1 (en) * | 2010-05-24 | 2012-04-19 | Marek Malecki | Multidomain biotags for cancer detection, diagnosis and therapy and methods of their use |
| EP2628008B1 (en) * | 2010-10-14 | 2017-05-31 | Janssen Diagnostics, LLC | Methods and kits for the detection of circulating tumor cells in pancreatic patients using polyspecific capture and cocktail detection reagents |
| CN102680456B (zh) * | 2011-03-16 | 2015-07-08 | 北京联众泰克科技有限公司 | 一种电化学发光免疫测定方法 |
| WO2013003624A2 (en) | 2011-06-29 | 2013-01-03 | Academia Sinica | The capture, purification and release of biological substance using a surface coating |
| CN103842813B (zh) * | 2011-09-06 | 2018-04-17 | 贝克顿·迪金森公司 | 用于对样品中的稀少目标细胞进行细胞计数检测的方法和组合物 |
| WO2014147631A1 (en) | 2013-03-22 | 2014-09-25 | Natco Pharma Limited | Formulation comprising gefitinib as oral suspension |
| EP3126814B1 (en) | 2014-04-01 | 2019-06-12 | Academia Sinica | Methods and systems for cancer diagnosis and prognosis |
| US10112198B2 (en) | 2014-08-26 | 2018-10-30 | Academia Sinica | Collector architecture layout design |
| JP7057668B2 (ja) * | 2014-09-18 | 2022-04-20 | アドナーゲン ゲーエムベーハー | 治療剤に対する抵抗性の診断に使用するためのＥＲＣＣ１アイソフォーム３のｍＲＮＡおよび／またはタンパク質ならびにこのｍＲＮＡおよび／またはタンパク質を使用する治療剤に対する抵抗性を診断するための方法 |
| US10107726B2 (en) | 2016-03-16 | 2018-10-23 | Cellmax, Ltd. | Collection of suspended cells using a transferable membrane |
| CN109991410B (zh) * | 2017-12-29 | 2022-07-05 | 上海白泽医学检验所有限公司 | 一种含抗cd45单抗的组合物及其使用方法 |
| CN114487059B (zh) * | 2021-12-29 | 2022-11-25 | 苏州大学 | 一种电化学发光免疫传感器及其制备和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991005264A1 (en) * | 1989-09-29 | 1991-04-18 | Oncogenetics Partners | Detection and quantification of neu related proteins in the biological fluids of humans |
| CA2223027A1 (en) * | 1995-06-07 | 1996-12-19 | Igen, Inc. | Electrochemiluminescent enzyme immunoassay |
| WO2000047998A1 (en) * | 1999-02-10 | 2000-08-17 | Cell Works Inc. | Class characterization of circulating cancer cells isolated from body fluids and methods of use |
| US7537938B2 (en) | 2000-04-28 | 2009-05-26 | Monogram Biosciences, Inc. | Biomarker detection in circulating cells |
| EP1360496A4 (en) | 2001-02-16 | 2005-03-09 | Immunivest Corp | METHOD AND REAGENTS FOR THE QUICK AND EFFICIENT INSULATION OF CIRCULATING CANCER CELLS |
| CA2465274A1 (en) * | 2001-10-26 | 2003-05-01 | Immunivest Corporation | Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample |
| DE60331310D1 (de) * | 2002-06-26 | 2010-04-01 | Univ Louisville Res Found | Verfahren zum apoptosenachweis |
| EP2263691B1 (en) | 2002-07-15 | 2012-08-29 | F.Hoffmann-La Roche Ag | Treatment of cancer with the recombinant humanized monoclonal anti-erbb2 antibody 2C4 (rhuMAb 2C4) |
| WO2004087887A2 (en) * | 2003-04-01 | 2004-10-14 | Monogram Biosciences, Inc. | Intracellular complexes as biomarkers |
| EP1668360A4 (en) * | 2003-08-15 | 2007-08-08 | Univ Pittsburgh | MULTI FACTOR CANCER DETECTION TEST |
| ES2553264T3 (es) * | 2004-05-27 | 2015-12-07 | The Regents Of The University Of Colorado | Métodos para la predicción del resultado clínico para inhibidores del receptor del factor de crecimiento epidérmico para pacientes de cáncer |
| EP1799857B1 (en) | 2004-09-14 | 2013-11-06 | John Wayne Cancer Institute | Detection of cancer cells in body fluids |
| JP4798801B2 (ja) | 2004-10-06 | 2011-10-19 | ウェルスタット バイオロジクス コーポレイション | 循環する癌細胞におけるＨｅｒ−２／ｎｅｕタンパク質のレベルの上昇の検出および処置 |
-
2007
- 2007-04-18 CA CA002647843A patent/CA2647843A1/en not_active Abandoned
- 2007-04-18 EP EP07760830A patent/EP2008102A4/en not_active Withdrawn
- 2007-04-18 MX MX2008013332A patent/MX2008013332A/es active IP Right Grant
- 2007-04-18 WO PCT/US2007/066857 patent/WO2007121465A2/en not_active Ceased
- 2007-04-18 JP JP2009506738A patent/JP5025724B2/ja not_active Expired - Fee Related
- 2007-04-18 US US12/297,420 patent/US8012480B2/en not_active Expired - Fee Related
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