JP2009534412A5 - - Google Patents

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Publication number
JP2009534412A5
JP2009534412A5 JP2009506760A JP2009506760A JP2009534412A5 JP 2009534412 A5 JP2009534412 A5 JP 2009534412A5 JP 2009506760 A JP2009506760 A JP 2009506760A JP 2009506760 A JP2009506760 A JP 2009506760A JP 2009534412 A5 JP2009534412 A5 JP 2009534412A5
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JP
Japan
Prior art keywords
tetrahydro
dichloro
pyrrolidin
benzimidazol
ylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009506760A
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English (en)
Japanese (ja)
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JP2009534412A (ja
JP5236628B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/066907 external-priority patent/WO2007124329A1/en
Publication of JP2009534412A publication Critical patent/JP2009534412A/ja
Publication of JP2009534412A5 publication Critical patent/JP2009534412A5/ja
Application granted granted Critical
Publication of JP5236628B2 publication Critical patent/JP5236628B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2009506760A 2006-04-21 2007-04-19 １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としての、シクロヘキシルイミダゾールラクタム誘導体 Expired - Fee Related JP5236628B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74532106P 2006-04-21 2006-04-21
US60/745,321 2006-04-21
PCT/US2007/066907 WO2007124329A1 (en) 2006-04-21 2007-04-19 Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1

Publications (3)

Publication Number Publication Date
JP2009534412A JP2009534412A (ja) 2009-09-24
JP2009534412A5 true JP2009534412A5 (cg-RX-API-DMAC7.html) 2011-01-13
JP5236628B2 JP5236628B2 (ja) 2013-07-17

Family

ID=38380722

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009506760A Expired - Fee Related JP5236628B2 (ja) 2006-04-21 2007-04-19 １１−β−ヒドロキシステロイドデヒドロゲナーゼ１阻害剤としての、シクロヘキシルイミダゾールラクタム誘導体

Country Status (11)

Country Link
US (1) US7820659B2 (cg-RX-API-DMAC7.html)
EP (1) EP2029576B1 (cg-RX-API-DMAC7.html)
JP (1) JP5236628B2 (cg-RX-API-DMAC7.html)
CN (1) CN101426780B (cg-RX-API-DMAC7.html)
AU (1) AU2007240450B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0710273A2 (cg-RX-API-DMAC7.html)
CA (1) CA2646678C (cg-RX-API-DMAC7.html)
EA (1) EA014717B1 (cg-RX-API-DMAC7.html)
ES (1) ES2422165T3 (cg-RX-API-DMAC7.html)
MX (1) MX2008013328A (cg-RX-API-DMAC7.html)
WO (1) WO2007124329A1 (cg-RX-API-DMAC7.html)

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EP2016047B1 (en) 2006-04-21 2013-08-28 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
EP2029579B1 (en) * 2006-04-21 2014-12-31 Eli Lilly And Company Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101432262B (zh) 2006-04-24 2011-06-01 伊莱利利公司 作为11-β-羟类固醇脱氢酶1的抑制剂的环己基取代的吡咯烷酮类
MY148079A (en) * 2006-04-24 2013-02-28 Lilly Co Eli Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA016959B1 (ru) 2006-04-24 2012-08-30 Эли Лилли Энд Компани Замещенные пирролидиноны в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 типа
CA2648019C (en) 2006-04-25 2014-04-01 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
JP5101602B2 (ja) * 2006-04-25 2012-12-19 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
PL2021337T3 (pl) 2006-04-25 2010-06-30 Lilly Co Eli Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1
EP2049513B1 (en) * 2006-04-28 2012-01-25 Eli Lilly & Company Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
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EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2009075835A1 (en) 2007-12-11 2009-06-18 Vitae Pharmaceutical, Inc CYCLIC UREA INHIBITORS OF 11β-HYDROXYSTEROID DEHYDROGENASE 1
TW200934490A (en) * 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
AU2009241727B2 (en) 2008-05-01 2013-05-02 Vitae Pharmaceuticals, Inc Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5379160B2 (ja) 2008-07-25 2013-12-25 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
CA2729998A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
CA2729993A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
CA2744946A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1
US8507493B2 (en) 2009-04-20 2013-08-13 Abbvie Inc. Amide and amidine derivatives and uses thereof
MA33216B1 (fr) 2009-04-30 2012-04-02 Boehringer Ingelheim Int Inhibiteurs cycliques de la 11béta-hydroxysteroïde déshydrogénase 1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
JP5749263B2 (ja) 2009-07-01 2015-07-15 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
US8552212B2 (en) 2009-11-05 2013-10-08 Boehringer Ingelheim International Gmbh Chiral phosphorus ligands
WO2011068927A2 (en) * 2009-12-04 2011-06-09 Abbott Laboratories 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
JP2013531636A (ja) 2010-05-26 2013-08-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ２−オキソ−１，２−ジヒドロピリジン−４−イルボロン酸誘導体
JP5860042B2 (ja) 2010-06-16 2016-02-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド 置換５、６及び７員複素環、そのような化合物を含有する医薬及びそれらの使用
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
CA2813671A1 (en) 2010-11-02 2012-05-10 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683700B1 (de) 2011-03-08 2015-02-18 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
PH12014500820A1 (en) * 2011-10-18 2014-05-19 Astellas Pharma Inc Bicyclic heterocyclic compound
TW201722957A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產（第二）有限公司 化學化合物

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WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
EA011097B1 (ru) 2004-05-07 2008-12-30 Янссен Фармацевтика Н.В. Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы
DE602005007344D1 (de) 2004-05-07 2008-07-17 Janssen Pharmaceutica Nv Adamantyl pyrrolidin-2-on-derivate als 11-beta hydroxysteroid dehydrogenas inhibitoren
JP2008515956A (ja) 2004-10-12 2008-05-15 ノボ ノルディスク アクティーゼルスカブ １１β−ヒドロキシステロイドデヒドロゲナーゼ１型活性スピロ化合物
PL1807072T3 (pl) 2004-10-29 2009-06-30 Lilly Co Eli Cykloalkilowe pochodne laktamów jako inhibitory 11-ß-HSD1
GEP20125565B (en) 2004-11-10 2012-07-10 Incyte Corp Lactam compounds and their pharmaceutical use
PL1830841T3 (pl) 2004-12-20 2008-12-31 Lilly Co Eli Cykloalkilowe pochodne laktamu jako inhibitory dehydrogenazy 11-beta hydroksysteroidowej typu 1
US7834194B2 (en) 2004-12-21 2010-11-16 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US20090264650A1 (en) 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
US7998959B2 (en) 2006-01-12 2011-08-16 Incyte Corporation Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same
EP2016047B1 (en) 2006-04-21 2013-08-28 Eli Lilly And Company Biphenyl amide lactam derivatives as inhibitors of 11- beta-hydroxysteroid dehydrogenase 1
EP2029579B1 (en) 2006-04-21 2014-12-31 Eli Lilly And Company Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CN101432262B (zh) 2006-04-24 2011-06-01 伊莱利利公司 作为11-β-羟类固醇脱氢酶1的抑制剂的环己基取代的吡咯烷酮类
MY148079A (en) 2006-04-24 2013-02-28 Lilly Co Eli Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA016959B1 (ru) 2006-04-24 2012-08-30 Эли Лилли Энд Компани Замещенные пирролидиноны в качестве ингибиторов 11-бета-гидроксистероиддегидрогеназы 1 типа
JP5101602B2 (ja) 2006-04-25 2012-12-19 イーライ リリー アンド カンパニー １１−β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
PL2021337T3 (pl) 2006-04-25 2010-06-30 Lilly Co Eli Inhibitory dehydrogenazy 11-beta-hydroksysteroidowej typu 1
CA2648019C (en) 2006-04-25 2014-04-01 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2049513B1 (en) 2006-04-28 2012-01-25 Eli Lilly & Company Piperidinyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

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