JP2009533476A5 - - Google Patents
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- Publication number
- JP2009533476A5 JP2009533476A5 JP2009505655A JP2009505655A JP2009533476A5 JP 2009533476 A5 JP2009533476 A5 JP 2009533476A5 JP 2009505655 A JP2009505655 A JP 2009505655A JP 2009505655 A JP2009505655 A JP 2009505655A JP 2009533476 A5 JP2009533476 A5 JP 2009533476A5
- Authority
- JP
- Japan
- Prior art keywords
- glp
- molecule
- diketopiperazine
- solution
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 claims 59
- 102100025101 GATA-type zinc finger protein 1 Human genes 0.000 claims 51
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 claims 51
- 238000000034 method Methods 0.000 claims 30
- BXRNXXXXHLBUKK-UHFFFAOYSA-N piperazine-2,5-dione Chemical compound O=C1CNC(=O)CN1 BXRNXXXXHLBUKK-UHFFFAOYSA-N 0.000 claims 24
- 239000002245 particle Substances 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 10
- 239000000843 powder Substances 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 8
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 claims 4
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 claims 4
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical group [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- 239000000725 suspension Substances 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 230000001851 biosynthetic effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000002500 ions Chemical class 0.000 claims 2
- 239000011859 microparticle Substances 0.000 claims 2
- 239000003960 organic solvent Substances 0.000 claims 2
- 230000000065 osmolyte Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 230000002685 pulmonary effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 238000001694 spray drying Methods 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 125000000349 (Z)-3-carboxyprop-2-enoyl group Chemical group O=C([*])/C([H])=C([H])\C(O[H])=O 0.000 claims 1
- 208000004476 Acute Coronary Syndrome Diseases 0.000 claims 1
- 208000032781 Diabetic cardiomyopathy Diseases 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- 208000020358 Learning disease Diseases 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000026139 Memory disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 230000001925 catabolic effect Effects 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 108010063245 glucagon-like peptide 1 (7-36)amide Proteins 0.000 claims 1
- -1 glutaryl Chemical group 0.000 claims 1
- 201000001421 hyperglycemia Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 210000004153 islets of langerhan Anatomy 0.000 claims 1
- 201000003723 learning disability Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 230000001172 regenerating effect Effects 0.000 claims 1
- 230000010410 reperfusion Effects 0.000 claims 1
- 125000002730 succinyl group Chemical group C(CCC(=O)*)(=O)* 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- QIQCZROILFZKAT-UHFFFAOYSA-N tetracarbon dioxide Chemical group O=C=C=C=C=O QIQCZROILFZKAT-UHFFFAOYSA-N 0.000 claims 1
- 230000000451 tissue damage Effects 0.000 claims 1
- 231100000827 tissue damage Toxicity 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74488206P | 2006-04-14 | 2006-04-14 | |
| US60/744,882 | 2006-04-14 | ||
| PCT/US2007/066728 WO2007121411A2 (en) | 2006-04-14 | 2007-04-16 | Glucagon-like peptide 1(glp-1) pharmaceutical formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013191549A Division JP5898156B2 (ja) | 2006-04-14 | 2013-09-17 | グルカゴン様ペプチド1(glp−1)医薬製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009533476A JP2009533476A (ja) | 2009-09-17 |
| JP2009533476A5 true JP2009533476A5 (https=) | 2010-05-27 |
| JP5415938B2 JP5415938B2 (ja) | 2014-02-12 |
Family
ID=38567214
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009505655A Expired - Fee Related JP5415938B2 (ja) | 2006-04-14 | 2007-04-16 | グルカゴン様ペプチド1(glp−1)医薬製剤 |
| JP2013191549A Active JP5898156B2 (ja) | 2006-04-14 | 2013-09-17 | グルカゴン様ペプチド1(glp−1)医薬製剤 |
| JP2015233125A Pending JP2016104736A (ja) | 2006-04-14 | 2015-11-30 | グルカゴン様ペプチド1(glp−1)医薬製剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013191549A Active JP5898156B2 (ja) | 2006-04-14 | 2013-09-17 | グルカゴン様ペプチド1(glp−1)医薬製剤 |
| JP2015233125A Pending JP2016104736A (ja) | 2006-04-14 | 2015-11-30 | グルカゴン様ペプチド1(glp−1)医薬製剤 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2010155A2 (https=) |
| JP (3) | JP5415938B2 (https=) |
| KR (3) | KR101438839B1 (https=) |
| CN (2) | CN101453988A (https=) |
| AU (1) | AU2007238000B2 (https=) |
| BR (1) | BRPI0709964A2 (https=) |
| CA (1) | CA2646400A1 (https=) |
| HK (1) | HK1206241A1 (https=) |
| MX (1) | MX2008013216A (https=) |
| RU (3) | RU2542500C2 (https=) |
| WO (1) | WO2007121411A2 (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1808438T3 (da) | 1999-06-29 | 2014-10-27 | Mannkind Corp | Rensning og stabilisering af peptid og proteiner i lægemidler |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| WO2003080149A2 (en) | 2002-03-20 | 2003-10-02 | Mannkind Corporation | Inhalation apparatus |
| US8921311B2 (en) | 2003-08-01 | 2014-12-30 | Mannkind Corporation | Method for treating hyperglycemia |
| US9078866B2 (en) * | 2003-08-01 | 2015-07-14 | Mannkind Corporation | Method for treating hyperglycemia with GLP-1 |
| PL1786784T3 (pl) | 2004-08-20 | 2011-04-29 | Mannkind Corp | Kataliza syntezy diketopiperazyn |
| KR101644250B1 (ko) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| CN104324362B (zh) | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| IN2015DN00888A (https=) | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| KR101438839B1 (ko) * | 2006-04-14 | 2014-10-02 | 맨카인드 코포레이션 | 글루카곤 유사 펩타이드 1 (glp-1) 약제학적 제제 |
| US8785396B2 (en) | 2007-10-24 | 2014-07-22 | Mannkind Corporation | Method and composition for treating migraines |
| JP2011500850A (ja) | 2007-10-24 | 2011-01-06 | マンカインド コーポレイション | Glp−1による副作用を防止する方法 |
| WO2009055742A2 (en) | 2007-10-24 | 2009-04-30 | Mannkind Corporation | Delivery of active agents |
| JP5856843B2 (ja) | 2008-05-27 | 2016-02-10 | アンピオ ファーマシューティカルズ,インコーポレイテッド | ジケトピペラジンを用いた医薬組成物 |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| ES2929343T3 (es) | 2008-06-13 | 2022-11-28 | Mannkind Corp | Inhalador de polvo seco accionado por aspiración para la administración de fármacos |
| KR101628410B1 (ko) | 2008-06-20 | 2016-06-08 | 맨카인드 코포레이션 | 흡입 활동에 관한 실시간 프로파일링을 위한 대화형 장치 및 방법 |
| TWI614024B (zh) | 2008-08-11 | 2018-02-11 | 曼凱公司 | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| MX2011009251A (es) * | 2009-03-04 | 2011-11-18 | Mannkind Corp | Sistema mejorado de suministro de farmaco en polvo seco. |
| DK2405963T3 (da) | 2009-03-11 | 2013-12-16 | Mannkind Corp | Apparat, system og fremgangsmåde til at måle modstand i en inhalator |
| CN104721825B (zh) | 2009-06-12 | 2019-04-12 | 曼金德公司 | 具有确定比表面积的二酮哌嗪颗粒 |
| EP3556356B1 (en) | 2009-06-12 | 2021-05-05 | MannKind Corporation | Diketopiperazine microparticles with defined isomer content |
| US8642548B2 (en) * | 2009-08-07 | 2014-02-04 | Mannkind Corporation | Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome |
| WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| EP2613786A4 (en) | 2010-09-07 | 2013-10-23 | Dmi Acquisition Corp | TREATMENT OF DISEASES |
| AU2012236150B2 (en) | 2011-04-01 | 2016-03-31 | Mannkind Corporation | Blister package for pharmaceutical cartridges |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| MY172699A (en) | 2011-10-10 | 2019-12-10 | Ampio Pharmaceuticals Inc | Implantable medical devices with increased immune tolerance, and methods for making and implanting |
| EA028343B1 (ru) | 2011-10-10 | 2017-11-30 | Ампио Фармасьютикалз, Инк. | Лечение дегенеративного заболевания сустава |
| BR112014009686A2 (pt) | 2011-10-24 | 2018-08-07 | Mannkind Corp | composição analgésica inalável, pó seco e método para tratar dor |
| EP2771007B1 (en) | 2011-10-28 | 2018-04-04 | Ampio Pharmaceuticals, Inc. | Treatment of rhinitis |
| EP2866825B1 (en) | 2012-07-01 | 2020-04-08 | Novo Nordisk A/S | Use of long-acting glp-1 peptides |
| CN104619369B (zh) | 2012-07-12 | 2018-01-30 | 曼金德公司 | 干粉药物输送系统和方法 |
| AU2013308693A1 (en) * | 2012-08-29 | 2015-03-12 | Mannkind Corporation | Method and composition for treating hyperglycemia |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2013366692B2 (en) | 2012-12-21 | 2017-11-23 | Sanofi | Dual GLP1/GIP or trigonal GLP1/GIP/Glucagon agonists |
| BR112015020469A2 (pt) | 2013-03-15 | 2020-01-28 | Ampio Pharmaceuticals Inc | Usos de da-dkp, composição e método para fornecimento de células-tronco a umindivíduo |
| AU2014228415B2 (en) * | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| MX375448B (es) * | 2013-07-18 | 2025-03-06 | Mannkind Corp | Composiciones farmacéuticas en polvo seco estables al calor y métodos. |
| US11446127B2 (en) | 2013-08-05 | 2022-09-20 | Mannkind Corporation | Insufflation apparatus and methods |
| WO2015027173A1 (en) * | 2013-08-22 | 2015-02-26 | Zp Opco, Inc. | Stable glucagon peptide formulations |
| US9782344B2 (en) | 2013-08-22 | 2017-10-10 | Zp Opco, Inc. | Stable glucagon peptide formulations |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| WO2015086733A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Dual glp-1/glucagon receptor agonists |
| EP3080152A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Non-acylated exendin-4 peptide analogues |
| WO2015140125A2 (en) * | 2014-03-18 | 2015-09-24 | Apeptico Forschung Und Entwicklung Gmbh | Dry-powder peptide medicament |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| RU2736513C2 (ru) | 2014-08-18 | 2020-11-17 | Ампио Фармасьютикалз, Инк. | Лечение патологических состояний суставов |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| EP3310375A4 (en) | 2015-06-22 | 2019-02-20 | Ampio Pharmaceuticals, Inc. | USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
| CN108066762B (zh) * | 2016-11-07 | 2022-04-01 | 赫兰 | Glp-1受体激动剂类药物的用途 |
| CA3078652A1 (en) | 2017-10-12 | 2019-04-18 | Novo Nordisk A/S | Semaglutide in medical therapy |
| TWI705820B (zh) * | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| CN109827875A (zh) * | 2019-04-10 | 2019-05-31 | 上海市食品药品检验所 | 一种用于测定吸入制剂溶出度的装置和方法 |
| KR20210062509A (ko) | 2019-11-21 | 2021-05-31 | 대한민국(전북기계공업고등학교장) | 필터리스 다이나믹 미세먼지 공기 청정기 |
| CN115192554A (zh) * | 2022-08-08 | 2022-10-18 | 浙江仙琚萃泽医药科技有限公司 | 无抛射剂的含肽吸入溶液剂及其制备方法 |
| WO2025159538A1 (ko) * | 2024-01-26 | 2025-07-31 | 주식회사 아울바이오 | Glp-1 ra 기반 계열 펩타이드를 포함하는 미립구, 이의 제조방법, 및 이를 포함하는 약학적 조성물 |
| WO2025220834A1 (ko) | 2024-04-16 | 2025-10-23 | 한미약품 주식회사 | 흡입제 조성물 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5352461A (en) * | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
| WO1999014239A1 (de) * | 1997-09-12 | 1999-03-25 | Wolf Georg Forssmann | Zusammensetzung zur therapie von diabetes mellitus und fettsucht |
| DK1808438T3 (da) * | 1999-06-29 | 2014-10-27 | Mannkind Corp | Rensning og stabilisering af peptid og proteiner i lægemidler |
| AU2002308706A1 (en) * | 2001-06-01 | 2002-12-16 | Eli Lilly And Company | Glp-1 formulations with protracted time action |
| PL209734B1 (pl) * | 2002-02-20 | 2011-10-31 | Emisphere Tech Inc | Preparat farmaceutyczny zawierający związek GLP-1 i czynnik dostarczający oraz jego zastosowanie |
| EP1485121A4 (en) * | 2002-03-08 | 2007-11-07 | Lilly Co Eli | ACTIVE C PROTEIN FORMULATIONS |
| US20040038865A1 (en) * | 2002-08-01 | 2004-02-26 | Mannkind Corporation | Cell transport compositions and uses thereof |
| WO2004012672A2 (en) * | 2002-08-01 | 2004-02-12 | Mannkind Corporation | Cell transport compositions and uses thereof |
| JP5557415B2 (ja) * | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
| KR101644250B1 (ko) * | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염 |
| CN104324362B (zh) * | 2005-09-14 | 2018-04-24 | 曼金德公司 | 以提高活性试剂对结晶微粒表面的亲和力为基础的药物配制方法 |
| IN2015DN00888A (https=) * | 2006-02-22 | 2015-07-10 | Mannkind Corp | |
| KR101438839B1 (ko) * | 2006-04-14 | 2014-10-02 | 맨카인드 코포레이션 | 글루카곤 유사 펩타이드 1 (glp-1) 약제학적 제제 |
-
2007
- 2007-04-16 KR KR1020087027774A patent/KR101438839B1/ko active Active
- 2007-04-16 RU RU2010137392/15A patent/RU2542500C2/ru not_active IP Right Cessation
- 2007-04-16 CN CNA200780013424XA patent/CN101453988A/zh active Pending
- 2007-04-16 CN CN201410514033.8A patent/CN104288756A/zh active Pending
- 2007-04-16 JP JP2009505655A patent/JP5415938B2/ja not_active Expired - Fee Related
- 2007-04-16 KR KR1020157008571A patent/KR20150042304A/ko not_active Ceased
- 2007-04-16 AU AU2007238000A patent/AU2007238000B2/en not_active Ceased
- 2007-04-16 EP EP20070760728 patent/EP2010155A2/en not_active Withdrawn
- 2007-04-16 KR KR1020147011316A patent/KR101558829B1/ko active Active
- 2007-04-16 MX MX2008013216A patent/MX2008013216A/es active IP Right Grant
- 2007-04-16 BR BRPI0709964-9A patent/BRPI0709964A2/pt not_active IP Right Cessation
- 2007-04-16 WO PCT/US2007/066728 patent/WO2007121411A2/en not_active Ceased
- 2007-04-16 CA CA002646400A patent/CA2646400A1/en active Pending
- 2007-04-16 RU RU2008144965/15A patent/RU2409349C2/ru not_active IP Right Cessation
-
2013
- 2013-09-17 JP JP2013191549A patent/JP5898156B2/ja active Active
-
2014
- 2014-12-23 RU RU2014152320A patent/RU2014152320A/ru not_active Application Discontinuation
-
2015
- 2015-07-16 HK HK15106772.4A patent/HK1206241A1/xx unknown
- 2015-11-30 JP JP2015233125A patent/JP2016104736A/ja active Pending
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