JP2009532477A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009532477A5 JP2009532477A5 JP2009504279A JP2009504279A JP2009532477A5 JP 2009532477 A5 JP2009532477 A5 JP 2009532477A5 JP 2009504279 A JP2009504279 A JP 2009504279A JP 2009504279 A JP2009504279 A JP 2009504279A JP 2009532477 A5 JP2009532477 A5 JP 2009532477A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- region
- sialic acid
- polypeptides
- unpurified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000004196 processed proteins & peptides Human genes 0.000 claims 35
- 108090000765 processed proteins & peptides Proteins 0.000 claims 35
- 229920001184 polypeptide Polymers 0.000 claims 34
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 14
- 102000003838 Sialyltransferases Human genes 0.000 claims 4
- 108090000141 Sialyltransferases Proteins 0.000 claims 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000004856 Lectins Human genes 0.000 claims 2
- 108090001090 Lectins Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 238000001042 affinity chromatography Methods 0.000 claims 2
- 238000005571 anion exchange chromatography Methods 0.000 claims 2
- 230000003013 cytotoxicity Effects 0.000 claims 2
- 231100000135 cytotoxicity Toxicity 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 239000002523 lectin Substances 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 230000009450 sialylation Effects 0.000 claims 2
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 241000251539 Vertebrata <Metazoa> Species 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78938406P | 2006-04-05 | 2006-04-05 | |
| US60/789,384 | 2006-04-05 | ||
| PCT/US2007/008396 WO2007117505A2 (en) | 2006-04-05 | 2007-04-03 | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182741A Division JP2015038086A (ja) | 2006-04-05 | 2014-09-08 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2016114709A Division JP6322849B2 (ja) | 2006-04-05 | 2016-06-08 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009532477A JP2009532477A (ja) | 2009-09-10 |
| JP2009532477A5 true JP2009532477A5 (https=) | 2010-05-13 |
| JP6084761B2 JP6084761B2 (ja) | 2017-02-22 |
Family
ID=38581601
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009504279A Active JP6084761B2 (ja) | 2006-04-05 | 2007-04-03 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2014182741A Pending JP2015038086A (ja) | 2006-04-05 | 2014-09-08 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2016114709A Expired - Fee Related JP6322849B2 (ja) | 2006-04-05 | 2016-06-08 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2018053298A Active JP6686058B2 (ja) | 2006-04-05 | 2018-03-20 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2020065891A Expired - Fee Related JP6989979B2 (ja) | 2006-04-05 | 2020-04-01 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2021192123A Active JP7357382B2 (ja) | 2006-04-05 | 2021-11-26 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
Family Applications After (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014182741A Pending JP2015038086A (ja) | 2006-04-05 | 2014-09-08 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2016114709A Expired - Fee Related JP6322849B2 (ja) | 2006-04-05 | 2016-06-08 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2018053298A Active JP6686058B2 (ja) | 2006-04-05 | 2018-03-20 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2020065891A Expired - Fee Related JP6989979B2 (ja) | 2006-04-05 | 2020-04-01 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
| JP2021192123A Active JP7357382B2 (ja) | 2006-04-05 | 2021-11-26 | 抗炎症特性が増強され、細胞毒性特性が減少したポリペプチドおよび関連する方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (14) | US10167332B2 (https=) |
| EP (3) | EP2010566B2 (https=) |
| JP (6) | JP6084761B2 (https=) |
| CN (1) | CN101432301B (https=) |
| AU (1) | AU2007235413B2 (https=) |
| CA (1) | CA2647524C (https=) |
| EA (1) | EA022780B1 (https=) |
| IL (1) | IL194526A (https=) |
| MX (1) | MX2008012843A (https=) |
| NZ (1) | NZ572379A (https=) |
| WO (1) | WO2007117505A2 (https=) |
| ZA (1) | ZA200808900B (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080206246A1 (en) * | 2006-04-05 | 2008-08-28 | Ravetch Jeffrey V | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| US8470318B2 (en) | 2005-11-07 | 2013-06-25 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| MX2008012843A (es) * | 2006-04-05 | 2009-01-19 | Univ Rockefeller | Polipeptidos con propiedades antiinflamatorias aumentadas y citotoxicas reducidas y metodos relacionados. |
| KR20100058509A (ko) | 2007-07-31 | 2010-06-03 | 메디뮨 엘엘씨 | 다중특이적 에피토프 결합 단백질 및 이의 용도 |
| JP2011509675A (ja) | 2008-01-18 | 2011-03-31 | メディミューン，エルエルシー | 部位特異的コンジュゲーションのためのシステイン操作抗体 |
| WO2009132130A2 (en) | 2008-04-22 | 2009-10-29 | The Rockefeller University | Methods of identifying anti-inflammatory compounds |
| EP2233499A1 (en) | 2009-03-26 | 2010-09-29 | CSL Behring AG | Antibody composition with altered Fab sialylation |
| EP2233502A1 (en) | 2009-03-27 | 2010-09-29 | Deutsches Rheuma-Forschungszentrum Berlin | Sialylated antigen-specific antibodies for treatment or prophylaxis of unwanted inflammatory immune reactions and methods of producing them |
| AU2010270979B2 (en) | 2009-06-22 | 2015-04-23 | Medimmune, Llc | Engineered Fc regions for site-specific conjugation |
| EP2566889A1 (en) | 2010-05-07 | 2013-03-13 | CSL Behring AG | Antibody composition obtained by fractionation of plasma immunoglobulins affinity chromatography on a sambucus nigra affinity column |
| CA2799595C (en) | 2010-05-27 | 2022-08-16 | Merck Sharp & Dohme Corp. | Method for preparing antibodies having improved properties |
| AR085302A1 (es) | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US12384848B2 (en) | 2011-12-19 | 2025-08-12 | The Rockefeller University | Anti-inflammatory polypeptides |
| EP2793943B1 (en) | 2011-12-19 | 2018-09-26 | The Rockefeller University | Non-sialylated anti-inflammatory polypeptides |
| JP2015502397A (ja) | 2011-12-23 | 2015-01-22 | ファイザー・インク | 部位特異的コンジュゲーションのための操作された抗体定常領域、ならびにそのための方法および使用 |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013158273A1 (en) | 2012-04-20 | 2013-10-24 | Abbvie Inc. | Methods to modulate c-terminal lysine variant distribution |
| US20150210753A1 (en) | 2012-07-26 | 2015-07-30 | Momenta Pharmaceuticals, Inc. | Glycoproteins with anti-inflammatory properties |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
| AU2014255285B2 (en) | 2013-04-18 | 2019-07-11 | Institut National De La Sante Et De La Recherche Medicale | Composition with reduced immunogenicity |
| EP3719122B1 (en) * | 2013-05-02 | 2026-04-01 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| WO2014186310A1 (en) | 2013-05-13 | 2014-11-20 | Momenta Pharmaceuticals, Inc. | Methods for the treatment of neurodegeneration |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| EP3058084A4 (en) | 2013-10-16 | 2017-07-05 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| AU2015270152A1 (en) * | 2014-06-02 | 2016-12-08 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Production of Fc fragments |
| US11725044B2 (en) | 2014-10-15 | 2023-08-15 | Xenothera | Method for producing polyclonal antibodies with improved complement-dependent cytotoxicity |
| AU2016226115B2 (en) | 2015-03-04 | 2021-03-25 | The Rockefeller University | Anti-inflammatory polypeptides |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| KR102878970B1 (ko) | 2016-08-03 | 2025-10-30 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 항-SIRPalpha 항체 요법의 대식세포 증진 효능에서 Fc 수용체 참여의 붕괴 |
| FI4050034T3 (fi) | 2016-09-14 | 2024-06-10 | Teneoone Inc | Cd3:een sitoutuvia vasta-aineita |
| NZ754713A (en) | 2016-12-21 | 2025-11-28 | Teneobio Inc | Anti-bcma heavy chain-only antibodies |
| WO2019023347A1 (en) | 2017-07-26 | 2019-01-31 | Forty Seven, Inc. | ANTI-SIRP-ALPHA ANTIBODIES AND ASSOCIATED METHODS |
| KR20200044094A (ko) | 2017-09-13 | 2020-04-28 | 테네오바이오, 인코포레이티드 | 엑토효소에 결합하는 중쇄 항체 |
| JP7774283B2 (ja) | 2017-12-19 | 2025-11-21 | ザ ロックフェラー ユニバーシティー | エフェクター機能を改良したヒトＩｇＧのＦｃ領域改変体 |
| RU2020124623A (ru) | 2017-12-27 | 2022-01-27 | Тенеобио, Инк. | Антитела, специфичные к гетеродимеру cd3-дельта/эпсилон |
| HRP20250618T1 (hr) | 2018-07-03 | 2025-07-18 | Gilead Sciences, Inc. | Protutijela koja ciljaju na hiv gp120 i postupci za uporabu |
| WO2020047326A2 (en) | 2018-08-31 | 2020-03-05 | ALX Oncology Inc. | Decoy polypeptides |
| CN112839959A (zh) | 2018-09-21 | 2021-05-25 | 特尼奥生物股份有限公司 | 用于纯化异源二聚多特异性抗体的方法 |
| KR20250160224A (ko) * | 2018-10-11 | 2025-11-11 | 모멘타 파머슈티컬스 인코포레이티드 | 고도로 실릴화된 IgG 조성물에 의한 치료 |
| BR112021000173A2 (pt) | 2018-10-26 | 2021-05-04 | Teneobio, Inc. | anticorpos de cadeia pesada com ligação a cd38 |
| CN110297093B (zh) * | 2019-03-18 | 2022-04-22 | 山西瑞豪生物科技有限公司 | 一种检测人免疫球蛋白g4的方法和试剂盒 |
| KR102549282B1 (ko) * | 2019-11-18 | 2023-06-30 | 건국대학교 산학협력단 | 시알산화된 면역글로불린을 유효성분으로 포함하는 염증성 질환의 치료용 조성물 |
| WO2021127489A1 (en) | 2019-12-18 | 2021-06-24 | Teneobio, Inc. | Heavy chain antibodies binding to cd38 |
| WO2022271987A1 (en) | 2021-06-23 | 2022-12-29 | TeneoFour, Inc. | Anti-cd38 antibodies and epitopes of same |
| JP2025542423A (ja) * | 2022-12-21 | 2025-12-25 | コングク ユニバーシティ インダストリアル コーオペレーション コーポレーション | α－２，６－シアル化免疫グロブリンの眼球乾燥症または炎症性眼疾患の予防または治療用途 |
| CN115819560A (zh) * | 2022-12-27 | 2023-03-21 | 河南赛诺特生物技术有限公司 | 制备第二抗体的方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| FR2556219B1 (fr) * | 1983-12-07 | 1987-06-26 | Merieux Inst | Nouveau medicament immunomodulateur, a base de fragments fc d'igg humaines |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| US5401650A (en) * | 1990-10-24 | 1995-03-28 | The Mount Sinai School Of Medicine Of The City University Of New York | Cloning and expression of biologically active α-galactosidase A |
| JPH06504619A (ja) * | 1990-11-23 | 1994-05-26 | ザ ジェネラル ホスピタル コーポレーション | 細胞接着蛋白質−糖質相互作用の阻害 |
| US5453272A (en) | 1992-10-02 | 1995-09-26 | Alberta Research Council | Lectin derived carbohydrate binding-peptide |
| US5702946A (en) * | 1994-03-03 | 1997-12-30 | Genentech, Inc. | Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders |
| US6656466B1 (en) | 1995-06-06 | 2003-12-02 | Genetech, Inc. | Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition |
| US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| US20020045207A1 (en) | 1997-10-31 | 2002-04-18 | Lynne A. Krummen | Glycoprotein production process |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| CN100457914C (zh) * | 1999-04-15 | 2009-02-04 | 荷兰克鲁塞尔公司 | 用编码腺病毒e1蛋白的序列在人体细胞中生产重组蛋白 |
| US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
| DE19927835A1 (de) * | 1999-06-18 | 2000-12-21 | Clariant Gmbh | Verwendung von verbesserten Cyanpigmenten in elektrophotographischen Tonern und Entwicklern, Pulverlacken und Ink-Jet-Tinten |
| CA2424977C (en) * | 2000-10-06 | 2008-03-18 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| US7064191B2 (en) * | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
| CA2467781C (en) | 2000-11-20 | 2014-09-23 | Canadian Blood Services | Use of a monoclonal antibody specific for a red blood cell to inhibit the reticuloendothelial system for the treatment of thrombocytopenia |
| US7473680B2 (en) * | 2001-11-28 | 2009-01-06 | Neose Technologies, Inc. | Remodeling and glycoconjugation of peptides |
| US7427469B2 (en) * | 2002-11-05 | 2008-09-23 | Institut Pasteur | Method of treating cytomegalovirus with DC-SIGN blockers |
| DE60335024D1 (de) * | 2002-12-23 | 2010-12-30 | Bristol Myers Squibb Co | Produktqualitätsverbesserung in säugerzellkulturverfahrenzur proteinproduktion |
| US20070048740A1 (en) * | 2003-02-14 | 2007-03-01 | Research Association For Biotechnology | Full-length cDNA |
| EP2062916A3 (en) * | 2003-04-09 | 2009-08-19 | Genentech, Inc. | Therapy of autoimmune disease in a patient with an inadequate response to a TNF-Alpha inhibitor |
| AU2003271194A1 (en) * | 2003-10-09 | 2005-04-21 | Daewoong Co., Ltd. | Process for purifying human thrombopoietin with high content of sialic acid |
| ES2672640T3 (es) * | 2003-11-05 | 2018-06-15 | Roche Glycart Ag | Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas |
| JP2008504222A (ja) * | 2003-12-15 | 2008-02-14 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 新規の抗ｄｃ−ｓｉｇｎ抗体 |
| JP2008504008A (ja) * | 2003-12-31 | 2008-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改良された薬物動態を有するＦｃ−エリスロポエチン融合タンパク質 |
| DK1896071T3 (en) * | 2005-06-30 | 2015-05-26 | Janssen Biotech Inc | Methods and compositions with increased therapeutic activity |
| EP1937306B1 (en) * | 2005-08-19 | 2016-02-17 | Janssen Biotech, Inc. | Proteolysis resistant antibody preparations |
| US20080206246A1 (en) * | 2006-04-05 | 2008-08-28 | Ravetch Jeffrey V | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| US8470318B2 (en) * | 2005-11-07 | 2013-06-25 | The Rockefeller University | Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods |
| US20080286819A1 (en) | 2005-11-07 | 2008-11-20 | Ravetch Jeffrey V | Reagents, Methods and Systems for Selecting a Cytotoxic Antibody or Variant Thereof |
| MX2008012843A (es) | 2006-04-05 | 2009-01-19 | Univ Rockefeller | Polipeptidos con propiedades antiinflamatorias aumentadas y citotoxicas reducidas y metodos relacionados. |
| EP2091969A4 (en) | 2006-10-27 | 2010-05-12 | Univ Rockefeller | POLYPEPTIDES WITH IMPROVED INFLAMMATORY INHIBITION AND REDUCED CYTOTOXIC PROPERTIES AND RELATED METHODS THEREFOR |
| NZ585530A (en) | 2007-12-27 | 2012-06-29 | Baxter Int | Methods for differentiating plasma-derived protein from recombinant protein in a sample |
-
2007
- 2007-04-03 MX MX2008012843A patent/MX2008012843A/es active IP Right Grant
- 2007-04-03 CN CN200780015563.6A patent/CN101432301B/zh active Active
- 2007-04-03 EP EP07754846.9A patent/EP2010566B2/en active Active
- 2007-04-03 CA CA2647524A patent/CA2647524C/en active Active
- 2007-04-03 WO PCT/US2007/008396 patent/WO2007117505A2/en not_active Ceased
- 2007-04-03 EP EP14183260.0A patent/EP2815768A3/en not_active Ceased
- 2007-04-03 US US12/294,883 patent/US10167332B2/en active Active
- 2007-04-03 JP JP2009504279A patent/JP6084761B2/ja active Active
- 2007-04-03 EA EA200870411A patent/EA022780B1/ru unknown
- 2007-04-03 AU AU2007235413A patent/AU2007235413B2/en active Active
- 2007-04-03 EP EP18188349.7A patent/EP3456351A1/en not_active Withdrawn
- 2007-04-03 NZ NZ572379A patent/NZ572379A/en not_active IP Right Cessation
-
2008
- 2008-10-05 IL IL194526A patent/IL194526A/en active IP Right Grant
- 2008-10-17 ZA ZA200808900A patent/ZA200808900B/xx unknown
-
2013
- 2013-05-16 US US13/896,070 patent/US20130273040A1/en not_active Abandoned
-
2014
- 2014-05-16 US US14/280,181 patent/US20140323696A1/en not_active Abandoned
- 2014-09-08 JP JP2014182741A patent/JP2015038086A/ja active Pending
-
2015
- 2015-02-17 US US14/624,483 patent/US20160176950A1/en not_active Abandoned
-
2016
- 2016-06-08 JP JP2016114709A patent/JP6322849B2/ja not_active Expired - Fee Related
- 2016-10-07 US US15/288,764 patent/US20170088608A1/en not_active Abandoned
-
2017
- 2017-04-20 US US15/492,987 patent/US20170218050A1/en not_active Abandoned
- 2017-06-21 US US15/629,056 patent/US20170283492A1/en not_active Abandoned
- 2017-06-21 US US15/629,119 patent/US20170320935A1/en not_active Abandoned
-
2018
- 2018-03-20 JP JP2018053298A patent/JP6686058B2/ja active Active
- 2018-09-28 US US16/145,688 patent/US20190031737A1/en not_active Abandoned
- 2018-10-02 US US16/150,058 patent/US20190031738A1/en not_active Abandoned
-
2019
- 2019-01-10 US US16/245,053 patent/US20190127446A1/en not_active Abandoned
- 2019-12-20 US US16/724,137 patent/US20200385443A1/en not_active Abandoned
-
2020
- 2020-04-01 JP JP2020065891A patent/JP6989979B2/ja not_active Expired - Fee Related
- 2020-12-14 US US17/121,622 patent/US20210101961A1/en not_active Abandoned
-
2021
- 2021-11-26 JP JP2021192123A patent/JP7357382B2/ja active Active
-
2022
- 2022-12-20 US US18/085,190 patent/US20230121427A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009532477A5 (https=) | ||
| ES2991621T3 (es) | Separación de oligosacáridos de caldo de fermentación | |
| Vollet Marson et al. | Membrane fractionation of protein hydrolysates from by-products: recovery of valuable compounds from spent yeasts | |
| Chollangi et al. | Development of robust antibody purification by optimizing protein‐A chromatography in combination with precipitation methodologies | |
| Nagae et al. | Function and 3D structure of the N-glycans on glycoproteins | |
| Mu et al. | A novel high-mannose specific lectin from the green alga Halimeda renschii exhibits a potent anti-influenza virus activity through high-affinity binding to the viral hemagglutinin | |
| Ligtenberg et al. | Deleted in malignant brain tumors-1 protein (DMBT1): a pattern recognition receptor with multiple binding sites | |
| JP2006526414A5 (https=) | ||
| JP2010512306A5 (https=) | ||
| Petrou et al. | IgA nephropathy: current treatment and new insights | |
| JP2006513978A5 (https=) | ||
| Gasparini et al. | Thermally-induced lactosylation of whey proteins: Identification and synthesis of lactosylated β-lactoglobulin epitope | |
| Gallaher et al. | Modeling of the Ebola virus delta peptide reveals a potential lytic sequence motif | |
| JP2021517805A5 (https=) | ||
| JP2017505620A5 (https=) | ||
| JP2009508476A5 (https=) | ||
| CN109843904A (zh) | 用于降低治疗性蛋白的异质性的连续方法 | |
| Mazalovska et al. | Transiently expressed mistletoe lectin II in nicotiana benthamiana demonstrates anticancer activity in vitro | |
| Kim et al. | Functional expression of the recombinant spike receptor binding domain of SARS-CoV-2 Omicron in the periplasm of Escherichia coli | |
| Noy-Porat et al. | Fc-independent protection from SARS-CoV-2 infection by recombinant human monoclonal antibodies | |
| Su et al. | Affinity purification and molecular characterization of angiotensin-converting enzyme (ACE)-inhibitory peptides from Takifugu flavidus | |
| ES2708759T3 (es) | Procedimientos para el tratamiento de la neurodegeneración | |
| Sakai et al. | Construction of recombinant hemagglutinin derived from the gingipain-encoding gene of Porphyromonas gingivalis, identification of its target protein on erythrocytes, and inhibition of hemagglutination by an interdomain regional peptide | |
| Kittur et al. | Asialo-rhuEPO as a potential neuroprotectant for ischemic stroke treatment | |
| Li et al. | Enhanced downstream processing for a cell-based avian influenza (H5N1) vaccine |