JP2009532371A5 - - Google Patents
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- Publication number
- JP2009532371A5 JP2009532371A5 JP2009503092A JP2009503092A JP2009532371A5 JP 2009532371 A5 JP2009532371 A5 JP 2009532371A5 JP 2009503092 A JP2009503092 A JP 2009503092A JP 2009503092 A JP2009503092 A JP 2009503092A JP 2009532371 A5 JP2009532371 A5 JP 2009532371A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- composition
- particles
- therapeutic agent
- cholesterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims 20
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 15
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 15
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 12
- 150000002632 lipids Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 10
- 229940124597 therapeutic agent Drugs 0.000 claims 10
- 235000012000 cholesterol Nutrition 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 230000005847 immunogenicity Effects 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102100022641 Coagulation factor IX Human genes 0.000 claims 2
- 102100023804 Coagulation factor VII Human genes 0.000 claims 2
- 108010076282 Factor IX Proteins 0.000 claims 2
- 108010014172 Factor V Proteins 0.000 claims 2
- 108010023321 Factor VII Proteins 0.000 claims 2
- 108010054218 Factor VIII Proteins 0.000 claims 2
- 102000001690 Factor VIII Human genes 0.000 claims 2
- 229960004222 factor ix Drugs 0.000 claims 2
- 229940012413 factor vii Drugs 0.000 claims 2
- 229960000301 factor viii Drugs 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000003951 Erythropoietin Human genes 0.000 claims 1
- 108090000394 Erythropoietin Proteins 0.000 claims 1
- 102000018997 Growth Hormone Human genes 0.000 claims 1
- 108010051696 Growth Hormone Proteins 0.000 claims 1
- 102000004877 Insulin Human genes 0.000 claims 1
- 108090001061 Insulin Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 102000016943 Muramidase Human genes 0.000 claims 1
- 108010014251 Muramidase Proteins 0.000 claims 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims 1
- 102000036693 Thrombopoietin Human genes 0.000 claims 1
- 108010041111 Thrombopoietin Proteins 0.000 claims 1
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 claims 1
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 208000015294 blood coagulation disease Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 229940105423 erythropoietin Drugs 0.000 claims 1
- 239000000122 growth hormone Substances 0.000 claims 1
- 229940125396 insulin Drugs 0.000 claims 1
- 229960000274 lysozyme Drugs 0.000 claims 1
- 235000010335 lysozyme Nutrition 0.000 claims 1
- 239000004325 lysozyme Substances 0.000 claims 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 238000004513 sizing Methods 0.000 claims 1
- 229960000187 tissue plasminogen activator Drugs 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78741106P | 2006-03-30 | 2006-03-30 | |
| US78758606P | 2006-03-30 | 2006-03-30 | |
| US60/787,586 | 2006-03-30 | ||
| US60/787,411 | 2006-03-30 | ||
| US86506206P | 2006-11-09 | 2006-11-09 | |
| US60/865,062 | 2006-11-09 | ||
| US87017706P | 2006-12-15 | 2006-12-15 | |
| US60/870,177 | 2006-12-15 | ||
| PCT/US2007/008311 WO2007117469A2 (en) | 2006-03-30 | 2007-03-30 | Compositions of less immunogenic and long-circulating protein-lipid complexes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009532371A JP2009532371A (ja) | 2009-09-10 |
| JP2009532371A5 true JP2009532371A5 (https=) | 2010-05-13 |
| JP5160534B2 JP5160534B2 (ja) | 2013-03-13 |
Family
ID=38581584
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009503092A Expired - Fee Related JP5160534B2 (ja) | 2006-03-30 | 2007-03-30 | 低免疫原性および長時間循環性タンパク質−脂質複合体の組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7875289B2 (https=) |
| EP (1) | EP2007357B1 (https=) |
| JP (1) | JP5160534B2 (https=) |
| AU (1) | AU2007235463B2 (https=) |
| CA (1) | CA2660310C (https=) |
| NZ (1) | NZ572308A (https=) |
| WO (1) | WO2007117469A2 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007235463B2 (en) * | 2006-03-30 | 2012-11-22 | The Research Foundation Of State University Of New York | Compositions of less immunogenic and long-circulating protein-lipid complexes |
| CA2700808C (en) | 2007-09-27 | 2017-11-14 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
| US20090252785A1 (en) * | 2008-03-26 | 2009-10-08 | University Of Oxford | Endoplasmic reticulum targeting liposomes |
| ES2524699T3 (es) | 2008-06-05 | 2014-12-11 | Immunovaccine Technologies Inc. | Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba |
| WO2013070362A1 (en) | 2011-10-06 | 2013-05-16 | The Research Foundation Of State University Of New York | Compositions and methods for immune tolerance induction |
| US10617640B2 (en) | 2009-07-07 | 2020-04-14 | The Research Foundation For The State University Of New York | Phosphoserine containing compositions for immune tolerance induction |
| EP2451485B1 (en) * | 2009-07-07 | 2016-03-02 | The Research Foundation Of State University Of New York | Lipidic compositions for induction of immune tolerance |
| JP6240077B2 (ja) | 2011-10-06 | 2017-11-29 | イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用 |
| CN104780914B (zh) | 2012-05-09 | 2018-02-09 | 健康科学西部大学 | 前体脂质体睾酮制剂 |
| WO2014160496A1 (en) * | 2013-03-13 | 2014-10-02 | Stemetrix, Inc. | Skin compositions and uses |
| EP3049103B1 (en) | 2013-09-24 | 2020-06-24 | The Research Foundation for the State University of New York | Compositions and methods for reducing antigen-specific immunogenicity |
| AU2021300189A1 (en) * | 2020-07-01 | 2023-03-02 | The Research Foundation For The State University Of New York | Method for preparation of liposomes |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4127502A (en) * | 1977-06-10 | 1978-11-28 | Eastman Kodak Company | Stabilizers for reconstituted, lyophilized samples |
| US4920016A (en) * | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US4795806A (en) * | 1987-07-16 | 1989-01-03 | Miles Laboratories, Inc. | Phospholipid affinity purification of Factor VIII:C |
| US5997864A (en) * | 1995-06-07 | 1999-12-07 | Novo Nordisk A/S | Modified factor VII |
| WO1993020801A1 (fr) * | 1992-04-10 | 1993-10-28 | Hisamitsu Pharmaceutical Co., Inc. | Composition de liposomes |
| DE4416180C2 (de) | 1994-05-06 | 1997-08-14 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen und Verfahren zur Herstellung dieses Präparats |
| DE4416166C2 (de) * | 1994-05-06 | 1997-11-20 | Immuno Ag | Stabiles Präparat zur Behandlung von Blutgerinnungsstörungen |
| US5580856A (en) * | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| CA2181390C (en) | 1995-07-18 | 2001-04-24 | Pankaj Modi | Phospholipid formulations |
| AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
| EP0981548A4 (en) * | 1997-04-30 | 2005-11-23 | Enzon Inc | GLYCOSYLATABLE SINGLE CHAIN ANTIGEN-BINDING PROTEINS, MANUFACTURE AND USE THEREOF |
| JP4545928B2 (ja) | 1998-04-27 | 2010-09-15 | ジリップ・ファーマ・ビー．ブイ． | 第ｖｉｉｉ因子及び中性リポソームを含有する薬学的組成物 |
| US20020132982A1 (en) * | 2000-11-30 | 2002-09-19 | Balasubramanian Sathyamangalam V. | AHF associated dispersion system and method for preparation |
| ZA200305980B (en) * | 2001-02-12 | 2007-01-31 | Res Dev Foundation | Modified proteins, designer toxins, and methods of making thereof |
| WO2003013245A1 (en) | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| CA2467064C (en) * | 2001-11-13 | 2011-02-08 | Murray Webb | Lipid carrier compositions with enhanced blood stability |
| US20040229793A1 (en) * | 2003-02-05 | 2004-11-18 | Balasubramanian Sathyamangalam V. | Compositions and methods for less immunogenic protein formulations |
| US7351688B2 (en) * | 2003-02-05 | 2008-04-01 | The Research Foundation Of State University Of New York | Compositions and methods for less immunogenic protein formulations |
| EP2314285B2 (en) * | 2003-02-14 | 2019-09-18 | Children's Hospital & Research Center at Oakland | Lipophilic drug delivery vehicle and methods of use thereof |
| US20060246124A1 (en) * | 2004-11-08 | 2006-11-02 | Pilkiewicz Frank G | Methods of treating cancer with lipid-based platinum compound formulations administered intraperitoneally |
| CN101304757A (zh) | 2005-06-29 | 2008-11-12 | 纽约州立大学研究基金会 | 免疫原性较低的蛋白质-脂质复合物的组合物和方法 |
| AU2007235463B2 (en) * | 2006-03-30 | 2012-11-22 | The Research Foundation Of State University Of New York | Compositions of less immunogenic and long-circulating protein-lipid complexes |
| US7875288B2 (en) * | 2006-03-30 | 2011-01-25 | The Research Foundation Of State University Of New York | Method for treating blood coagulation disorders |
-
2007
- 2007-03-30 AU AU2007235463A patent/AU2007235463B2/en not_active Ceased
- 2007-03-30 US US11/731,648 patent/US7875289B2/en not_active Expired - Fee Related
- 2007-03-30 JP JP2009503092A patent/JP5160534B2/ja not_active Expired - Fee Related
- 2007-03-30 EP EP07754777.6A patent/EP2007357B1/en not_active Not-in-force
- 2007-03-30 WO PCT/US2007/008311 patent/WO2007117469A2/en not_active Ceased
- 2007-03-30 NZ NZ572308A patent/NZ572308A/en not_active IP Right Cessation
- 2007-03-30 CA CA2660310A patent/CA2660310C/en not_active Expired - Fee Related
-
2010
- 2010-12-28 US US12/979,621 patent/US20110123625A1/en not_active Abandoned
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