JP2009530271A5 - - Google Patents

Info

Publication number

JP2009530271A5

JP2009530271A5 JP2009500312A JP2009500312A JP2009530271A5 JP 2009530271 A5 JP2009530271 A5 JP 2009530271A5 JP 2009500312 A JP2009500312 A JP 2009500312A JP 2009500312 A JP2009500312 A JP 2009500312A JP 2009530271 A5 JP2009530271 A5 JP 2009530271A5

Authority

JP

Japan

Prior art keywords

oral dosage

dosage form

solid oral

solid

antibody

Prior art date

2006-05-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000006186 oral dosage form Substances 0.000 claims description 19
• 239000007787 solid Substances 0.000 claims description 16
• 239000003814 drug Substances 0.000 claims description 14
• 229940079593 drug Drugs 0.000 claims description 12
• 239000000243 solution Substances 0.000 claims description 10
• 238000000034 method Methods 0.000 claims description 9
• 230000007935 neutral effect Effects 0.000 claims description 9
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
• GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
• 239000008101 lactose Substances 0.000 claims description 5
• 238000010790 dilution Methods 0.000 claims description 4
• 239000012895 dilution Substances 0.000 claims description 4
• 239000000654 additive Substances 0.000 claims description 3
• 238000001035 drying Methods 0.000 claims description 3
• 239000002245 particle Substances 0.000 claims description 3
• 238000013207 serial dilution Methods 0.000 claims description 3
• 230000000996 additive effect Effects 0.000 claims description 2
• 238000002156 mixing Methods 0.000 claims description 2
• 238000003825 pressing Methods 0.000 claims description 2
• 239000011230 binding agent Substances 0.000 claims 2
• 239000000314 lubricant Substances 0.000 claims 2
• 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 150000001875 compounds Chemical class 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000010907 mechanical stirring Methods 0.000 claims 1
• 238000000465 moulding Methods 0.000 claims 1
• 238000000527 sonication Methods 0.000 claims 1
• QACUPNAKIPYZAW-RMQWDSPGSA-N O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O QACUPNAKIPYZAW-RMQWDSPGSA-N 0.000 description 1
• 239000004480 active ingredient Substances 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 239000008187 granular material Substances 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• 230000001632 homeopathic effect Effects 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 238000005453 pelletization Methods 0.000 description 1
• 239000000825 pharmaceutical preparation Substances 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 239000000126 substance Substances 0.000 description 1