JP2009527488A5 - - Google Patents
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- Publication number
- JP2009527488A5 JP2009527488A5 JP2008555480A JP2008555480A JP2009527488A5 JP 2009527488 A5 JP2009527488 A5 JP 2009527488A5 JP 2008555480 A JP2008555480 A JP 2008555480A JP 2008555480 A JP2008555480 A JP 2008555480A JP 2009527488 A5 JP2009527488 A5 JP 2009527488A5
- Authority
- JP
- Japan
- Prior art keywords
- oral film
- degradable
- nicotine
- film
- oral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013543 active substance Substances 0.000 claims 10
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 7
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 7
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 7
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 7
- 229960002715 nicotine Drugs 0.000 claims 7
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 3
- 210000002200 mouth mucosa Anatomy 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- 244000215068 Acacia senegal Species 0.000 claims 2
- 229920000084 Gum arabic Polymers 0.000 claims 2
- 241000208125 Nicotiana Species 0.000 claims 2
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims 2
- 206010057852 Nicotine dependence Diseases 0.000 claims 2
- 238000010521 absorption reaction Methods 0.000 claims 2
- 239000000205 acacia gum Substances 0.000 claims 2
- 235000010489 acacia gum Nutrition 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- 239000000230 xanthan gum Substances 0.000 claims 2
- 229920001285 xanthan gum Polymers 0.000 claims 2
- 235000010493 xanthan gum Nutrition 0.000 claims 2
- 229940082509 xanthan gum Drugs 0.000 claims 2
- RFEJUZJILGIRHQ-OMDKHLBYSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;3-[(2s)-1-methylpyrrolidin-2-yl]pyridine Chemical group OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 RFEJUZJILGIRHQ-OMDKHLBYSA-N 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000003296 saliva Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77459206P | 2006-02-17 | 2006-02-17 | |
| US60/774,592 | 2006-02-17 | ||
| PCT/US2007/062176 WO2007095600A2 (en) | 2006-02-17 | 2007-02-15 | Disintegrable oral films |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013188331A Division JP2014037415A (ja) | 2006-02-17 | 2013-09-11 | 分解可能な口腔フィルム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009527488A JP2009527488A (ja) | 2009-07-30 |
| JP2009527488A5 true JP2009527488A5 (enExample) | 2010-04-02 |
| JP5469868B2 JP5469868B2 (ja) | 2014-04-16 |
Family
ID=38372253
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555480A Expired - Fee Related JP5469868B2 (ja) | 2006-02-17 | 2007-02-15 | 分解可能な口腔フィルム |
| JP2013188331A Pending JP2014037415A (ja) | 2006-02-17 | 2013-09-11 | 分解可能な口腔フィルム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013188331A Pending JP2014037415A (ja) | 2006-02-17 | 2013-09-11 | 分解可能な口腔フィルム |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20070202057A1 (enExample) |
| EP (1) | EP1993509A2 (enExample) |
| JP (2) | JP5469868B2 (enExample) |
| CN (1) | CN101384249B (enExample) |
| AU (1) | AU2007214474B2 (enExample) |
| BR (1) | BRPI0708068A2 (enExample) |
| CA (1) | CA2640243C (enExample) |
| MX (1) | MX2008010548A (enExample) |
| RU (1) | RU2436565C2 (enExample) |
| WO (1) | WO2007095600A2 (enExample) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2351315C2 (ru) * | 2003-07-24 | 2009-04-10 | Смитклайн Бичам Корпорейшн | Пленки, растворяющиеся в полости рта |
| EP1993509A2 (en) * | 2006-02-17 | 2008-11-26 | Novartis AG | Disintegrable oral films |
| US9125434B2 (en) * | 2007-10-11 | 2015-09-08 | Philip Morris Products S.A. | Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet |
| SG187480A1 (en) | 2007-10-11 | 2013-02-28 | Philip Morris Prod | Smokeless tobacco product |
| AU2014202362B2 (en) * | 2007-10-11 | 2016-07-14 | Philip Morris Products, S.A. | Method for delivering nicotine |
| US20090098192A1 (en) * | 2007-10-11 | 2009-04-16 | Fuisz Richard C | Extrudable and Extruded Compositions for Delivery of Bioactive Agents, Method of Making Same and Method of Using Same |
| EP2229159A2 (en) * | 2007-12-11 | 2010-09-22 | Novartis AG | Multi-zone films |
| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
| JP5284070B2 (ja) * | 2008-12-12 | 2013-09-11 | 救急薬品工業株式会社 | 口腔内粘膜貼付製剤 |
| US20100256197A1 (en) * | 2009-04-02 | 2010-10-07 | Silver Eagle Labs Nv, Llc | Nicotine Dissolving Film With Or Without Menthol |
| US20100286587A1 (en) * | 2009-05-07 | 2010-11-11 | Yossi Gross | Sublingual electrical drug delivery |
| US9549842B2 (en) | 2011-02-04 | 2017-01-24 | Joseph E. Kovarik | Buccal bioadhesive strip and method of treating snoring and sleep apnea |
| US8701671B2 (en) | 2011-02-04 | 2014-04-22 | Joseph E. Kovarik | Non-surgical method and system for reducing snoring |
| PT2519225E (pt) * | 2009-12-30 | 2015-07-27 | Novartis Ag | Tiras finas de nicotina extrudidas por fusão |
| US11998479B2 (en) | 2011-02-04 | 2024-06-04 | Seed Health, Inc. | Method and system for addressing adverse effects on the oral microbiome and restoring gingival health caused by sodium lauryl sulphate exposure |
| US12279989B2 (en) | 2011-02-04 | 2025-04-22 | Seed Health, Inc. | Method and system for increasing beneficial bacteria and decreasing pathogenic bacteria in the oral cavity |
| US11357722B2 (en) | 2011-02-04 | 2022-06-14 | Seed Health, Inc. | Method and system for preventing sore throat in humans |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US12257272B2 (en) | 2015-12-24 | 2025-03-25 | Seed Health, Inc. | Method and system for reducing the likelihood of developing depression in an individual |
| US10085938B2 (en) | 2011-02-04 | 2018-10-02 | Joseph E. Kovarik | Method and system for preventing sore throat in humans |
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US20130125907A1 (en) * | 2011-11-17 | 2013-05-23 | Michael Francis Dube | Method for Producing Triethyl Citrate from Tobacco |
| CN103039688B (zh) | 2012-01-20 | 2016-01-06 | 奥驰亚客户服务公司 | 口腔用产品 |
| CN102754907B (zh) * | 2012-01-20 | 2015-06-24 | 奥驰亚客户服务公司 | 口腔用产品 |
| US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
| CN102754908B (zh) | 2012-01-20 | 2015-06-10 | 奥驰亚客户服务公司 | 口腔用烟草产品 |
| MX2015007794A (es) * | 2012-12-21 | 2015-09-04 | Teva Pharma | Suministro transmucosal de acetato de glatiramer mediante parches orales. |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11998574B2 (en) | 2013-12-20 | 2024-06-04 | Seed Health, Inc. | Method and system for modulating an individual's skin microbiome |
| US12005085B2 (en) | 2013-12-20 | 2024-06-11 | Seed Health, Inc. | Probiotic method and composition for maintaining a healthy vaginal microbiome |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11980643B2 (en) | 2013-12-20 | 2024-05-14 | Seed Health, Inc. | Method and system to modify an individual's gut-brain axis to provide neurocognitive protection |
| US12246043B2 (en) | 2013-12-20 | 2025-03-11 | Seed Health, Inc. | Topical application to treat acne vulgaris |
| US12329783B2 (en) | 2013-12-20 | 2025-06-17 | Seed Health, Inc. | Method and system to improve the health of a person's skin microbiome |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US9265284B2 (en) | 2014-01-17 | 2016-02-23 | R.J. Reynolds Tobacco Company | Process for producing flavorants and related materials |
| US9186386B2 (en) | 2014-04-17 | 2015-11-17 | Gary J. Speier | Pharmaceutical composition and method of manufacturing |
| US9044390B1 (en) | 2014-04-17 | 2015-06-02 | Gary J. Speier | Pharmaceutical composition and method of manufacturing |
| US10732162B2 (en) | 2014-08-06 | 2020-08-04 | Hexal Ag | Method and device for determining the disintegration time of film-shaped pharmaceutical dosage forms |
| US10881133B2 (en) | 2015-04-16 | 2021-01-05 | R.J. Reynolds Tobacco Company | Tobacco-derived cellulosic sugar |
| CN105055378B (zh) * | 2015-08-19 | 2017-09-12 | 山东省药学科学院 | 一种盐酸美克洛嗪的口腔速释膜剂及其制备方法 |
| US10532046B2 (en) | 2015-12-03 | 2020-01-14 | Niconovum Usa, Inc. | Multi-phase delivery compositions and products incorporating such compositions |
| US10499684B2 (en) | 2016-01-28 | 2019-12-10 | R.J. Reynolds Tobacco Company | Tobacco-derived flavorants |
| EP4424190A3 (en) | 2016-12-30 | 2024-11-06 | Philip Morris Products S.A. | Nicotine and cellulose containing sheet |
| US11091446B2 (en) | 2017-03-24 | 2021-08-17 | R.J. Reynolds Tobacco Company | Methods of selectively forming substituted pyrazines |
| CN107441068B (zh) * | 2017-08-24 | 2021-02-26 | 正大制药（青岛）有限公司 | 一种盐酸可乐定口腔膜剂及其制备方法 |
| KR101998288B1 (ko) * | 2018-03-09 | 2019-07-09 | (주)씨엘팜 | 무연 담배용 조성물 및 이를 포함하는 구강 용해 필름형 무연 담배 |
| US12342847B2 (en) | 2019-09-11 | 2025-07-01 | Nicoventures Trading Limited | Oral product with cellulosic flavor stabilizer |
| US12213510B2 (en) | 2019-09-11 | 2025-02-04 | Nicoventures Trading Limited | Pouched products with enhanced flavor stability |
| US12439949B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Oral compositions with reduced water activity |
| US12491250B2 (en) | 2019-12-09 | 2025-12-09 | Nicoventures Trading Limited | Oral composition with nanocrystalline cellulose |
| US11826462B2 (en) | 2019-12-09 | 2023-11-28 | Nicoventures Trading Limited | Oral product with sustained flavor release |
| US11672862B2 (en) | 2019-12-09 | 2023-06-13 | Nicoventures Trading Limited | Oral products with reduced irritation |
| US11872231B2 (en) | 2019-12-09 | 2024-01-16 | Nicoventures Trading Limited | Moist oral product comprising an active ingredient |
| US11883527B2 (en) | 2019-12-09 | 2024-01-30 | Nicoventures Trading Limited | Oral composition and method of manufacture |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
| US12310959B2 (en) | 2019-12-09 | 2025-05-27 | Nicoventures Trading Limited | Oral compositions with reduced water content |
| JP2023504756A (ja) | 2019-12-09 | 2023-02-06 | ニコベンチャーズ トレーディング リミテッド | カンナビノイドを含む口腔用製品 |
| US11889856B2 (en) | 2019-12-09 | 2024-02-06 | Nicoventures Trading Limited | Oral foam composition |
| US12433321B2 (en) | 2019-12-09 | 2025-10-07 | Nicoventures Trading Limited | Oral composition with beet material |
| US12171872B2 (en) | 2019-12-09 | 2024-12-24 | Nicoventures Trading Limited | Oral compositions and methods of manufacture |
| US12151023B2 (en) | 2019-12-09 | 2024-11-26 | Nicoventures Trading Limited | Oral composition with beet material |
| US11617744B2 (en) | 2019-12-09 | 2023-04-04 | Nico Ventures Trading Limited | Moist oral compositions |
| JP2023505351A (ja) | 2019-12-09 | 2023-02-08 | ニコベンチャーズ トレーディング リミテッド | 口腔用組成物のための薬剤 |
| US12137723B2 (en) | 2019-12-09 | 2024-11-12 | Nicoventures Trading Limited | Oral products with active ingredient combinations |
| US12520867B2 (en) | 2019-12-09 | 2026-01-13 | Nicoventures Trading Limited | Buffered oral compositions |
| US11969502B2 (en) | 2019-12-09 | 2024-04-30 | Nicoventures Trading Limited | Oral products |
| US11793230B2 (en) | 2019-12-09 | 2023-10-24 | Nicoventures Trading Limited | Oral products with improved binding of active ingredients |
| JP2023530239A (ja) | 2020-06-08 | 2023-07-14 | ニコベンチャーズ トレーディング リミテッド | 発泡性口腔組成物 |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| CA3223902A1 (en) | 2021-06-25 | 2022-12-29 | Richard Svensson | Oral products and method of manufacture |
| WO2023007440A1 (en) | 2021-07-30 | 2023-02-02 | Nicoventures Trading Limited | Aerosol generating substrate comprising microcrystalline cellulose |
| CN117398365B (zh) * | 2022-07-08 | 2025-08-05 | 西安远大科创医药科技有限公司 | 一种吡仑帕奈口溶膜及其制备方法 |
| WO2024037043A1 (zh) * | 2023-04-28 | 2024-02-22 | 深圳华宝协同创新技术研究院有限公司 | 用于口腔粘膜的包含尼古丁的薄膜组合物 |
| CN117205183A (zh) * | 2023-09-28 | 2023-12-12 | 深圳华宝协同创新技术研究院有限公司 | 一种尼古丁口腔膜剂及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2879695B2 (ja) * | 1990-02-22 | 1999-04-05 | 日本曹達株式会社 | 口腔内粘膜付着性フィルム製剤 |
| WO1996000072A1 (en) * | 1994-06-23 | 1996-01-04 | The Procter & Gamble Company | Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine |
| DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US6596298B2 (en) * | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| DE10018834A1 (de) * | 2000-04-15 | 2001-10-25 | Lohmann Therapie Syst Lts | Transdermale oder transmucosale Darreichungsformen mit einer nicotinhaltigen Wirkstoffkombination zur Raucherentwöhnung |
| NZ530439A (en) | 2001-04-20 | 2004-11-26 | Lavipharm Lab Inc | Intraoral delivery of nicotine for smoking cessation |
| JP5089840B2 (ja) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | ニコチン含有フィルム製剤 |
| US8765167B2 (en) * | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US20040037879A1 (en) * | 2001-11-02 | 2004-02-26 | Adusumilli Prasad S. | Oral controlled release forms useful for reducing or preventing nicotine cravings |
| DE10256775A1 (de) * | 2002-12-05 | 2004-06-24 | Lts Lohmann Therapie-Systeme Ag | Filmförmige Zubereitungen zur transmucosalen Verabreichung von Nicotin, sowie Verfahren zu deren Herstellung |
| US20070059346A1 (en) * | 2003-07-01 | 2007-03-15 | Todd Maibach | Film comprising therapeutic agents |
| RU2351315C2 (ru) * | 2003-07-24 | 2009-04-10 | Смитклайн Бичам Корпорейшн | Пленки, растворяющиеся в полости рта |
| DE10354894A1 (de) * | 2003-11-24 | 2005-07-07 | Hf Arzneimittelforschung Gmbh | Orale Formulierungen des Desoxypeganins und deren Anwendungen |
| JP4413665B2 (ja) * | 2004-03-19 | 2010-02-10 | 救急薬品工業株式会社 | 口腔内粘膜フィルム剤 |
| EP1993509A2 (en) * | 2006-02-17 | 2008-11-26 | Novartis AG | Disintegrable oral films |
| KR101784001B1 (ko) * | 2006-04-04 | 2017-10-23 | 케이지 액퀴지션 엘엘씨 | 항혈소판제와 산 억제제를 포함하는 경구 투여용 약학 조성물 |
| US20070298105A1 (en) * | 2006-06-27 | 2007-12-27 | Hwang Stephen S | Methods of treating conditions by sustained release administration of benzimidazole derivatives |
-
2007
- 2007-02-15 EP EP07757022A patent/EP1993509A2/en not_active Ceased
- 2007-02-15 CA CA2640243A patent/CA2640243C/en not_active Expired - Fee Related
- 2007-02-15 WO PCT/US2007/062176 patent/WO2007095600A2/en not_active Ceased
- 2007-02-15 JP JP2008555480A patent/JP5469868B2/ja not_active Expired - Fee Related
- 2007-02-15 CN CN2007800052451A patent/CN101384249B/zh not_active Expired - Fee Related
- 2007-02-15 RU RU2008137032A patent/RU2436565C2/ru not_active IP Right Cessation
- 2007-02-15 BR BRPI0708068-9A patent/BRPI0708068A2/pt not_active Application Discontinuation
- 2007-02-15 AU AU2007214474A patent/AU2007214474B2/en not_active Ceased
- 2007-02-15 MX MX2008010548A patent/MX2008010548A/es active IP Right Grant
- 2007-02-16 US US11/675,822 patent/US20070202057A1/en not_active Abandoned
-
2011
- 2011-12-19 US US13/329,390 patent/US8871243B2/en not_active Expired - Fee Related
-
2013
- 2013-09-11 JP JP2013188331A patent/JP2014037415A/ja active Pending
-
2014
- 2014-10-24 US US14/522,795 patent/US20150111928A1/en not_active Abandoned
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