CA2640243C - Disintegrable oral films - Google Patents
Disintegrable oral films Download PDFInfo
- Publication number
- CA2640243C CA2640243C CA2640243A CA2640243A CA2640243C CA 2640243 C CA2640243 C CA 2640243C CA 2640243 A CA2640243 A CA 2640243A CA 2640243 A CA2640243 A CA 2640243A CA 2640243 C CA2640243 C CA 2640243C
- Authority
- CA
- Canada
- Prior art keywords
- nicotine
- film
- oral
- disintegrable
- active
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 106
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 98
- 229960002715 nicotine Drugs 0.000 claims abstract description 96
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 68
- 210000002200 mouth mucosa Anatomy 0.000 claims abstract description 16
- 238000010521 absorption reaction Methods 0.000 claims abstract description 12
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- 229940069688 nicotine bitartrate Drugs 0.000 claims description 17
- LDMPZNTVIGIREC-ZGPNLCEMSA-N nicotine bitartrate Chemical group O.O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O.CN1CCC[C@H]1C1=CC=CN=C1 LDMPZNTVIGIREC-ZGPNLCEMSA-N 0.000 claims description 17
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 14
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 14
- 206010057852 Nicotine dependence Diseases 0.000 claims description 13
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 13
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- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 13
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- 239000008240 homogeneous mixture Substances 0.000 description 4
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- 238000002670 nicotine replacement therapy Methods 0.000 description 4
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- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
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- 239000001785 acacia senegal l. willd gum Substances 0.000 description 3
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
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- 239000003961 penetration enhancing agent Substances 0.000 description 3
- 239000004014 plasticizer Substances 0.000 description 3
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- 230000000391 smoking effect Effects 0.000 description 3
- 239000001962 taste-modifying agent Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 235000010493 xanthan gum Nutrition 0.000 description 3
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- 229940082509 xanthan gum Drugs 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- 239000007995 HEPES buffer Substances 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 2
- WINXNKPZLFISPD-UHFFFAOYSA-M Saccharin sodium Chemical compound [Na+].C1=CC=C2C(=O)[N-]S(=O)(=O)C2=C1 WINXNKPZLFISPD-UHFFFAOYSA-M 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77459206P | 2006-02-17 | 2006-02-17 | |
| US60/774,592 | 2006-02-17 | ||
| PCT/US2007/062176 WO2007095600A2 (en) | 2006-02-17 | 2007-02-15 | Disintegrable oral films |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2640243A1 CA2640243A1 (en) | 2007-08-23 |
| CA2640243C true CA2640243C (en) | 2015-08-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2640243A Expired - Fee Related CA2640243C (en) | 2006-02-17 | 2007-02-15 | Disintegrable oral films |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20070202057A1 (enExample) |
| EP (1) | EP1993509A2 (enExample) |
| JP (2) | JP5469868B2 (enExample) |
| CN (1) | CN101384249B (enExample) |
| AU (1) | AU2007214474B2 (enExample) |
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Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20050496A1 (es) * | 2003-07-24 | 2005-06-12 | Smithkline Beecham Corp | Peliculas que se disuelven por via oral |
| CN101384249B (zh) * | 2006-02-17 | 2011-11-30 | 诺瓦提斯公司 | 可崩解口腔膜剂 |
| AU2014202362B2 (en) * | 2007-10-11 | 2016-07-14 | Philip Morris Products, S.A. | Method for delivering nicotine |
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| US20090098192A1 (en) * | 2007-10-11 | 2009-04-16 | Fuisz Richard C | Extrudable and Extruded Compositions for Delivery of Bioactive Agents, Method of Making Same and Method of Using Same |
| US9125434B2 (en) * | 2007-10-11 | 2015-09-08 | Philip Morris Products S.A. | Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet |
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| US8715715B2 (en) * | 2008-11-03 | 2014-05-06 | Nal Pharmaceuticals Ltd. | Dosage form for insertion into the mouth |
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| US20100256197A1 (en) * | 2009-04-02 | 2010-10-07 | Silver Eagle Labs Nv, Llc | Nicotine Dissolving Film With Or Without Menthol |
| US20100286587A1 (en) * | 2009-05-07 | 2010-11-11 | Yossi Gross | Sublingual electrical drug delivery |
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| HUE025446T2 (en) * | 2009-12-30 | 2016-04-28 | Novartis Ag | Melt extruded nicotine thin strips |
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| US20130125907A1 (en) * | 2011-11-17 | 2013-05-23 | Michael Francis Dube | Method for Producing Triethyl Citrate from Tobacco |
| CN102754908B (zh) | 2012-01-20 | 2015-06-10 | 奥驰亚客户服务公司 | 口腔用烟草产品 |
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| US9854831B2 (en) | 2012-01-20 | 2018-01-02 | Altria Client Services Llc | Oral product |
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| US9265284B2 (en) | 2014-01-17 | 2016-02-23 | R.J. Reynolds Tobacco Company | Process for producing flavorants and related materials |
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| US10499684B2 (en) | 2016-01-28 | 2019-12-10 | R.J. Reynolds Tobacco Company | Tobacco-derived flavorants |
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| CN107441068B (zh) * | 2017-08-24 | 2021-02-26 | 正大制药（青岛）有限公司 | 一种盐酸可乐定口腔膜剂及其制备方法 |
| KR101998288B1 (ko) * | 2018-03-09 | 2019-07-09 | (주)씨엘팜 | 무연 담배용 조성물 및 이를 포함하는 구강 용해 필름형 무연 담배 |
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| US12491250B2 (en) | 2019-12-09 | 2025-12-09 | Nicoventures Trading Limited | Oral composition with nanocrystalline cellulose |
| BR112022024943A2 (pt) | 2020-06-08 | 2022-12-27 | Nicoventures Trading Ltd | Composição oral efervescente compreendendo um ingrediente ativo |
| US11839602B2 (en) | 2020-11-25 | 2023-12-12 | Nicoventures Trading Limited | Oral cannabinoid product with lipid component |
| US12382982B2 (en) | 2021-06-25 | 2025-08-12 | Nicoventures Trading Limited | Oral products and method of manufacture |
| WO2023007440A1 (en) | 2021-07-30 | 2023-02-02 | Nicoventures Trading Limited | Aerosol generating substrate comprising microcrystalline cellulose |
| CN117398365B (zh) * | 2022-07-08 | 2025-08-05 | 西安远大科创医药科技有限公司 | 一种吡仑帕奈口溶膜及其制备方法 |
| WO2024037043A1 (zh) * | 2023-04-28 | 2024-02-22 | 深圳华宝协同创新技术研究院有限公司 | 用于口腔粘膜的包含尼古丁的薄膜组合物 |
| CN117205183A (zh) * | 2023-09-28 | 2023-12-12 | 深圳华宝协同创新技术研究院有限公司 | 一种尼古丁口腔膜剂及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2879695B2 (ja) * | 1990-02-22 | 1999-04-05 | 日本曹達株式会社 | 口腔内粘膜付着性フィルム製剤 |
| AU2703795A (en) * | 1994-06-23 | 1996-01-19 | Procter & Gamble Company, The | Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine |
| DE19646392A1 (de) * | 1996-11-11 | 1998-05-14 | Lohmann Therapie Syst Lts | Zubereitung zur Anwendung in der Mundhöhle mit einer an der Schleimhaut haftklebenden, Pharmazeutika oder Kosmetika zur dosierten Abgabe enthaltenden Schicht |
| US6596298B2 (en) * | 1998-09-25 | 2003-07-22 | Warner-Lambert Company | Fast dissolving orally comsumable films |
| DE10018834A1 (de) * | 2000-04-15 | 2001-10-25 | Lohmann Therapie Syst Lts | Transdermale oder transmucosale Darreichungsformen mit einer nicotinhaltigen Wirkstoffkombination zur Raucherentwöhnung |
| EP1389910A4 (en) | 2001-04-20 | 2005-11-02 | Lavipharm Lab Inc | INTRABUCAL DISTRIBUTION OF NICOTINE INTENDED TO STOP SMOKING |
| JP5089840B2 (ja) * | 2001-09-25 | 2012-12-05 | 救急薬品工業株式会社 | ニコチン含有フィルム製剤 |
| US8765167B2 (en) * | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US20040037879A1 (en) * | 2001-11-02 | 2004-02-26 | Adusumilli Prasad S. | Oral controlled release forms useful for reducing or preventing nicotine cravings |
| DE10256775A1 (de) * | 2002-12-05 | 2004-06-24 | Lts Lohmann Therapie-Systeme Ag | Filmförmige Zubereitungen zur transmucosalen Verabreichung von Nicotin, sowie Verfahren zu deren Herstellung |
| US20070059346A1 (en) * | 2003-07-01 | 2007-03-15 | Todd Maibach | Film comprising therapeutic agents |
| PE20050496A1 (es) * | 2003-07-24 | 2005-06-12 | Smithkline Beecham Corp | Peliculas que se disuelven por via oral |
| DE10354894A1 (de) * | 2003-11-24 | 2005-07-07 | Hf Arzneimittelforschung Gmbh | Orale Formulierungen des Desoxypeganins und deren Anwendungen |
| JP4413665B2 (ja) * | 2004-03-19 | 2010-02-10 | 救急薬品工業株式会社 | 口腔内粘膜フィルム剤 |
| CN101384249B (zh) * | 2006-02-17 | 2011-11-30 | 诺瓦提斯公司 | 可崩解口腔膜剂 |
| EP2007362B1 (en) * | 2006-04-04 | 2018-09-05 | KG Acquisition LLC | Oral dosage forms including an antiplatelet agent and an acid inhibitor |
| US20070298105A1 (en) * | 2006-06-27 | 2007-12-27 | Hwang Stephen S | Methods of treating conditions by sustained release administration of benzimidazole derivatives |
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- 2007-02-15 RU RU2008137032A patent/RU2436565C2/ru not_active IP Right Cessation
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- 2007-02-16 US US11/675,822 patent/US20070202057A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| MX2008010548A (es) | 2008-10-20 |
| CA2640243A1 (en) | 2007-08-23 |
| JP2009527488A (ja) | 2009-07-30 |
| EP1993509A2 (en) | 2008-11-26 |
| JP5469868B2 (ja) | 2014-04-16 |
| US20070202057A1 (en) | 2007-08-30 |
| CN101384249B (zh) | 2011-11-30 |
| WO2007095600A2 (en) | 2007-08-23 |
| US20120125351A1 (en) | 2012-05-24 |
| WO2007095600A3 (en) | 2008-04-17 |
| BRPI0708068A2 (pt) | 2011-05-17 |
| JP2014037415A (ja) | 2014-02-27 |
| CN101384249A (zh) | 2009-03-11 |
| RU2008137032A (ru) | 2010-03-27 |
| US8871243B2 (en) | 2014-10-28 |
| US20150111928A1 (en) | 2015-04-23 |
| AU2007214474B2 (en) | 2011-01-20 |
| RU2436565C2 (ru) | 2011-12-20 |
| AU2007214474A1 (en) | 2007-08-23 |
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| EEER | Examination request | ||
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