JP2009526865A5 - - Google Patents
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- JP2009526865A5 JP2009526865A5 JP2008555472A JP2008555472A JP2009526865A5 JP 2009526865 A5 JP2009526865 A5 JP 2009526865A5 JP 2008555472 A JP2008555472 A JP 2008555472A JP 2008555472 A JP2008555472 A JP 2008555472A JP 2009526865 A5 JP2009526865 A5 JP 2009526865A5
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- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- moiety
- branched
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000002252 acyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000002015 acyclic group Chemical group 0.000 claims 10
- 125000001931 aliphatic group Chemical group 0.000 claims 10
- 125000004122 cyclic group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 102000003964 Histone deacetylase Human genes 0.000 claims 5
- 108090000353 Histone deacetylase Proteins 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000005110 aryl thio group Chemical group 0.000 claims 5
- 125000004104 aryloxy group Chemical group 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 5
- 125000005368 heteroarylthio group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 125000005122 aminoalkylamino group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical group C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 102100022537 Histone deacetylase 6 Human genes 0.000 claims 1
- 101000899330 Homo sapiens Histone deacetylase 6 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical group C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000009905 Neurofibromatoses Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 208000031066 hyperpigmentation of the skin Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- -1 monosubstituted phenyl Chemical group 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 201000004931 neurofibromatosis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000008470 skin growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77317206P | 2006-02-14 | 2006-02-14 | |
| US60/773,172 | 2006-02-14 | ||
| PCT/US2007/062152 WO2007095584A2 (en) | 2006-02-14 | 2007-02-14 | Histone Deacetylase Inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013008195A Division JP2013100327A (ja) | 2006-02-14 | 2013-01-21 | ヒストンデアセチラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526865A JP2009526865A (ja) | 2009-07-23 |
| JP2009526865A5 true JP2009526865A5 (cg-RX-API-DMAC7.html) | 2011-09-15 |
| JP5409015B2 JP5409015B2 (ja) | 2014-02-05 |
Family
ID=38372243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555472A Active JP5409015B2 (ja) | 2006-02-14 | 2007-02-14 | ヒストンデアセチラーゼ阻害剤 |
| JP2013008195A Pending JP2013100327A (ja) | 2006-02-14 | 2013-01-21 | ヒストンデアセチラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013008195A Pending JP2013100327A (ja) | 2006-02-14 | 2013-01-21 | ヒストンデアセチラーゼ阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8383855B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2010168B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP5409015B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN101528679A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007214458C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0707826B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2642288C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2010168T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2481413T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL193458A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2008010462A (cg-RX-API-DMAC7.html) |
| PL (1) | PL2010168T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2007095584A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| SG171690A1 (en) | 2005-03-22 | 2011-06-29 | Harvard College | Treatment of protein degradation disorders |
| AU2007345292B2 (en) | 2006-02-14 | 2013-10-31 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
| DK2010168T3 (da) * | 2006-02-14 | 2014-07-21 | Harvard College | Histondeacetylase-inhibitore |
| US8304451B2 (en) * | 2006-05-03 | 2012-11-06 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
| CN102164888B (zh) | 2008-07-23 | 2015-06-03 | 哈佛大学校长及研究员协会 | 脱乙酰酶抑制剂和其用途 |
| AU2010248292B2 (en) * | 2009-05-12 | 2014-06-12 | Amorepacific Corporation | Composition for preventing hair loss or for stimulating hair growth |
| WO2011019393A2 (en) | 2009-08-11 | 2011-02-17 | President And Fellows Of Harvard College | Class- and isoform-specific hdac inhibitors and uses thereof |
| CA2814696C (en) | 2010-10-13 | 2019-03-12 | Shape Pharmaceuticals, Inc. | Pharmaceutical formulation for histone deacetylase inhibitors |
| CN104447608B (zh) * | 2014-11-10 | 2017-01-11 | 华东师范大学 | 含有噻唑啉酮结构的异羟肟酸类小分子有机化合物及其衍生物、用途及其制备方法 |
| CN104744431A (zh) * | 2015-03-06 | 2015-07-01 | 芜湖杨燕制药有限公司 | 一种组蛋白去乙酰化酶抑制剂及其制备方法和用途 |
| US20230190717A1 (en) * | 2017-04-10 | 2023-06-22 | City Of Hope | P38 gamma inhibitors and method of use thereof |
| CN108299313B (zh) * | 2018-01-16 | 2020-10-02 | 长沙霍滋生物科技有限公司 | 一种化合物及其在药学上的应用 |
| CN111943892B (zh) * | 2019-05-17 | 2022-04-05 | 上海中泽医药科技有限公司 | 组蛋白去乙酰化酶亚型抑制剂硫乙酰芳胺类化合物及用途 |
| CN114748463A (zh) * | 2022-05-25 | 2022-07-15 | 中南大学湘雅医院 | Remetinostat在制备治疗银屑病的药物中的应用 |
| CN115364226A (zh) * | 2022-09-23 | 2022-11-22 | 华中科技大学同济医学院附属同济医院 | 组蛋白去乙酰化酶hdac3在制备防治支架及内膜剥脱术后血管再狭窄的药物中的应用 |
Family Cites Families (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3242252A1 (de) * | 1982-11-15 | 1984-05-17 | Bayer Ag, 5090 Leverkusen | Heterocyclisch substituierte hydroxyalkyl-azolyl-derivate |
| US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
| ES2008962A6 (es) | 1987-12-17 | 1989-08-16 | Marga Investigacion | Proceso para la preparacion de nuevos compuestos de 2-guanidinotiazol |
| JPH01224381A (ja) | 1988-03-04 | 1989-09-07 | Japan Tobacco Inc | トリコスタチン酸、トリコスタチンａの新規な合成中間体、及びトリコスタチン酸、トリコスタチンａの製造方法。 |
| EP0347381B1 (de) * | 1988-06-13 | 1992-02-12 | Ciba-Geigy Ag | Ungesättigte beta-Ketoesteracetale und ihre Anwendungen |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
| US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| AU6886791A (en) | 1989-11-13 | 1991-06-13 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| US5045538A (en) * | 1990-06-28 | 1991-09-03 | The Research Foundation Of State University Of New York | Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines |
| GB9026114D0 (en) * | 1990-11-30 | 1991-01-16 | Norsk Hydro As | New compounds |
| EP1046421B8 (en) | 1990-12-06 | 2006-01-11 | Affymetrix, Inc. (a Delaware Corporation) | Methods and reagents for very large scale immobilized polymer synthesis |
| EP0501919A1 (de) * | 1991-03-01 | 1992-09-02 | Ciba-Geigy Ag | Strahlungsempfindliche Zusammensetzungen auf der Basis von Polyphenolen und Acetalen |
| US5225173A (en) * | 1991-06-12 | 1993-07-06 | Idaho Research Foundation, Inc. | Methods and devices for the separation of radioactive rare earth metal isotopes from their alkaline earth metal precursors |
| USRE38506E1 (en) | 1991-10-04 | 2004-04-20 | Sloan-Kettering Institute For Cancer Research | Potent inducers of terminal differentiation and methods of use thereof |
| US5239113A (en) | 1991-10-15 | 1993-08-24 | Monsanto Company | Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof |
| ATE262374T1 (de) | 1991-11-22 | 2004-04-15 | Affymetrix Inc | Kombinatorische strategien für polymersynthese |
| US5359115A (en) | 1992-03-26 | 1994-10-25 | Affymax Technologies, N.V. | Methods for the synthesis of phosphonate esters |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| HUT72495A (en) | 1992-10-01 | 1996-05-28 | Cold Spring Harbor Lab | Complex combinatorial chemical libraries encoded with tags |
| US5480971A (en) | 1993-06-17 | 1996-01-02 | Houghten Pharmaceuticals, Inc. | Peralkylated oligopeptide mixtures |
| US5440016A (en) | 1993-06-18 | 1995-08-08 | Torrey Pines Institute For Molecular Studies | Peptides of the formula (KFmoc) ZZZ and their uses |
| US20030203976A1 (en) | 1993-07-19 | 2003-10-30 | William L. Hunter | Anti-angiogenic compositions and methods of use |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| US5362899A (en) | 1993-09-09 | 1994-11-08 | Affymax Technologies, N.V. | Chiral synthesis of alpha-aminophosponic acids |
| US5659016A (en) | 1994-09-22 | 1997-08-19 | Cancer Institute | RPDL protein and DNA encoding the same |
| US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
| US5837313A (en) | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| JP3330781B2 (ja) | 1995-05-22 | 2002-09-30 | 三菱エンジニアリングプラスチックス株式会社 | ポリカーボネート樹脂組成物 |
| WO1997011366A1 (en) | 1995-09-20 | 1997-03-27 | Merck & Co., Inc. | Histone deacetylase as target for antiprotozoal agents |
| JPH09124918A (ja) | 1995-10-30 | 1997-05-13 | Mitsubishi Eng Plast Kk | ポリカーボネート樹脂組成物 |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| US6777217B1 (en) * | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| TW517089B (en) | 1996-09-03 | 2003-01-11 | Res Dev Foundation | Assessment of intracellular cysteine and glutathione concentrations |
| US6068987A (en) * | 1996-09-20 | 2000-05-30 | Merck & Co., Inc. | Histone deacetylase as target for antiprotozoal agents |
| WO1998016830A2 (en) | 1996-10-16 | 1998-04-23 | The President And Fellows Of Harvard College | Droplet assay system |
| ZA9710342B (en) * | 1996-11-25 | 1998-06-10 | Alza Corp | Directional drug delivery stent and method of use. |
| US6273913B1 (en) | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
| ATE289295T1 (de) | 1997-04-22 | 2005-03-15 | Euro Celtique Sa | Die verwendung von durch carbozyklische und heterozyklische reste substituierte semicarbazonen und thiosemicarbazonen als natriumkanalblocker |
| US6190619B1 (en) * | 1997-06-11 | 2001-02-20 | Argonaut Technologies, Inc. | Systems and methods for parallel synthesis of compounds |
| US5891507A (en) | 1997-07-28 | 1999-04-06 | Iowa-India Investments Company Limited | Process for coating a surface of a metallic stent |
| US6195612B1 (en) * | 1998-01-05 | 2001-02-27 | Tama L. Pack-Harris | Pharmacy benefit management system and method of using same |
| US6428960B1 (en) | 1998-03-04 | 2002-08-06 | Onyx Pharmaceuticals, Inc. | Selection method for producing recombinant baculovirus |
| US6306866B1 (en) * | 1998-03-06 | 2001-10-23 | American Cyanamid Company | Use of aryl-substituted pyrimidines as insecticidal and acaricidal agents |
| US6153252A (en) | 1998-06-30 | 2000-11-28 | Ethicon, Inc. | Process for coating stents |
| US6248127B1 (en) * | 1998-08-21 | 2001-06-19 | Medtronic Ave, Inc. | Thromboresistant coated medical device |
| DE19846008A1 (de) | 1998-10-06 | 2000-04-13 | Bayer Ag | Phenylessigsäure-heterocyclylamide |
| WO2000034313A1 (en) * | 1998-12-10 | 2000-06-15 | F. Hoffmann-La Roche Ag | Procollagen c-proteinase inhibitors |
| AU3118200A (en) | 1998-12-14 | 2000-07-03 | Merck & Co., Inc. | Hiv integrase inhibitors |
| EP1140916B1 (en) | 1998-12-16 | 2002-11-13 | Aventis Pharma Limited | Heteroaryl-cyclic acetals |
| AR035313A1 (es) * | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
| US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
| SK3302002A3 (en) | 1999-09-08 | 2002-07-02 | Sloan Kettering Inst Cancer | Novel class of cytodifferentiating agents and histone deacetylase inhibitors, and methods of use thereof |
| US6203551B1 (en) | 1999-10-04 | 2001-03-20 | Advanced Cardiovascular Systems, Inc. | Chamber for applying therapeutic substances to an implant device |
| CA2391952C (en) | 1999-11-23 | 2012-01-31 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US6251136B1 (en) | 1999-12-08 | 2001-06-26 | Advanced Cardiovascular Systems, Inc. | Method of layering a three-coated stent using pharmacological and polymeric agents |
| US20030129724A1 (en) | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| ATE310719T1 (de) * | 2000-09-29 | 2005-12-15 | Topotarget Uk Ltd | Carbaminsäurederivate enthaltend eine amidgruppe als hdac-inhibitoren |
| US6495719B2 (en) | 2001-03-27 | 2002-12-17 | Circagen Pharmaceutical | Histone deacetylase inhibitors |
| AR035455A1 (es) | 2001-04-23 | 2004-05-26 | Hoffmann La Roche | Derivados triciclicos de alquilhidroxamato , procesos para su elaboracion, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos en la preparacion de medicamentos |
| WO2002089782A2 (en) | 2001-05-09 | 2002-11-14 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US6517889B1 (en) | 2001-11-26 | 2003-02-11 | Swaminathan Jayaraman | Process for coating a surface of a stent |
| US7148257B2 (en) | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| PL372239A1 (en) * | 2002-03-04 | 2005-07-11 | Aton Pharma, Inc. | Methods of inducing terminal differentiation |
| US7902185B2 (en) * | 2002-06-03 | 2011-03-08 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative diseases using proteasome modulators |
| TW200401638A (en) | 2002-06-20 | 2004-02-01 | Bristol Myers Squibb Co | Heterocyclic inhibitors of kinases |
| JP2006503082A (ja) * | 2002-10-17 | 2006-01-26 | メシルジーン、インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| JP5354836B2 (ja) * | 2002-11-06 | 2013-11-27 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | プロテアソームインヒビターを使用する癌を処置するための方法および組成物 |
| JP2006508986A (ja) | 2002-11-20 | 2006-03-16 | エルラント ゲネ セラペウチクス エルエルシー | ヒストンデアセチラーゼ阻害剤による肺細胞の治療方法 |
| US7652036B2 (en) * | 2003-02-25 | 2010-01-26 | Topotarget Uk Limited | Carbamic acid compounds comprising a bicyclic heteroaryl group as HDAC inhibitors |
| PE20050206A1 (es) | 2003-05-26 | 2005-03-26 | Schering Ag | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa |
| EP1644323B1 (en) | 2003-07-07 | 2015-03-18 | Georgetown University | Histone deacetylase inhibitors and methods of use thereof |
| WO2005012247A1 (en) | 2003-07-30 | 2005-02-10 | Hôpital Sainte-Justine | Compounds and methods for the rapid quantitative analysis of proteins and polypeptides |
| RU2356547C2 (ru) | 2003-08-26 | 2009-05-27 | Мерк ЭйчДиЭйСи Рисерч ЛЛС | Способы лечения рака с использованием ингибиторов hdac |
| US20050137234A1 (en) | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
| EP1718611A4 (en) * | 2004-02-13 | 2009-09-23 | Harvard College | 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION |
| WO2006006080A2 (en) | 2004-07-08 | 2006-01-19 | Bizmedic Co., Ltd. | Sodium channel agonist |
| US20070225350A1 (en) | 2004-12-03 | 2007-09-27 | Anderson Kenneth C | Compositions and methods for treating neoplastic diseases |
| JP2008522975A (ja) | 2004-12-03 | 2008-07-03 | ネレアス ファーマシューティカルズ インコーポレイテッド | ［３．２．０］複素環式化合物及びそれらのアナログを使用する方法 |
| SG171690A1 (en) * | 2005-03-22 | 2011-06-29 | Harvard College | Treatment of protein degradation disorders |
| AU2007345292B2 (en) | 2006-02-14 | 2013-10-31 | Dana-Farber Cancer Institute, Inc. | Bifunctional histone deacetylase inhibitors |
| DK2010168T3 (da) * | 2006-02-14 | 2014-07-21 | Harvard College | Histondeacetylase-inhibitore |
| US8304451B2 (en) * | 2006-05-03 | 2012-11-06 | President And Fellows Of Harvard College | Histone deacetylase and tubulin deacetylase inhibitors |
| US8088951B2 (en) * | 2006-11-30 | 2012-01-03 | Massachusetts Institute Of Technology | Epigenetic mechanisms re-establish access to long-term memory after neuronal loss |
-
2007
- 2007-02-14 DK DK07757000.0T patent/DK2010168T3/da active
- 2007-02-14 CA CA2642288A patent/CA2642288C/en active Active
- 2007-02-14 AU AU2007214458A patent/AU2007214458C1/en active Active
- 2007-02-14 CN CNA2007800087840A patent/CN101528679A/zh active Pending
- 2007-02-14 US US12/279,398 patent/US8383855B2/en active Active
- 2007-02-14 JP JP2008555472A patent/JP5409015B2/ja active Active
- 2007-02-14 WO PCT/US2007/062152 patent/WO2007095584A2/en not_active Ceased
- 2007-02-14 PL PL07757000T patent/PL2010168T3/pl unknown
- 2007-02-14 MX MX2008010462A patent/MX2008010462A/es active IP Right Grant
- 2007-02-14 BR BRPI0707826-9A patent/BRPI0707826B1/pt active IP Right Grant
- 2007-02-14 EP EP07757000.0A patent/EP2010168B1/en active Active
- 2007-02-14 ES ES07757000.0T patent/ES2481413T3/es active Active
- 2007-02-14 CN CN201310483521.2A patent/CN103739515B/zh active Active
-
2008
- 2008-08-14 IL IL193458A patent/IL193458A/en active IP Right Grant
-
2013
- 2013-01-21 JP JP2013008195A patent/JP2013100327A/ja active Pending
- 2013-07-17 US US13/944,320 patent/US20140213620A1/en not_active Abandoned
-
2014
- 2014-03-06 US US14/198,764 patent/US9199923B2/en active Active
-
2015
- 2015-09-23 US US14/862,679 patent/US9724321B2/en active Active
-
2017
- 2017-06-29 US US15/637,078 patent/US10172821B2/en active Active
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