JP2009526832A5 - - Google Patents
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- Publication number
- JP2009526832A5 JP2009526832A5 JP2008554878A JP2008554878A JP2009526832A5 JP 2009526832 A5 JP2009526832 A5 JP 2009526832A5 JP 2008554878 A JP2008554878 A JP 2008554878A JP 2008554878 A JP2008554878 A JP 2008554878A JP 2009526832 A5 JP2009526832 A5 JP 2009526832A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxo
- alkyl
- benzo
- oxazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000000217 alkyl group Chemical group 0.000 claims 29
- 150000001875 compounds Chemical class 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 8
- GTCAXTIRRLKXRU-UHFFFAOYSA-N methyl carbamate Chemical compound COC(N)=O GTCAXTIRRLKXRU-UHFFFAOYSA-N 0.000 claims 7
- -1 1,2,3-triazol-1-ylmethyl Chemical group 0.000 claims 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 5
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 241000894006 Bacteria Species 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 241000588621 Moraxella Species 0.000 claims 2
- 241000186367 Mycobacterium avium Species 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229910052757 nitrogen Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- UEWSCJGPMVIYJQ-LLVKDONJSA-N (5r)-3-(1-methyl-2-oxo-4,5-dihydro-3,1-benzoxazepin-7-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound C1=C2CCOC(=O)N(C)C2=CC=C1N1C[C@H](C(N)=O)OC1=O UEWSCJGPMVIYJQ-LLVKDONJSA-N 0.000 claims 1
- WLICVOPNJBIGRE-SNVBAGLBSA-N (5r)-3-(1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound C=1C=C2N(C)C(=O)OCC2=CC=1N1C[C@H](C(N)=O)OC1=O WLICVOPNJBIGRE-SNVBAGLBSA-N 0.000 claims 1
- UXPJRMKAUHGOCE-SECBINFHSA-N (5r)-3-(8-fluoro-1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound C=1C(F)=C2N(C)C(=O)OCC2=CC=1N1C[C@H](C(N)=O)OC1=O UXPJRMKAUHGOCE-SECBINFHSA-N 0.000 claims 1
- YKWCPZKKMHGBQK-SNVBAGLBSA-N (5r)-3-(8-fluoro-1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-n-methyl-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound O=C1O[C@@H](C(=O)NC)CN1C1=CC(F)=C(N(C)C(=O)OC2)C2=C1 YKWCPZKKMHGBQK-SNVBAGLBSA-N 0.000 claims 1
- XIUMCEOEBCANMI-GFCCVEGCSA-N (5r)-n-methyl-3-(1-methyl-2-oxo-4,5-dihydro-3,1-benzoxazepin-7-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound O=C1O[C@@H](C(=O)NC)CN1C1=CC=C(N(C)C(=O)OCC2)C2=C1 XIUMCEOEBCANMI-GFCCVEGCSA-N 0.000 claims 1
- SEVVMFJXWHWBJX-LLVKDONJSA-N (5r)-n-methyl-3-(1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound O=C1O[C@@H](C(=O)NC)CN1C1=CC=C(N(C)C(=O)OC2)C2=C1 SEVVMFJXWHWBJX-LLVKDONJSA-N 0.000 claims 1
- MJPNBDMITRCENY-LBPRGKRZSA-N 1-methyl-6-[(5r)-2-oxo-5-(triazol-1-ylmethyl)-1,3-oxazolidin-3-yl]-4h-3,1-benzoxazin-2-one Chemical compound C([C@H]1CN(C(O1)=O)C=1C=C2COC(=O)N(C2=CC=1)C)N1C=CN=N1 MJPNBDMITRCENY-LBPRGKRZSA-N 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241001112696 Clostridia Species 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 1
- 241000194032 Enterococcus faecalis Species 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000588655 Moraxella catarrhalis Species 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000194017 Streptococcus Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 208000009361 bacterial endocarditis Diseases 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 208000011323 eye infectious disease Diseases 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000007119 infective endocarditis Diseases 0.000 claims 1
- NYXHSRNBKJIQQG-UHFFFAOYSA-N methyl n-methylcarbamate Chemical compound CNC(=O)OC NYXHSRNBKJIQQG-UHFFFAOYSA-N 0.000 claims 1
- JEJNBRKUZXERTF-ZDUSSCGKSA-N n-[[(5s)-3-(1-methyl-2-oxo-4,5-dihydro-3,1-benzoxazepin-7-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound C1=C2CCOC(=O)N(C)C2=CC=C1N1C[C@H](CNC(C)=O)OC1=O JEJNBRKUZXERTF-ZDUSSCGKSA-N 0.000 claims 1
- XVTYGXVIJSGQKE-ZDUSSCGKSA-N n-[[(5s)-3-(1-methyl-2-oxo-4,5-dihydro-3,1-benzoxazepin-7-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]propanamide Chemical compound O=C1O[C@@H](CNC(=O)CC)CN1C1=CC=C(N(C)C(=O)OCC2)C2=C1 XVTYGXVIJSGQKE-ZDUSSCGKSA-N 0.000 claims 1
- PWHQRHQZASRMQE-LBPRGKRZSA-N n-[[(5s)-3-(1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound C=1C=C2N(C)C(=O)OCC2=CC=1N1C[C@H](CNC(C)=O)OC1=O PWHQRHQZASRMQE-LBPRGKRZSA-N 0.000 claims 1
- CJUXGGKJFYBDDN-LBPRGKRZSA-N n-[[(5s)-3-(1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]propanamide Chemical compound O=C1O[C@@H](CNC(=O)CC)CN1C1=CC=C(N(C)C(=O)OC2)C2=C1 CJUXGGKJFYBDDN-LBPRGKRZSA-N 0.000 claims 1
- RFHPWKPYKDTZNH-QMMMGPOBSA-N n-[[(5s)-3-(5,8-difluoro-1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound C=1C(F)=C2N(C)C(=O)OCC2=C(F)C=1N1C[C@H](CNC(C)=O)OC1=O RFHPWKPYKDTZNH-QMMMGPOBSA-N 0.000 claims 1
- BHAJBNXXGVSKTM-NSHDSACASA-N n-[[(5s)-3-(8-fluoro-1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound C=1C(F)=C2N(C)C(=O)OCC2=CC=1N1C[C@H](CNC(C)=O)OC1=O BHAJBNXXGVSKTM-NSHDSACASA-N 0.000 claims 1
- XQTFYTLXFLTPQF-NSHDSACASA-N n-[[(5s)-3-(8-fluoro-1-methyl-2-oxo-4h-3,1-benzoxazin-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]propanamide Chemical compound O=C1O[C@@H](CNC(=O)CC)CN1C1=CC(F)=C(N(C)C(=O)OC2)C2=C1 XQTFYTLXFLTPQF-NSHDSACASA-N 0.000 claims 1
- LVCYPXAIOVKHRW-LBPRGKRZSA-N n-[[(5s)-3-(9-fluoro-1-methyl-2-oxo-4,5-dihydro-3,1-benzoxazepin-7-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound C1=C2CCOC(=O)N(C)C2=C(F)C=C1N1C[C@H](CNC(C)=O)OC1=O LVCYPXAIOVKHRW-LBPRGKRZSA-N 0.000 claims 1
- JYMXDJZYWJPLHH-LBPRGKRZSA-N n-[[(5s)-3-(9-fluoro-1-methyl-2-oxo-4,5-dihydro-3,1-benzoxazepin-7-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]propanamide Chemical compound O=C1O[C@@H](CNC(=O)CC)CN1C1=CC(F)=C(N(C)C(=O)OCC2)C2=C1 JYMXDJZYWJPLHH-LBPRGKRZSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77307106P | 2006-02-14 | 2006-02-14 | |
| PCT/IB2007/000377 WO2007093904A1 (en) | 2006-02-14 | 2007-02-05 | Benzoxazinone and benzoxazepinone oxazolidinones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526832A JP2009526832A (ja) | 2009-07-23 |
| JP2009526832A5 true JP2009526832A5 (enExample) | 2011-04-07 |
Family
ID=38068038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554878A Withdrawn JP2009526832A (ja) | 2006-02-14 | 2007-02-05 | 抗菌剤としてのベンゾオキサジノンおよびベンゾオキサゼピノンオキサゾリジノン |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20090318431A1 (enExample) |
| EP (1) | EP1987025B1 (enExample) |
| JP (1) | JP2009526832A (enExample) |
| AT (1) | ATE443061T1 (enExample) |
| CA (1) | CA2642406A1 (enExample) |
| DE (1) | DE602007002476D1 (enExample) |
| DK (1) | DK1987025T3 (enExample) |
| ES (1) | ES2331930T3 (enExample) |
| WO (1) | WO2007093904A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010008922A (es) * | 2008-02-20 | 2010-09-07 | Actelion Pharmaceuticals Ltd | Compuestos antibioticos azatriciclicos. |
| ES2398939T3 (es) * | 2008-02-22 | 2013-03-22 | Actelion Pharmaceuticals Ltd. | Derivados de oxazolidinona |
| KR100980681B1 (ko) | 2008-09-16 | 2010-09-07 | 한국과학기술연구원 | 디플루오로페닐 유도체를 갖는 신규한 옥사졸리디논 유도체또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 하는 항생제 조성물 |
| US8722686B2 (en) | 2008-09-19 | 2014-05-13 | Pfizer Inc. | Hydroxamic acid derivatives useful as antibacterial agents |
| MY158520A (en) | 2008-10-07 | 2016-10-14 | Actelion Pharmaceuticals Ltd | Tricyclic oxazolidinone antibiotic compounds |
| CN102224151A (zh) | 2008-11-20 | 2011-10-19 | 万能药生物有限公司 | 新的抗微生物剂 |
| JP5696142B2 (ja) | 2009-06-26 | 2015-04-08 | パナセア バイオテック リミテッド | 新規アザビシクロヘキサン類 |
| CA2899583A1 (en) | 2009-12-16 | 2011-06-23 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| AU2012238374B2 (en) * | 2011-04-08 | 2015-04-02 | Pfizer Inc. | Isoxazole derivatives useful as antibacterial agents |
| UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
| GB2550437B (en) * | 2016-05-20 | 2021-06-23 | Bugworks Res Inc | Heterocyclic compounds useful as anti-bacterial agents and method for production |
| CN113264949B (zh) * | 2021-05-31 | 2022-04-05 | 西南大学 | 一类螺苯并噁嗪哌啶α,β-不饱和酮类衍生物的设计合成与应用 |
| CN114133360A (zh) * | 2021-11-30 | 2022-03-04 | 南京工业大学 | 一种含氟苯并[d]-1,3-氧氮杂卓化合物及其合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19802239A1 (de) * | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| WO2000029409A1 (de) * | 1998-11-17 | 2000-05-25 | Bayer Aktiengesellschaft | Neue heterocyclyl-substituierte oxazolidon-derivate |
| WO2005082897A1 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone antibacterial agents |
-
2007
- 2007-02-05 AT AT07705605T patent/ATE443061T1/de not_active IP Right Cessation
- 2007-02-05 EP EP07705605A patent/EP1987025B1/en active Active
- 2007-02-05 US US12/279,120 patent/US20090318431A1/en not_active Abandoned
- 2007-02-05 DK DK07705605T patent/DK1987025T3/da active
- 2007-02-05 WO PCT/IB2007/000377 patent/WO2007093904A1/en not_active Ceased
- 2007-02-05 JP JP2008554878A patent/JP2009526832A/ja not_active Withdrawn
- 2007-02-05 ES ES07705605T patent/ES2331930T3/es active Active
- 2007-02-05 CA CA002642406A patent/CA2642406A1/en not_active Abandoned
- 2007-02-05 DE DE602007002476T patent/DE602007002476D1/de active Active
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