JP2009525318A5 - - Google Patents
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- Publication number
- JP2009525318A5 JP2009525318A5 JP2008552906A JP2008552906A JP2009525318A5 JP 2009525318 A5 JP2009525318 A5 JP 2009525318A5 JP 2008552906 A JP2008552906 A JP 2008552906A JP 2008552906 A JP2008552906 A JP 2008552906A JP 2009525318 A5 JP2009525318 A5 JP 2009525318A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- bacteria
- pharmaceutical composition
- methyl
- isoxazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 241000894006 Bacteria Species 0.000 claims 6
- 208000035143 Bacterial infection Diseases 0.000 claims 5
- 208000022362 bacterial infectious disease Diseases 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- -1 1,2,3-triazol-1-ylmethyl Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 2
- 241000588621 Moraxella Species 0.000 claims 2
- 241000186359 Mycobacterium Species 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 241000194017 Streptococcus Species 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- FHNCXMGWWSWATC-SNVBAGLBSA-N (5r)-3-(3-methyl-1,2-benzoxazol-6-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound C=1C=C2C(C)=NOC2=CC=1N1C[C@H](C(N)=O)OC1=O FHNCXMGWWSWATC-SNVBAGLBSA-N 0.000 claims 1
- YBHCQYXCJGYJAQ-NSHDSACASA-N (5r)-3-(3-methyl-1,2-benzoxazol-6-yl)-5-(triazol-1-ylmethyl)-1,3-oxazolidin-2-one Chemical compound C([C@H]1CN(C(O1)=O)C=1C=C2ON=C(C2=CC=1)C)N1C=CN=N1 YBHCQYXCJGYJAQ-NSHDSACASA-N 0.000 claims 1
- MLBTUBZPBFSYLU-INIZCTEOSA-N (5r)-3-(3-methyl-1,2-benzoxazol-6-yl)-5-[[4-(2-trimethylsilylethynyl)triazol-1-yl]methyl]-1,3-oxazolidin-2-one Chemical compound C([C@H]1CN(C(O1)=O)C=1C=C2ON=C(C2=CC=1)C)N1C=C(C#C[Si](C)(C)C)N=N1 MLBTUBZPBFSYLU-INIZCTEOSA-N 0.000 claims 1
- LFIBOKAJICZQNE-LLVKDONJSA-N (5r)-n-methoxy-3-(3-methyl-1,2-benzoxazol-6-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound O=C1O[C@@H](C(=O)NOC)CN1C1=CC=C(C(C)=NO2)C2=C1 LFIBOKAJICZQNE-LLVKDONJSA-N 0.000 claims 1
- XPPNZDTXJBVDOT-LLVKDONJSA-N (5r)-n-methyl-3-(3-methyl-1,2-benzoxazol-6-yl)-2-oxo-1,3-oxazolidine-5-carboxamide Chemical compound O=C1O[C@@H](C(=O)NC)CN1C1=CC=C(C(C)=NO2)C2=C1 XPPNZDTXJBVDOT-LLVKDONJSA-N 0.000 claims 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241001112695 Clostridiales Species 0.000 claims 1
- 208000008960 Diabetic foot Diseases 0.000 claims 1
- 206010014666 Endocarditis bacterial Diseases 0.000 claims 1
- 241000194033 Enterococcus Species 0.000 claims 1
- 208000001860 Eye Infections Diseases 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 1
- 206010031252 Osteomyelitis Diseases 0.000 claims 1
- 208000005141 Otitis Diseases 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 241000295644 Staphylococcaceae Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000191963 Staphylococcus epidermidis Species 0.000 claims 1
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 1
- 241000193996 Streptococcus pyogenes Species 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 208000033354 avian tuberculosis Diseases 0.000 claims 1
- 208000009361 bacterial endocarditis Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000019258 ear infection Diseases 0.000 claims 1
- 206010014665 endocarditis Diseases 0.000 claims 1
- 208000011323 eye infectious disease Diseases 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 201000007119 infective endocarditis Diseases 0.000 claims 1
- 230000003902 lesion Effects 0.000 claims 1
- XSINJLZLAJNGPA-JTQLQIEISA-N methyl n-[[(5s)-3-(3-methyl-1,2-benzoxazol-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]carbamate Chemical compound O=C1O[C@@H](CNC(=O)OC)CN1C1=CC=C(C(C)=NO2)C2=C1 XSINJLZLAJNGPA-JTQLQIEISA-N 0.000 claims 1
- CDVAHUJLILRHKN-NSHDSACASA-N n-[[(5s)-3-(3-methyl-1,2-benzoxazol-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C1=CC=C(C(C)=NO2)C2=C1 CDVAHUJLILRHKN-NSHDSACASA-N 0.000 claims 1
- MAXZJAMYVNMHMI-NSHDSACASA-N n-[[(5s)-3-(3-methyl-1,2-benzoxazol-6-yl)-2-oxo-1,3-oxazolidin-5-yl]methyl]propanamide Chemical compound O=C1O[C@@H](CNC(=O)CC)CN1C1=CC=C(C(C)=NO2)C2=C1 MAXZJAMYVNMHMI-NSHDSACASA-N 0.000 claims 1
- 229910052757 nitrogen Chemical group 0.000 claims 1
- AQFWNELGMODZGC-UHFFFAOYSA-N o-ethylhydroxylamine Chemical compound CCON AQFWNELGMODZGC-UHFFFAOYSA-N 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76411306P | 2006-02-01 | 2006-02-01 | |
| PCT/IB2007/000179 WO2007088438A2 (en) | 2006-02-01 | 2007-01-22 | Benzisoxazole oxazolidinones as antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009525318A JP2009525318A (ja) | 2009-07-09 |
| JP2009525318A5 true JP2009525318A5 (enExample) | 2010-03-04 |
Family
ID=38222566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008552906A Withdrawn JP2009525318A (ja) | 2006-02-01 | 2007-01-22 | 抗菌剤としてのベンズイソオキサゾールオキサゾリジノン |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090221655A1 (enExample) |
| EP (1) | EP2032565A2 (enExample) |
| JP (1) | JP2009525318A (enExample) |
| CA (1) | CA2637811A1 (enExample) |
| WO (1) | WO2007088438A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7973065B2 (en) * | 2009-10-07 | 2011-07-05 | Shaw Intellectual Properties Holding, Inc. | Antimicrobial compounds |
| PL236949B1 (pl) * | 2018-06-07 | 2021-03-08 | Politechnika Wroclawska | 1-(Bromometylo)-2,6,6-trimetylooktahydro-2-benzofuran, sposób jego wytwarzania oraz zastosowanie w inhibicji aktywności ureazy bakteryjnej |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US112832A (en) * | 1871-03-21 | Improvement in apparatus for removing paint, varnish | ||
| US247622A (en) * | 1881-09-27 | Waltee e | ||
| US3597321A (en) * | 1969-04-17 | 1971-08-03 | Warner Lambert Pharmaceutical | Diagnostic compostion for the differentiation of staphylococci |
| WO1995024404A1 (en) * | 1994-03-11 | 1995-09-14 | Shaman Pharmaceuticals, Inc. | Preparation of symmetrical and unsymmetrical dithiin compounds |
| DE19514313A1 (de) * | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
| PL183919B1 (pl) * | 1995-06-02 | 2002-08-30 | Sanofi Synthelabo | Pochodne oksazolidynonu, sposób ich otrzymywania oraz ich farmaceutyczne zastosowanie |
| US20040247622A1 (en) * | 1999-06-02 | 2004-12-09 | Genesis Research And Development Corporation Limited | Methods and compounds for the treatment of immunologically-mediated diseases using Mycobacterium vaccae |
| US6942802B2 (en) * | 2001-04-13 | 2005-09-13 | Wyeth Holdings Corporation | Removal of bacterial endotoxin in a protein solution by immobilized metal affinity chromatography |
-
2007
- 2007-01-22 US US12/278,006 patent/US20090221655A1/en not_active Abandoned
- 2007-01-22 CA CA002637811A patent/CA2637811A1/en not_active Abandoned
- 2007-01-22 EP EP07700520A patent/EP2032565A2/en not_active Withdrawn
- 2007-01-22 WO PCT/IB2007/000179 patent/WO2007088438A2/en not_active Ceased
- 2007-01-22 JP JP2008552906A patent/JP2009525318A/ja not_active Withdrawn
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