JP2009526076A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009526076A5 JP2009526076A5 JP2008554430A JP2008554430A JP2009526076A5 JP 2009526076 A5 JP2009526076 A5 JP 2009526076A5 JP 2008554430 A JP2008554430 A JP 2008554430A JP 2008554430 A JP2008554430 A JP 2008554430A JP 2009526076 A5 JP2009526076 A5 JP 2009526076A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- substituted
- group
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SPEWLPMVLIUTHW-QFIPXVFZSA-N CC[C@](C(C=C1N2Cc3c(CC)c(cc(cc4)O)c4nc13)=C(CO1)C2=O)(C1=O)OS Chemical compound CC[C@](C(C=C1N2Cc3c(CC)c(cc(cc4)O)c4nc13)=C(CO1)C2=O)(C1=O)OS SPEWLPMVLIUTHW-QFIPXVFZSA-N 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77246406P | 2006-02-09 | 2006-02-09 | |
| US60/772,464 | 2006-02-09 | ||
| US80439106P | 2006-06-09 | 2006-06-09 | |
| US60/804,391 | 2006-06-09 | ||
| US84493806P | 2006-09-15 | 2006-09-15 | |
| US60/844,938 | 2006-09-15 | ||
| US86451606P | 2006-11-06 | 2006-11-06 | |
| US60/864,516 | 2006-11-06 | ||
| PCT/US2007/003808 WO2007092646A2 (en) | 2006-02-09 | 2007-02-09 | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526076A JP2009526076A (ja) | 2009-07-16 |
| JP2009526076A5 true JP2009526076A5 (https=) | 2010-03-25 |
| JP5265384B2 JP5265384B2 (ja) | 2013-08-14 |
Family
ID=38345853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008554430A Expired - Fee Related JP5265384B2 (ja) | 2006-02-09 | 2007-02-09 | 乳癌、結腸直腸癌、膵臓癌、卵巣癌及び肺癌の治療のための７−エチル−１０−ヒドロキシカンプトセシンのマルチアーム・ポリマー複合体 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1996208B1 (https=) |
| JP (1) | JP5265384B2 (https=) |
| KR (1) | KR20080091829A (https=) |
| CN (1) | CN101420963B (https=) |
| AU (1) | AU2007212201B2 (https=) |
| CA (1) | CA2640013A1 (https=) |
| ES (1) | ES2436109T3 (https=) |
| IL (1) | IL193164A0 (https=) |
| MX (1) | MX2008010303A (https=) |
| TW (1) | TWI426905B (https=) |
| WO (1) | WO2007092646A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7462627B2 (en) * | 2006-02-09 | 2008-12-09 | Enzon Pharmaceuticals, Inc. | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers |
| US7671067B2 (en) | 2006-02-09 | 2010-03-02 | Enzon Pharmaceuticals, Inc. | Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin |
| KR20090108082A (ko) * | 2007-02-09 | 2009-10-14 | 엔존 파마슈티컬즈, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신 다분지형 고분자 접합체를 이용한 내성 또는 불응성 암의 치료방법 |
| TW201010732A (en) * | 2008-08-29 | 2010-03-16 | Enzon Pharmaceuticals Inc | Method of treating RAS associated cancer |
| KR20110075029A (ko) * | 2008-10-21 | 2011-07-05 | 엔즌 파마슈티칼스, 인코포레이티드 | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 |
| CN102395370A (zh) * | 2009-04-17 | 2012-03-28 | 安龙制药公司 | 用7-乙基-10-羟基喜树碱的多臂聚合缀合物抑制血管生成的方法 |
| EP2771034B1 (en) | 2011-10-25 | 2018-08-08 | Nektar Therapeutics | Topoisomerase-i and-ii inhibitors for use in the treatment of patients suffering from cancer |
| WO2014085571A1 (en) | 2012-11-28 | 2014-06-05 | Nektar Therapeutics | Method for assessing and predicting efficacy of breast cancer treatment with a long-acting topoisomerase i inhibitor |
| WO2014194289A1 (en) | 2013-05-31 | 2014-12-04 | Nektar Therapeutics | Method for predicting and evaluating responsiveness to cancer treatment with dna-damaging chemotherapeutic agents |
| CN104650342B (zh) * | 2013-11-18 | 2018-07-10 | 江苏豪森药业集团有限公司 | 多支链聚合药物前体及其应用 |
| MX386070B (es) | 2014-01-14 | 2025-03-18 | Nektar Therapeutics | Metodo de tratamiento basado en combinacion. |
| CN110448533B (zh) * | 2014-12-05 | 2022-03-29 | 天津键凯科技有限公司 | 一种聚乙二醇修饰的喜树碱类衍生物的药物组合物及其制备方法 |
| CN106831853B (zh) * | 2017-02-15 | 2019-02-22 | 浙江海正药业股份有限公司 | 7-乙基-10-o-叔丁基二苯基硅基喜树碱-20-o-甘氨酸盐酸盐的制备工艺 |
| CN108727584B (zh) * | 2017-04-21 | 2021-01-05 | 博瑞生物医药（苏州）股份有限公司 | 抗癌偶联物 |
| CN108727583B (zh) * | 2017-04-21 | 2022-03-22 | 高瑞耀业(北京)科技有限公司 | 多臂靶向抗癌偶联物 |
| CN108164419B (zh) * | 2017-12-25 | 2021-03-16 | 武汉大学 | 单分散聚乙二醇单甲醚修饰的丙泊酚前药的制备与应用 |
| CN115515652A (zh) * | 2021-04-14 | 2022-12-23 | 北京博辉瑞进生物科技有限公司 | 一种医用水凝胶及其制备方法和用途 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880131A (en) * | 1993-10-20 | 1999-03-09 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
| AU722492B2 (en) * | 1996-08-30 | 2000-08-03 | University Of Hawaii | Pharmaceutical compounds |
| US20040009229A1 (en) * | 2000-01-05 | 2004-01-15 | Unger Evan Charles | Stabilized nanoparticle formulations of camptotheca derivatives |
| US6548488B2 (en) * | 2000-03-17 | 2003-04-15 | Aventis Pharma S.A. | Composition comprising camptothecin or a camptothecin derivative and an alkylating agent for the treatment of cancer |
| US7132423B2 (en) * | 2001-09-21 | 2006-11-07 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| CA2513133A1 (en) * | 2003-01-16 | 2004-07-29 | Techno Mart Co., Ltd. | Porphyrin derivatives |
| DE10307787A1 (de) * | 2003-02-24 | 2004-09-02 | Ktb Tumorforschungsgesellschaft Mbh | Protein-bindende Camptothecin-Derivate |
| AU2004228668B2 (en) * | 2003-04-03 | 2011-10-27 | Park Funding, Llc | PI-3 kinase inhibitor prodrugs |
| HUE047569T2 (hu) * | 2003-04-11 | 2020-04-28 | Ptc Therapeutics Inc | 1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása |
| TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
| US20040247624A1 (en) * | 2003-06-05 | 2004-12-09 | Unger Evan Charles | Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility |
| CA2537336C (en) * | 2003-09-17 | 2013-02-26 | Nektar Therapeutics Al, Corporation | Multi-arm polymer prodrugs |
| WO2005068424A1 (en) * | 2004-01-20 | 2005-07-28 | Cell Therapeutics Europe S.R.L. | Indolinone derivatives as receptor tyrosine kinase ihibitors |
| TW200530236A (en) * | 2004-02-23 | 2005-09-16 | Chugai Pharmaceutical Co Ltd | Heteroaryl phenylurea |
| ITRM20040239A1 (it) * | 2004-05-13 | 2004-08-13 | Sigma Tau Ind Farmaceuti | Derivati ciclopeptidici ad attivita' antintegrine. |
-
2007
- 2007-02-09 KR KR1020087021163A patent/KR20080091829A/ko not_active Withdrawn
- 2007-02-09 EP EP07763709.8A patent/EP1996208B1/en not_active Not-in-force
- 2007-02-09 JP JP2008554430A patent/JP5265384B2/ja not_active Expired - Fee Related
- 2007-02-09 AU AU2007212201A patent/AU2007212201B2/en not_active Ceased
- 2007-02-09 ES ES07763709T patent/ES2436109T3/es active Active
- 2007-02-09 CN CN2007800127903A patent/CN101420963B/zh not_active Expired - Fee Related
- 2007-02-09 MX MX2008010303A patent/MX2008010303A/es unknown
- 2007-02-09 CA CA002640013A patent/CA2640013A1/en not_active Abandoned
- 2007-02-09 WO PCT/US2007/003808 patent/WO2007092646A2/en not_active Ceased
- 2007-02-09 TW TW096104772A patent/TWI426905B/zh not_active IP Right Cessation
-
2008
- 2008-07-31 IL IL193164A patent/IL193164A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009526076A5 (https=) | ||
| JP2010518120A5 (https=) | ||
| JP2010503691A5 (https=) | ||
| ES2436109T3 (es) | Conjugados poliméricos de múltiples brazos de 7-etil-10-hidroxicamptotecina para el tratamiento del cáncer de mama, del cáncer colorrectal, del cáncer de páncreas, de ovario y de pulmón | |
| US7462627B2 (en) | Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers | |
| RU2009133793A (ru) | Лечение резистентных или невосприимчивых форм рака конъюгатами 7-этил-10-гидроксикампотецина с множеством ответвлений цепи | |
| RU2388765C2 (ru) | Натрийуретические соединения, конъюгаты и их применение | |
| CN107412740B (zh) | 聚乙二醇基肾上腺髓质素前药及其用途 | |
| FI20050932A7 (fi) | Heterobifunktionaaliset polymeeriset biokonjugaatit | |
| BR0009338A (pt) | Composto, processo para a preparação do mesmo,composição farmacêutica, processo para apreparação da mesma, uso de um composto, e,método de tratamento de uma doençainflamatória em um paciente sofrendo ou em riscode dita doença | |
| KR930000512A (ko) | 헤테로사이클 화합물, 이의 제조방법 및 용도 | |
| KR20120057588A (ko) | 가변 속도 방출 링커를 포함하는 폴리알 약물 접합체 | |
| KR20090057235A (ko) | 리신계 폴리머 링커 | |
| CA2537336A1 (en) | Multi-arm polymer prodrugs | |
| JP2010533202A (ja) | 多置換芳香族部分を含むポリマー性薬剤送達システム | |
| JP2004339237A (ja) | 治療効果のあるペプチド誘導体 | |
| KR20090085080A (ko) | 중합체 컨쥬게이트의 제조 방법 | |
| TW200510429A (en) | Heterocyclic MCHR1 antagonists | |
| KR20110075029A (ko) | 7-에틸-10-하이드록시캄토테신의 다중-암 고분자 컨쥬게이트로 신경모세포종의 치료 | |
| ES2325832T3 (es) | Procedimiento de preparacion de derivados de taxano aminoacidicos y conjugados polimericos que contienen los mismos. | |
| JP2008504235A5 (https=) | ||
| CN116133693B (zh) | 载药的大分子及其制备方法 | |
| US6593334B1 (en) | Camptothecin-taxoid conjugates as antimitotic and antitumor agents | |
| EP1142883A4 (en) | HETEROCYCLIC COMPOUNDS AND MEDICINAL COMPOSITIONS THAT CONTAIN THEM | |
| CN101287500A (zh) | 多药物配体缀合物 |