JP2009525991A - 医薬製剤 - Google Patents
医薬製剤 Download PDFInfo
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- JP2009525991A JP2009525991A JP2008553612A JP2008553612A JP2009525991A JP 2009525991 A JP2009525991 A JP 2009525991A JP 2008553612 A JP2008553612 A JP 2008553612A JP 2008553612 A JP2008553612 A JP 2008553612A JP 2009525991 A JP2009525991 A JP 2009525991A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
当該副次的単位は、EP 1 185 253 B1の状況において、固体薬物製剤形態であり、これは、特定の活性化合物および/またはその特定の生理学的に許容し得る塩に加えて、通常の補助添加剤を含む[0010]。
EP 1 185 253 B1に記載されている経口投与単位は、小袋、カプセルまたは錠剤の形態であり得る[0023]。
本発明の医薬製剤のための微小錠剤はすべて、同一の密度を有し、この結果容易に投薬し、混ぜ合わせて、個別の製剤を得ることができる。
本発明の製剤を、患者により容易に投与することができる。
構成成分は、本発明の医薬製剤中に、概して均一に分布する。同一の密度を有する個別の微小錠剤の結果、当該構成成分の均一な分布は、依然として一定であり;異なる密度による本発明の製剤における微小錠剤の分離は、起こり得ない。
本発明の状況において、異なるの活性化合物または活性化合物の組み合わせを、種々の微小錠剤にわたり分布させる。この手段により、個別の製剤において活性化合物の含量を変化させ、かつこれを、個別の患者の個別の要求に適合させることが、容易に可能である。
本発明の状況において、個別化された標準的な製剤を提供することもまた、当然可能である。
本発明の医薬製剤を、投薬スプーンにより容易に投与することができる。その理由は、微小錠剤の均一な分布により、構成成分もまた均一に分布するからである。したがって、当該微小錠剤をカプセル中に包装する必要はない。
本発明の状況での活性化合物には、例えば、自体公知の医薬品、ホモエオパシカル的に(homoeopathically)作用する物質、ビタミン類、ミネラル、プロバイオティック活性化合物、酵素、食物サプリメントおよび植物エキスが含まれる。
ビタミン類、例えばビオチン、コリン、コバラミン(B12)、葉酸塩類、イノシトール、ナイアシン(B3)、PABA(パラ−アミノ安息香酸)、パントテン酸(B5)、ピリドキシン(B6)、リボフラビン(B2)、チアミン(B1)、トコフェロール類、トコトリエノール類、ビタミンA、ビタミンB、ビタミンC、ビタミンD、天然のビタミンE、合成のビタミンEおよびビタミンK。当該ビタミン類は、合成の、または天然の起源であってもよく、またカプセル封入された状態であってもよい。
他の製剤の場合において、異なるの重量および他の空間的形状を有する微小錠剤を、当然用いることができる。
微小錠剤の空間的形状を、原則として、所望により選択することができる。しかし、当該空間的形状は、均質化の間個別の微小錠剤からの妨害がないようにしなければならない。
本発明の状況での円筒形形状の微小錠剤の大きさは、一般的に、各々の場合において約1〜約4mm、好ましくは1〜2.5mmの高さおよび直径を有することができる。
本発明の製剤の状況での微小錠剤は、極めて正確に作用し、国際薬局方の状況において極めて軽微な逸脱のみを可能にする。
本発明の製剤中の微小錠剤の均質化(即ち均一な分布)を、自体公知の方法により行うことができる。微小錠剤は、この間破壊されない。
本発明に従って調製された製剤を、ビン中に安定な方式で長期間にわたり貯蔵することができ、投与の間ビンから計量器中に充填することができる。処方箋の組成および流動性は、ここで維持される。
本発明の製剤を、有利な方式で容易に調製し、個別化された形態で容易に投与することができる。これらは、疾患の処置および防止のための剤の投与可能性を、新規な方式で拡張する。
疾患兆候の処置のための糖尿病患者用の製剤。以下の4つのタイプがある。
Bio - fruits n Greens 1日あたり2,000mg×30日=60グラム−酸化防止剤
Bio-Glucoban 1日あたり350mg×30=10.5グラム−4種のエキス(Mormodica charantia、Legerstroemia speciosa、Centella asiaticaおよびアルファ−リポ酸)、これは、フィトインスリン(phytoinsulin)として、細胞中へのグルコースの一層良好な輸送のための、およびインスリン耐性を低下させるための循環を改善する効果を有する。
Bio-Eye Health 1日あたり250mg×30=7.5グラム−カロテノイド、ルテイン、アスタキサンチンの組み合わせ、視力がすでに損なわれている場合。
Bio-CardioHealth−1日あたり500mg×30=15グラム−天然トコトリエノール類およびトコフェロール類(広範囲のビタミンE)、天然のビタミンCおよびコエンザイムQ10の組み合わせ。
投与量は、患者の体重および臨床像に依存する。
微小錠剤は、円筒形であり、2mmの高さおよび2mmの直径を有する。
所定の投与量に従って、4種の異なるタイプの微小錠剤を、振盪ビーカー中で均質にし、計量器で取り出すことができる。製剤は、容易に流動性である。
Claims (8)
- 微小錠剤をベースとする医薬製剤であって、該医薬製剤が、異なる構成成分を含む種々の微小錠剤を含み、各々の微小錠剤が、同一の空間的形状および同一の重量を有することを特徴とする、前記医薬製剤。
- 微小錠剤が、均質な混合物で存在することを特徴とする、請求項1に記載の医薬製剤。
- 医薬活性化合物、補助物質および充填剤を、微小錠剤の構成成分として用いることを特徴とする、請求項1または2に記載の医薬製剤。
- 微小錠剤が、円筒形の、楕円形の、または球形の空間的形状を有することを特徴とする、請求項1〜3のいずれかに記載の医薬製剤。
- 微小錠剤が、1〜3mmの高さおよび1〜3mmの直径を有する円筒形の形状を有することを特徴とする、請求項1〜4のいずれかに記載の医薬製剤。
- 微小錠剤が、4〜8mgの範囲内の重量を有することを特徴とする、請求項1〜5のいずれかに記載の医薬製剤。
- 異なる構成成分を含む微小錠剤をベースとする医薬製剤の製造方法であって、同一の空間的形状および同一の重量を有する微小錠剤を均質に混合することを特徴とする、前記方法。
- 各々の微小錠剤が同一の空間的形状および同一の重量を有する、異なるの構成成分を有する種々の微小錠剤を含む製剤の、疾患の処置および防止のための組成物としての使用。
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DE102006006532.8 | 2006-02-10 | ||
PCT/DE2007/000415 WO2007090393A2 (de) | 2006-02-10 | 2007-02-09 | Pharmazeutische zubereitung auf basis vom mikrotabletten |
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EP (1) | EP1986613B1 (ja) |
JP (1) | JP5756589B2 (ja) |
CN (1) | CN101378734B (ja) |
AU (1) | AU2007214173B2 (ja) |
BR (1) | BRPI0708037A2 (ja) |
CA (1) | CA2642082C (ja) |
DE (1) | DE102006006532B4 (ja) |
ES (1) | ES2391201T3 (ja) |
HK (1) | HK1125295A1 (ja) |
MX (1) | MX2008010217A (ja) |
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Also Published As
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MX2008010217A (es) | 2008-10-31 |
CN101378734B (zh) | 2015-06-03 |
WO2007090393A2 (de) | 2007-08-16 |
DE102006006532A1 (de) | 2007-08-23 |
EP1986613A2 (de) | 2008-11-05 |
AU2007214173B2 (en) | 2012-11-15 |
HK1125295A1 (en) | 2009-08-07 |
BRPI0708037A2 (pt) | 2011-05-17 |
CN101378734A (zh) | 2009-03-04 |
RU2448689C2 (ru) | 2012-04-27 |
CA2642082C (en) | 2015-04-14 |
RU2008136408A (ru) | 2010-03-20 |
EP1986613B1 (de) | 2012-07-11 |
ES2391201T3 (es) | 2012-11-22 |
US8883205B2 (en) | 2014-11-11 |
DE102006006532B4 (de) | 2007-11-08 |
US20090175936A1 (en) | 2009-07-09 |
CA2642082A1 (en) | 2007-08-16 |
AU2007214173A1 (en) | 2007-08-16 |
JP5756589B2 (ja) | 2015-07-29 |
WO2007090393A3 (de) | 2008-02-21 |
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