JP2009521926A5 - - Google Patents
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- Publication number
- JP2009521926A5 JP2009521926A5 JP2008548690A JP2008548690A JP2009521926A5 JP 2009521926 A5 JP2009521926 A5 JP 2009521926A5 JP 2008548690 A JP2008548690 A JP 2008548690A JP 2008548690 A JP2008548690 A JP 2008548690A JP 2009521926 A5 JP2009521926 A5 JP 2009521926A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- human
- inhibits
- proteases
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000018102 proteins Nutrition 0.000 claims 106
- 102000004169 proteins and genes Human genes 0.000 claims 106
- 108090000623 proteins and genes Proteins 0.000 claims 106
- 102000035195 Peptidases Human genes 0.000 claims 85
- 108091005804 Peptidases Proteins 0.000 claims 85
- 239000004365 Protease Substances 0.000 claims 79
- 235000019419 proteases Nutrition 0.000 claims 45
- 239000000203 mixture Substances 0.000 claims 25
- 230000002401 inhibitory effect Effects 0.000 claims 22
- 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 claims 12
- 102000052502 human ELANE Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 11
- 229920001184 polypeptide Polymers 0.000 claims 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims 11
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 239000003814 drug Substances 0.000 claims 9
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 claims 7
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 claims 7
- 239000011159 matrix material Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- LKDMKWNDBAVNQZ-UHFFFAOYSA-N 4-[[1-[[1-[2-[[1-(4-nitroanilino)-1-oxo-3-phenylpropan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoic acid Chemical compound OC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC=1C=CC(=CC=1)[N+]([O-])=O)CC1=CC=CC=C1 LKDMKWNDBAVNQZ-UHFFFAOYSA-N 0.000 claims 6
- 102100025975 Cathepsin G Human genes 0.000 claims 6
- 108090000617 Cathepsin G Proteins 0.000 claims 6
- 108010088842 Fibrinolysin Proteins 0.000 claims 6
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 6
- 102000005741 Metalloproteases Human genes 0.000 claims 6
- 108010006035 Metalloproteases Proteins 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108010077021 depelestat Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 229940012957 plasmin Drugs 0.000 claims 6
- 235000019833 protease Nutrition 0.000 claims 6
- 101000605522 Homo sapiens Kallikrein-1 Proteins 0.000 claims 5
- 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 claims 5
- 101001091371 Homo sapiens Kallikrein-8 Proteins 0.000 claims 5
- 108060005989 Tryptase Proteins 0.000 claims 5
- 102000001400 Tryptase Human genes 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 5
- 102000053974 human KLK6 Human genes 0.000 claims 5
- 101001091365 Homo sapiens Plasma kallikrein Proteins 0.000 claims 4
- 101000872580 Homo sapiens Serine protease hepsin Proteins 0.000 claims 4
- 102000016387 Pancreatic elastase Human genes 0.000 claims 4
- 108010067372 Pancreatic elastase Proteins 0.000 claims 4
- 235000018417 cysteine Nutrition 0.000 claims 4
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 102000046144 human HPN Human genes 0.000 claims 4
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 108020004705 Codon Proteins 0.000 claims 3
- 208000011231 Crohn disease Diseases 0.000 claims 3
- 101001008919 Homo sapiens Kallikrein-10 Proteins 0.000 claims 3
- 102100034870 Kallikrein-8 Human genes 0.000 claims 3
- 108010028275 Leukocyte Elastase Proteins 0.000 claims 3
- 102000016799 Leukocyte elastase Human genes 0.000 claims 3
- 208000019693 Lung disease Diseases 0.000 claims 3
- 102100027998 Macrophage metalloelastase Human genes 0.000 claims 3
- 101710187853 Macrophage metalloelastase Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000003827 Plasma Kallikrein Human genes 0.000 claims 3
- 108090000113 Plasma Kallikrein Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000013595 glycosylation Effects 0.000 claims 3
- 238000006206 glycosylation reaction Methods 0.000 claims 3
- 102000057647 human KLK10 Human genes 0.000 claims 3
- 201000006417 multiple sclerosis Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 230000000414 obstructive effect Effects 0.000 claims 3
- 230000002685 pulmonary effect Effects 0.000 claims 3
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 3
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 2
- 102100026802 72 kDa type IV collagenase Human genes 0.000 claims 2
- 101710151806 72 kDa type IV collagenase Proteins 0.000 claims 2
- 108010039627 Aprotinin Proteins 0.000 claims 2
- 108090000317 Chymotrypsin Proteins 0.000 claims 2
- 102100027995 Collagenase 3 Human genes 0.000 claims 2
- 108050005238 Collagenase 3 Proteins 0.000 claims 2
- 101000655897 Homo sapiens Serine protease 1 Proteins 0.000 claims 2
- 101000661807 Homo sapiens Suppressor of tumorigenicity 14 protein Proteins 0.000 claims 2
- 101000848014 Homo sapiens Trypsin-2 Proteins 0.000 claims 2
- 108090000973 Myeloblastin Proteins 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims 2
- 102100030416 Stromelysin-1 Human genes 0.000 claims 2
- 101710108790 Stromelysin-1 Proteins 0.000 claims 2
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims 2
- 201000003229 acute pancreatitis Diseases 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 229960002376 chymotrypsin Drugs 0.000 claims 2
- 102000057705 human KLK8 Human genes 0.000 claims 2
- 102000048529 human PRSS1 Human genes 0.000 claims 2
- 102000043864 human PRSS2 Human genes 0.000 claims 2
- 102000051039 human ST14 Human genes 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims 2
- 210000000440 neutrophil Anatomy 0.000 claims 2
- 208000020431 spinal cord injury Diseases 0.000 claims 2
- 102000005572 Cathepsin A Human genes 0.000 claims 1
- 108010059081 Cathepsin A Proteins 0.000 claims 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims 1
- 108010054265 Factor VIIa Proteins 0.000 claims 1
- 108010074860 Factor Xa Proteins 0.000 claims 1
- 108090001101 Hepsin Proteins 0.000 claims 1
- 102000004989 Hepsin Human genes 0.000 claims 1
- 101800001691 Inter-alpha-trypsin inhibitor light chain Proteins 0.000 claims 1
- 102400001240 Inter-alpha-trypsin inhibitor light chain Human genes 0.000 claims 1
- 102000001399 Kallikrein Human genes 0.000 claims 1
- 108060005987 Kallikrein Proteins 0.000 claims 1
- 108010091175 Matriptase Proteins 0.000 claims 1
- 102100024131 Matrix metalloproteinase-25 Human genes 0.000 claims 1
- 230000004988 N-glycosylation Effects 0.000 claims 1
- 101800000838 Neutrophil cationic peptide 1 Proteins 0.000 claims 1
- 102100030411 Neutrophil collagenase Human genes 0.000 claims 1
- 101710118230 Neutrophil collagenase Proteins 0.000 claims 1
- 101710180012 Protease 7 Proteins 0.000 claims 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims 1
- 102000012479 Serine Proteases Human genes 0.000 claims 1
- 108010022999 Serine Proteases Proteins 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 102100037942 Suppressor of tumorigenicity 14 protein Human genes 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 230000015556 catabolic process Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000003776 cleavage reaction Methods 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 238000006731 degradation reaction Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 229940012414 factor viia Drugs 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 230000002209 hydrophobic effect Effects 0.000 claims 1
- 125000001165 hydrophobic group Chemical group 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 108090000440 matrix metalloproteinase 25 Proteins 0.000 claims 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 230000007017 scission Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75490305P | 2005-12-29 | 2005-12-29 | |
| US60/754,903 | 2005-12-29 | ||
| PCT/US2006/049322 WO2007079096A2 (en) | 2005-12-29 | 2006-12-27 | Protease inhibition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012196306A Division JP2012235793A (ja) | 2005-12-29 | 2012-09-06 | プロテアーゼ阻害 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009521926A JP2009521926A (ja) | 2009-06-11 |
| JP2009521926A5 true JP2009521926A5 (https=) | 2010-01-21 |
| JP5632126B2 JP5632126B2 (ja) | 2014-11-26 |
Family
ID=38228815
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548690A Active JP5632126B2 (ja) | 2005-12-29 | 2006-12-27 | プロテアーゼ阻害 |
| JP2012196306A Pending JP2012235793A (ja) | 2005-12-29 | 2012-09-06 | プロテアーゼ阻害 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012196306A Pending JP2012235793A (ja) | 2005-12-29 | 2012-09-06 | プロテアーゼ阻害 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8828703B2 (https=) |
| EP (1) | EP1981519B1 (https=) |
| JP (2) | JP5632126B2 (https=) |
| AU (1) | AU2006332774A1 (https=) |
| CA (1) | CA2635589C (https=) |
| CY (1) | CY1119967T1 (https=) |
| DK (1) | DK1981519T3 (https=) |
| ES (1) | ES2663497T3 (https=) |
| HU (1) | HUE038243T2 (https=) |
| LT (1) | LT1981519T (https=) |
| PL (1) | PL1981519T3 (https=) |
| PT (1) | PT1981519T (https=) |
| SI (1) | SI1981519T1 (https=) |
| WO (1) | WO2007079096A2 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6057287A (en) | 1994-01-11 | 2000-05-02 | Dyax Corp. | Kallikrein-binding "Kunitz domain" proteins and analogues thereof |
| US20050222023A1 (en) * | 2002-02-07 | 2005-10-06 | Hans-Peter Hauser | Albumin-fused kunitz domain peptides |
| ES2348230T3 (es) * | 2002-06-07 | 2010-12-01 | Dyax Corp. | Prevención y reducción de la isquemia. |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| EP2386310B1 (en) | 2002-08-28 | 2018-11-07 | Dyax Corp. | Methods for preserving organs and tissues |
| US20050089515A1 (en) * | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| JP5362349B2 (ja) | 2005-04-15 | 2013-12-11 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | タンパク質を精製する方法 |
| JP2010505437A (ja) | 2006-10-13 | 2010-02-25 | ノボ ノルディスク ヘルス ケア アーゲー | 塩基性タンパク質タグに融合したプロセシング酵素 |
| US20090075887A1 (en) * | 2007-08-21 | 2009-03-19 | Genzyme Corporation | Treatment with Kallikrein Inhibitors |
| WO2009026539A1 (en) * | 2007-08-23 | 2009-02-26 | Genzyme Corporation | Treatment with kallikrein inhibitors |
| JP2013533206A (ja) * | 2008-10-22 | 2013-08-22 | ダイアクス コーポレーション | 炎症性障害のための、プロテアーゼ結合タンパク質を含む併用療法 |
| US8637454B2 (en) | 2009-01-06 | 2014-01-28 | Dyax Corp. | Treatment of mucositis with kallikrein inhibitors |
| AU2010222537B2 (en) * | 2009-03-10 | 2016-06-30 | Med Discovery Sa | Use of serine protease inhibitors in the treatment of neutropenia |
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| SMT201800552T1 (it) | 2010-01-06 | 2018-11-09 | Dyax Corp | Proteine che legano la callicreina plasmatica |
| US9597379B1 (en) * | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| KR102320178B1 (ko) | 2011-01-06 | 2021-11-02 | 다케다 파머수티컬 컴패니 리미티드 | 혈장 칼리크레인 결합 단백질 |
| WO2013059439A2 (en) | 2011-10-21 | 2013-04-25 | Dyax Corp. | Combination therapy comprising an mmp-14 binding protein |
| ES2886531T3 (es) | 2013-01-07 | 2021-12-20 | Omniox Inc | Formas poliméricas de proteínas H-NOX |
| EP4234583A3 (en) | 2013-01-20 | 2024-01-24 | Takeda Pharmaceutical Company Limited | Evaluation and treatment of bradykinin-mediated disorders |
| WO2015061183A1 (en) | 2013-10-21 | 2015-04-30 | Dyax Corp. | Assays for determining plasma kallikrein system biomarkers |
| CA2927695C (en) * | 2013-10-21 | 2022-03-01 | Dyax Corp. | Diagnosis and treatment of autoimmune diseases |
| PL3110434T3 (pl) | 2014-02-24 | 2019-01-31 | Takeda Gmbh | Białka fuzyjne uti |
| US10428158B2 (en) | 2014-03-27 | 2019-10-01 | Dyax Corp. | Compositions and methods for treatment of diabetic macular edema |
| CA2979974A1 (en) | 2015-03-17 | 2016-09-22 | Omniox, Inc. | Modulation of tumor immunity by protein-mediated o2 delivery |
| EP4354146B1 (en) | 2015-10-19 | 2026-04-15 | Takeda Pharmaceutical Company Limited | Immunoassay for the detection of cleaved high molecular weight kininogen |
| EP3387018A1 (en) | 2015-12-11 | 2018-10-17 | Dyax Corp. | Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack |
| JP6467073B2 (ja) * | 2018-01-04 | 2019-02-06 | オムニオクス， インコーポレイテッド | Ｈ−ｎｏｘタンパク質の重合体形態 |
| EP3765459A1 (en) * | 2018-03-13 | 2021-01-20 | Shire Human Genetic Therapies, Inc. | Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof |
| CA3148611A1 (en) * | 2019-08-12 | 2021-02-18 | Regeneron Pharmaceuticals, Inc. | Macrophage stimulating 1 receptor (mst1r) variants and uses thereof |
| DK4031547T3 (da) | 2019-09-18 | 2024-09-09 | Takeda Pharmaceuticals Co | Plasmakallikreininhibitorer og anvendelser deraf |
| EP4031245A1 (en) | 2019-09-18 | 2022-07-27 | Takeda Pharmaceutical Company Limited | Heteroaryl plasma kallikrein inhibitors |
| EP4090427A1 (en) | 2020-01-13 | 2022-11-23 | Takeda Pharmaceutical Company Limited | Plasma kallikrein inhibitors and uses thereof for treating pediatric hereditary angioedema attack |
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| EP0332640A1 (en) | 1986-11-17 | 1989-09-20 | California Biotechnology, Inc. | Recombinant alzheimer's amyloid protein |
| US5106833A (en) | 1987-07-23 | 1992-04-21 | Washington University | Coagulation inhibitors |
| US4966852A (en) | 1987-07-23 | 1990-10-30 | Monsanto Company | DNA clone of human tissue factor inhibitor |
| IL87172A (en) | 1987-07-23 | 1994-12-29 | Univ Washington | Method of isolating highly purified tissue factor inhibitor |
| IL87171A (en) | 1987-11-23 | 1995-08-31 | Monsanto Co | cDNA of human tissue factor inhibitor |
| US7078383B2 (en) | 1988-09-02 | 2006-07-18 | Dyax Corp. | ITI-D1 Kunitz domain mutants as HNE inhibitors |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US5378614A (en) | 1989-08-18 | 1995-01-03 | Novo Nordisk A/S | Vector and method for making tissue factor pathway inhibitor (TFPI) analogues in yeast |
| DK408089D0 (da) | 1989-08-18 | 1989-08-18 | Novo Nordisk As | Proteiner |
| IL104314A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Human kunitz-type protease inhibitor and variants thereof,their production and pharmaceutical compositions containing them |
| IL104327A0 (en) | 1992-01-07 | 1993-05-13 | Novo Nordisk As | Variant of human kunitz-type protease inhibitor |
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| US6063764A (en) | 1992-06-01 | 2000-05-16 | Washington University & Chiron Corp. | Method for using lipoprotein associated coagulation inhibitor to treat sepsis |
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| WO1995021601A2 (en) | 1994-01-11 | 1995-08-17 | Protein Engineering Corporation | Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof |
| US5795954A (en) | 1994-03-04 | 1998-08-18 | Genentech, Inc. | Factor VIIa inhibitors from Kunitz domain proteins |
| NZ284766A (en) | 1994-06-02 | 1998-06-26 | Merrell Pharma Inc | Perfluoro amino ketones; medicaments as elastase inhibitors |
| DE69528591T2 (de) | 1994-08-05 | 2003-02-20 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Herstellung des inhibitors fuer die komplexbildung des gewebefaktors |
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| JP3469584B2 (ja) | 1996-03-11 | 2003-11-25 | バイエル コーポレイション | ヒト ビクニン |
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| US6180607B1 (en) | 1999-08-05 | 2001-01-30 | Christopher Davies | Protein having proteinase inhibitor activity |
| US6544760B2 (en) | 1999-12-22 | 2003-04-08 | Zymogenetics, Inc. | Kunitz domain polypeptide Zkun11 |
| US20020102703A1 (en) | 1999-12-29 | 2002-08-01 | Sheppard Paul O. | Kunitz domain polypeptide zkun10 |
| WO2001068707A1 (en) | 2000-03-13 | 2001-09-20 | Eli Lilly And Company | Human hepatocyte growth factor activator inhibitor homologue |
| US20040152633A1 (en) * | 2001-05-31 | 2004-08-05 | Jorgensen Marianne Ulrich | Kunitz-type sequences and polypeptides |
| AU2002353018A1 (en) | 2001-12-03 | 2003-06-17 | Dyax Corporation | Library screening |
| WO2003066824A2 (en) * | 2002-02-07 | 2003-08-14 | Aventis Behring Gmbh | Albumin-fused kunitz domain peptides |
| US7153829B2 (en) | 2002-06-07 | 2006-12-26 | Dyax Corp. | Kallikrein-inhibitor therapies |
| US6989369B2 (en) * | 2003-02-07 | 2006-01-24 | Dyax Corp. | Kunitz domain peptides |
| JP2007528721A (ja) | 2003-08-14 | 2007-10-18 | ダイアックス コーポレイション | エンドセリアーゼ−２リガンド |
| AU2004268144A1 (en) | 2003-08-29 | 2005-03-10 | Dyax Corp. | Modified protease inhibitors |
| US20050089515A1 (en) | 2003-08-29 | 2005-04-28 | Dyax Corp. | Poly-pegylated protease inhibitors |
| US20050164945A1 (en) * | 2003-10-21 | 2005-07-28 | Andrew Nixon | Endotheliase-1 ligands |
| US7235530B2 (en) | 2004-09-27 | 2007-06-26 | Dyax Corporation | Kallikrein inhibitors and anti-thrombolytic agents and uses thereof |
| EP1835926A4 (en) | 2004-11-22 | 2009-04-01 | Dyax Corp | PLASMINE-INHIBITING THERAPIES |
-
2006
- 2006-12-27 PL PL06848187T patent/PL1981519T3/pl unknown
- 2006-12-27 AU AU2006332774A patent/AU2006332774A1/en not_active Abandoned
- 2006-12-27 EP EP06848187.8A patent/EP1981519B1/en active Active
- 2006-12-27 LT LTEP06848187.8T patent/LT1981519T/lt unknown
- 2006-12-27 US US11/646,148 patent/US8828703B2/en active Active
- 2006-12-27 PT PT68481878T patent/PT1981519T/pt unknown
- 2006-12-27 DK DK06848187.8T patent/DK1981519T3/en active
- 2006-12-27 WO PCT/US2006/049322 patent/WO2007079096A2/en not_active Ceased
- 2006-12-27 CA CA2635589A patent/CA2635589C/en active Active
- 2006-12-27 HU HUE06848187A patent/HUE038243T2/hu unknown
- 2006-12-27 ES ES06848187.8T patent/ES2663497T3/es active Active
- 2006-12-27 SI SI200632240T patent/SI1981519T1/en unknown
- 2006-12-27 JP JP2008548690A patent/JP5632126B2/ja active Active
-
2012
- 2012-09-06 JP JP2012196306A patent/JP2012235793A/ja active Pending
-
2018
- 2018-02-09 CY CY20181100165T patent/CY1119967T1/el unknown
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