JP2009520690A5 - - Google Patents
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- Publication number
- JP2009520690A5 JP2009520690A5 JP2008543539A JP2008543539A JP2009520690A5 JP 2009520690 A5 JP2009520690 A5 JP 2009520690A5 JP 2008543539 A JP2008543539 A JP 2008543539A JP 2008543539 A JP2008543539 A JP 2008543539A JP 2009520690 A5 JP2009520690 A5 JP 2009520690A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- dihydroxyphenyl
- phenylcarbonyloxypropyl
- propanoate
- propanoate mesylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74187605P | 2005-12-05 | 2005-12-05 | |
| US60/741,876 | 2005-12-05 | ||
| PCT/US2006/046273 WO2007067495A2 (en) | 2005-12-05 | 2006-12-04 | Levodopa prodrug mesylate, compositions thereof, and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009520690A JP2009520690A (ja) | 2009-05-28 |
| JP2009520690A5 true JP2009520690A5 (https=) | 2010-01-21 |
| JP5153641B2 JP5153641B2 (ja) | 2013-02-27 |
Family
ID=38123406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008543539A Expired - Fee Related JP5153641B2 (ja) | 2005-12-05 | 2006-12-04 | レボドパプロドラッグメシラート、その組成物、およびその使用法 |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US7563821B2 (https=) |
| EP (1) | EP1959948B1 (https=) |
| JP (1) | JP5153641B2 (https=) |
| KR (1) | KR101396639B1 (https=) |
| CN (1) | CN101365439B (https=) |
| AU (1) | AU2006322051B2 (https=) |
| BR (1) | BRPI0619425A2 (https=) |
| CA (1) | CA2631643C (https=) |
| CY (1) | CY1113108T1 (https=) |
| DK (1) | DK1959948T3 (https=) |
| ES (1) | ES2391575T3 (https=) |
| IL (1) | IL191937A (https=) |
| NO (1) | NO20082768L (https=) |
| NZ (1) | NZ569485A (https=) |
| PL (1) | PL1959948T3 (https=) |
| PT (1) | PT1959948E (https=) |
| RU (1) | RU2429223C2 (https=) |
| TW (1) | TWI403493B (https=) |
| WO (1) | WO2007067495A2 (https=) |
| ZA (1) | ZA200805511B (https=) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2365580C2 (ru) * | 2004-06-04 | 2009-08-27 | Ксенопорт, Инк. | Пролекарства леводопа, композиции на их основе и их применения |
| US7323585B2 (en) | 2004-06-04 | 2008-01-29 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| TWI403493B (zh) * | 2005-12-05 | 2013-08-01 | Xenoport Inc | 左旋多巴前藥的甲磺酸鹽,其組成物,及其用途 |
| WO2008034087A2 (en) * | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Treating schizophrenia with combinations of levodopa and an antipsychotic agent |
| US7829592B2 (en) | 2006-12-21 | 2010-11-09 | Xenoport, Inc. | Catechol protected levodopa diester prodrugs, compositions, and methods of use |
| CA2673336A1 (en) * | 2006-12-21 | 2008-06-26 | Xenoport, Inc. | Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use |
| US8802681B2 (en) | 2008-10-17 | 2014-08-12 | Signature Therapeutics, Inc. | Pharmaceutical compositions with attenuated release of phenolic opioids |
| US8399513B2 (en) * | 2008-10-20 | 2013-03-19 | Xenoport, Inc. | Levodopa prodrug mesylate hydrate |
| CN102186804A (zh) * | 2008-10-20 | 2011-09-14 | 克塞诺波特公司 | 合成左旋多巴酯前药的方法 |
| US8784847B2 (en) * | 2009-04-17 | 2014-07-22 | Merz Pharma Gmbh & Co. Kgaa | Synthesis of 1-amino-1,3,3,5,5,-cyclohexane mesylate |
| BR112012005124B1 (pt) | 2009-09-08 | 2021-11-09 | Signature Therapeutics, Inc. | Pro-fármaco de opioide modificado por cetona, seu método de preparação, sua composição farmacêutica, sua unidade de dose, métodos e usos |
| WO2011056240A2 (en) | 2009-11-09 | 2011-05-12 | Xenoport, Inc. | Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use |
| AU2011222856B2 (en) | 2010-03-04 | 2015-10-15 | Orion Corporation | Use of levodopa, carbidopa and entacapone for treating Parkinson's disease |
| US20110262355A1 (en) | 2010-04-21 | 2011-10-27 | Jenkins Thomas E | Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof |
| US20130059914A1 (en) | 2010-04-21 | 2013-03-07 | Signature Therapeutics, Inc. | Compositions Comprising Enzyme-Cleavable Amphetamine Prodrugs and Inhibitors Thereof |
| US9238020B2 (en) | 2010-04-21 | 2016-01-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable phenol-modified tapentadol prodrug |
| US10150792B2 (en) | 2010-11-08 | 2018-12-11 | Synthonics, Inc. | Bismuth-containing compounds, coordination polymers, methods for modulating pharmacokinetic properties of biologically active agents, and methods for treating patients |
| EP2647619B1 (en) | 2010-12-02 | 2015-01-21 | Ono Pharmaceutical Co., Ltd. | Novel compound and medical use thereof |
| ES2584634T3 (es) | 2011-01-11 | 2016-09-28 | Signature Therapeutics, Inc. | Composiciones que comprenden un profármaco de oxicodona escindible enzimáticamente |
| WO2012096886A1 (en) | 2011-01-11 | 2012-07-19 | Signature Therapeutics, Inc. | Compositions comprising enzyme-cleavable oxycodone prodrug |
| AU2012225337B2 (en) | 2011-03-09 | 2016-04-28 | Signature Therapeutics, Inc. | Active agent prodrugs with heterocyclic linkers |
| WO2012122420A2 (en) | 2011-03-09 | 2012-09-13 | Pharmacofore, Inc. | Opioid prodrugs with heterocyclic linkers |
| CA2853251A1 (en) * | 2011-10-24 | 2013-05-02 | Endo Pharmaceuticals Solutions Inc. | Implantable rasagiline compositions and methods of treatment thereof |
| US9575244B2 (en) | 2013-01-04 | 2017-02-21 | Bal Makund Dhar | Light guide apparatus and fabrication method thereof |
| FR3008411B1 (fr) | 2013-07-12 | 2015-07-03 | Servier Lab | Nouveau sel de la 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione, sa preparation, et les formulations qui le contiennent |
| CN103554078B (zh) * | 2013-11-22 | 2016-03-02 | 浙江安赛生物科技有限公司 | 低级醛(c2-c10)丙二醇缩醛的合成方法 |
| RU2743347C2 (ru) | 2014-10-21 | 2021-02-17 | Эббви Инк. | Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона |
| AU2016258179B2 (en) | 2015-05-06 | 2021-07-01 | Synagile Corporation | Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use |
| MY190011A (en) | 2016-04-11 | 2022-03-22 | Univ Canberra | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier |
| HRP20221279T1 (hr) | 2016-07-14 | 2022-12-23 | Crinetics Pharmaceuticals, Inc. | Modulatori somatostatina i njihove uporabe |
| WO2019097120A1 (en) | 2017-11-16 | 2019-05-23 | Orion Corporation | New use and pharmaceutical dosage forms |
| EP3849533A4 (en) | 2018-09-13 | 2022-06-22 | University of Canberra | PROCEDURE FOR INHIBITION |
| CA3107139C (en) * | 2018-09-21 | 2023-01-03 | Kashiv Biosciences, Llc | Extended release compositions comprising trihexyphenidyl |
| CN113015531A (zh) | 2018-11-15 | 2021-06-22 | 艾伯维公司 | 用于皮下施用的药物调配物 |
| EP3999509A4 (en) * | 2019-07-17 | 2023-07-19 | Crinetics Pharmaceuticals, Inc. | Crystalline forms of somatostatin modulators |
| FI4210700T3 (fi) | 2020-09-09 | 2025-09-16 | Crinetics Pharmaceuticals Inc | Somatostatiinimodulaatorin formulaatioita |
| WO2022056360A1 (en) * | 2020-09-11 | 2022-03-17 | Synagile Corporation | Methods for continuous oral drug delivery |
| US12599578B2 (en) | 2021-03-09 | 2026-04-14 | Ensysce Biosciences Inc. | Compositions comprising enzyme-cleavable prodrugs and controlled release nafamostat and methods of use thereof |
| MX2024003466A (es) | 2021-09-29 | 2024-06-04 | Ensysce Biosciences Inc | Profarmacos de metadona escindibles por enzimas y metodos de uso de los mismos. |
| CN116500162A (zh) * | 2023-04-27 | 2023-07-28 | 北京和合医学诊断技术股份有限公司 | 一种同时检测6种药物浓度的液相色谱-质谱分析方法 |
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| US3962414A (en) | 1972-04-27 | 1976-06-08 | Alza Corporation | Structured bioerodible drug delivery device |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3811444A (en) | 1972-12-27 | 1974-05-21 | Alza Corp | Bioerodible ocular device |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| DE2336218C3 (de) | 1973-07-17 | 1985-11-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Orale Arzneiform |
| US3983138A (en) | 1973-09-25 | 1976-09-28 | Merck & Co., Inc. | Amino acid esters |
| US4038411A (en) | 1973-09-25 | 1977-07-26 | Merck & Co., Inc. | Antihypertensive amino acid esters |
| US3992518A (en) | 1974-10-24 | 1976-11-16 | G. D. Searle & Co. | Method for making a microsealed delivery device |
| US4093709A (en) | 1975-01-28 | 1978-06-06 | Alza Corporation | Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates) |
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| US4066747A (en) | 1976-04-08 | 1978-01-03 | Alza Corporation | Polymeric orthoesters housing beneficial drug for controlled release therefrom |
| US4070347A (en) | 1976-08-16 | 1978-01-24 | Alza Corporation | Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality |
| FR2365341A1 (fr) | 1976-09-28 | 1978-04-21 | Synthelabo | Derives de l'acide l-(phenyl-3 amino-2 propionyloxy)-2 acetique |
| US4180509A (en) * | 1977-07-01 | 1979-12-25 | Merrell Toraude Et Compagnie | α-Ethynyl tryptophanes |
| US4311706A (en) | 1980-01-22 | 1982-01-19 | Interx Research Corporation | Novel dopa/dopamine prodrugs |
| JPS5824547A (ja) | 1981-08-06 | 1983-02-14 | Nippon Zoki Pharmaceut Co Ltd | 新規アミノ酸誘導体 |
| US4914222A (en) | 1983-08-29 | 1990-04-03 | Merck & Co., Inc. | Crystalline salts of L or (S)-3-(3,4-dihydroxyphenyl)-2-methylalanine esters and process |
| LU85757A1 (fr) | 1985-02-04 | 1986-09-02 | Univ Catholique Louvain | Derives nouveaux de la l-dopa,procedes pour leur preparation et compositions pharmaceutiques concernant de tels composes |
| US4663349A (en) | 1985-12-30 | 1987-05-05 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
| US4771073A (en) | 1985-12-30 | 1988-09-13 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
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| JPS62258347A (ja) * | 1986-05-02 | 1987-11-10 | Banyu Pharmaceut Co Ltd | 無水結晶形態のl−スレオ−3−(3,4−ジヒドロキシフエニル)−n−メチルセリン |
| ES2042520T3 (es) | 1986-06-10 | 1993-12-16 | Chiesi Farma Spa | Composiciones farmaceuticas que contienen el ester metilico de levodopa, preparacion y aplicaciones terapeuticas del mismo. |
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| DK406686D0 (da) | 1986-08-26 | 1986-08-26 | Hans Bundgaard | Carboxylsyrederivater |
| US5283352A (en) * | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
| JPH02138A (ja) | 1987-09-18 | 1990-01-05 | Banyu Pharmaceut Co Ltd | L‐ドーパ誘導体 |
| US5133974A (en) * | 1989-05-05 | 1992-07-28 | Kv Pharmaceutical Company | Extended release pharmaceutical formulations |
| DE3930696A1 (de) | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| US5190763A (en) * | 1990-05-07 | 1993-03-02 | Alza Corporation | Dosage form indicated for the management of abnormal posture, tremor and involuntary movement |
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| IL159812A0 (en) | 2001-07-12 | 2004-06-20 | Teva Pharma | Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester in a controlled release core |
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| US20030158254A1 (en) | 2002-01-24 | 2003-08-21 | Xenoport, Inc. | Engineering absorption of therapeutic compounds via colonic transporters |
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| US7323585B2 (en) * | 2004-06-04 | 2008-01-29 | Xenoport, Inc. | Levodopa prodrugs, and compositions and uses thereof |
| RU2365580C2 (ru) * | 2004-06-04 | 2009-08-27 | Ксенопорт, Инк. | Пролекарства леводопа, композиции на их основе и их применения |
| DE102005022276A1 (de) | 2005-05-13 | 2006-11-16 | Ellneuroxx Ltd. | Derivate von Dihydroxyphenylalanin |
| TWI403493B (zh) * | 2005-12-05 | 2013-08-01 | Xenoport Inc | 左旋多巴前藥的甲磺酸鹽,其組成物,及其用途 |
| US9603941B2 (en) | 2006-01-24 | 2017-03-28 | Minghui Chai | Method of preparing dendritic drugs |
| WO2008034087A2 (en) | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Treating schizophrenia with combinations of levodopa and an antipsychotic agent |
| CA2673336A1 (en) * | 2006-12-21 | 2008-06-26 | Xenoport, Inc. | Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use |
| US7829592B2 (en) | 2006-12-21 | 2010-11-09 | Xenoport, Inc. | Catechol protected levodopa diester prodrugs, compositions, and methods of use |
| CN102186804A (zh) * | 2008-10-20 | 2011-09-14 | 克塞诺波特公司 | 合成左旋多巴酯前药的方法 |
| US8399513B2 (en) * | 2008-10-20 | 2013-03-19 | Xenoport, Inc. | Levodopa prodrug mesylate hydrate |
| WO2011056240A2 (en) * | 2009-11-09 | 2011-05-12 | Xenoport, Inc. | Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use |
-
2006
- 2006-12-04 TW TW095144993A patent/TWI403493B/zh not_active IP Right Cessation
- 2006-12-04 ZA ZA200805511A patent/ZA200805511B/xx unknown
- 2006-12-04 EP EP06844799A patent/EP1959948B1/en not_active Not-in-force
- 2006-12-04 KR KR1020087016252A patent/KR101396639B1/ko not_active Expired - Fee Related
- 2006-12-04 US US11/634,354 patent/US7563821B2/en not_active Expired - Fee Related
- 2006-12-04 RU RU2008127312/04A patent/RU2429223C2/ru not_active IP Right Cessation
- 2006-12-04 CA CA2631643A patent/CA2631643C/en not_active Expired - Fee Related
- 2006-12-04 BR BRPI0619425-7A patent/BRPI0619425A2/pt not_active IP Right Cessation
- 2006-12-04 PL PL06844799T patent/PL1959948T3/pl unknown
- 2006-12-04 JP JP2008543539A patent/JP5153641B2/ja not_active Expired - Fee Related
- 2006-12-04 CN CN200680045534XA patent/CN101365439B/zh not_active Expired - Fee Related
- 2006-12-04 ES ES06844799T patent/ES2391575T3/es active Active
- 2006-12-04 NZ NZ569485A patent/NZ569485A/en not_active IP Right Cessation
- 2006-12-04 PT PT06844799T patent/PT1959948E/pt unknown
- 2006-12-04 DK DK06844799.4T patent/DK1959948T3/da active
- 2006-12-04 WO PCT/US2006/046273 patent/WO2007067495A2/en not_active Ceased
- 2006-12-04 AU AU2006322051A patent/AU2006322051B2/en not_active Ceased
-
2008
- 2008-06-04 IL IL191937A patent/IL191937A/en not_active IP Right Cessation
- 2008-06-16 NO NO20082768A patent/NO20082768L/no not_active Application Discontinuation
- 2008-12-31 US US12/347,807 patent/US7968597B2/en not_active Expired - Fee Related
-
2009
- 2009-06-22 US US12/489,146 patent/US7893105B2/en not_active Expired - Fee Related
-
2011
- 2011-01-20 US US13/010,419 patent/US8193242B2/en not_active Expired - Fee Related
-
2012
- 2012-05-16 US US13/473,503 patent/US20120296109A1/en not_active Abandoned
- 2012-09-12 CY CY20121100822T patent/CY1113108T1/el unknown
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