JP2009520040A5 - - Google Patents

Download PDF

Info

Publication number
JP2009520040A5
JP2009520040A5 JP2008547735A JP2008547735A JP2009520040A5 JP 2009520040 A5 JP2009520040 A5 JP 2009520040A5 JP 2008547735 A JP2008547735 A JP 2008547735A JP 2008547735 A JP2008547735 A JP 2008547735A JP 2009520040 A5 JP2009520040 A5 JP 2009520040A5
Authority
JP
Japan
Prior art keywords
composition
hydrophobic
carrier
group
molecule
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2008547735A
Other languages
English (en)
Japanese (ja)
Other versions
JP2009520040A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/062328 external-priority patent/WO2007076371A2/en
Publication of JP2009520040A publication Critical patent/JP2009520040A/ja
Publication of JP2009520040A5 publication Critical patent/JP2009520040A5/ja
Pending legal-status Critical Current

Links

JP2008547735A 2005-12-19 2006-12-19 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法 Pending JP2009520040A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81362905P 2005-12-19 2005-12-19
PCT/US2006/062328 WO2007076371A2 (en) 2005-12-19 2006-12-19 Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013094413A Division JP6148062B2 (ja) 2005-12-19 2013-04-26 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法

Publications (2)

Publication Number Publication Date
JP2009520040A JP2009520040A (ja) 2009-05-21
JP2009520040A5 true JP2009520040A5 (enExample) 2013-06-20

Family

ID=38218806

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2008547735A Pending JP2009520040A (ja) 2005-12-19 2006-12-19 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
JP2013094413A Active JP6148062B2 (ja) 2005-12-19 2013-04-26 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
JP2014082502A Withdrawn JP2014132036A (ja) 2005-12-19 2014-04-14 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
JP2016020812A Withdrawn JP2016074744A (ja) 2005-12-19 2016-02-05 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2013094413A Active JP6148062B2 (ja) 2005-12-19 2013-04-26 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
JP2014082502A Withdrawn JP2014132036A (ja) 2005-12-19 2014-04-14 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
JP2016020812A Withdrawn JP2016074744A (ja) 2005-12-19 2016-02-05 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法

Country Status (8)

Country Link
US (3) US20070141145A1 (enExample)
EP (2) EP1971372B1 (enExample)
JP (4) JP2009520040A (enExample)
KR (3) KR101529318B1 (enExample)
CN (1) CN101365490B (enExample)
AU (1) AU2006330610B2 (enExample)
CA (1) CA2633070C (enExample)
WO (1) WO2007076371A2 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7635463B2 (en) 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
CA2476589C (en) * 2002-02-27 2014-02-25 Pharmain, Ltd. Compositions for delivery of therapeutics and other materials, and methods of making and using the same
WO2005112977A2 (en) * 2004-04-23 2005-12-01 Pharmain, Ltd. Compositions for treatment with glucagon-like peptide, and methods of making and using the same
US9492400B2 (en) 2004-11-04 2016-11-15 Massachusetts Institute Of Technology Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals
WO2007070682A2 (en) 2005-12-15 2007-06-21 Massachusetts Institute Of Technology System for screening particles
EP1971372B1 (en) 2005-12-19 2018-11-14 PharmaIN Corporation Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
EP2019691B1 (en) 2006-05-15 2020-08-12 Massachusetts Institute of Technology Polymers for functional particles
US9381477B2 (en) 2006-06-23 2016-07-05 Massachusetts Institute Of Technology Microfluidic synthesis of organic nanoparticles
EP2124895A2 (en) * 2006-12-22 2009-12-02 Imuthes Limited Lipids and their use as non-viral delivery vehicle
EP2134830A2 (en) 2007-02-09 2009-12-23 Massachusetts Institute of Technology Oscillating cell culture bioreactor
WO2008124632A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Amphiphilic compound assisted nanoparticles for targeted delivery
US20080312134A1 (en) * 2007-06-11 2008-12-18 Thomas Hirt Vesicles for active macromolecule delivery
CN101795695B (zh) * 2007-07-19 2016-01-06 阿列克斯塞尔公司 作为抗癌剂的自组装的两亲性聚合物
US7960336B2 (en) 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
EP2197454A4 (en) * 2007-09-25 2012-07-04 Idexx Lab Inc PHARMACEUTICAL COMPOSITIONS FOR THE ADMINISTRATION OF OLIGONUCLEOTIDES
CA2917512C (en) 2007-10-12 2025-08-05 President And Fellows Of Harvard College VACCINE NANOTECHNOLOGY
US20090176892A1 (en) 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same
WO2009114520A2 (en) * 2008-03-10 2009-09-17 Pharmain Corporation Compositions for treatment with metallopeptidases, methods of making and using the same
JP2011522224A (ja) * 2008-04-21 2011-07-28 メルク・シャープ・エンド・ドーム・コーポレイション 膵ベータ細胞質量生物マーカー
KR101078302B1 (ko) * 2008-05-29 2011-10-31 (주)프로넥스 약물전달체
WO2010028217A1 (en) * 2008-09-05 2010-03-11 The Board Of Trustees Of The University Of Illinois Poly(ethylene glycol) methyl ether carbodiimide coupling reagents for the biological and chemical functionalization of water soluble nanoparticles
US8343498B2 (en) 2008-10-12 2013-01-01 Massachusetts Institute Of Technology Adjuvant incorporation in immunonanotherapeutics
US8277812B2 (en) 2008-10-12 2012-10-02 Massachusetts Institute Of Technology Immunonanotherapeutics that provide IgG humoral response without T-cell antigen
US8591905B2 (en) 2008-10-12 2013-11-26 The Brigham And Women's Hospital, Inc. Nicotine immunonanotherapeutics
US8343497B2 (en) 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
CN105396139A (zh) 2009-09-09 2016-03-16 药明公司 用于递送治疗剂的阴离子核心组合物以及制备和使用所述组合物的方法
US20110135704A1 (en) * 2009-12-08 2011-06-09 Shipp John I Infection Control for Surgical and Trauma Patients
CN101829338A (zh) * 2010-04-23 2010-09-15 武汉理工大学 基于巯嘌呤类药物的新型两亲性大分子前药及其制备方法
KR102229478B1 (ko) 2012-11-01 2021-03-18 인피니티 파마슈티칼스, 인코포레이티드 Pi3 키나아제 동형단백질 조절인자를 사용하는 암의 치료
ES2731678T3 (es) * 2013-07-31 2019-11-18 Pharnext Herramientas de diagnóstico para la enfermedad de Alzheimer
US20160303242A1 (en) 2013-12-09 2016-10-20 Durect Corporation Pharmaceutically Active Agent Complexes, Polymer Complexes, and Compositions and Methods Involving the Same
KR101665176B1 (ko) * 2014-04-24 2016-10-13 영남대학교 산학협력단 성장촉진용 약학조성물
CN107106658B (zh) * 2014-10-27 2021-07-09 久光制药株式会社 含有基因重组型卵泡刺激激素的微针装置
US10035885B2 (en) 2014-11-03 2018-07-31 Pharmain Corporation Method of production of graft co-polymer excipient with a superior peptide and protein binding property
WO2016210098A1 (en) 2015-06-24 2016-12-29 Board Of Regents, The University Of Texas System Dual assembly nanoparticles
EP3334435A4 (en) 2015-08-14 2019-08-07 Synedgen, Inc. POLYMERS AND THEIR METHODS OF USE
WO2018045077A1 (en) * 2016-08-30 2018-03-08 Particle Sciences, Inc. Formulations comprising heterocyclic ring systems and uses thereof
CN106620677B (zh) * 2017-02-06 2020-05-08 北京大学第一医院 一种基于高分子载体的尿激酶制剂及其制备方法
JP7196850B2 (ja) * 2017-09-05 2022-12-27 味の素株式会社 ポリリジン誘導体
PL3505157T3 (pl) 2017-12-29 2022-04-11 Celon Pharma S.A. Kompozycja ketaminy w postaci suchego proszku do podawania dopłucnego w leczeniu depresji opornej na leczenie
KR20190127277A (ko) * 2018-05-04 2019-11-13 주식회사 삼양바이오팜 mRNA 전달용 고분자 나노입자 조성물 및 그 제조방법
US20210308075A1 (en) * 2020-04-07 2021-10-07 Joseph Habboushe Prevention and treatment of virial infections
CN111467499A (zh) * 2020-04-18 2020-07-31 中山市君泽科技有限公司 一种石墨烯负载联合治疗癌症方法
WO2021242644A1 (en) * 2020-05-24 2021-12-02 Zhaoyang Li Composition and methods of retinoic acid
JP2023530272A (ja) * 2020-06-12 2023-07-14 ファーマイン コーポレイション 急性肺障害の治療におけるｃ型ナトリウム利尿ペプチド及びその方法
CN116437929B (zh) 2020-07-02 2025-11-11 普渡研究基金会 抗微生物化合物的吸入制剂
CN112358492B (zh) * 2020-11-13 2022-04-15 兰州大学 碳硼烷基塞来昔布及其制备和在头颈癌硼中子俘获治疗药物中的应用
CN112402625B (zh) * 2020-11-19 2022-12-09 健进制药有限公司 负载光敏剂的peg化肝素纳米胶束及其制备方法
CN112618481B (zh) * 2021-02-22 2021-11-09 山东第一医科大学附属省立医院(山东省立医院) 一种改性水凝胶、改性水凝胶微球及其制备方法和应用
CN113444250B (zh) * 2021-06-18 2022-10-25 绍兴文理学院附属医院 一种含有聚谷氨酸基团的聚甘油脂肪酸酯衍生物及其合成方法和其在药物制剂中的应用
US12128063B2 (en) 2021-10-05 2024-10-29 International Business Machines Corporation Biocompatible and biodegradable antiviral polymers
CN114042148B (zh) * 2022-01-13 2022-04-15 浙江湃肽生物有限公司深圳分公司 一种盐酸依特卡肽稳定剂

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118666A (en) * 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US6849708B1 (en) * 1986-05-05 2005-02-01 The General Hospital Corporation Insulinotropic hormone and uses thereof
US5120712A (en) * 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5614492A (en) * 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
US7138486B2 (en) * 1986-05-05 2006-11-21 The General Hospital Corporation Insulinotropic hormone derivatives and uses thereof
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US4857311A (en) 1987-07-31 1989-08-15 Massachusetts Institute Of Technology Polyanhydrides with improved hydrolytic degradation properties
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
US5116603A (en) * 1989-01-31 1992-05-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Oral antifungal preventative, and method of use
US5744166A (en) * 1989-02-25 1998-04-28 Danbiosyst Uk Limited Drug delivery compositions
US5554388A (en) * 1989-02-25 1996-09-10 Danbiosyst Uk Limited Systemic drug delivery compositions comprising a polycationi substance
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
CA2121129A1 (en) * 1991-10-29 1993-05-13 Patrick Soon-Shiong Crosslinkable polysaccharides, polycations and lipids useful for encapsulation and drug release
US5770563A (en) * 1991-12-06 1998-06-23 The United States Of America As Represented By The Department Of Health And Human Services Heparin- and sulfatide binding peptides from the type I repeats of human thrombospondin and conjugates thereof
DE69333434T2 (de) * 1992-04-03 2005-03-03 The Regents Of The University Of California, Oakland Selbstorganisierendes system zur verabreichung von polynukleotiden enthaltend ein amphiphatisches peptid
US6113946A (en) * 1992-04-03 2000-09-05 The Regents Of The University Of California Self-assembling polynucleotide delivery system comprising dendrimer polycations
WO1994005203A1 (en) * 1992-09-04 1994-03-17 The General Hospital Corporation Biocompatible polymers containing diagnostic or therapeutic moieties
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
US5395619A (en) * 1993-03-03 1995-03-07 Liposome Technology, Inc. Lipid-polymer conjugates and liposomes
US6284727B1 (en) * 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5763585A (en) * 1993-10-13 1998-06-09 Anergen, Inc. Method of making MHC-peptide complexes using metal chelate affinity chromatography
ATE277640T1 (de) * 1994-03-07 2004-10-15 Dow Chemical Co Bioaktive und/oder gezielte dendrimere-konjugate enthaltend genetisches material
US5466467A (en) 1994-03-30 1995-11-14 The United States Of America As Represented By The Secretary Of The Navy Liposomes containing polymerized lipids for non-covalent immobilization of proteins and enzymes
GB9409496D0 (en) * 1994-05-12 1994-06-29 London Health Ass Method for improving glycaemic control in diabetes
US20010006943A1 (en) 1994-12-23 2001-07-05 Ejvind Jensen Protracted GLP-1 compositions
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
CA2224253A1 (en) * 1995-06-09 1996-12-27 Martin J. Macphee Chitin hydrogels, methods of their production and use
US5942253A (en) 1995-10-12 1999-08-24 Immunex Corporation Prolonged release of GM-CSF
AU730969B2 (en) 1995-10-19 2001-03-22 University Of Washington Discrete-length polyethylene glycols
US5683387A (en) * 1996-01-29 1997-11-04 Garito; Jon C. Electrosurgical electrode for skin grafting
US5977163A (en) 1996-03-12 1999-11-02 Pg-Txl Company, L. P. Water soluble paclitaxel prodrugs
US6254854B1 (en) 1996-05-24 2001-07-03 The Penn Research Foundation Porous particles for deep lung delivery
US7235627B2 (en) 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6006753A (en) * 1996-08-30 1999-12-28 Eli Lilly And Company Use of GLP-1 or analogs to abolish catabolic changes after surgery
US6277819B1 (en) 1996-08-30 2001-08-21 Eli Lilly And Company Use of GLP-1 or analogs in treatment of myocardial infarction
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
US6458373B1 (en) * 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
TR200001021T2 (tr) 1997-07-18 2000-09-21 Infimed Inc. Aktif maddelerin kontrollü salınması için biyo aşındırılabilir makromerler.
US6468532B1 (en) 1998-01-22 2002-10-22 Genentech, Inc. Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
US6703359B1 (en) * 1998-02-13 2004-03-09 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and GLP-1
US6998387B1 (en) 1998-03-19 2006-02-14 Amylin Pharmaceuticals, Inc. Human appetite control by glucagon-like peptide receptor binding compounds
GB9811059D0 (en) * 1998-05-23 1998-07-22 Univ Strathclyde Polyamino acid vesicles
US6509323B1 (en) 1998-07-01 2003-01-21 California Institute Of Technology Linear cyclodextrin copolymers
JP4624558B2 (ja) 1998-08-10 2011-02-02 ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ， アズ レプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ ＧＬＰ−１またはＥｘｅｎｄｉｎ−４による、非インスリン産生細胞のインスリン産生細胞への分化、およびその使用
IL140892A0 (en) * 1998-08-12 2002-02-10 Yissum Res Dev Co Liposomal bupivacaine compositions prepared using an ammonium sulfate gradient
US6284725B1 (en) * 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
JP2002534363A (ja) * 1999-01-08 2002-10-15 エミスフェアー・テクノロジーズ・インク ポリマー性デリバリー剤及びデリバリー剤化合物
US6365173B1 (en) * 1999-01-14 2002-04-02 Efrat Biopolymers Ltd. Stereocomplex polymeric carriers for drug delivery
JP4812167B2 (ja) * 1999-02-12 2011-11-09 モレキュラー インサイト ファーマスーティカルズ インコーポレイテッド 薬物輸送用マトリックス、ならびにその作成方法および使用方法
US6569832B1 (en) 1999-11-12 2003-05-27 Novo Nordisk A/S Inhibition of beta cell degeneration
JP2003526671A (ja) * 2000-03-14 2003-09-09 レストラゲン，インコーポレイテッド 幽門洞−十二指腸運動性に対するグルカゴン様ペプチド‐１（７−３６）の作用
US6998137B2 (en) * 2000-04-07 2006-02-14 Macromed, Inc. Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix
US6589549B2 (en) * 2000-04-27 2003-07-08 Macromed, Incorporated Bioactive agent delivering system comprised of microparticles within a biodegradable to improve release profiles
CN103356996A (zh) * 2000-05-19 2013-10-23 埃米林药品公司 Glp-1用于制备治疗急性冠脉综合征的药物的用途
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
JP5610659B2 (ja) 2000-07-21 2014-10-22 ルバンス セラピュティックス インク．Ｒｅｖａｎｃｅ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 多成分生物学的輸送システム
US20040092432A1 (en) * 2000-08-24 2004-05-13 Thomas Jefferson University Peptide compositions with effects on cerebral health
US6521736B2 (en) 2000-09-15 2003-02-18 University Of Massachusetts Amphiphilic polymeric materials
WO2002034285A2 (en) * 2000-10-20 2002-05-02 Coolidge Thomas R Treatment of hibernating myocardium and diabetic cardiomyopathy with a glp-1 peptide
EP2186824A3 (en) * 2000-12-13 2010-09-22 Eli Lilly & Company Chronic treatment regimen using glucagon-like insulinotropic peptides
US7199217B2 (en) * 2000-12-13 2007-04-03 Eli Lilly And Company Amidated glucagon-like peptide-1
JP4775985B2 (ja) * 2000-12-27 2011-09-21 三井化学株式会社 重合体及びその製造方法
ES2315350T3 (es) * 2001-01-12 2009-04-01 Waratah Pharmaceuticals Inc. Composiciones para la introduccion de la neogenesis de islotes, que contienen unos ligandos para el receptor de gastrina/cck y ligandos para el receptor de efg.
JP2005506956A (ja) * 2001-06-01 2005-03-10 イーライ・リリー・アンド・カンパニー 長時間作用性ｇｌｐ−１製剤
US20030119734A1 (en) 2001-06-28 2003-06-26 Flink James M. Stable formulation of modified GLP-1
US6586524B2 (en) * 2001-07-19 2003-07-01 Expression Genetics, Inc. Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier
CA2458371A1 (en) * 2001-08-23 2003-03-06 Eli Lilly And Company Glucagon-like peptide-1 analogs
CA2462543A1 (en) 2001-10-01 2003-04-10 Eli Lilly And Company Glucagon-like peptides (glp-1) and treatment of respiratory distress
US7041646B2 (en) 2001-10-05 2006-05-09 Bayer Pharmaceuticals Corporation Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists
IL161446A0 (en) 2001-11-26 2004-09-27 Daiichi Suntory Pharma Co Ltd Medicinal compositions for nasal absorption
CN1332711C (zh) 2002-02-20 2007-08-22 埃米球科技有限公司 施用glp－1分子的方法
CA2476589C (en) * 2002-02-27 2014-02-25 Pharmain, Ltd. Compositions for delivery of therapeutics and other materials, and methods of making and using the same
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
US7649023B2 (en) * 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
ES2327328T3 (es) 2002-07-04 2009-10-28 Zealand Pharma A/S Glp-1 y procedimientos para el tratamiento de la diabetes.
WO2004014451A1 (en) * 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
JP2006501820A (ja) 2002-09-06 2006-01-19 バイエル・フアーマシユーチカルズ・コーポレーシヨン 修飾ｇｌｐ−１受容体アゴニストおよびそれらの薬理学的使用法
GB0221941D0 (en) 2002-09-20 2002-10-30 Univ Strathclyde Polysoaps
US7648962B2 (en) * 2002-11-26 2010-01-19 Biocon Limited Natriuretic compounds, conjugates, and uses thereof
US20040209803A1 (en) 2002-12-19 2004-10-21 Alain Baron Compositions for the treatment and prevention of nephropathy
US7790681B2 (en) 2002-12-17 2010-09-07 Amylin Pharmaceuticals, Inc. Treatment of cardiac arrhythmias with GLP-1 receptor ligands
BRPI0408925A (pt) 2003-03-31 2006-04-04 Alza Corp veìculos de fase simples não-aquosos e formulações utilizando tais veìculos
ES2425221T3 (es) 2003-05-30 2013-10-14 Amylin Pharmaceuticals, Llc Nuevos métodos y composiciones para suministro por vía transmucosa potenciado de péptidos y proteínas
JP4936884B2 (ja) 2003-06-03 2012-05-23 ノボ・ノルデイスク・エー／エス 安定化された薬学的ペプチド組成物
CN1812808B (zh) 2003-06-03 2012-07-04 诺沃挪第克公司 稳定化的药物肽组合物
US20060247167A1 (en) 2003-09-01 2006-11-02 Novo Nordisk A/S Stable formulations of peptides
CA2550695A1 (en) 2003-12-16 2005-06-30 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Glp-1 pharmaceutical compositions
WO2005062854A2 (en) 2003-12-19 2005-07-14 University Of Cincinnati Polyamides for nucleic acid delivery
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
US20050143303A1 (en) 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
SG150570A1 (en) 2004-03-03 2009-03-30 Revance Therapeutics Inc Compositions and methods for topical diagnostic and therapeutic transport
FR2867679B1 (fr) 2004-03-17 2008-08-22 Oreal Composition cosmetiques comprenant des polyamines modifiees et utilisations desdites compositions.
BRPI0510093B8 (pt) 2004-04-20 2022-12-27 Dendritic Nanotechnologies Inc polímeros dendríticos
US7985424B2 (en) 2004-04-20 2011-07-26 Dendritic Nanotechnologies Inc. Dendritic polymers with enhanced amplification and interior functionality
WO2005112977A2 (en) * 2004-04-23 2005-12-01 Pharmain, Ltd. Compositions for treatment with glucagon-like peptide, and methods of making and using the same
US20060134166A1 (en) 2004-05-25 2006-06-22 Luthra Ajay K Absorbable biocompatible materials
AU2005326322B2 (en) * 2004-07-01 2009-02-05 Yale University Targeted and high density drug loaded polymeric materials
WO2006014425A1 (en) 2004-07-02 2006-02-09 Biovalve Technologies, Inc. Methods and devices for delivering glp-1 and uses thereof
CN103223160B (zh) 2004-07-19 2015-02-18 比奥孔有限公司 胰岛素-低聚物共轭物,制剂及其用途
US20060233857A1 (en) * 2005-04-14 2006-10-19 Amsden Brian G Degradable elastomeric network
US20090202497A1 (en) 2005-08-23 2009-08-13 The General Hospital Corporation Use of glp-1, glp-1 derivatives or glp-1 fragments for skin regeneration, stimulation of hair growth, or treatment of diabetes
US20100041612A1 (en) 2005-09-08 2010-02-18 Martin Beinborn Fragments of the Glucagon-Like Peptide-1 and Uses Thereof
CN101277726B (zh) 2005-10-05 2012-05-30 Sca卫生用品公司 含亲水区和疏水区的吸收性制品
CA2626865C (en) 2005-10-25 2014-12-30 Starpharma Pty Limited Macromolecular compounds having controlled stoichiometry
HUE029798T2 (en) 2005-11-04 2017-03-28 Glaxosmithkline Llc Methods of administering hypoglycemic agents
EP1971372B1 (en) 2005-12-19 2018-11-14 PharmaIN Corporation Hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
CN101420962A (zh) 2006-01-20 2009-04-29 星药股份有限公司 经修饰的大分子
US7960336B2 (en) * 2007-08-03 2011-06-14 Pharmain Corporation Composition for long-acting peptide analogs
US8563527B2 (en) * 2007-08-20 2013-10-22 Pharmain Corporation Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same
US20090176892A1 (en) * 2008-01-09 2009-07-09 Pharmain Corporation Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same

Similar Documents

Publication Publication Date Title
JP6148062B2 (ja) 治療薬の送達のための疎水性コアの担体組成物、及び同担体組成物の作製法及び使用法
JP7714087B2 (ja) 増加したｎｅｐ安定性を有する徐放ｃｎｐ作動薬
JP7692454B2 (ja) 大型のキャリアー部分を有するｃｎｐプロドラッグ
JP7816947B2 (ja) 環部分にキャリア結合を有するｃｎｐプロドラッグ
US7589169B2 (en) Compositions for treatment with glucagon-like peptide, and methods of making and using the same
KR102611820B1 (ko) 낮은 피크 대 트로프 비를 가진 pth 화합물
EP2240165B1 (en) Soluble hydrophobic core carrier compositions for delivery of therapeutic agents, methods of making and using the same
CA3007987C (en) Controlled-release cnp agonists with low npr-c binding
CN101511380A (zh) 用于持续释放递送肽的药物组合物
CN101111268A (zh) 多肽和五糖的偶联物
EP4710947A2 (en) Controlled-release cnp agonists with reduced side-effects
US20190071483A1 (en) Antibody peptide conjugates that have agonist activity at both the glucagon and glucagon-like peptide 1 receptors
JPH1192405A (ja) 薬物複合体
JP2025535128A (ja) カーゴ及びインテレクチン１に結合する標的化部分を含む複合体
HK1262548A1 (en) Cnp prodrugs with carrier attachment at the ring moiety
HK1262548B (en) Cnp prodrugs with carrier attachment at the ring moiety