JP2009519326A5 - - Google Patents
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- Publication number
- JP2009519326A5 JP2009519326A5 JP2008545503A JP2008545503A JP2009519326A5 JP 2009519326 A5 JP2009519326 A5 JP 2009519326A5 JP 2008545503 A JP2008545503 A JP 2008545503A JP 2008545503 A JP2008545503 A JP 2008545503A JP 2009519326 A5 JP2009519326 A5 JP 2009519326A5
- Authority
- JP
- Japan
- Prior art keywords
- solid dispersion
- produced
- same manner
- molten solid
- except
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007962 solid dispersion Substances 0.000 description 12
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000007939 sustained release tablet Substances 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 238000007922 dissolution test Methods 0.000 description 4
- 239000012729 immediate-release (IR) formulation Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000008108 microcrystalline cellulose Substances 0.000 description 2
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 2
- 229940016286 microcrystalline cellulose Drugs 0.000 description 2
- 239000000811 xylitol Substances 0.000 description 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 2
- 229960002675 xylitol Drugs 0.000 description 2
- 235000010447 xylitol Nutrition 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 229920002785 Croscarmellose sodium Polymers 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229940024545 aluminum hydroxide Drugs 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 229940009868 aluminum magnesium silicate Drugs 0.000 description 1
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
- HEFNNWSXXWATRW-JTQLQIEISA-N dexibuprofen Chemical compound CC(C)CC1=CC=C([C@H](C)C(O)=O)C=C1 HEFNNWSXXWATRW-JTQLQIEISA-N 0.000 description 1
- 229960003428 dexibuprofen Drugs 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000011978 dissolution method Methods 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000007970 homogeneous dispersion Substances 0.000 description 1
- 229910001701 hydrotalcite Inorganic materials 0.000 description 1
- 229960001545 hydrotalcite Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- -1 hydroxypropyl Chemical group 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20050124386 | 2005-12-16 | ||
| PCT/KR2006/005526 WO2007069874A1 (en) | 2005-12-16 | 2006-12-18 | Solid dispersion comprising an active ingredient having a low melting point and tablet for oral administration comprising same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009519326A JP2009519326A (ja) | 2009-05-14 |
| JP2009519326A5 true JP2009519326A5 (https=) | 2012-03-01 |
Family
ID=38163142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008545503A Pending JP2009519326A (ja) | 2005-12-16 | 2006-12-18 | 低融点の活性成分を含む溶融状の固体分散体、及びこれを含む経口投与用錠剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20080292702A1 (https=) |
| EP (1) | EP1968542B1 (https=) |
| JP (1) | JP2009519326A (https=) |
| CN (1) | CN101330904B (https=) |
| AU (1) | AU2006325658B2 (https=) |
| BR (1) | BRPI0619868A8 (https=) |
| CA (1) | CA2633266C (https=) |
| ES (1) | ES2429097T3 (https=) |
| IL (1) | IL191804A0 (https=) |
| NO (1) | NO339674B1 (https=) |
| NZ (1) | NZ569813A (https=) |
| RU (1) | RU2403013C2 (https=) |
| WO (1) | WO2007069874A1 (https=) |
| ZA (1) | ZA200806138B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060119971A (ko) | 2003-09-11 | 2006-11-24 | 제노포트 인코포레이티드 | Ｇａｂａ 유사체의 전구약물을 이용한 요실금의 치료및/또는 예방 |
| KR101005391B1 (ko) * | 2008-07-22 | 2010-12-30 | 한국콜마 주식회사 | 덱시부프로펜 함유 서방출성 시럽제 및 그의 제조방법 |
| KR101067224B1 (ko) * | 2008-07-22 | 2011-09-22 | 한국콜마 주식회사 | 이부프로펜 함유 서방출성 시럽제 및 그의 제조방법 |
| CN101961306B (zh) * | 2009-07-24 | 2011-11-09 | 北京化工大学 | 一种低熔点药物固体分散体的制备方法 |
| CN102144982B (zh) * | 2011-03-30 | 2012-12-12 | 江苏神龙药业有限公司 | 一种米诺膦酸片及其制备方法 |
| CN102406940B (zh) * | 2011-11-01 | 2013-07-03 | 温州大学 | 一种纳米级片状羧甲基淀粉钠在固体分散体中的应用 |
| WO2013154511A1 (en) * | 2012-04-13 | 2013-10-17 | Mahmut Bilgic | Film tablet formulations comprising dexibuprofen |
| UY36046A (es) | 2014-03-26 | 2015-10-30 | Millennium Pharm Inc | Formulaciones farmacéuticas, procesos para la preparación y métodos de uso |
| JP6647902B2 (ja) * | 2015-10-30 | 2020-02-14 | 株式会社ファンケル | 徐放性顆粒剤 |
| CN106265522A (zh) * | 2016-08-30 | 2017-01-04 | 铜陵翔宇商贸有限公司 | 布洛芬‑pvp共沉淀物及其制备方法 |
| JP7109255B2 (ja) * | 2017-05-23 | 2022-07-29 | ライオン株式会社 | 粉砕物の製造方法及び錠剤の製造方法 |
| JP7147262B2 (ja) * | 2017-05-23 | 2022-10-05 | 大正製薬株式会社 | 固形製剤 |
| US10792249B2 (en) * | 2017-07-24 | 2020-10-06 | Acryspharm Llc | High drug loading pharmaceutical compositions |
| RU2685294C1 (ru) * | 2018-05-10 | 2019-04-17 | Общество с ограниченной ответственностью "ДИНОН" (ООО "ДИНОН") | Поглотитель, способ его приготовления (варианты) и способ удаления диоксида углерода из газовых смесей |
| CN112263567B (zh) * | 2020-10-19 | 2022-05-03 | 南京易亨制药有限公司 | 一种布洛芬缓释胶囊及制备方法 |
| CN117363320B (zh) * | 2023-12-07 | 2024-02-13 | 黑龙江省鑫博鑫交通科技有限公司 | 一种公路用融雪剂及其制备方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56120616A (en) * | 1980-02-27 | 1981-09-22 | Kaken Pharmaceut Co Ltd | Ibuprofen-containing granule, its preparation, and internal medicine comprising it |
| GB8601204D0 (en) * | 1986-01-18 | 1986-02-19 | Boots Co Plc | Therapeutic agents |
| CH669523A5 (https=) * | 1986-06-25 | 1989-03-31 | Mepha Ag | |
| US4806359A (en) * | 1987-04-22 | 1989-02-21 | Mcneilab, Inc. | Iburprofen sustained release matrix and process |
| DE19509807A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Verfahren zur Herstellung von Wirkstoffzubereitungen in Form einer festen Lösung des Wirkstoffs in einer Polymermatrix sowie mit diesem Verfahren hergestellte Wirkstoffzubereitungen |
| IE80467B1 (en) * | 1995-07-03 | 1998-07-29 | Elan Corp Plc | Controlled release formulations for poorly soluble drugs |
| US6391338B1 (en) * | 1995-09-07 | 2002-05-21 | Biovail Technologies Ltd. | System for rendering substantially non-dissoluble bio-affecting agents bio-available |
| DE19536394A1 (de) * | 1995-09-29 | 1997-04-03 | Basf Ag | Feste Arzneiformen, erhältlich durch Extrusion einer Isomalt enthaltenden Polymer-Wirkstoff-Schmelze |
| MX9801835A (es) * | 1996-07-08 | 1998-08-30 | Mendell Co Inc Edward | Matriz de liberacion sostenida para medicamentos insolubles de dosis altas. |
| US6787157B1 (en) * | 1998-03-10 | 2004-09-07 | Abbott Laboratories | Multiphase active ingredient-containing formulations |
| US6183779B1 (en) * | 1999-03-22 | 2001-02-06 | Pharmascience Inc. | Stabilized pharmaceutical composition of a nonsteroidal anti-inflammatory agent and a prostaglandin |
| US8124124B2 (en) * | 1999-12-09 | 2012-02-28 | Reckitt Benckiser Healthcare (Uk) Limited | Compressed tablet formulation comprising non-steroidal anti-inflammatory drugs and methods |
| GB0113839D0 (en) * | 2001-06-07 | 2001-08-01 | Boots Co Plc | Therapeutic agents |
-
2006
- 2006-12-18 ZA ZA200806138A patent/ZA200806138B/xx unknown
- 2006-12-18 CA CA2633266A patent/CA2633266C/en not_active Expired - Fee Related
- 2006-12-18 US US12/097,299 patent/US20080292702A1/en not_active Abandoned
- 2006-12-18 NZ NZ569813A patent/NZ569813A/en not_active IP Right Cessation
- 2006-12-18 AU AU2006325658A patent/AU2006325658B2/en not_active Ceased
- 2006-12-18 WO PCT/KR2006/005526 patent/WO2007069874A1/en not_active Ceased
- 2006-12-18 EP EP06824193.4A patent/EP1968542B1/en not_active Not-in-force
- 2006-12-18 BR BRPI0619868A patent/BRPI0619868A8/pt not_active IP Right Cessation
- 2006-12-18 JP JP2008545503A patent/JP2009519326A/ja active Pending
- 2006-12-18 RU RU2008129041/15A patent/RU2403013C2/ru not_active IP Right Cessation
- 2006-12-18 CN CN2006800474904A patent/CN101330904B/zh not_active Expired - Fee Related
- 2006-12-18 ES ES06824193T patent/ES2429097T3/es active Active
-
2008
- 2008-05-29 IL IL191804A patent/IL191804A0/en unknown
- 2008-07-15 NO NO20083151A patent/NO339674B1/no not_active IP Right Cessation
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