JP2009515558A5 - - Google Patents
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- Publication number
- JP2009515558A5 JP2009515558A5 JP2008541461A JP2008541461A JP2009515558A5 JP 2009515558 A5 JP2009515558 A5 JP 2009515558A5 JP 2008541461 A JP2008541461 A JP 2008541461A JP 2008541461 A JP2008541461 A JP 2008541461A JP 2009515558 A5 JP2009515558 A5 JP 2009515558A5
- Authority
- JP
- Japan
- Prior art keywords
- extracellular matrix
- progenitor cells
- liver
- hepatic progenitor
- stem cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000000130 stem cell Anatomy 0.000 claims 15
- 238000000034 method Methods 0.000 claims 14
- 230000002440 hepatic effect Effects 0.000 claims 10
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 claims 8
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 claims 8
- 210000002744 extracellular matrix Anatomy 0.000 claims 8
- 210000004185 liver Anatomy 0.000 claims 6
- 102000016611 Proteoglycans Human genes 0.000 claims 5
- 108010067787 Proteoglycans Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- 102000001187 Collagen Type III Human genes 0.000 claims 3
- 108010069502 Collagen Type III Proteins 0.000 claims 3
- 238000012258 culturing Methods 0.000 claims 3
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims 2
- 229920001287 Chondroitin sulfate Polymers 0.000 claims 2
- 102000004266 Collagen Type IV Human genes 0.000 claims 2
- 108010042086 Collagen Type IV Proteins 0.000 claims 2
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 2
- 229920002971 Heparan sulfate Polymers 0.000 claims 2
- 102000007547 Laminin Human genes 0.000 claims 2
- 108010085895 Laminin Proteins 0.000 claims 2
- 229940059329 chondroitin sulfate Drugs 0.000 claims 2
- 229920002674 hyaluronan Polymers 0.000 claims 2
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 2
- 229940099552 hyaluronan Drugs 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 229920000045 Dermatan sulfate Polymers 0.000 claims 1
- 102000016942 Elastin Human genes 0.000 claims 1
- 108010014258 Elastin Proteins 0.000 claims 1
- 102000016359 Fibronectins Human genes 0.000 claims 1
- 108010067306 Fibronectins Proteins 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims 1
- 229940051593 dermatan sulfate Drugs 0.000 claims 1
- 229920002549 elastin Polymers 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 210000003566 hemangioblast Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 239000002198 insoluble material Substances 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 239000012679 serum free medium Substances 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73687305P | 2005-11-16 | 2005-11-16 | |
| PCT/US2006/060904 WO2007059501A2 (en) | 2005-11-16 | 2006-11-15 | Extracellular matrix components for expansion or differentiation of hepatic progenitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009515558A JP2009515558A (ja) | 2009-04-16 |
| JP2009515558A5 true JP2009515558A5 (enExample) | 2010-01-07 |
Family
ID=38049393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008541461A Withdrawn JP2009515558A (ja) | 2005-11-16 | 2006-11-15 | 肝前駆細胞の増殖又は分化用細胞外マトリックス成分 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20070155009A1 (enExample) |
| EP (1) | EP1954804A4 (enExample) |
| JP (1) | JP2009515558A (enExample) |
| KR (1) | KR20080097985A (enExample) |
| CN (1) | CN101384705A (enExample) |
| AU (1) | AU2006315163A1 (enExample) |
| BR (1) | BRPI0618724A2 (enExample) |
| CA (1) | CA2630355A1 (enExample) |
| CR (1) | CR10073A (enExample) |
| IL (1) | IL191533A0 (enExample) |
| RU (1) | RU2008124158A (enExample) |
| TW (1) | TW200730627A (enExample) |
| WO (1) | WO2007059501A2 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020045260A1 (en) * | 2000-10-17 | 2002-04-18 | Shih-Chieh Hung | Method of isolating mesenchymal stem cells |
| US8084023B2 (en) | 2007-01-22 | 2011-12-27 | The Board Of Trustees Of The University Of Arkansas | Maintenance and propagation of mesenchymal stem cells |
| CN101855340A (zh) * | 2007-03-06 | 2010-10-06 | 北卡罗来纳大学查珀尔希尔分校 | 用于细胞维持、扩增和/或分化的透明质酸、其他基质成分、激素和生长因子的复合物 |
| TW200916581A (en) * | 2007-06-15 | 2009-04-16 | Univ North Carolina | Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same |
| CA2693481A1 (en) * | 2007-07-20 | 2009-01-29 | Cellartis Ab | A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts derived stem cells |
| WO2009072990A1 (en) * | 2007-12-06 | 2009-06-11 | Agency For Science, Technology And Research | Method for extracellular matrix mediated differentiation and proliferation of stem cells |
| US8877497B2 (en) * | 2008-05-22 | 2014-11-04 | Vesta Therapeutics Inc. | Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells |
| US8298584B2 (en) * | 2008-12-30 | 2012-10-30 | Collagen Matrix, Inc. | Biopolymeric membrane for wound protection and repair |
| US20100227393A1 (en) * | 2009-03-06 | 2010-09-09 | Eric Lagasse | Liver stem cells: isolation of hepatic progenitor cells from the human gall bladder |
| ES2819028T3 (es) * | 2009-10-30 | 2021-04-14 | Univ North Carolina Chapel Hill | Células madre multipotentes del árbol biliar extrahepático y métodos para su aislamiento |
| WO2011077894A1 (ja) * | 2009-12-25 | 2011-06-30 | Ｓｃｉｖａｘ株式会社 | スフェロイド形成促進方法およびスフェロイド形成促進培地 |
| WO2011102532A1 (ja) * | 2010-02-16 | 2011-08-25 | 国立大学法人九州大学 | 誘導肝細胞 |
| TW201202424A (en) * | 2010-05-07 | 2012-01-16 | Univ North Carolina | Method of engrafting cells from solid tissues |
| AU2011299327B2 (en) * | 2010-09-07 | 2015-07-16 | The Board Of Regents Of The University Of Texas System | Tissue-specific differentiation matrices and uses thereof |
| US9938502B2 (en) | 2010-11-10 | 2018-04-10 | Wake Forest University Health Sciences | Tissue-specific extracellular matrix with or without tissue protein components for cell culture |
| BR112015010256A2 (pt) * | 2012-11-08 | 2017-07-11 | Arthrodynamic Tech Animal Health Division Inc | meio para cultivar, preservar e administrar células regenerativas |
| US9533013B2 (en) | 2013-03-13 | 2017-01-03 | University Of North Carolina At Chapel Hill | Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree |
| US20160046904A1 (en) * | 2013-04-08 | 2016-02-18 | National Institutes Of Biomedical Innovation, Health And Nutrition | Method For Culturing Hepatoblast-Like Cells And Culture Product Thereof |
| CN106559994A (zh) * | 2014-07-16 | 2017-04-05 | 国立大学法人大阪大学 | 层粘连蛋白片段的细胞培养基质活性增强方法 |
| US10683484B2 (en) * | 2015-06-12 | 2020-06-16 | National University Of Singapore | Derivation of hepatic stem cells and mature liver cell types and uses thereof |
| JP6605618B2 (ja) * | 2015-11-10 | 2019-11-20 | 日機装株式会社 | 細胞支持複合体および細胞支持複合体の製造方法 |
| JP6755085B2 (ja) * | 2015-11-10 | 2020-09-16 | 日機装株式会社 | 細胞支持複合体および細胞支持複合体の製造方法 |
| RU2618989C1 (ru) * | 2016-03-09 | 2017-05-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ лечения печеночной недостаточности |
| US20170369849A1 (en) * | 2016-05-11 | 2017-12-28 | The University Of North Carolina At Chapel Hill | Compositions and methods for bioengineered tissues |
| KR101895669B1 (ko) * | 2016-06-22 | 2018-09-05 | 한국과학기술원 | 접착성 헤파린과 콜라겐을 이용한 줄기세포의 배양방법 |
| GB2569463A (en) | 2016-07-18 | 2019-06-19 | Harvard College | Human lymphoid tissue-on-chip |
| CN106434532A (zh) * | 2016-12-22 | 2017-02-22 | 叶宗耀 | 一种培养肝细胞的培养基及其制备方法 |
| US11559603B2 (en) * | 2016-12-28 | 2023-01-24 | Koken Co., Ltd. | High-strength collagen sponge |
| CN115948331B (zh) * | 2022-10-17 | 2024-10-22 | 中国人民解放军西部战区总医院 | 一种从小鼠胆囊中分离获取间充质干细胞的方法 |
| WO2025244838A1 (en) * | 2024-05-21 | 2025-11-27 | Corning Incorporated | Improved collagen coatings |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2115140A1 (en) * | 1991-08-07 | 1993-02-18 | Lola M. Reid | Proliferation of hepatocyte precursors |
| US6069005A (en) * | 1991-08-07 | 2000-05-30 | Albert Einstein College Of Medicine Of Yeshwa University | Hapatoblasts and method of isolating same |
| DE4222345A1 (de) * | 1992-07-08 | 1994-01-13 | Augustinus Dr Med Bader | Verfahren zum Züchten einer Zellart im Kokulturverfahren mit Leberzellen |
| CA2877233A1 (en) | 1999-01-19 | 2000-07-27 | Lola M. Reid | Human liver progenitors |
| US20020187133A1 (en) * | 1999-10-01 | 2002-12-12 | Hiroshi Kubota | Methods of isolating bipotent hepatic progenitor cells |
| US7456017B2 (en) * | 1999-10-01 | 2008-11-25 | University Of North Carolina At Chapel Hill | Processes for clonal growth of hepatic progenitor cells |
| HUE032238T2 (en) * | 2002-03-15 | 2017-09-28 | Univ North Carolina Chapel Hill | Primitive and proximal liver stem cells |
| CN101855340A (zh) * | 2007-03-06 | 2010-10-06 | 北卡罗来纳大学查珀尔希尔分校 | 用于细胞维持、扩增和/或分化的透明质酸、其他基质成分、激素和生长因子的复合物 |
-
2006
- 2006-11-15 RU RU2008124158/13A patent/RU2008124158A/ru not_active Application Discontinuation
- 2006-11-15 WO PCT/US2006/060904 patent/WO2007059501A2/en not_active Ceased
- 2006-11-15 CA CA002630355A patent/CA2630355A1/en not_active Abandoned
- 2006-11-15 CN CNA2006800509212A patent/CN101384705A/zh active Pending
- 2006-11-15 BR BRPI0618724-2A patent/BRPI0618724A2/pt not_active IP Right Cessation
- 2006-11-15 EP EP06839887A patent/EP1954804A4/en not_active Withdrawn
- 2006-11-15 JP JP2008541461A patent/JP2009515558A/ja not_active Withdrawn
- 2006-11-15 AU AU2006315163A patent/AU2006315163A1/en not_active Abandoned
- 2006-11-15 KR KR1020087014599A patent/KR20080097985A/ko not_active Withdrawn
- 2006-11-15 US US11/560,049 patent/US20070155009A1/en not_active Abandoned
- 2006-11-16 TW TW095142412A patent/TW200730627A/zh unknown
-
2008
- 2008-05-18 IL IL191533A patent/IL191533A0/en unknown
- 2008-06-16 CR CR10073A patent/CR10073A/es not_active Application Discontinuation
-
2009
- 2009-10-02 US US12/572,711 patent/US20100093077A1/en not_active Abandoned
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